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  1. Article: Editorial for 'Lower Urinary Tract Symptoms: Clinical and Translational Science'.

    Birder, Lori A

    International neurourology journal

    2024  Volume 28, Issue Suppl 1, Page(s) 1

    Language English
    Publishing date 2024-02-29
    Publishing country Korea (South)
    Document type Editorial
    ZDB-ID 2584447-7
    ISSN 2093-6931 ; 2093-4777
    ISSN (online) 2093-6931
    ISSN 2093-4777
    DOI 10.5213/inj.2424edi01
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Re: EV-301 Long-term Outcomes: 24-month Findings from the Phase III Trial of Enfortumab Vedotin Versus Chemotherapy in Patients with Previously Treated Advanced Urothelial Carcinoma.

    Drake, Marcus J / Birder, Lori A

    European urology

    2024  

    Language English
    Publishing date 2024-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2024.03.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 294: Show issues

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  3. Article: Commentary on "Cognitive Function and Urologic Medications for Lower Urinary Tract Symptoms".

    Birder, Lori

    International neurourology journal

    2020  Volume 24, Issue 3, Page(s) 295

    Language English
    Publishing date 2020-09-30
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2584447-7
    ISSN 2093-6931 ; 2093-4777
    ISSN (online) 2093-6931
    ISSN 2093-4777
    DOI 10.5213/inj.2040286.143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Is there a role for oxidative stress and mitochondrial dysfunction in age-associated bladder disorders?

    Birder, Lori A

    Ci ji yi xue za zhi = Tzu-chi medical journal

    2020  Volume 32, Issue 3, Page(s) 223–226

    Abstract: Millions of individuals worldwide are affected by age-related lower urinary tract symptoms (LUTSs), including impaired detrusor contractility, detrusor overactivity, decreased bladder sensation, as well as increased bladder capacity often resulting in ... ...

    Abstract Millions of individuals worldwide are affected by age-related lower urinary tract symptoms (LUTSs), including impaired detrusor contractility, detrusor overactivity, decreased bladder sensation, as well as increased bladder capacity often resulting in incomplete bladder emptying. Yet, the underlying factors that contribute to these symptoms are not known and there are few therapies to treat these disorders. Because of the complex pathophysiology, a number of animal models have been studied over the years to better understand mechanisms underlying patient symptoms. Such animal models can aid in the investigation of aspects of age-associated LUTSs that cannot be pursued in humans as well as to develop and test potential therapies. In addition, the search for urinary factors that may be a causative agent has resulted in the discovery of a number of potential targets that could serve as predictive biomarkers which can aid in early diagnosis and treatment of these chronic disorders. Recent evidence has supported a role for chronic changes in mitochondrial function and oxidative stress (along with production of reactive oxygen species) and abnormal urodynamic behavior in older patients. This review discusses new insights into how aging alters fundamental cellular processes that impair signaling in the bladder wall, resulting in abnormal voiding function.
    Language English
    Publishing date 2020-01-03
    Publishing country China (Republic : 1949- )
    Document type Journal Article ; Review
    ZDB-ID 2452925-4
    ISSN 1016-3190
    ISSN 1016-3190
    DOI 10.4103/tcmj.tcmj_250_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Purine nucleoside phosphorylase as a target to treat age-associated lower urinary tract dysfunction.

    Birder, Lori A / Jackson, Edwin K

    Nature reviews. Urology

    2022  Volume 19, Issue 11, Page(s) 681–687

    Abstract: The lower urinary tract (LUT), including the bladder, urethra and external striated muscle, becomes dysfunctional with age; consequently, many older individuals suffer from lower urinary tract disorders (LUTDs). By compromising urine storage and voiding, ...

    Abstract The lower urinary tract (LUT), including the bladder, urethra and external striated muscle, becomes dysfunctional with age; consequently, many older individuals suffer from lower urinary tract disorders (LUTDs). By compromising urine storage and voiding, LUTDs degrade quality of life for millions of individuals worldwide. Treatments for LUTDs have been disappointing, frustrating both patients and their physicians; however, emerging evidence suggests that partial inhibition of the enzyme purine nucleoside phosphorylase (PNPase) with 8-aminoguanine (an endogenous PNPase inhibitor that moderately reduces PNPase activity) reverses age-associated defects in the LUT and restores the LUT to that of a younger state. Thus, 8-aminoguanine improves LUT biochemistry, structure and function by rebalancing the LUT purine metabolome, making 8-aminoguanine a novel potential treatment for LUTDs.
    MeSH term(s) Humans ; Purine-Nucleoside Phosphorylase ; Urinary Bladder/metabolism ; Quality of Life ; Urination/physiology ; Urethra/metabolism ; Urologic Diseases ; Urinary Tract/metabolism
    Chemical Substances Purine-Nucleoside Phosphorylase (EC 2.4.2.1)
    Language English
    Publishing date 2022-09-07
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2493737-X
    ISSN 1759-4820 ; 1759-4812
    ISSN (online) 1759-4820
    ISSN 1759-4812
    DOI 10.1038/s41585-022-00642-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6030: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Re: PIEZO2 in Sensory Neurons and Urothelial Cells Coordinate Urination.

    Michel, Martin C / Birder, Lori A

    European urology

    2021  Volume 80, Issue 2, Page(s) 255–256

    MeSH term(s) Cell Count ; Sensory Receptor Cells ; Urination
    Language English
    Publishing date 2021-04-17
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2021.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    Zs.MO 294: Show issues

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  7. Article ; Online: Pathophysiology of interstitial cystitis.

    Birder, Lori A

    International journal of urology : official journal of the Japanese Urological Association

    2019  Volume 26 Suppl 1, Page(s) 12–15

    Abstract: Interstitial cystitis/bladder pain syndrome is a chronic pain syndrome whose causes remains elusive with no generally accepted treatment. A hallmark of functional pain syndromes such as interstitial cystitis/bladder pain syndrome is pain in the absence ... ...

    Abstract Interstitial cystitis/bladder pain syndrome is a chronic pain syndrome whose causes remains elusive with no generally accepted treatment. A hallmark of functional pain syndromes such as interstitial cystitis/bladder pain syndrome is pain in the absence of demonstrable pathology of the viscera or associated nerves. Patients with chronic pain experience a greater impairment in quality of life than healthy controls. In addition, interstitial cystitis/bladder pain syndrome symptoms can frequently overlap with other conditions including irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, anxiety disorders, and a number of other syndromes not directly related to the urinary bladder. Because of the complex pathophysiology, a number of animal models have been studied over the years to better understand mechanisms underlying patient symptoms. These models can include: bladder centric, complex mechanisms and psychological and physical stress models. Such animal models can aid in the investigation of aspects of interstitial cystitis/bladder pain syndrome that cannot be pursued in humans as well as to develop and test potential therapies. In addition, the search for urinary factors that may be a cause of interstitial cystitis/bladder pain syndrome has resulted in the discovery of a number of potential targets that could serve as predictive biomarkers which can aid in early diagnosis and treatment of this chronic disorder.
    MeSH term(s) Animals ; Biomarkers ; Chronic Disease ; Comorbidity ; Cystitis, Interstitial/physiopathology ; Disease Models, Animal ; Humans ; Irritable Bowel Syndrome/physiopathology ; Pelvic Pain/physiopathology ; Quality of Life ; Urinary Bladder/physiopathology
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-05-30
    Publishing country Australia
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1328401-0
    ISSN 1442-2042 ; 0919-8172
    ISSN (online) 1442-2042
    ISSN 0919-8172
    DOI 10.1111/iju.13985
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4460: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 278: Show issues

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  8. Article ; Online: Pathophysiology, clinical presentation, and management of ketamine-induced cystitis.

    Jhang, Jia-Fong / Birder, Lori A / Kuo, Hann-Chorng

    Tzu chi medical journal

    2023  Volume 35, Issue 3, Page(s) 205–212

    Abstract: Ketamine is illegally used as a recreational drug in many Asian countries. Long-term ketamine abusers often develop irritable bladder symptoms that gradually develop into more severe urinary frequency and urgency and eventually into a painful ulcerated ... ...

    Abstract Ketamine is illegally used as a recreational drug in many Asian countries. Long-term ketamine abusers often develop irritable bladder symptoms that gradually develop into more severe urinary frequency and urgency and eventually into a painful ulcerated bladder. These patients typically have reduced functional bladder capacity, increased bladder sensation, detrusor overactivity, severe urgency, urinary incontinence, and bladder contracture. Ketamine metabolites can cause severe inflammation of the urothelium, urothelial barrier deficits, vascular endothelial fibrinoid changes, increased oxidative stress, and bladder wall fibrosis. A decrease in bladder compliance, urinary tract infection, severe bladder pain with a full bladder, and painful micturition are also common symptoms. Finally, with continued abuse of ketamine, hydronephrosis, ureteral stricture, vesicoureteral reflux, and renal failure may develop. Cessation of ketamine is the mainstay of treatment. Lower urinary tract symptoms usually relapse if patients reuse ketamine after stopping. In cases of severe ketamine cystitis, only augmentation enterocystoplasty can relieve bladder pain and restore normal lower urinary tract function. This article reviews the underlying pathophysiology, clinical characteristics, and management of ketamine cystitis.
    Language English
    Publishing date 2023-06-13
    Publishing country India
    Document type Journal Article
    ZDB-ID 2452925-4
    ISSN 2223-8956 ; 2223-8956
    ISSN (online) 2223-8956
    ISSN 2223-8956
    DOI 10.4103/tcmj.tcmj_94_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Urothelial Layers: Not All Created Equal.

    Birder, Lori

    The Journal of urology

    2016  Volume 195, Issue 3, Page(s) 544–545

    MeSH term(s) Animals ; Mitomycin/pharmacokinetics ; Ureter/metabolism ; Urinary Bladder/metabolism ; Urothelium/metabolism
    Chemical Substances Mitomycin (50SG953SK6)
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1016/j.juro.2015.12.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui VI Zs.91: Show issues Location:
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    Zs.MO 331: Show issues

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  10. Article: Dysregulated Purine Metabolism Contributes to Age-Associated Lower Urinary Tract Dysfunctions.

    Birder, Lori A / Jackson, Edwin K

    Advances in geriatric medicine and research

    2021  Volume 3, Issue 4

    Abstract: Lower urinary tract (LUT) dysfunction is common in the older adult. Aging is associated with a number of both storage and voiding problems which are classified into syndromes with overlapping symptoms. Despite the prevalence and consequences of these ... ...

    Abstract Lower urinary tract (LUT) dysfunction is common in the older adult. Aging is associated with a number of both storage and voiding problems which are classified into syndromes with overlapping symptoms. Despite the prevalence and consequences of these syndromes, LUT disorders continue to be undertreated as few therapeutic options exist. Here, we propose that dysregulated metabolism of purine nucleotides results in an accumulation of uro-damaging hypoxanthine (a source of reactive oxygen species or ROS), which provides a mechanism for defects in sensory signaling and contractility, culminating in abnormal urodynamic behavior.
    Language English
    Publishing date 2021-09-29
    Publishing country England
    Document type Journal Article
    DOI 10.20900/agmr20210018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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