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Article ; Online: Identification of chemical constituents in traditional Chinese medicine formula using HPLC coupled with linear ion trap-Orbitrap MS from high doses of medicinal materials to equivalent doses of formula: Study on Xiang-Sha-Liu-Jun-Zi-Jia-Jian granules.

Wang, Fengyun / Zhang, Qingqing / Lu, Zhiwei / Wang, Qing / Wang, Meiling / Liu, Yuehong / Fu, Shuang / Gao, Xiaoyan / Tang, Xudong

Journal of separation science

2016 Volume 39, Issue 9, Page(s) 1619–1627

Abstract: ... of constituents in Xiang-Sha-Liu-Jun-Zi-Jia-Jian granules was described. 169 compounds were unambiguously or ... for comprehensive identification of constituents of Xiang-Sha-Liu-Jun-Zi-Jia-Jian granules extracts and reveal ...

Abstract	High-resolution mass spectrometry has been a powerful tool for the research of chemical constituents in traditional Chinese medicine (TCM) formulas. However, the chromatographic peaks were difficult to discriminate clearly in data collection or analysis because of the complexity and the greatly different content of the constituents in TCM formula, which increased the difficulty of identification. In this study, a high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometry based strategy focused on the comprehensive identification of TCM formula constituents was developed. Identification was carried out from a high dose of medicinal materials to equivalent dose of formula. Meanwhile, combined with mass spectrometry data, chromatographic behaviors, reference standards and previous reports, the identification of constituents in Xiang-Sha-Liu-Jun-Zi-Jia-Jian granules was described. 169 compounds were unambiguously or tentatively characterized, mainly including flavonoids, alkaloids, triterpenic acids, triterpene saponins, lactones, sesquiterpenoids and some other compounds. Among them, 11 compounds were unambiguously confirmed by comparing with reference standards. These results demonstrated that the method was effective and reliable for comprehensive identification of constituents of Xiang-Sha-Liu-Jun-Zi-Jia-Jian granules extracts and reveal the material basis of its therapeutic effects. This strategy might propose a research idea for the characterization of multi-constituents in TCM formula.
Language	English
Publishing date	2016-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.201501223
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Jia-Jian-Di-Huang-Yin-Zi decoction exerts neuroprotective effects on dopaminergic neurons and their microenvironment.

Zhang, Jingsi / Zhang, Zhennian / Zhang, Wen / Li, Xiangting / Wu, Ting / Li, Tingting / Cai, Min / Yu, Zhonghai / Xiang, Jun / Cai, Dingfang

Scientific reports

2018 Volume 8, Issue 1, Page(s) 9886

Abstract: As a classical prescription of Traditional Chinese medicine, the Jia-Jian-Di-Huang-Yin-Zi (JJDHYZ ...

Abstract	As a classical prescription of Traditional Chinese medicine, the Jia-Jian-Di-Huang-Yin-Zi (JJDHYZ) decoction has long been used to treat movement disorders. The present study evaluated the effects of JJDHYZ on dopaminergic (DA) neurons and their survival-enhancing microenvironment as well as the possible mechanisms involved using a mouse model of Parkinson's disease. In MPTP-lesioned mice, a high dosage of JJDHYZ (34 g/kg/day) attenuated the loss of DA neurons, reversed the dopamine depletion, and improved the expression of glial-derived neurotrophic factor (GDNF) compared to the untreated model group. JJDHYZ also protected the ultrastructure of the blood-brain barrier (BBB) and tight junction proteins by inhibiting the activation of microglia and astrocytes besides the increase in three types of matrix metalloproteinases in the substantia nigra. In conclusion, the JJDHYZ-high dosage (JJDHYZ-H) group exhibited the neuroprotection of DA neurons, and the underlying mechanism may be related to the survival-enhancing microenvironment of the DA neurons.
MeSH term(s)	Animals ; Antioxidants/metabolism ; Astrocytes/cytology ; Astrocytes/drug effects ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/ultrastructure ; Cellular Microenvironment/drug effects ; Chemokine CCL2/metabolism ; Chemokine CCL4/metabolism ; Claudin-5/metabolism ; Dopaminergic Neurons/cytology ; Dopaminergic Neurons/drug effects ; Dopaminergic Neurons/metabolism ; Drugs, Chinese Herbal/pharmacology ; Gene Expression Regulation/drug effects ; Glial Cell Line-Derived Neurotrophic Factor/metabolism ; Interleukin-23/metabolism ; Matrix Metalloproteinases/metabolism ; Mice ; Microglia/cytology ; Microglia/drug effects ; Microvessels/drug effects ; Neuroprotective Agents/pharmacology ; Occludin/metabolism ; Permeability/drug effects
Chemical Substances	Antioxidants ; Chemokine CCL2 ; Chemokine CCL4 ; Claudin-5 ; Drugs, Chinese Herbal ; Glial Cell Line-Derived Neurotrophic Factor ; Interleukin-23 ; Neuroprotective Agents ; Occludin ; di huang yin zi ; Matrix Metalloproteinases (EC 3.4.24.-)
Language	English
Publishing date	2018-06-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-018-27852-w
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Jia-Jian-Di-Huang-Yin-Zi decoction reduces apoptosis induced by both mitochondrial and endoplasmic reticulum caspase12 pathways in the mouse model of Parkinson's disease.

Zhang, Jingsi / Zhang, Zhennian / Bao, Jie / Yu, Zhonghai / Cai, Min / Li, Xiangting / Wu, Ting / Xiang, Jun / Cai, Dingfang

Journal of ethnopharmacology

2017 Volume 203, Page(s) 69–79

Abstract: ... Jia-Jian-Di-Huang-Yin-Zi decoction (JJDHYZ) has been used to treat the symptoms of neurological ...

Abstract	Ethnopharmacological relevance: As a classical prescription of traditional Chinese medicine (TCM), Jia-Jian-Di-Huang-Yin-Zi decoction (JJDHYZ) has been used to treat the symptoms of neurological disorders with a long history. Aim of the study: To evaluate the effects and possible mechanisms of JJDHYZ on a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced subacute mouse model of Parkinson's disease. Materials and methods: Adult male C57BL/6 mice were randomly divided into five groups: control, MPTP, JJDHYZ low dosage (JJDHYZ-L, 8.5g/kg/day), medium dosage (JJDHYZ-M, 17g/kg/day) and high dosage (JJDHYZ-H, 34g/kg/day). Behavioral tests, immunohistochemistry, immunofluorescence, and high-performance liquid chromatography (HPLC) were conducted to evaluate the neuroprotective effects of JJDHYZ. The mechanism was further explored using TdT-mediated dUTP nick end labeling staining and transmission electron microscopy. The protein expression of Bax, Bcl-2, cytochrome c, full-length caspase9, cleaved caspase9, cleaved caspase3, caspase12 and C/EBP homologous protein was assessed. The toxicity on hepatocytes and renal cells was detected using the enzyme-linked immunosorbent assay kits. Results: JJDHYZ-H restored the behavior performance impaired by MPTP, and reduced the loss of tyrosine hydroxylase. Additionally, it blocked the apoptosis, activated cleaved caspase3 and protected the ultrastructural integrity of mitochondria by regulating the expression of proteins in both mitochondrial and endoplasmic reticulum (ER) caspase12 pathways. Conclusions: JJDHYZ-H showed behavior recovery and dopamine neuron protection by inhibiting the apoptotic activities associated with mitochondrial and ER caspase12 pathways.
Language	English
Publishing date	2017-05-05
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2016.12.053
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Jia-Jian-Di-Huang-Yin-Zi decoction exerts neuroprotective effects on dopaminergic neurons and their microenvironment

Jingsi Zhang / Zhennian Zhang / Wen Zhang / Xiangting Li / Ting Wu / Tingting Li / Min Cai / Zhonghai Yu / Jun Xiang / Dingfang Cai

Scientific Reports, Vol 8, Iss 1, Pp 1-

2018 Volume 13

Abstract: Abstract As a classical prescription of Traditional Chinese medicine, the Jia-Jian-Di-Huang-Yin-Zi ...

Abstract	Abstract As a classical prescription of Traditional Chinese medicine, the Jia-Jian-Di-Huang-Yin-Zi (JJDHYZ) decoction has long been used to treat movement disorders. The present study evaluated the effects of JJDHYZ on dopaminergic (DA) neurons and their survival-enhancing microenvironment as well as the possible mechanisms involved using a mouse model of Parkinson’s disease. In MPTP-lesioned mice, a high dosage of JJDHYZ (34 g/kg/day) attenuated the loss of DA neurons, reversed the dopamine depletion, and improved the expression of glial-derived neurotrophic factor (GDNF) compared to the untreated model group. JJDHYZ also protected the ultrastructure of the blood-brain barrier (BBB) and tight junction proteins by inhibiting the activation of microglia and astrocytes besides the increase in three types of matrix metalloproteinases in the substantia nigra. In conclusion, the JJDHYZ-high dosage (JJDHYZ-H) group exhibited the neuroprotection of DA neurons, and the underlying mechanism may be related to the survival-enhancing microenvironment of the DA neurons.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2018-06-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Jia-Jian-Di-Huang-Yin-Zi decoction reduces apoptosis induced by both mitochondrial and endoplasmic reticulum caspase12 pathways in the mouse model of Parkinson’s disease

Zhang, Jingsi / Dingfang Cai / Jie Bao / Jun Xiang / Min Cai / Ting Wu / Xiangting Li / Zhennian Zhang / Zhonghai Yu

Journal of ethnopharmacology. 2017 May 05, v. 203

2017

Abstract: As a classical prescription of traditional Chinese medicine (TCM), Jia-Jian-Di-Huang-Yin-Zi ...

Abstract	As a classical prescription of traditional Chinese medicine (TCM), Jia-Jian-Di-Huang-Yin-Zi decoction (JJDHYZ) has been used to treat the symptoms of neurological disorders with a long history.To evaluate the effects and possible mechanisms of JJDHYZ on a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced subacute mouse model of Parkinson’s disease.Adult male C57BL/6 mice were randomly divided into five groups: control, MPTP, JJDHYZ low dosage (JJDHYZ-L, 8.5g/kg/day), medium dosage (JJDHYZ-M, 17g/kg/day) and high dosage (JJDHYZ-H, 34g/kg/day). Behavioral tests, immunohistochemistry, immunofluorescence, and high-performance liquid chromatography (HPLC) were conducted to evaluate the neuroprotective effects of JJDHYZ. The mechanism was further explored using TdT-mediated dUTP nick end labeling staining and transmission electron microscopy. The protein expression of Bax, Bcl-2, cytochrome c, full-length caspase9, cleaved caspase9, cleaved caspase3, caspase12 and C/EBP homologous protein was assessed. The toxicity on hepatocytes and renal cells was detected using the enzyme-linked immunosorbent assay kits.JJDHYZ-H restored the behavior performance impaired by MPTP, and reduced the loss of tyrosine hydroxylase. Additionally, it blocked the apoptosis, activated cleaved caspase3 and protected the ultrastructural integrity of mitochondria by regulating the expression of proteins in both mitochondrial and endoplasmic reticulum (ER) caspase12 pathways.JJDHYZ-H showed behavior recovery and dopamine neuron protection by inhibiting the apoptotic activities associated with mitochondrial and ER caspase12 pathways.
Keywords	animal models ; apoptosis ; cytochrome c ; dopamine ; endoplasmic reticulum ; enzyme-linked immunosorbent assay ; fluorescent antibody technique ; hepatocytes ; high performance liquid chromatography ; immunohistochemistry ; kidney cells ; males ; mice ; mitochondria ; neurons ; neuroprotective effect ; Oriental traditional medicine ; Parkinson disease ; protein synthesis ; staining ; toxicity ; transmission electron microscopy ; tyrosine 3-monooxygenase
Language	English
Dates of publication	2017-0505
Size	p. 69-79.
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2016.12.053
Database	NAL-Catalogue (AGRICOLA)

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Z 90/710: Show issues

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Book: Zhang lao shi jiao Han zi

Zhang, Huifen

= Learning Chinese characters from Ms. Zhang

2005

Author's details	Zhang Huifen bian zhu
Language	Chinese
Size	212 S.
Publisher	Beijing yu yan da xue chu ban she
Publishing place	Beijing
Document type	Book
ISBN	9787561912959 ; 7561912951
Database	Former special subject collection: coastal and deep sea fishing

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Article: [Clinical observation on prevention of "jia wei si jun zi tang" from damage of hepatic reserving function after intervention of liver cancer].

Zhang, Bei / Huang, Guoxian / Zhang, Yaqi / Chen, Xuxian / Hu, Pili / Xu, Boping

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

2004 Volume 27, Issue 5, Page(s) 387–389

Abstract: Objective: To observe prevention of "Jia Wei Si Jun Zi Tang" (JWSJZT) from damage of hepatic ...

Abstract	Objective: To observe prevention of "Jia Wei Si Jun Zi Tang" (JWSJZT) from damage of hepatic reserving function after intervention of liver cancer. Methods: 65 patients with advance stage of liver cancer were randomly into two groups, the control group (regular protective therapy) and the treatment group (regular protective therapy + JWSJZT). There were 33 and 32 cases in the control group and treatment group,respectively. ICGR15 was detected before the first and the second intervention treatment and one month after the second intervention treatment, respectively. ICGR15 change was observed before and after the intervention treatment in the two groups. Results: ICGR15 was 11.13% +/- 7.28% in the treatment group and 11.81% +/- 7.43% in the control group (P > 0.05) before the first intervention; 18.36% +/- 9.82% in the control group and 12.18% +/- 5.22% in the treatment group, before the second invention treatment (P < 0.05); 19.12% +/- 9.96% in the control group and 12.83% +/- 5.28% in the treatment group one month after the second intervention treatment (P < 0.05). Conclusion: The western medicine + JWSJZT group is superior in curative effect to western medicine group.
MeSH term(s)	Adult ; Aged ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/physiopathology ; Chemoembolization, Therapeutic/adverse effects ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Inosine/administration & dosage ; Inosine/therapeutic use ; Liver Function Tests ; Liver Neoplasms/drug therapy ; Liver Neoplasms/physiopathology ; Male ; Middle Aged ; Phytotherapy
Chemical Substances	Drugs, Chinese Herbal ; si-jun-zi-tang ; Inosine (5A614L51CT)
Language	Chinese
Publishing date	2004-05
Publishing country	China
Document type	Clinical Trial ; English Abstract ; Journal Article ; Randomized Controlled Trial
ISSN	1001-4454
ISSN	1001-4454
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Adaptive Estimation Distribution Distributed Differential Evolution for Multimodal Optimization Problems.

Wang, Zi-Jia / Zhou, Yu-Ren / Zhang, Jun

IEEE transactions on cybernetics

2022 Volume 52, Issue 7, Page(s) 6059–6070

Abstract: Multimodal optimization problems (MMOPs) require algorithms to locate multiple optima simultaneously. When using evolutionary algorithms (EAs) to deal with MMOPs, an intuitive idea is to divide the population into several small "niches," where different ... ...

Abstract	Multimodal optimization problems (MMOPs) require algorithms to locate multiple optima simultaneously. When using evolutionary algorithms (EAs) to deal with MMOPs, an intuitive idea is to divide the population into several small "niches," where different niches focus on locating different optima. These population partition strategies are called "niching" techniques, which have been frequently used for MMOPs. The algorithms for simultaneously locating multiple optima of MMOPs are called multimodal algorithms. However, many multimodal algorithms still face the difficulty of population partition since most of the niching techniques involve the sensitive niching parameters. Considering this issue, in this article, we propose a parameter-free niching method based on adaptive estimation distribution (AED) and develop a distributed differential evolution (DDE) algorithm, which is called AED-DDE, for solving MMOPs. In AED-DDE, each individual finds its own appropriate niche size to form a niche and acts as an independent unit to find a global optimum. Therefore, we can avoid the difficulty of population partition and the sensitivity of niching parameters. Different niches are co-evolved by using the master-slave multiniche distributed model. The multiniche co-evolution mechanism can improve the population diversity for fully exploring the search space and finding more global optima. Moreover, the AED-DDE algorithm is further enhanced by a probabilistic local search (PLS) to refine the solution accuracy. Compared with other multimodal algorithms, even the winner of CEC2015 multimodal competition, the comparison results fully demonstrate the superiority of AED-DDE.
MeSH term(s)	Algorithms ; Dichlorodiphenyl Dichloroethylene
Chemical Substances	Dichlorodiphenyl Dichloroethylene (4M7FS82U08)
Language	English
Publishing date	2022-07-04
Publishing country	United States
Document type	Journal Article
ISSN	2168-2275
ISSN (online)	2168-2275
DOI	10.1109/TCYB.2020.3038694
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Different nitrogen saturation thresholds for above-, below-, and total net primary productivity in a temperate steppe.

Yang, Guo-Jiao / Stevens, Carly / Zhang, Zi-Jia / Lü, Xiao-Tao / Han, Xing-Guo

Global change biology

2023 Volume 29, Issue 16, Page(s) 4586–4594

Abstract: Identifying the thresholds for the positive responses of total net primary productivity (NPP) to nitrogen (N) enrichment is an essential prerequisite for predicting the benefits of N deposition on ecosystem carbon sequestration. However, the responses of ...

Abstract	Identifying the thresholds for the positive responses of total net primary productivity (NPP) to nitrogen (N) enrichment is an essential prerequisite for predicting the benefits of N deposition on ecosystem carbon sequestration. However, the responses of below-ground NPP (BNPP) to N enrichment are unknown in many ecosystems, which limits our ability to understand the carbon cycling under the scenario of increasing N availability. We examined the changes in above-ground NPP (ANPP), BNPP, and NPP of a temperate meadow steppe across a wide-ranging N addition gradient (0, 2, 5, 10, 20, and 50 g N m
MeSH term(s)	Ecosystem ; Grassland ; Nitrogen ; Carbon Cycle ; Soil
Chemical Substances	Nitrogen (N762921K75) ; Soil
Language	English
Publishing date	2023-06-02
Publishing country	England
Document type	Journal Article
ZDB-ID	1281439-8
ISSN	1365-2486 ; 1354-1013
ISSN (online)	1365-2486
ISSN	1354-1013
DOI	10.1111/gcb.16803
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Parotid metastasis of rare lung adenocarcinoma: A case report.

Yan, Ru-Xi / Dou, Lin-Bo / Wang, Zi-Jia / Qiao, Xue / Ji, Hong-Hai / Zhang, Yan-Cong

World journal of clinical cases

2024 Volume 12, Issue 6, Page(s) 1182–1189

Abstract: Background: Lung cancer (LC) is the leading cause of malignancy-related deaths worldwide. The most common sites of metastasis include the nervous system, bone, liver, respiratory system, and adrenal glands. LC metastasis in the parotid gland is very ... ...

Abstract	Background: Lung cancer (LC) is the leading cause of malignancy-related deaths worldwide. The most common sites of metastasis include the nervous system, bone, liver, respiratory system, and adrenal glands. LC metastasis in the parotid gland is very rare, and its diagnosis presents a challenge. Here, we report a case of parotid metastasis in primary LC. Case summary: The patient was a 74-year-old male who was discovered to have bilateral facial asymmetry inadvertently two years ago. The right earlobe was slightly swollen and without pain or numbness. Computed tomography (CT) examination showed bilateral lung space-occupying lesions. Pulmonary biopsy was performed and revealed adenocarcinoma (right-upper-lung nodule tissue). Positron emission tomography-CT examination showed: (1) Two hypermetabolic nodules in the right upper lobe of the lung, enlarged hypermetabolic lymph nodes in the right hilar and mediastinum, and malignant space-occupying lesion in the right upper lobe of the lung and possible metastasis to the right hilar and mediastinal lymph nodes; and (2) multiple hypermetabolic nodules in bilateral parotid glands. Parotid puncture biopsy was performed considering lung adenocarcinoma metastasis. Gene detection of lung biopsy specimens revealed an Conclusion: This case report highlights the challenging diagnosis of parotid metastasis in LC given its rare nature. Such lesions should be differentiated from primary tumors of the parotid gland. Simple radiological imaging is unreliable, and puncture biopsy is needed for final diagnosis of this condition.
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v12.i6.1182
Database	MEDical Literature Analysis and Retrieval System OnLINE

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