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Article ; Online: Investigations of specialised metabolites of endophyte Diaporthe destruens hosted in Illigera orbiculata C. Y. Wu.

Zhang, Sheng-Qi / Wang, Jia-Peng / Zhang, Feng-Mei / Yao, Lin-Lin / Li, Bing-Xian / Li, Ya-Ni / Gan, Dong / Mei, Rui-Feng / Cai, Le / Ding, Zhong-Tao

Phytochemistry

2022 Volume 203, Page(s) 113357

Abstract: ... Illigera orbiculata C. Y. Wu collected from southern Yunnan Province, China, led to the isolation of six ...

Abstract	A chemical investigation of the endophytic fungus Diaporthe destruens from the Hernandiaceae plant Illigera orbiculata C. Y. Wu collected from southern Yunnan Province, China, led to the isolation of six undescribed compounds, including two azaphilone analogs, which are a pair of epimers (13R-hydroxy-chermesinone A and 13S-hydroxy-chermesinone A); a pyrrole derivative (1-(4-(methoxymethyl)-1H-pyrrol-3-yl)ethan-1-one); an isoindolone derivative (4-hydroxy-6-methoxyisoindolin-1-one); a benzylbenzene derivative (destruensine A) and a conjectural fragment of polyketide ((2R,4R)-2-(methoxymethyl)pentane-1,4-diol) along with nine known compounds. Their structures were elucidated by spectroscopic methods and HRESIMS, and the absolute configurations were further confirmed by electronic circular dichroism (ECD) and chemical derivatization. The antimicrobial activities, anti-acetylcholinesterase activities, antiproliferation, and NO production inhibitory effects of compounds 1-15 were evaluated.
MeSH term(s)	Anti-Infective Agents/metabolism ; China ; Endophytes ; Hernandiaceae/chemistry ; Molecular Structure ; Pentanes/metabolism ; Polyketides ; Pyrroles/metabolism
Chemical Substances	Anti-Infective Agents ; Pentanes ; Polyketides ; Pyrroles
Language	English
Publishing date	2022-08-13
Publishing country	England
Document type	Journal Article
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2022.113357
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Article ; Online: Investigations of specialised metabolites of endophyte Diaporthe destruens hosted in Illigera orbiculata C. Y. Wu

Zhang, Sheng-Qi / Wang, Jia-Peng / Zhang, Feng-Mei / Yao, Lin-Lin / Li, Bing-Xian / Li, Ya-Ni / Gan, Dong / Mei, Rui-Feng / Cai, Le / Ding, Zhong-Tao

Phytochemistry. 2022 Nov., v. 203 p.113357-

2022

Abstract: ... Illigera orbiculata C. Y. Wu collected from southern Yunnan Province, China, led to the isolation of six ...

Abstract	A chemical investigation of the endophytic fungus Diaporthe destruens from the Hernandiaceae plant Illigera orbiculata C. Y. Wu collected from southern Yunnan Province, China, led to the isolation of six undescribed compounds, including two azaphilone analogs, which are a pair of epimers (13R-hydroxy-chermesinone A and 13S-hydroxy-chermesinone A); a pyrrole derivative (1-(4-(methoxymethyl)-1H-pyrrol-3-yl)ethan-1-one); an isoindolone derivative (4-hydroxy-6-methoxyisoindolin-1-one); a benzylbenzene derivative (destruensine A) and a conjectural fragment of polyketide ((2R,4R)-2-(methoxymethyl)pentane-1,4-diol) along with nine known compounds. Their structures were elucidated by spectroscopic methods and HRESIMS, and the absolute configurations were further confirmed by electronic circular dichroism (ECD) and chemical derivatization. The antimicrobial activities, anti-acetylcholinesterase activities, antiproliferation, and NO production inhibitory effects of compounds 1–15 were evaluated.
Keywords	Diaporthe ; Hernandiaceae ; circular dichroism spectroscopy ; derivatization ; endophytes ; fungi ; metabolites ; plant biochemistry ; polyketides ; pyrroles ; China ; Diaporthe destruens ; Diaporthaceae ; Illigera orbiculata C. Y. Wu ; endophyte ; specialised metabolites
Language	English
Dates of publication	2022-11
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	208884-8
ISSN	1873-3700 ; 0031-9422
ISSN (online)	1873-3700
ISSN	0031-9422
DOI	10.1016/j.phytochem.2022.113357
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Article ; Online: Approximately diagonalizing matrices over C(Y).

Lin, Huaxin

Proceedings of the National Academy of Sciences of the United States of America

2012 Volume 109, Issue 8, Page(s) 2842–2847

Abstract: Let X be a compact metric space which is locally absolutely retract and let ϕ: C(X) → C(Y,M(n)) be ... rank-one projections {p(1,m),p(2,m),…,p(n,m)} C(Y,M(n)) such that [see formula]. This is closely ... a unital homomorphism, where Y is a compact metric space with dim Y ≤ 2. It is proved that there exists ...

Abstract	Let X be a compact metric space which is locally absolutely retract and let ϕ: C(X) → C(Y,M(n)) be a unital homomorphism, where Y is a compact metric space with dim Y ≤ 2. It is proved that there exists a sequence of n continuous maps α(i,m): Y → X (i = 1,2,…,n) and a sequence of sets of mutually orthogonal rank-one projections {p(1,m),p(2,m),…,p(n,m)} C(Y,M(n)) such that [see formula]. This is closely related to the Kadison diagonal matrix question. It is also shown that this approximate diagonalization could not hold in general when dim Y ≥ 3.
Language	English
Publishing date	2012-02-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1101079108
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Article: Approximately diagonalizing matrices over C(Y)

Lin, Huaxin

Proceedings of the National Academy of Sciences of the United States of America. 2012 Feb. 21, v. 109, no. 8

2012

Abstract: Let X be a compact metric space which is locally absolutely retract and let ϕ: C(X) → C(Y,Mn) be ... rank-one projections {p1,m,p2,m,...,pn,m}⊂C(Y,Mn) such that Formula This is closely related ... a unital homomorphism, where Y is a compact metric space with dim Y ≤ 2. It is proved that there exists ...

Abstract	Let X be a compact metric space which is locally absolutely retract and let ϕ: C(X) → C(Y,Mn) be a unital homomorphism, where Y is a compact metric space with dim Y ≤ 2. It is proved that there exists a sequence of n continuous maps αi,m: Y → X (i = 1,2,...,n) and a sequence of sets of mutually orthogonal rank-one projections {p1,m,p2,m,...,pn,m}⊂C(Y,Mn) such that Formula This is closely related to the Kadison diagonal matrix question. It is also shown that this approximate diagonalization could not hold in general when dim Y≥3.
Keywords	mathematics and statistics
Language	English
Dates of publication	2012-0221
Size	p. 2842-2847.
Publishing place	National Academy of Sciences
Document type	Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
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Article: [Analysis of clinical outcome of synchronous micro-dissection testicular sperm extraction and intracytoplasmic sperm injection in male infertility with Y chromosome azoospermia factor c region deletion].

Mao, J M / Zhao, L M / Liu, D F / Lin, H C / Yang, Y Z / Zhang, H T / Hong, K / Li, R / Jiang, H

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences

2022 Volume 54, Issue 4, Page(s) 652–657

Abstract: Objective: To analyze the clinical treatment results of male infertility caused by Y chromosome ... azoospermia factor c region(AZFc) deletion after synchronous micro-dissection testicular sperm extraction ...

Abstract	Objective: To analyze the clinical treatment results of male infertility caused by Y chromosome azoospermia factor c region(AZFc) deletion after synchronous micro-dissection testicular sperm extraction (micro-TESE) and intracytoplasmic sperm injection (ICSI) and to guide the treatment of infer- tile patients caused by AZFc deletion. Methods: The clinical data of infertile patients with AZFc deletion who underwent synchronous micro-TESE in Peking University Third Hospitalfrom January 2015 to December 2019 were retrospectively analyzed. The clinical outcomes of ICSI in the patients who successfully obtained sperm were followed up and we compared the outcomes between the first and second synchronous procedures, including fertilization rate, high-quality embryo rate, clinical pregnancy rate, abortion rate and live birth rate. Results: A total of 195 male infertile patients with AZFc deletion underwent micro-TESE. Fourteen patients were cryptozoospermia and their sperms were successfully obtained in all of them during the operation, and the sperm retrieval rate (SRR) was 100%(14/14). The remaining 181 cases were non obstructive azoospermia, and 122 cases were successfully found the sperm, the SRR was 67.4%(122/181). The remaining 59 patients with NOA could not found mature sperm during micro-TESE, accounting for 32.6% (59/181). We followed up the clinical treatment outcomes of the patients with successful sperm retrieved by synchronous micro-TESE and 99 patients were enrolled in the study. A total of 118 micro-TESE procedures and 120 ICSI cycles were carried out. Finally 38 couples successfully gave birth to 22 male and 22 female healthy infants, with a cumulative live birth rate of 38.4% (38/99). In the fresh-sperm ICSI cycle of the first and second synchronous operation procedures, the high-quality embryo rate, clinical pregnancy rate of the fresh embryo transfer cycle and live birth rate of the oocyte retrieve cycle were 47.7% Conclusion: Male infertility patients caused by AZFc deletion have a high probability of successfully obtaining sperm in testis through micro-TESE for ICSI and give birth to their own offspring with their own biological characteristics. For patients who failed in the first synchronous procedure, they still have the opportunity to successfully conceive offspring through reoperation and ICSI.
MeSH term(s)	Azoospermia/genetics ; Azoospermia/therapy ; Chromosome Deletion ; Chromosomes, Human, Y ; Female ; Humans ; Infertility, Male/genetics ; Infertility, Male/therapy ; Male ; Pregnancy ; Retrospective Studies ; Semen ; Sex Chromosome Aberrations ; Sex Chromosome Disorders of Sex Development ; Sperm Injections, Intracytoplasmic/methods ; Sperm Retrieval ; Spermatozoa ; Testis
Language	Chinese
Publishing date	2022-08-06
Publishing country	China
Document type	Journal Article
ZDB-ID	2452593-5
ISSN	1671-167X
ISSN	1671-167X
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Article: Shoot organogenesis and somatic embryogenesis in leaf tissue of Pulsatilla tongkangensis Y.N. Lee & T.C. Lee

Zhao, Xiao-mei / Lian, Yu-ji / Jin, Ze-lin / Zhang, Xue-jie / Y, Yan / Fan, Shou-jin

Plant biotechnology reports. 2022 Aug., v. 16, no. 4

2022

Abstract: Leaf material explants of Pulsatilla tongkangensis Y. N. Lee & T. C. Lee were used to regenerate ...

Abstract	Leaf material explants of Pulsatilla tongkangensis Y. N. Lee & T. C. Lee were used to regenerate plants of this endangered species by somatic embryogenesis and organogenesis from meristematic nodules, induced by MS medium supplemented with zeatin (Zn) and indole-3-acetic acid (IAA). Globular structures were induced on the surface of the explants after 2 weeks and after 6–7 weeks of culture, multiple shoots developed from the nodules. Morpho-histological analysis of light green globular, heart-shaped structures resembling somatic embryos revealed, however, that these were organogenic, with strongly vacuolated parenchymatous cells surrounded by a single layer of epithermal cells, and tracheid elements, but no root pole. Milky-white callus also developed around the nodules after 4–6 weeks. Morpho-histological analysis of the globular, heart-, and torpedo-shaped stages of regenerants present in this callus confirmed the development of somatic embryos in the milky-white structures, characterized by deeply staining, small cells with rich cytoplasm, very little vascular tissue in the developing embryos, and no vascular connection with the surrounding callus. The highest rooting frequency (93.33%) was achieved on MS medium containing 1.5 mg/l NAA. Plantlets were acclimatized and successfully transferred to pots. Our results provide a plant regeneration system with potential for germplasm conservation of endangered plants and the rapid propagation and molecular breeding of P. tongkangensis.
Keywords	Pulsatilla ; biotechnology ; callus ; cytoplasm ; endangered species ; germplasm conservation ; indole acetic acid ; leaves ; meristems ; organogenesis ; plantlets ; somatic embryogenesis ; tracheids ; zeatin
Language	English
Dates of publication	2022-08
Size	p. 389-400.
Publishing place	Springer Nature Singapore
Document type	Article
ZDB-ID	2364226-9
ISSN	1863-5474 ; 1863-5466
ISSN (online)	1863-5474
ISSN	1863-5466
DOI	10.1007/s11816-021-00727-9
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Article: [Studies on the structure of gnetifolin A of Gnetum parvifolium (Warb.) C.Y. Cheng].

Li, J B / Lin, M / Li, S Z / Song, W Z

Yao xue xue bao = Acta pharmaceutica Sinica

1991 Volume 26, Issue 6, Page(s) 437–441

Abstract: ... parvifolium (Warb.) C.Y. Cheng together with three known components isorhapontigenin, resveratrol and beta ...

Abstract	A new component, gnetifolin A, was isolated from the ethyl acetate fraction of the stem of Gnetum parvifolium (Warb.) C.Y. Cheng together with three known components isorhapontigenin, resveratrol and beta-sitosterol. The structure of gnetifolin A has been established as 2-(3',5'-dihydroxy-4'-methoxyphenyl)-3-methoxy-5-hydroxybenzofuran by spectroscopic methods (UV, IR, MS, 1HNMR, 13CNMR, 2D-NMR).
MeSH term(s)	Benzofurans/chemistry ; Benzofurans/isolation & purification ; Drugs, Chinese Herbal/chemistry
Chemical Substances	Benzofurans ; Drugs, Chinese Herbal ; gnetifolin A (137476-72-3)
Language	Chinese
Publishing date	1991
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	788758-9
ISSN	0513-4870
ISSN	0513-4870
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Article: Correction: Hseu, Y.-C., et al. The In Vitro and In Vivo Anticancer Properties of Chalcone Flavokawain B through Induction of ROS-Mediated Apoptotic and Autophagic Cell Death in Human Melanoma Cells.

Hseu, You-Cheng / Chiang, Yu-Chi / Vudhya Gowrisankar, Yugandhar / Lin, Kai-Yuan / Huang, Sheng-Teng / Shrestha, Sirjana / Chang, Geng-Ruei / Yang, Hsin-Ling

Cancers

2021 Volume 13, Issue 2

Abstract: In the original article [ ... ]. ...

Abstract	In the original article [...].
Language	English
Publishing date	2021-01-15
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers13020303
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Article ; Online: Eosin Y as a Direct Hydrogen-Atom Transfer Photocatalyst for the Functionalization of C-H Bonds.

Fan, Xuan-Zi / Rong, Jia-Wei / Wu, Hao-Lin / Zhou, Quan / Deng, Hong-Ping / Tan, Jin Da / Xue, Cheng-Wen / Wu, Li-Zhu / Tao, Hai-Rong / Wu, Jie

Angewandte Chemie (International ed. in English)

2018 Volume 57, Issue 28, Page(s) 8514–8518

Abstract: Eosin Y, a well-known economical alternative to metal catalysts in visible-light-driven single ... This eosin Y-based photocatalytic hydrogen-atom transfer strategy is promising for diverse functionalization ... for C-H activation. Using the alkylation of C-H bonds with electron-deficient alkenes as a model study ...

Abstract	Eosin Y, a well-known economical alternative to metal catalysts in visible-light-driven single-electron transfer-based organic transformations, can behave as an effective direct hydrogen-atom transfer catalyst for C-H activation. Using the alkylation of C-H bonds with electron-deficient alkenes as a model study revealed an extremely broad substrate scope, enabling easy access to a variety of important synthons. This eosin Y-based photocatalytic hydrogen-atom transfer strategy is promising for diverse functionalization of a wide range of native C-H bonds in a green and sustainable manner.
Language	English
Publishing date	2018-05-16
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.201803220
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Article ; Online: c-Fos mediates α1, 2-fucosyltransferase 1 and Lewis y expression in response to TGF-β1 in ovarian cancer.

Hao, Yingying / Zhu, Liancheng / Yan, Limei / Liu, Juanjuan / Liu, Dawo / Gao, Na / Tan, Mingzi / Gao, Song / Lin, Bei

Oncology reports

2017 Volume 38, Issue 6, Page(s) 3355–3366

Abstract: ... TGF-β1-induced c-Fos and Lewis y expression. Silencing of c-Fos prevented TGF-β1-induced Lewis y ... FUT1 is a key rate-limiting enzyme in the synthesis of Lewis y, a membrane-associated carbohydrate ... antigen. The aberrant upregulation of FUT1 and Lewis y antigen is related to proliferation, invasion and ...

Abstract	FUT1 is a key rate-limiting enzyme in the synthesis of Lewis y, a membrane-associated carbohydrate antigen. The aberrant upregulation of FUT1 and Lewis y antigen is related to proliferation, invasion and prognosis in malignant epithelial tumors. A c-Fos/activator protein-1 (AP-1) binding site was found in the FUT1 promoter. However, the mechanisms of transcriptional regulation of FUT1 remain poorly understood. TGF-β1 is positively correlated to Lewis y. In the present study, we investigated the molecular mechanism of FUT1 gene expression in response to TGF-β1. We demonstrated that c-Fos was highly expressed in 77.50% of ovarian epithelial carcinoma cases and was significantly correlated with Lewis y. Using luciferase activity and chromatin immunoprecipitation (ChIP) assay, we further revealed that c-Fos interacted with the FUT1 promoter in ovarian cancer cells and transcriptional capacity of the heterodimer formed by c-Fos and c-Jun was stronger than that of the c-Fos or c-Jun homodimers. Then, we demonstrated that TGF-β1 induced dose-dependent c-Fos expression, which was involved in TGF-β1-induced ovarian cancer cell proliferation. In addition, inhibition of MAPK activation or TGF-β1 receptor by pharmacological agents prevented TGF-β1-induced c-Fos and Lewis y expression. Silencing of c-Fos prevented TGF-β1-induced Lewis y expression. Collectively, the results of these studies demonstrated that TGF-β1 regulated FUT1 and Lewis y expression by activating the MAPK/c-Fos pathway.
MeSH term(s)	Adolescent ; Adult ; Aged ; Binding Sites ; Cell Line, Tumor ; Cell Proliferation ; Female ; Fucosyltransferases/genetics ; Fucosyltransferases/metabolism ; Humans ; Lewis Blood Group Antigens/metabolism ; MAP Kinase Signaling System ; Middle Aged ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Promoter Regions, Genetic ; Proto-Oncogene Proteins c-fos/metabolism ; Transforming Growth Factor beta1/metabolism ; Up-Regulation ; Young Adult ; Galactoside 2-alpha-L-fucosyltransferase
Chemical Substances	Lewis Blood Group Antigens ; Lewis Y antigen ; Proto-Oncogene Proteins c-fos ; TGFB1 protein, human ; Transforming Growth Factor beta1 ; Fucosyltransferases (EC 2.4.1.-)
Language	English
Publishing date	2017-10-23
Publishing country	Greece
Document type	Journal Article
ZDB-ID	1222484-4
ISSN	1791-2431 ; 1021-335X
ISSN (online)	1791-2431
ISSN	1021-335X
DOI	10.3892/or.2017.6052
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