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Article: Molecular characterization of multidrug resistant E. coli associated to urinary tract infection in Taif, Saudi Arabia.

Abdallah, Fethi Ben / Lagha, Rihab / Al-Sarhan, Badriah / Mabrouk, Imed / Alhomrani, Majid / Gaber, Ahmed / Hassan, Mohamed M

Pakistan journal of pharmaceutical sciences

2021 Volume 33, Issue 6(Supplementary), Page(s) 2759–2766

Abstract: ... caused as a consequence of the urinary tract bacterial invasion. E. coli were isolated from the urine ... any genes in their genomes. Multi-drug resistant E. coli have antibiotics profiles highly variable and ...

Abstract	Escherichia coli account approximately to 85% of the Urinary tract infection. UTI affect the different parts of the urinary tract and is considered as a common bacterial infection. The infection is caused as a consequence of the urinary tract bacterial invasion. E. coli were isolated from the urine of UTI patients referred to King Abdulaziz Specialist Hospital, Taif, Saudi Arabia. Antibiotics susceptibility was tested on 25 antibiotics using the disc diffusion method. The prevalence of antibiotics resistance genes was realized by Polymerase Chain Reaction (PCR). Results showed heterogenicity in the percentage of antibiotics resistance from 100% for penicillin to 2% for imipenem. 30% of the isolates appeared as for Extended-Spectrum Beta-Lactamase (ESBL) positive and 74% are multidrug resistance strains. Distribution of antibiotic resistance genes showed that aac(3)-IV and blaSHV genes were identified in 33.33% of isolates. In addition, qnrA, blaCMY and dfrA1 genes were founded in 37.25%, 19.60% and 17.64% of the isolates respectively. In total, 17 different genotypes were detected, and 12 isolates (24%) do not include any genes in their genomes. Multi-drug resistant E. coli have antibiotics profiles highly variable and the mechanism of resistance was not correlated to the investigated genes.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Drug Resistance, Multiple, Bacterial ; Escherichia coli/drug effects ; Escherichia coli/genetics ; Female ; Humans ; Infant ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Urinary Tract Infections/microbiology ; Young Adult
Language	English
Publishing date	2021-04-21
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	885131-1
ISSN	1011-601X
ISSN	1011-601X
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Zs.A 6588: Show issues

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Article ; Online: HLA class II polymorphisms as prognostic biomarkers for right and left-sided colon cancer.

Attia, Amani / Lagha, Awatef / Mezlini, Amel / Ghazouani, Ezzedine / Yacoubi-Loueslati, Besma / Namouchi, Imene

The International journal of biological markers

2024 Volume 39, Issue 1, Page(s) 40–51

Abstract: Background: Colon cancer (CC) is one of the most common malignancies worldwide. Characterization of new prognostic biomarkers for right-sided CC (RCC) and left-sided CC (LCC) may contribute to improving early detection. An association of human leukocyte ...

Abstract	Background: Colon cancer (CC) is one of the most common malignancies worldwide. Characterization of new prognostic biomarkers for right-sided CC (RCC) and left-sided CC (LCC) may contribute to improving early detection. An association of human leukocyte antigens class II (HLA-II) with the predisposition to CC was suggested. Aim of the study: We evaluated the association of DRB1 and DQB1 with the risk of LCC and RCC. Patients and methods: Our study comprised 93 CC patients and 100 healthy controls. Genotyping of HLA class II alleles were performed by the Polymerase Chain Reaction Sequence-Specific Primers (PCR-SSP). Results: DRB103 was positively associated with CC. In contrast, DRB111, DRB113, DQB103, and DQB105 were negatively linked to CC. Haplotype analysis revealed that DRB104-DQB104 and DRB109-DQB102 were positive, while DRB101-DQB105, DRB104-DQB103, DRB107-DQB102, DRB111-DQB103, DRB111-DQB105, and DRB113-DQB106 were negatively associated with CC. For sigmoid CC, DRB113, DRB111, and DQB105 were negative, while DRB104-DQB102, and DRB107-DQB103 were positively associated. DRB103 and DRB104-DQB104 were positive, while DRB111 and DQB103 were negatively linked to RCC. According to the LCC, DRB107, DRB111, DQB103, DQB105, and DRB107-DQB102 were negative. In contrast, DRB109-DQB102 was positively associated with LCC. Stratified analysis revealed that DRB111 is associated with higher risk of metastasis in CC and sigmoid CC, and tolerance to treatment in RCC. DQB103 was associated with lymph-node invasion in CC. Conclusion:* DRB1 and DQB1 polymorphisms could be used as future biomarkers for the early detection of subjects at a higher risk of developing RCC and LCC, metastasis in sigmoid CC, and tolerance to treatment in RCC.
MeSH term(s)	Humans ; Gene Frequency ; Carcinoma, Renal Cell ; Prognosis ; HLA-DQ beta-Chains/genetics ; Haplotypes ; Kidney Neoplasms ; Colonic Neoplasms/genetics ; Alleles ; Genetic Predisposition to Disease
Chemical Substances	HLA-DQ beta-Chains
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	645113-5
ISSN	1724-6008 ; 0393-6155
ISSN (online)	1724-6008
ISSN	0393-6155
DOI	10.1177/03936155231224469
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Zs.A 2491: Show issues

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Article ; Online: Restless legs syndrome in the dominant Parkinson's side related to subthalamic deep-brain stimulation.

Tordjman, Lionel / Lagha-Boukbiza, Ouhaïd / Anheim, Mathieu / Tranchant, Christine / Bourgin, Patrice / Ruppert, Elisabeth

Sleep medicine

2024 Volume 115, Page(s) 174–176

Abstract: Background: Restless legs syndrome (RLS) has an increased estimated prevalence in patients with Parkinson's disease (PS). RLS frequently mimics symptoms intrinsic to PD, such as motor restlessness, contributing to making its diagnosis challenging in ... ...

Abstract	Background: Restless legs syndrome (RLS) has an increased estimated prevalence in patients with Parkinson's disease (PS). RLS frequently mimics symptoms intrinsic to PD, such as motor restlessness, contributing to making its diagnosis challenging in this population. We report the case of a patient with new-onset RLS following subthalamic deep-brain stimulation (DBS-STN). We assessed symptoms using suggested immobilization test (SIT) with both DBS-STN activated and switched off. Case description: A 59-year-old man with idiopathic PD developed disabling RLS following DBS-STN at age 58, with PD onset at 50 manifesting as left arm tremor. Despite improved motor symptoms during the month following surgery, the patient experienced left leg discomfort at rest, transiently alleviated by movements due to an irrepressible urge to move, and worsened at night. Symptoms had no temporal relationship with oral dopa-therapy and disappeared when DBS-STN was deactivated. A 1 h SIT assessed motor behavior with irrepressible urge to move, as well as sensory symptoms by visual analog scale. After 30 m DBS-STN was switched off followed by the appearance of tremor in the left arm while both motor and sensory symptoms of RLS disappeared in the left leg. Discussion: The mechanisms of DBS-STN's impact on RLS remain controversial. We hypothesize the DBS-STN to induce in our patient a hyperdopaminergic tone. DBS-induced and DBS-ameliorated RLS represent interesting conditions to further understand the pathophysiology of RLS. Moreover, the present observation suggests that SIT can be a valuable tool to assess RLS in PD patients before and after DBS-STN in future prospective studies.
MeSH term(s)	Male ; Humans ; Middle Aged ; Parkinson Disease/complications ; Parkinson Disease/therapy ; Parkinson Disease/diagnosis ; Restless Legs Syndrome ; Tremor/etiology ; Tremor/therapy ; Deep Brain Stimulation/adverse effects ; Subthalamic Nucleus/physiology
Language	English
Publishing date	2024-02-13
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	2012041-2
ISSN	1878-5506 ; 1389-9457
ISSN (online)	1878-5506
ISSN	1389-9457
DOI	10.1016/j.sleep.2024.02.025
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Zs.A 5315: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 635: Show issues

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Article ; Online: BurstDECONV: a signal deconvolution method to uncover mechanisms of transcriptional bursting in live cells.

Douaihy, Maria / Topno, Rachel / Lagha, Mounia / Bertrand, Edouard / Radulescu, Ovidiu

Nucleic acids research

2023 Volume 51, Issue 16, Page(s) e88

Abstract: Monitoring transcription in living cells gives access to the dynamics of this complex fundamental process. It reveals that transcription is discontinuous, whereby active periods (bursts) are separated by one or several types of inactive periods of ... ...

Abstract	Monitoring transcription in living cells gives access to the dynamics of this complex fundamental process. It reveals that transcription is discontinuous, whereby active periods (bursts) are separated by one or several types of inactive periods of distinct lifetimes. However, decoding temporal fluctuations arising from live imaging and inferring the distinct transcriptional steps eliciting them is a challenge. We present BurstDECONV, a novel statistical inference method that deconvolves signal traces into individual transcription initiation events. We use the distribution of waiting times between successive polymerase initiation events to identify mechanistic features of transcription such as the number of rate-limiting steps and their kinetics. Comparison of our method to alternative methods emphasizes its advantages in terms of precision and flexibility. Unique features such as the direct determination of the number of promoter states and the simultaneous analysis of several potential transcription models make BurstDECONV an ideal analytic framework for live cell transcription imaging experiments. Using simulated realistic data, we found that our method is robust with regards to noise or suboptimal experimental designs. To show its generality, we applied it to different biological contexts such as Drosophila embryos or human cells.
MeSH term(s)	Animals ; Humans ; Transcription, Genetic ; Drosophila/genetics ; Promoter Regions, Genetic
Language	English
Publishing date	2023-07-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	186809-3
ISSN	1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
ISSN (online)	1362-4962 ; 1362-4954
ISSN	0301-5610 ; 0305-1048
DOI	10.1093/nar/gkad629
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Zs.A 1067: Show issues

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Article: Lateral luxation: Is root resorption an unavoidable complication?

Kallel, Ines / Lagha, Malek / Moussaoui, Eya / Douki, Nabiha

Clinical case reports

2022 Volume 10, Issue 5, Page(s) e05880

Abstract: Lateral luxation is defined as a traumatic displacement of a tooth in any direction other than axially. A laterally luxated tooth is often immobile because of its bony lock. It produces a high metallic sound during percussion. Pulp sensibility testing is ...

Abstract	Lateral luxation is defined as a traumatic displacement of a tooth in any direction other than axially. A laterally luxated tooth is often immobile because of its bony lock. It produces a high metallic sound during percussion. Pulp sensibility testing is likely to be negative during the initial follow-up. However, the tooth should be monitored until a definitive pulp diagnosis is made. Treatment includes local anesthesia, suturing soft tissue injuries, manual repositioning of the luxated tooth, and stabilization with a flexible splint for 4 weeks. Given the risk of pulp necrosis following lateral luxation, particularly in teeth with radiographically closed apices and severe displacement, an immediate (prophylactic) root canal treatment is recommended. The objective of this work was to report and discuss the management of a case of lateral luxation involving a permanent tooth treated by reduction, followed by contention with 0.4 steel wire and composite resin, and endodontic treatment, and which was complicated by root resorption 3 months later. We also highlighted the possible complications following lateral luxation, especially root resorption.
Language	English
Publishing date	2022-05-18
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.5880
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Article: Heart Failure Associated With Ventricular Septal Defect, Mitral Valve Prolapse, Non-stenotic Bicuspid Aortic Valve, and Patent Foramen Ovale.

El Khoury, Antoine / Lagha, Elham / Butchakdjian, Zela Maria / Touma, Mary-Joe / Kharrat, Chady / Maalouf, Assaad

Cureus

2022 Volume 14, Issue 2, Page(s) e22020

Abstract: Ventricular septal defect (VSD) and bicuspid aortic valve (BAV) are the two most common congenital heart defects. BAV may occur sporadically or in association with other cardiac malformations. VSDs have decreased incidence in the adult population due to ... ...

Abstract	Ventricular septal defect (VSD) and bicuspid aortic valve (BAV) are the two most common congenital heart defects. BAV may occur sporadically or in association with other cardiac malformations. VSDs have decreased incidence in the adult population due to spontaneous closure. Mitral valve prolapse (MVP) and patent foramen ovale (PFO) can be associated with these conditions but the simultaneous association of these defects has never been reported in the literature. We report the case of a 35-year-old male patient with persistent VSD, BAV, and PFO associated with new-onset heart failure and MVP. We aim to study the association between the coexistence of structural heart malformations and the increased risk of heart failure.
Language	English
Publishing date	2022-02-08
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.22020
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Article: Acute Multiple In-Stent Thromboses in a Patient With Clopidogrel-Fluconazole Interaction.

El Khoury, Antoine / Butchakdjian, Zela Maria / Lagha, Elham / Semaan, Peter / Soueidy, Maroun

Cureus

2022 Volume 14, Issue 3, Page(s) e23718

Abstract: Clopidogrel is an anti-platelet that exerts its function by selectively inhibiting the binding of adenosine di-phosphate (ADP) to the P2Y12 receptor. Fluconazole is a fungistatic agent that alters fungal cell membranes. Both of these drugs act on the ... ...

Abstract	Clopidogrel is an anti-platelet that exerts its function by selectively inhibiting the binding of adenosine di-phosphate (ADP) to the P2Y12 receptor. Fluconazole is a fungistatic agent that alters fungal cell membranes. Both of these drugs act on the cytochrome P450 2C19. We report the case of an 83-year-old male that presented two days following coronary angioplasty with stent thrombosis, following the concomitant use of clopidogrel and fluconazole. We aim to study the interaction between clopidogrel and fluconazole. We hypothesize that fluconazole decreases the therapeutic level of clopidogrel, requiring an increase in dosage to achieve the same anti-thrombotic effect.
Language	English
Publishing date	2022-03-31
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.23718
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bacillus Calmette-Guerin (BCG)-induced systemic infection and granulomatous lesions of the glans penis following intravesical BCG therapy.

Sanchez, Adrien / Demonchy, Elisa / Buscot, Mathieu / Cardot-Leccia, Nathalie / Lagha, Kamel / Montaudie, Henri / Passeron, Thierry

Journal of the European Academy of Dermatology and Venereology : JEADV

2023

Language	English
Publishing date	2023-03-28
Publishing country	England
Document type	Letter
ZDB-ID	1128828-0
ISSN	1468-3083 ; 0926-9959
ISSN (online)	1468-3083
ISSN	0926-9959
DOI	10.1111/jdv.19074
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Zs.A 3492: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 413: Show issues

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Article ; Online: A rare case of concurrent left ventricular aneurysm and ventricular septal rupture complicating an inferior myocardial infarction: a case report.

Drissa, Mariem / Azaiez, Fares / Jaoued, Fekher / Khelifa, Rouaida / Lagha, Elyes / Romdhane, Rim Ben / Tlili, Rami / Ameur, Youssef Ben

The Pan African medical journal

2023 Volume 45, Page(s) 74

Abstract: Complications following acute myocardial infarction (MI) such as ventricular septal rupture (VSR) and left ventricular (LV) aneurysm are rare and can be dreadful. Their simultaneous presence in the same patient is extremely rare. We aimed to present a ... ...

Abstract	Complications following acute myocardial infarction (MI) such as ventricular septal rupture (VSR) and left ventricular (LV) aneurysm are rare and can be dreadful. Their simultaneous presence in the same patient is extremely rare. We aimed to present a rare case of concomitant association of ventricular aneurysm and VSR complicating an inferior myocardial infarction. We report the unusual case of Mr. A. D, a 63-year-old, active smoker, with a history of diabetes mellitus and hypertension, admitted for the management of inferior MI within 6 days. The MI was complicated by an LV aneurysm in the inferoposterior and the inferoseptal walls associated with a VSR in the inferoseptal wall. The patient had only signs of right heart failure on admission. This observation illustrates on the one hand the rarity of the association of VSR and LV aneurysm after an inferior myocardial infarction, and on the other hand the possibility of founding them at an early stage of MI without any signs of cardiogenic shock.
MeSH term(s)	Humans ; Middle Aged ; Inferior Wall Myocardial Infarction/complications ; Inferior Wall Myocardial Infarction/diagnosis ; Ventricular Septal Rupture/diagnosis ; Ventricular Septal Rupture/etiology ; Myocardial Infarction/complications ; Myocardial Infarction/diagnosis ; Shock, Cardiogenic ; Heart Aneurysm/diagnostic imaging ; Heart Aneurysm/etiology
Language	English
Publishing date	2023-06-02
Publishing country	Uganda
Document type	Case Reports
ZDB-ID	2514347-5
ISSN	1937-8688 ; 1937-8688
ISSN (online)	1937-8688
ISSN	1937-8688
DOI	10.11604/pamj.2023.45.74.39612
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Role of Dermoscopy in Provider-to-Provider Store-and-Forward Dermatology eConsults: A Scoping Review of the Recent Literature.

Gellatly, Zhuoqing S / Lagha, Imene B / Ternov, Niels Kvorning / Berry, Elizabeth / Nelson, Kelly C / Seiverling, Elizabeth V

Current dermatology reports

2023 Volume 12, Issue 4, Page(s) 169–179

Abstract: Purpose of review: This scoping review maps recent literature on dermatology provider-to-provider asynchronous store-and-forward (SAF) electronic consult (eConsult) platforms with dermoscopy. It offers a descriptive overview, highlighting benefits and ... ...

Abstract	Purpose of review: This scoping review maps recent literature on dermatology provider-to-provider asynchronous store-and-forward (SAF) electronic consult (eConsult) platforms with dermoscopy. It offers a descriptive overview, highlighting benefits and challenges. Recent findings: Incorporating dermoscopy into SAF eConsults improves diagnostic accuracy for benign and malignant skin neoplasms. Diagnostic and treatment concordance with traditional face-to-face (FTF) visits is high. SAF eConsults with dermoscopy enhance access to dermatological care by improving triage and reducing wait times for FTF visits. Pediatric patients benefit with improved evaluation of melanocytic and vascular growths. eConsult platforms with dermoscopy serve as a telementoring opportunity for clinicians interested in improving their dermoscopy skills. Summary: Adding dermoscopy to SAF eConsults is valuable and results in improved diagnostic accuracy and reduced need for FTF visits. Implementation barriers can be overcome through collaboration between primary care and dermatology. Dermoscopy in SAF eConsults has significant potential for managing skin conditions and reducing the burden caused by unnecessary FTF visit and biopsies.
Language	English
Publishing date	2023-10-10
Publishing country	United States
Document type	Journal Article
ISSN	2162-4933
ISSN	2162-4933
DOI	10.1007/s13671-023-00407-7
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