LIVIVO - Search results -

Search results

Result 1 - 10 of total 28

Search options

Article ; Online: Evaluation of a novel triplex immunochromatographic test for rapid simultaneous detection of norovirus, rotavirus, and adenovirus on a single strip test.

Ushijima, Hiroshi / Pham, Ngan Thi Kim / Hoque, Sheikh Ariful / Nomura, Akiko / Kumthip, Kattareeya / Shimizu-Onda, Yuko / Okitsu, Shoko / Kawata, Kimiko / Hanaoka, Nozomu / Müller, Werner Eg / Maneekarn, Niwat / Hayakawa, Satoshi / Khamrin, Pattara

Journal of infection and public health

2024 Volume 17, Issue 4, Page(s) 619–623

Abstract: Background: Acute gastroenteritis is one of the major causes of morbidity and mortality in young children worldwide. Among these, rotavirus, norovirus, and adenovirus have been reported as the primary viral pathogens associated with the disease. Rapid ... ...

Abstract	Background: Acute gastroenteritis is one of the major causes of morbidity and mortality in young children worldwide. Among these, rotavirus, norovirus, and adenovirus have been reported as the primary viral pathogens associated with the disease. Rapid diagnosis of viral pathogens is crucial when diarrhea outbreaks occur to ensure the timely administration of appropriate treatment and control measures. Methods: We evaluated three immunochromatographic test kits designed for the detection of norovirus, rotavirus, and adenovirus in 71 stool specimens collected from children with diarrhea who visited clinics in Japan. The first kit is a triplex immunochromatographic test kit designed for simultaneous detections of norovirus, rotavirus, and adenovirus on a single strip (this kit was referred to as IC-A). The other two immunochromatographic test kits are a dual detection kit for rotavirus and adenovirus, and a single detection kit for norovirus (IC-B). The RT-PCR/PCR was used as the gold standard method. Results: The results revealed that both IC-A and IC-B kits exhibited the same level of sensitivity of detection for rotavirus (72.7%) and adenovirus (22.7%), although the detection rate was lower than that of the RT-PCR/PCR method. However, there was a slight difference in the sensitivity of detection for norovirus between IC-A and IC-B, at 86.7% and 93.3%, respectively. The sensitivity of detection for adenovirus of both kits was relatively lower than those of RT-PCR method. This could be due to low viral load of adenovirus in clinical specimens below the detection limit of IC-A and IC-B kits. However, both immunochromatographic test kits (IC-A and IC-B) exhibited 100% specificity for norovirus, rotavirus, and adenovirus. Conclusions: The triplex immunochromatographic test kit (IC-A) designed for simultaneous detection of norovirus, rotavirus, and adenovirus has been proved to be more practical and convenient than the use of single or dual detection kits with more or less the same sensitivity and specificity of detections.
MeSH term(s)	Child ; Humans ; Child, Preschool ; Rotavirus ; Adenoviridae ; Norovirus ; Feces ; Diarrhea/diagnosis ; Sensitivity and Specificity ; Caliciviridae Infections/diagnosis
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2467587-8
ISSN	1876-035X ; 1876-0341
ISSN (online)	1876-035X
ISSN	1876-0341
DOI	10.1016/j.jiph.2024.02.010
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: Evaluation of an Immunochromatographic Test for Rapid Detection of Astrovirus in Acute Gastroenteritis Pediatric Patients.

Khamrin, Pattara / Pham, Ngan Thi Kim / Shimizu-Onda, Yuko / Trinh, Quang Duy / Hoque, Sheikh Ariful / Kumthip, Kattareeya / Nomura, Akiko / Okitsu, Shoko / Maneekarn, Niwat / Müller, Werner E G / Hayakawa, Satoshi / Ushijima, Hiroshi

Clinical laboratory

2023 Volume 69, Issue 8

MeSH term(s)	Child ; Humans ; Infant ; Gastroenteritis/diagnosis ; Rotavirus ; Immunologic Tests ; Feces
Language	English
Publishing date	2023-08-10
Publishing country	Germany
Document type	Letter
ZDB-ID	1307629-2
ISSN	1433-6510 ; 0941-2131
ISSN	1433-6510 ; 0941-2131
DOI	10.7754/Clin.Lab.2023.230314
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.170: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 25: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation.

Kimura, Yoshitaka / Yanagida, Tamiko / Onda, Akiko / Tsukui, Daisuke / Hosoyamada, Makoto / Kono, Hajime

Arteriosclerosis, thrombosis, and vascular biology

2020 Volume 40, Issue 3, Page(s) 570–582

Abstract: Objective: Uric acid is supposed but not yet determined to be associated with atherosclerosis. Uric acid is released from damaged cells to form urate crystal, which is recognized by the immune system to produce IL (interleukin)-1. Danger signals and IL- ... ...

Abstract	Objective: Uric acid is supposed but not yet determined to be associated with atherosclerosis. Uric acid is released from damaged cells to form urate crystal, which is recognized by the immune system to produce IL (interleukin)-1. Danger signals and IL-1 have been shown to play an important role in atherosclerosis. We determined whether the physiological level of soluble uric acid promotes inflammation and develops atherosclerosis. Approach and Results: The secretion of IL-1β from human peripheral blood mononuclear cells mediated by NLRP3 (NACHT, LRR, and PYD domain-containing protein 3) inflammasome was promoted by physiological levels in serum uric acid. This augmentation of inflammation was mediated by the regulation of the AMPK (AMP-activated protein kinase)-mTOR (mammalian target of rapamycin) mitochondrial reactive oxygen species and HIF-1α (hypoxia-inducible factor-1α) pathway. In both of uricase transgenic and xanthine oxidase inhibitor-treated mice, decreased levels of uric acid resulted in the activation of AMPK and attenuation of the development of atherosclerotic plaques. Further, acute uric acid reduction by the administration of benzbromarone in healthy humans for 2 weeks significantly decreased plasma IL-18-an inflammasome-dependent cytokine. Conclusions: The data indicate that the development of atherosclerosis and inflammation is promoted by uric acid in vivo. Moreover, the lowering of uric acid levels attenuated inflammation via the activation of the AMPK pathway. This study provides mechanistic evidence of uric acid-lowering therapies for atherosclerosis.
MeSH term(s)	AMP-Activated Protein Kinases/metabolism ; Adult ; Animals ; Atherosclerosis/blood ; Atherosclerosis/enzymology ; Atherosclerosis/pathology ; Atherosclerosis/prevention & control ; Benzbromarone/administration & dosage ; Biomarkers/blood ; Disease Models, Animal ; Enzyme Inhibitors/pharmacology ; Female ; HEK293 Cells ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Inflammasomes/genetics ; Inflammasomes/metabolism ; Inflammation/blood ; Inflammation/enzymology ; Inflammation/pathology ; Inflammation/prevention & control ; Inflammation Mediators/blood ; Interleukin-18/blood ; Interleukin-1beta/blood ; Interleukin-1beta/genetics ; Leukocytes, Mononuclear/drug effects ; Leukocytes, Mononuclear/enzymology ; Male ; Mice, Inbred C57BL ; Mice, Knockout, ApoE ; Middle Aged ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Nuclear Factor 45 Protein/blood ; Plaque, Atherosclerotic ; Reactive Oxygen Species/metabolism ; Receptors, LDL/deficiency ; Receptors, LDL/genetics ; Urate Oxidase/genetics ; Urate Oxidase/metabolism ; Uric Acid/blood ; Uricosuric Agents/administration & dosage ; Xanthine Oxidase/antagonists & inhibitors ; Xanthine Oxidase/metabolism ; Young Adult
Chemical Substances	Biomarkers ; Enzyme Inhibitors ; HIF1A protein, human ; Hypoxia-Inducible Factor 1, alpha Subunit ; IL1B protein, human ; ILF2 protein, human ; Inflammasomes ; Inflammation Mediators ; Interleukin-18 ; Interleukin-1beta ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLRP3 protein, human ; Nuclear Factor 45 Protein ; Reactive Oxygen Species ; Receptors, LDL ; Uricosuric Agents ; Uric Acid (268B43MJ25) ; Benzbromarone (4POG0RL69O) ; Xanthine Oxidase (EC 1.17.3.2) ; Urate Oxidase (EC 1.7.3.3) ; AMP-Activated Protein Kinases (EC 2.7.11.31)
Language	English
Publishing date	2020-01-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1221433-4
ISSN	1524-4636 ; 1079-5642
ISSN (online)	1524-4636
ISSN	1079-5642
DOI	10.1161/ATVBAHA.119.313224
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1705: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Chronological Changes in Mucosal Deformity by Endoscopic Suturing after Gastric Endoscopic Submucosal Dissection: A Multicenter Retrospective Analysis.

Higuchi, Kazutoshi / Goto, Osamu / Takahashi, Akiko / Akimoto, Teppei / Habu, Tsugumi / Ishikawa, Yumiko / Kirita, Kumiko / Koizumi, Eriko / Noda, Hiroto / Onda, Takeshi / Omori, Jun / Akimoto, Naohiko / Kaise, Mitsuru / Yahagi, Naohisa / Oyama, Tsuneo / Iwakiri, Katsuhiko

Digestion

2022 Volume 104, Issue 2, Page(s) 121–128

Abstract: Introduction: Endoscopic suturing of a mucosal defect is expected to prevent postoperative bleeding after endoscopic submucosal dissection (ESD). Endoscopic suturing causes mucosal deformity, which may interfere with endoscopic surveillance thereafter. ... ...

Abstract	Introduction: Endoscopic suturing of a mucosal defect is expected to prevent postoperative bleeding after endoscopic submucosal dissection (ESD). Endoscopic suturing causes mucosal deformity, which may interfere with endoscopic surveillance thereafter. We retrospectively investigated long-term chronological changes in mucosal suturing by endoscopic suturing. Methods: Forty-three patients who underwent endoscopic hand suturing (EHS) after gastric ESD at three institutions were enrolled. First, our hypothesis that the suturing sites healed via inflammation, disappearance of mucosal inversion, and flattening was validated. Subsequently, the duration required to reach each healing step was evaluated. Results: A total of 137 follow-up endoscopies were assessed, in which all cases showed the hypothesized chronological course on the suturing sites. The 95th percentiles of the duration when showing the disappearance of the inflammatory change and the inverted change were 63 days and 15.5 months after the procedure, respectively. Discussion/conclusion: The data show that the mucosal deformity induced by EHS disappeared within 16 months. Endoscopic suturing is thus considered to have a negligible effect on endoscopic surveillance following the procedure.
MeSH term(s)	Humans ; Endoscopic Mucosal Resection/adverse effects ; Endoscopic Mucosal Resection/methods ; Gastric Mucosa/diagnostic imaging ; Gastric Mucosa/surgery ; Retrospective Studies ; Stomach Neoplasms/surgery
Language	English
Publishing date	2022-12-07
Publishing country	Switzerland
Document type	Multicenter Study ; Journal Article
ZDB-ID	1712-7
ISSN	1421-9867 ; 0012-2823
ISSN (online)	1421-9867
ISSN	0012-2823
DOI	10.1159/000527350
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 572: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Stimulus frequency-dependent inhibition of micturition contractions of the urinary bladder by electrical stimulation of afferent Aβ, Aδ, and C fibers in cutaneous branches of the pudendal nerve.

Onda, Akiko / Uchida, Sae / Suzuki, Harue / Hotta, Harumi

The journal of physiological sciences : JPS

2016 Volume 66, Issue 6, Page(s) 491–496

Abstract: We aimed to examine the afferent mechanisms for the reflex inhibition of the rhythmic micturition contractions (RMCs) of the urinary bladder induced by stimulation of the perineal skin afferents in urethane-anesthetized rats. Electrical stimulation ( ... ...

Abstract	We aimed to examine the afferent mechanisms for the reflex inhibition of the rhythmic micturition contractions (RMCs) of the urinary bladder induced by stimulation of the perineal skin afferents in urethane-anesthetized rats. Electrical stimulation (pulse duration: 0.5 ms) was applied to the cutaneous branches of the pudendal nerve (CBPN) at frequencies of 0.1, 1, and 10 Hz for 1 min. Nerve fiber groups were defined by recording compound action potentials from CBPN. Activation of only Aβ fibers (0.2 V) produced an inhibition of RMCs at 7-11 min after the onset of stimulation (late inhibition), at any tested frequency. Additional activation of Aδ fibers (1 V) produced additional early inhibition (immediately after stimulation) at 1 and 10 Hz. Furthermore, additional activation of C fibers (10 V) at 10 Hz completely stopped RMCs for >10 min. This strong inhibition persisted after local application of capsaicin to the stimulating CBPN. We conclude that activities of Aβ, Aδ, and C afferent fibers, without capsaicin-sensitive channels, can contribute to the inhibition of bladder contractions.
Language	English
Publishing date	2016-11
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2234472-X
ISSN	1880-6562 ; 1880-6546
ISSN (online)	1880-6562
ISSN	1880-6546
DOI	10.1007/s12576-016-0468-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.360: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Modulation of Calcitonin, Parathyroid Hormone, and Thyroid Hormone Secretion by Electrical Stimulation of Sympathetic and Parasympathetic Nerves in Anesthetized Rats.

Hotta, Harumi / Onda, Akiko / Suzuki, Harue / Milliken, Philip / Sridhar, Arun

Frontiers in neuroscience

2017 Volume 11, Page(s) 375

Abstract: The thyroid and parathyroid glands are dually innervated by sympathetic (cervical sympathetic trunk [CST]) and parasympathetic (superior laryngeal nerve [SLN]) nerve fibers. We examined the effects of electrical stimulation of efferent or afferent nerve ... ...

Abstract	The thyroid and parathyroid glands are dually innervated by sympathetic (cervical sympathetic trunk [CST]) and parasympathetic (superior laryngeal nerve [SLN]) nerve fibers. We examined the effects of electrical stimulation of efferent or afferent nerve fibers innervating the thyroid and parathyroid glands on the secretion of immunoreactive calcitonin (iCT), parathyroid hormone (iPTH), 3,3',5-triiodothyronine (iT3), and thyroxine (iT4) from the thyroid and parathyroid glands. In anesthetized and artificially ventilated rats, thyroid venous blood was collected. The rate of hormone secretion from the glands was calculated from plasma hormone levels, measured by ELISA, and the flow rate of thyroid venous plasma. SLNs or CSTs were stimulated bilaterally with rectangular pulses with a 0.5-ms width. To define the role of unmyelinated nerve fibers (typically efferent), the cut peripheral segments were stimulated at various frequencies (up to 40 Hz) with a supramaximal intensity to excite all nerve fibers. The secretion of iCT, iT3, and iT4 increased during SLN stimulation and decreased during CST stimulation. iPTH secretion increased during CST stimulation, but was not affected by SLN stimulation. To examine the effects of selective stimulation of myelinated nerve fibers (typically afferent) in the SLN, intact SLNs were stimulated with a subthreshold intensity for unmyelinated nerve fibers. iCT, iT3, and iT4 secretion increased during stimulation of intact SLNs at 40 Hz. These results suggest that excitation of myelinated afferents induced by low intensity and high frequency stimulation of intact SLNs promotes secretion of CT and thyroid hormones from the thyroid gland, potentially via reflex activation of parasympathetic efferent nerve fibers in the SLN.
Language	English
Publishing date	2017-06-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2017.00375
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: A familial case of alveolar capillary dysplasia with misalignment of the pulmonary veins: the clinicopathological features and unusual glomeruloid endothelial proliferation.

Kitano, Akiko / Nakaguro, Masato / Tomotaki, Seiichi / Hanaoka, Shintaro / Kawai, Masahiko / Saito, Akiko / Hayakawa, Masahiro / Takahashi, Yoshiyuki / Kawasaki, Hidenori / Yamada, Takahiro / Ikeda, Masahiko / Onda, Tetsuo / Cho, Kazutoshi / Haga, Hironori / Nakazawa, Atsuko / Minamiguchi, Sachiko

Diagnostic pathology

2020 Volume 15, Issue 1, Page(s) 48

Abstract: Background: Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is a rare disorder of pulmonary vascular abnormality with persistent pulmonary hypertension of the newborn. The symptom usually presents within hours after birth, ... ...

Abstract	Background: Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is a rare disorder of pulmonary vascular abnormality with persistent pulmonary hypertension of the newborn. The symptom usually presents within hours after birth, leading to an early demise. Heterozygous de novo point mutations and genomic deletions of the FOXF1 (forkhead box F1) gene or its upstream enhancer have been identified in most patients with ACD/MPV. Most cases of ACD/MPV are sporadic; however, familial cases are also reported in 10% of patients. Case presentation: We herein report a case of familial ACD/MPV that showed unusual glomeruloid proliferation of endothelial cells. In this family, three of the four siblings died within two to 3 days after birth because of persistent pulmonary hypertension and respiratory failure. Only the second child remains alive and healthy. An autopsy was performed for the third and fourth children, resulting in a diagnosis of ACD/MPV based on the characteristic features, including misalignment of smaller pulmonary veins and lymphangiectasis. In both of these children, glomeruloid endothelial proliferation of vessels was noted in the interlobular septa. The vessels were immunohistochemically positive for D2-40, CD31, Factor VIII, and ERG, suggestive of differentiation for both lymphatic and blood vessels. Conclusions: Unusual glomeruloid endothelial proliferation was observed in a familial ACD/MPV case. This histologic feature has not been described previously in ACD/MPV or any other pulmonary disease. Although the histogenesis of this histologic feature is unclear, this finding may suggest that ACD/MPV is a compound vascular and lymphovascular system disorder that exhibits various histologic features.
MeSH term(s)	Endothelial Cells/pathology ; Female ; Forkhead Transcription Factors/genetics ; Humans ; Infant, Newborn ; Male ; Mutation ; Persistent Fetal Circulation Syndrome/genetics ; Persistent Fetal Circulation Syndrome/pathology
Chemical Substances	FOXF1 protein, human ; Forkhead Transcription Factors
Language	English
Publishing date	2020-05-09
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1746-1596
ISSN (online)	1746-1596
DOI	10.1186/s13000-020-00972-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Molecular determinants of sterile inflammation.

Kono, Hajime / Onda, Akiko / Yanagida, Tamiko

Current opinion in immunology

2014 Volume 26, Page(s) 147–156

Abstract: Necrotic cell death alerts the acquired immune system to activate naïve T cells even in the absence of non-self derived molecules (e.g. pathogens). In addition, sterile necrosis leads to innate immune-mediated acute inflammation. The dying cells still ... ...

Abstract	Necrotic cell death alerts the acquired immune system to activate naïve T cells even in the absence of non-self derived molecules (e.g. pathogens). In addition, sterile necrosis leads to innate immune-mediated acute inflammation. The dying cells still represent a threat to the body that should be eliminated by the host immune response. Although the inflammatory response plays important roles in protecting the host and repairing tissues, it can also cause the collateral damage to normal tissues that underlies disease pathogenesis. Tissue resident macrophages recognize the danger signals released from necrotic cells via the pattern recognition receptors and secrete IL-1 that results in acute neutrophilic inflammation. This article will review our current knowledge especially focusing on the role of IL-1 in the sterile necrotic cell death induced inflammation.
MeSH term(s)	Acute Disease ; Adaptive Immunity ; Carrier Proteins/physiology ; Cell Death/immunology ; Humans ; Immunity, Innate ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/pathology ; Interleukin-1alpha/physiology ; Interleukin-1beta/physiology ; Models, Molecular ; NLR Family, Pyrin Domain-Containing 3 Protein ; Necrosis
Chemical Substances	Carrier Proteins ; Interleukin-1alpha ; Interleukin-1beta ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLRP3 protein, human
Language	English
Publishing date	2014-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1035767-1
ISSN	1879-0372 ; 0952-7915
ISSN (online)	1879-0372
ISSN	0952-7915
DOI	10.1016/j.coi.2013.12.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2773: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 13: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Incidence of alveolar capillary dysplasia with misalignment of pulmonary veins in infants with unexplained severe pulmonary hypertension: The roles of clinical, pathological, and genetic testing.

Onda, Tetsuo / Akimoto, Takuma / Hayasaka, Itaru / Ikeda, Masahiko / Furuse, Yuta / Ando, Akiko / Nakamura, Yuichi / Honjo, Ryota / Manabe, Atsushi / Furuta, Itsuko / Cho, Kazutoshi

Early human development

2021 Volume 155, Page(s) 105323

Abstract: Background: Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a rare and fatal disorder that occurs in the developing fetal lungs; at birth, infants exhibit an oxygenation disorder accompanied by severe pulmonary hypertension ...

Abstract	Background: Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a rare and fatal disorder that occurs in the developing fetal lungs; at birth, infants exhibit an oxygenation disorder accompanied by severe pulmonary hypertension (PH) and have a very short life span. ACDMPV is definitively diagnosed by pathological findings, and infants born with unexplained severe PH may not be properly diagnosed without a biopsy or autopsy. Methods: Japanese infants with unexplained severe PH were enrolled in this study. Genetic analyses were performed on DNA extracted from peripheral blood leukocytes. Sanger sequencing or next-generation sequencing was performed by coding exons and introns for FOXF1 in all samples. For individuals without pathogenic exonic variants, multiplex ligation-dependent probe amplification was performed to identify copy number variations (CNVs) in exons, introns, and in the upstream region of FOXF1. Results: This study included 30 infants who were diagnosed over the course of nine years. Four individuals had the pathogenic variations on the exon 1 of FOXF1, including two frameshift and two missense variations. Pathogenic CNVs were found in another five individuals. Conclusion: In the pathologically proven ACDMPV patients, the ratios of cases with exonic variations, CNVs, and no genetic findings were reported as 45%, 45% and 10%, respectively. We estimate that about 30% (10 (9 + 1) out of 30) of individuals with unexplained severe PH had ACDMPV.
MeSH term(s)	DNA Copy Number Variations ; Forkhead Transcription Factors/genetics ; Genetic Testing ; Humans ; Hypertension, Pulmonary/epidemiology ; Hypertension, Pulmonary/genetics ; Incidence ; Infant ; Infant, Newborn ; Persistent Fetal Circulation Syndrome/epidemiology ; Persistent Fetal Circulation Syndrome/genetics
Chemical Substances	FOXF1 protein, human ; Forkhead Transcription Factors
Language	English
Publishing date	2021-01-26
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752532-1
ISSN	1872-6232 ; 0378-3782
ISSN (online)	1872-6232
ISSN	0378-3782
DOI	10.1016/j.earlhumdev.2021.105323
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1373: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Effect of canopy openness and meteorological factors on spatial variability of throughfall isotopic composition in a Japanese cypress plantation

Sun, Xinchao / Akiko Hirata / Hiroaki Kato / Takashi Gomi / Xueyan Liu / Yuichi Onda

Hydrological processes. 2018 Apr. 15, v. 32, no. 8

2018

Abstract: Spatial variability of throughfall (TF) isotopic composition, used as tracer input, influences isotope hydrological applications in forested watersheds. Notwithstanding, identification of the dominant canopy factors and processes that affect the patterns ...

Abstract	Spatial variability of throughfall (TF) isotopic composition, used as tracer input, influences isotope hydrological applications in forested watersheds. Notwithstanding, identification of the dominant canopy factors and processes that affect the patterns of TF isotopic variability remains ambiguous. Here, we examined the spatio‐temporal variability of TF isotopic composition in a Japanese cypress plantation, in which intensive strip thinning was performed and investigated whether canopy structure at a fine resolution of canopy effect analysis is related to TF isotopic composition and how this is affected by meteorological factors. Canopy openness, as an index of canopy structure, was calculated from hemispherical photographs at different zenith angles. TF samples were collected in a 10 × 10 m experimental plot in both pre‐thinning (from July to November 2010) and post‐thinning (from May 2012 to March 2013) periods. Our results show that thinning resulted in a smaller alteration of input δ18O of gross precipitation, whereas the changes in deuterium excess varied in both directions. Despite the temporal stability of spatial patterns in TF amount, the spatial variability of TF isotopic composition was not temporally stable in both pre‐ and post‐thinning periods. Additionally, after thinning, the isotopic composition of TF was best related to canopy openness calculated at the zenith angle of 7°, exhibiting three different relationships, that is, significantly negative, significantly positive, and nonsignificant. Changes in meteorological factors (wind speed, rainfall intensity, and temperature) were found to affect the relationships between TF δ18O and canopy openness. The observed shifts in the relationships reveal different dominant factors (partial evaporation and the selection), and canopy water flowpaths control such differences. This study provides useful insights into the spatial variability of TF isotopic composition and improves our understanding of the physical processes of interception through canopy passage.
Keywords	canopy ; deuterium ; evaporation ; forested watersheds ; oxygen ; photographs ; rain intensity ; stable isotopes ; temperature ; throughfall ; wind speed
Language	English
Dates of publication	2018-0415
Size	p. 1038-1049.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	1479953-4
ISSN	1099-1085 ; 0885-6087
ISSN (online)	1099-1085
ISSN	0885-6087
DOI	10.1002/hyp.11475
Database	NAL-Catalogue (AGRICOLA)

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito