Article: P-glycoprotein expression influences the result of 99mTc-MIBI scintigraphy in tertiary hyperparathyroidism.
International journal of molecular medicine
2005 Volume 16, Issue 2, Page(s) 215–219
Abstract: ... that radiotracer retention could be controlled by members of multidrug resistance (MDR) system, especially P ... glycoprotein (P-gp). Since the role of P-gp in tertiary hyperparathyroidism (T-HPTH) scintigraphic studies is ... poorly recognized, the aim of the study was to compare the correlation between parathyroid P ...
| Abstract | Precise localization of parathyroid glands using 99mTc-labeled hexakis-2-methoxyisobutylisonitrile (99mTc-MIBI) scintigraphy could be affected by various biological factors. There is increasing evidence that radiotracer retention could be controlled by members of multidrug resistance (MDR) system, especially P-glycoprotein (P-gp). Since the role of P-gp in tertiary hyperparathyroidism (T-HPTH) scintigraphic studies is poorly recognized, the aim of the study was to compare the correlation between parathyroid P-gp expression and results of their scintigraphy in T-HPTH versus primary hyperparathyroidism (P-HPTH). P-HPTH (n = 19) and T-HPTH (n = 18) patients were subjected to 99mTc-MIBI scintigraphy followed by surgical treatment. The parathyroid glands were assessed in routine hematoxylin-eosin staining and P-gp expression was analyzed using immunohistochemistry. Parathyroids collected during cadaver donor multi-organ harvesting were used as a control. It has been found that P-HPTH-derived parathyroid glands with predominating adenoma morphology expressed less P-gp, as compared to P-gp-rich T-HPTH glands, mainly displaying nodular or diffused hyperplasia phenotype. This finding reversely correlated with results of 99mTc-MIBI scintigraphy. However, we did not observe any difference in P-gp expression nor scintigraphy result between nodular or diffused hyperplasia. Altogether, these data suggest that P-gp overexpression in T-HPTH could be responsible for decreased sensitivity of 99mTc-MIBI scintigraphy in those patients. Therefore, the recently proposed reduced neck exploration or limited parathyroid resection on the basis of scintigraphy could create the risk of persisted/recurrent hyperparathyroidism. However, this problem requires further study. |
|---|---|
| MeSH term(s) | ATP Binding Cassette Transporter, Sub-Family B/biosynthesis ; Adenoma/diagnostic imaging ; Adenoma/metabolism ; Adenoma/pathology ; Humans ; Hyperparathyroidism/classification ; Hyperparathyroidism/diagnostic imaging ; Hyperparathyroidism/metabolism ; Hyperplasia ; Immunohistochemistry ; Parathyroid Glands/diagnostic imaging ; Parathyroid Glands/metabolism ; Parathyroid Glands/pathology ; Radionuclide Imaging ; Sensitivity and Specificity ; Technetium Tc 99m Sestamibi/pharmacokinetics |
| Chemical Substances | ATP Binding Cassette Transporter, Sub-Family B ; Technetium Tc 99m Sestamibi (971Z4W1S09) |
| Language | English |
| Publishing date | 2005-08 |
| Publishing country | Greece |
| Document type | Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 1444428-8 |
| ISSN | 1107-3756 |
| ISSN | 1107-3756 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
| Zs.A 4942: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.