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Article ; Online: Trehalose Improved 20-min Cycling Time-Trial Performance After 100-min Cycling in Amateur Cyclists.

de Oliveira, Nathan Gobbi / de Oliveira, Luana Farias / da Silva, Rafael Pires / Oliveira, Tamires Nunes / Möller, Gabriella Berwig / Murasaki, Juliana / Ramires, Manoel Antônio / Azevedo, Rafael de Almeida / Artioli, Guilherme Giannini / Roschel, Hamilton / Gualano, Bruno / Saunders, Bryan

International journal of sport nutrition and exercise metabolism

2024 , Page(s) 1–8

Abstract: ... supplementation with distinct GIs, namely, (a) trehalose (30 g/hr), (b) isomaltulose (30 g/hr), (c) maltodextrin ...

Abstract	Carbohydrate (CHO) supplementation during endurance exercise can improve performance. However, it is unclear whether low glycemic index (GI) CHO leads to differential ergogenic and metabolic effects compared with a standard high GI CHO. This study investigated the ergogenic and metabolic effects of CHO supplementation with distinct GIs, namely, (a) trehalose (30 g/hr), (b) isomaltulose (30 g/hr), (c) maltodextrin (60 g/hr), and (d) placebo (water). In this double-blind, crossover, counterbalanced, placebo-controlled study, 13 male cyclists cycled a total of 100 min at varied exercise intensity (i.e., 10-min stages at 1.5, 2.0, and 2.5 W/kg; repeated three times plus two 5-min stages at 1.0 W/kg before and after the protocol), followed by a 20-min time trial on four separated occasions. Blood glucose and lactate (every 20 min), heart rate, and ratings of perceived exertion were collected throughout, and muscle biopsies were taken before and immediately after exercise. The results showed that trehalose improved time-trial performance compared with placebo (total work done 302 ± 39 vs. 287 ± 48 kJ; p = .01), with no other differences between sessions (all p ≥ .07). Throughout the 100-min protocol, blood glucose was higher with maltodextrin compared with the other supplements at all time points (all p < .05). Heart rate, ratings of perceived exertion, muscle glycogen content, blood glucose, and lactate were not different between conditions when considering the 20-min time trial (all p > .05). Trehalose supplementation throughout endurance exercise improved cycling performance and appears to be an appropriate CHO source for exercise tasks up to 2 hr. No ergogenic superiority between the different types of CHO was established.
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1101115-4
ISSN	1543-2742 ; 1050-1606 ; 1526-484X
ISSN (online)	1543-2742
ISSN	1050-1606 ; 1526-484X
DOI	10.1123/ijsnem.2023-0241
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Article: Acute Disseminated Encephalomyelitis Related to a Cytomegalovirus Infection in an Immunocompetent Patient.

Da Silva, Rafael C / Aguiar, Guilherme B / Kamer, Carolina / Farias, Lais / Matsuda, Josie

Cureus

2021 Volume 13, Issue 1, Page(s) e12795

Abstract: Cytomegalovirus (CMV) infection can cause acute disseminated encephalomyelitis (ADEM). However, it is rare in immunocompetent people. We describe a 17-year-old patient who was brought with flu-like symptoms. After one week, she experienced rapidly ... ...

Abstract	Cytomegalovirus (CMV) infection can cause acute disseminated encephalomyelitis (ADEM). However, it is rare in immunocompetent people. We describe a 17-year-old patient who was brought with flu-like symptoms. After one week, she experienced rapidly progressive weakness in all four extremities, followed by coma. The neurologic examination showed no response to verbal and pain stimuli. A Babinski sign was noted in both lower extremities, along with clonus and hyperreflexia in all four limbs. Brain magnetic resonance imaging (MRI) demonstrated extensive areas of hyperintense signal on fluid-attenuated inversion recovery (FLAIR) sequences in the white matter which was asymmetrically distributed in both hemispheres, as well as in the brainstem and cerebellar peduncles, compatible with acute demyelinating lesions. Cerebrospinal fluid (CSF) showed mild lymphocytic pleocytosis and normal glucose levels. Polymerase chain reaction to herpes simplex virus was negative. Serum immunoglobulin G (IgG) and immunoglobulin M (IgM) were positive for cytomegalovirus. The patient was treated with methylprednisolone pulse therapy for five days. Subsequently, the patient showed neurologic improvement with the recovery of consciousness and muscle strength. In terms of prognosis, in patients with ADEM, the sooner the diagnosis, the better the outcome. The cornerstone of treatment is immunosuppression with steroids. Some patients require intravenous immunoglobulin G (IVIG) or plasmapheresis, and in refractory cases, cyclophosphamide is used.
Language	English
Publishing date	2021-01-19
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.12795
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Article ; Online: Solid-liquid equilibria of triacylglycerols and vitamin E mixtures.

Andrade, Sabrina S / Ferreira, Ramon S B / Farias, Fabiane O / Soares, Rafael de P / Costa, Mariana C / Corbi, Pedro P / Meirelles, Antonio J A / Batista, Eduardo A C / Maximo, Guilherme J

Food research international (Ottawa, Ont.)

2023 Volume 173, Issue Pt 2, Page(s) 113440

Abstract: Oils and fats are important ingredients for food and pharmaceutical industries. Their main compounds, such as triacylglycerols (TAG), are responsible for determining their physical properties during food storage and consumption. Lipid-rich foods are also ...

Abstract	Oils and fats are important ingredients for food and pharmaceutical industries. Their main compounds, such as triacylglycerols (TAG), are responsible for determining their physical properties during food storage and consumption. Lipid-rich foods are also sources of minority compounds, which is the case of vitamin E, mainly represented by (±)-α-tocopherol. These compounds can interact with the main lipid molecules in food formulation leading to modification on lipids' physicochemical properties during processes, storage, as well as during digestion, possibly altering their nutritional functionalities, which is the case of vitamin E antioxidant abilities, but also their solubility in the systems. In this case, the study of the phase-behavior between (±)-α-tocopherol and lipid compounds can elucidate these physicochemical changings. Therefore, this work was aimed at determining the solid-liquid equilibrium (SLE) of binary mixtures of TAG (tripalmitin, triolein and tristearin) and (±)-α-tocopherol including the complete description of their phase diagrams. Melting data were evaluated by Differential Scanning Calorimetry, Microscopy, X-Ray Diffraction, and thermodynamic modeling by using Margules, UNIFAC, and COSMO-SAC models. Experimental results showed that systems presented a monotectic-like behavior, with a significant decreasing in TAG melting temperature by the addition of (±)-α-tocopherol. This high affinity and attractive strengths between these molecules were also observed by thermodynamic modeling, whose absolute deviations were below 2 %. Micrographs and X-ray diffraction evidenced the possible formation of solid solutions. Both behaviors are interesting by avoiding phase separation on food in solid and liquid phases, possibly improving the antioxidant role the (±)-α-tocopherol in lipid-base systems.
MeSH term(s)	Vitamin E/chemistry ; alpha-Tocopherol/chemistry ; Antioxidants ; Triglycerides/chemistry ; Temperature
Chemical Substances	Vitamin E (1406-18-4) ; alpha-Tocopherol (H4N855PNZ1) ; Antioxidants ; Triglycerides
Language	English
Publishing date	2023-09-09
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2023.113440
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Article ; Online: Phenotype of BTK-lacking myeloid cells during prolonged COVID-19 and upon convalescent plasma.

Gomes, André M C / Farias, Guilherme B / Trombetta, Amelia C / Godinho-Santos, Ana / Parreira, Inês / Gonçalves, Hélder Diogo / Simões, Mariana Lessa / Aguiar, Patrício / Deveza, Maria Manuel / Inácio, João / Sousa, Ana E / da Silva, Susana Lopes

European journal of haematology

2022 Volume 110, Issue 2, Page(s) 209–212

Abstract: XLA patient with 7-month course of COVID-19 with persistent plasma SARS-CoV-2 load revealed a sustained non-inflammatory profile of myeloid cells in association with contained severity of disease, arguing in favor of the use of BTK inhibitors in SARS-COV- ...

Abstract	XLA patient with 7-month course of COVID-19 with persistent plasma SARS-CoV-2 load revealed a sustained non-inflammatory profile of myeloid cells in association with contained severity of disease, arguing in favor of the use of BTK inhibitors in SARS-COV-2 infection.
MeSH term(s)	Humans ; Protein-Tyrosine Kinases ; Agammaglobulinaemia Tyrosine Kinase/genetics ; COVID-19 ; SARS-CoV-2 ; COVID-19 Serotherapy ; Myeloid Cells ; Phenotype ; Genetic Diseases, X-Linked
Chemical Substances	Protein-Tyrosine Kinases (EC 2.7.10.1) ; Agammaglobulinaemia Tyrosine Kinase (EC 2.7.10.2)
Language	English
Publishing date	2022-10-19
Publishing country	England
Document type	Case Reports
ZDB-ID	392482-8
ISSN	1600-0609 ; 0902-4441
ISSN (online)	1600-0609
ISSN	0902-4441
DOI	10.1111/ejh.13881
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Article ; Online: Factors associated with HIV care and treatment cascade in Rio Grande do Sul, Brazil, 2014-2017: A cross-sectional study.

Shimocomaqui, Guilherme B / Meyer, Craig S / Ikeda, Maria L / Romeu Farias, Elson / Gonçalves, Tonantzin R / Rutherford, George W / Tregnago Barcellos, Nêmora

International journal of STD & AIDS

2021 Volume 32, Issue 5, Page(s) 462–469

Abstract: In 2018, Rio Grande do Sul (RS) had some of the highest HIV/AIDS rates in Brazil, and we did not find any studies about the HIV care and treatment cascade (HCTC) related to this state. We aimed to estimate the indicators of HCTC of RS, Brazil, and ... ...

Abstract	In 2018, Rio Grande do Sul (RS) had some of the highest HIV/AIDS rates in Brazil, and we did not find any studies about the HIV care and treatment cascade (HCTC) related to this state. We aimed to estimate the indicators of HCTC of RS, Brazil, and associated factors. A cross-sectional study with all people living with HIV (PLWH) in RS between 1 January 2014 and 31 December 2017 was conducted using a national database which registers all HIV notifications, CD4 and viral load laboratory data and antiretroviral therapy (ART) usage in the public health system. We considered sex, age, education, race, year of HIV diagnosis, and health region as predictor factors, and defined linkage to care, retention to care, being on ART, and having undetectable viral load as the HCTC indicators. Descriptive analysis and multivariable logistic regression were performed using Stata 15.2. A total of 116,121 PLWH were diagnosed, 79,959 were linked to care, 72,117 retained in care, 69,219 on ART, and 54,857 had undetectable viral load from 2014 to 2017. We observed greatest attrition for younger age, non-white, and lower education in all HCTC indicators. Women are more likely to have undetectable viral load (OR = 1.04, 95% CI: 1.01-1.07), even though they are less likely to be retained to care (OR = 0.92; 95% CI: 0.89-0.96) and on ART (OR = 0.82; 95% CI: 0.78-0.86). Although all HCTC indicators have increased over the period and the "test and treat" policy indicates improvements in ART and in undetectable viral load outcomes, evidence suggests specific attrition and disparities such as those related to HIV healthcare facilities should be addressed. These findings may be used by researchers, health professionals, and policymakers in order to investigate and implement interventions to better engage PLWH across the HCTC.
MeSH term(s)	Acquired Immunodeficiency Syndrome ; Brazil ; Cross-Sectional Studies ; Female ; HIV Infections/diagnosis ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Viral Load
Language	English
Publishing date	2021-02-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1018089-8
ISSN	1758-1052 ; 0956-4624
ISSN (online)	1758-1052
ISSN	0956-4624
DOI	10.1177/0956462420975947
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Article: Geometric and Thermo-Gravimetric Evaluation of Bananas during Convective Drying: An Experimental Investigation

Farias, Raimundo P. / Gomez, Ricardo S. / Lima, Elisiane S. / Silva, Wilton P. / Santos, Ivonete B. / Figueredo, Maria J. / Almeida, Genival S. / Rolim, Fagno D. / Oliveira, Vital A. B. / Oliveira Neto, Guilherme L. / Lima, Antonio G. B.

Agriculture (Basel). 2022 Aug. 09, v. 12, no. 8

2022

Abstract: Fresh bananas are fruits with high moisture content after harvest and are submitted to a drying process to minimize waste and increase shelf life. This work aims to experimentally study the convective drying of bananas in an oven with hot-air ... ...

Abstract	Fresh bananas are fruits with high moisture content after harvest and are submitted to a drying process to minimize waste and increase shelf life. This work aims to experimentally study the convective drying of bananas in an oven with hot-air recirculation, evaluating the geometric shape during moisture removal and product heating. Hand-peeled whole-banana samples, cut into longitudinal and transversal slices were dried at temperatures of 40 and 70 °C. Results of drying kinetics, heating and dimensional variations in terms of surface area and volume are presented and analyzed. It was found that cut bananas dry, heat up and change their dimensions faster than bananas in their natural form and that the area/volume relationships and the air temperature influence the drying kinetics, heating and volumetric variations of the fruit.
Keywords	agriculture ; air temperature ; fruits ; geometry ; heat ; ovens ; shelf life ; surface area ; thermogravimetry ; water content
Language	English
Dates of publication	2022-0809
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2651678-0
ISSN	2077-0472
ISSN	2077-0472
DOI	10.3390/agriculture12081181
Database	NAL-Catalogue (AGRICOLA)

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Article: Chemical composition and biological activities of two chemotype-oils from

Farias, Ana Patrícia P / Monteiro, Odair Dos S / da Silva, Joyce Kelly R / Figueiredo, Pablo Luis B / Rodrigues, Antonia Alice C / Monteiro, Ildenice N / Maia, José Guilherme S

Journal of food science and technology

2020 Volume 57, Issue 9, Page(s) 3176–3183

Abstract: Chemical composition and antioxidant and antifungal action of the oils from leaves and wood bark of two chemotypes ... ...

Abstract	Chemical composition and antioxidant and antifungal action of the oils from leaves and wood bark of two chemotypes of
Language	English
Publishing date	2020-02-06
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	242498-8
ISSN	0975-8402 ; 0022-1155
ISSN (online)	0975-8402
ISSN	0022-1155
DOI	10.1007/s13197-020-04288-7
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Article: Hydrodynamic and Performance Evaluation of a Porous Ceramic Membrane Module Used on the Water-Oil Separation Process: An Investigation by CFD.

Oliveira Neto, Guilherme L / Oliveira, Nívea G N / Delgado, João M P Q / Nascimento, Lucas P C / Magalhães, Hortência L F / Oliveira, Paloma L de / Gomez, Ricardo S / Farias Neto, Severino R / Lima, Antonio G B

Membranes

2021 Volume 11, Issue 2

Abstract: Wastewater from the oil industry can be considered a dangerous contaminant for the environment and needs to be treated before disposal or re-use. Currently, membrane separation is one of the most used technologies for the treatment of produced water. ... ...

Abstract	Wastewater from the oil industry can be considered a dangerous contaminant for the environment and needs to be treated before disposal or re-use. Currently, membrane separation is one of the most used technologies for the treatment of produced water. Therefore, the present work aims to study the process of separating oily water in a module equipped with a ceramic membrane, based on the Eulerian-Eulerian approach and the Shear-Stress Transport (SST k-ω) turbulence model, using the Ansys Fluent
Language	English
Publishing date	2021-02-08
Publishing country	Switzerland
Document type	Journal Article
ISSN	2077-0375
ISSN	2077-0375
DOI	10.3390/membranes11020121
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Article ; Online: Acute HIV-1 and SARS-CoV-2 Infections Share Slan+ Monocyte Depletion-Evidence from an Hyperacute HIV-1 Case Report.

Farias, Guilherme B / Badura, Robert / Conceição, Carolina M / Gomes, André M C / Godinho-Santos, Ana / Laia, Joel / Rosmaninho, Pedro / Santos, Diana F / Mota, Catarina / Almeida, Afonso R M / Fernandes, Susana M / Trombetta, Amelia C / Sousa, Ana E

Viruses

2021 Volume 13, Issue 9

Abstract: ... development of specific B- and T-cell responses. Recently, these cells were shown to be associated ...

Abstract	Monocytes are key modulators in acute viral infections, determining both inflammation and development of specific B- and T-cell responses. Recently, these cells were shown to be associated to different SARS-CoV-2 infection outcome. However, their role in acute HIV-1 infection remains unclear. We had the opportunity to evaluate the mononuclear cell compartment in an early hyper-acute HIV-1 patient in comparison with an untreated chronic HIV-1 and a cohort of SARS-CoV-2 infected patients, by high dimensional flow cytometry using an unsupervised approach. A distinct polarization of the monocyte phenotype was observed in the two viral infections, with maintenance of pro-inflammatory M1-like profile in HIV-1, in contrast to the M2-like immunosuppressive shift in SARS-CoV-2. Noticeably, both acute infections had reduced CD14
MeSH term(s)	Adult ; Aged ; Amino Sugars/immunology ; COVID-19/immunology ; Cohort Studies ; Female ; HIV Infections/immunology ; HIV-1/immunology ; Humans ; Leukocyte Count ; Male ; Middle Aged ; Monocytes/immunology ; Young Adult
Chemical Substances	6-sulfo-LacNac ; Amino Sugars
Language	English
Publishing date	2021-09-10
Publishing country	Switzerland
Document type	Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13091805
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Article ; Online: Factors associated to mortality in children with critical COVID-19 and multisystem inflammatory syndrome in a resource-poor setting.

de Farias, Emmerson C F / Pavão Junior, Manoel J C / de Sales, Susan C D / do Nascimento, Luciana M P P / Pavão, Dalila C A / Pinheiro, Anna P S / Pinheiro, Andreza H O / Alves, Marília C B / Ferraro, Kíssila M M M / Aires, Larisse F Q / Dias, Luana G / Machado, Mayara M M / Serrão, Michaelle J D / Gomes, Raphaella R / de Moraes, Sara M P / Moura, Gabriella M G / de Sousa, Adriana M B / Pontes, Gabriela C L / Carvalho, Railana D F P /

Silva, Cristiane T C / Lemes, Guilherme / da C G Diniz, Bruna / Chermont, Aurimery G / de Almeida, Kellen F S / Saraty, Salma B / Maia, Mary L F / Lima, Miriam R C / Carvalho, Patricia B / de B Braga, Renata / de O Harada, Kathia / Justino, Maria C A / Clemente, Gleice / Terreri, Maria Teresa / Monteiro, Marta C

Scientific reports

2024 Volume 14, Issue 1, Page(s) 5539

Abstract: SARS-CoV-2 infection in children is usually asymptomatic/mild. However, some patients may develop critical forms. We aimed to describe characteristics and evaluate the factors associated to in-hospital mortality of patients with critical COVID-19/MIS-C ... ...

Abstract	SARS-CoV-2 infection in children is usually asymptomatic/mild. However, some patients may develop critical forms. We aimed to describe characteristics and evaluate the factors associated to in-hospital mortality of patients with critical COVID-19/MIS-C in the Amazonian region. This multicenter prospective cohort included critically ill children (1 mo-18 years old), with confirmed COVID-19/MIS-C admitted to 3 tertiary Pediatric Intensive Care Units (PICU) in the Brazilian Amazon, between April/2020 and May/2023. The main outcome was in-hospital mortality and were evaluated using a multivariable Cox proportional regression. We adjusted the model for pediatric risk of mortality score version IV (PRISMIV) score and age/comorbidity. 266 patients were assessed with 187 in the severe COVID-19 group, 79 included in the MIS-C group. In the severe COVID-19 group 108 (57.8%) were male, median age was 23 months, 95 (50.8%) were up to 2 years of age. Forty-two (22.5%) patients in this group died during follow-up in a median time of 11 days (IQR, 2-28). In the MIS-C group, 56 (70.9%) were male, median age was 23 months and median follow-up was 162 days (range, 3-202). Death occurred in 17 (21.5%) patients with a median death time of 7 (IQR, 4-13) days. The mortality was associated with higher levels of Vasoactive Inotropic-Score (VIS), presence of acute respiratory distress syndrome (ARDS), higher levels of Erythrocyte Sedimentation Rate, (ESR) and thrombocytopenia. Critically ill patients with severe COVID-19 and MIS-C from the Brazilian Amazon showed a high mortality rate, within 12 days of hospitalization.
MeSH term(s)	Child ; Humans ; Male ; Infant ; Child, Preschool ; Female ; Critical Illness ; Prospective Studies ; COVID-19/epidemiology ; COVID-19/complications ; SARS-CoV-2 ; Connective Tissue Diseases ; Systemic Inflammatory Response Syndrome
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-55065-x
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