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Article ; Online: NF-YA transcription factors suppress jasmonic acid-mediated antiviral defense and facilitate viral infection in rice.

Tan, Xiaoxiang / Zhang, Hehong / Yang, Zihang / Wei, Zhongyan / Li, Yanjun / Chen, Jianping / Sun, Zongtao

2022 Volume 18, Issue 5, Page(s) e1010548

Abstract: ... roles of rice NF-YA family genes in antiviral defense against two different plant viruses, Rice stripe ... both induced the expression of OsNF-YA family genes. Overexpression of OsNF-YAs enhanced rice susceptibility ... that the expression of jasmonic acid (JA)-related genes was significantly decreased in plants overexpressing OsNF-YA ...

Abstract	NF-Y transcription factors are known to play many diverse roles in the development and physiological responses of plants but little is known about their role in plant defense. Here, we demonstrate the negative roles of rice NF-YA family genes in antiviral defense against two different plant viruses, Rice stripe virus (RSV, Tenuivirus) and Southern rice black-streaked dwarf virus (SRBSDV, Fijivirus). RSV and SRBSDV both induced the expression of OsNF-YA family genes. Overexpression of OsNF-YAs enhanced rice susceptibility to virus infection, while OsNF-YAs RNAi mutants were more resistant. Transcriptome sequencing showed that the expression of jasmonic acid (JA)-related genes was significantly decreased in plants overexpressing OsNF-YA when they were infected by viruses. qRT-PCR and JA sensitivity assays confirmed that OsNF-YAs play negative roles in regulating the JA pathway. Further experiments showed that OsNF-YAs physically interact with JA signaling transcription factors OsMYC2/3 and interfere with JA signaling by dissociating the OsMYC2/3-OsMED25 complex, which inhibits the transcriptional activation activity of OsMYC2/3. Together, our results reveal that OsNF-YAs broadly inhibit plant antiviral defense by repressing JA signaling pathways, and provide new insight into how OsNF-YAs are directly associated with the JA pathway.
MeSH term(s)	Antiviral Agents/metabolism ; Cyclopentanes ; Gene Expression Regulation, Plant ; Oryza/metabolism ; Oxylipins ; Plant Diseases ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Plants, Genetically Modified/metabolism ; Tenuivirus/genetics ; Tenuivirus/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Virus Diseases
Chemical Substances	Antiviral Agents ; Cyclopentanes ; Oxylipins ; Plant Proteins ; Transcription Factors ; jasmonic acid (6RI5N05OWW)
Language	English
Publishing date	2022-05-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2205412-1
ISSN	1553-7374 ; 1553-7374
ISSN (online)	1553-7374
ISSN	1553-7374
DOI	10.1371/journal.ppat.1010548
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Article ; Online: Identification and expression analysis of maize NF-YA subunit genes

Mingyue Lv / Hongzhe Cao / Xue Wang / Kang Zhang / Helong Si / Jinping Zang / Jihong Xing / Jingao Dong

PeerJ, Vol 10, p e

2022 Volume 14306

Abstract: ... as resistance to biotic and abiotic stress. In this study, 16 maize (Zea mays) NF-YA subunit genes were ... _NF-YA domain. Maize NF-YA subunit genes showed very obvious tissue expression characteristics ... The expression level of the NF-YA subunit genes significantly changed under different abiotic stresses, including ...

Abstract	NF-YAs encode subunits of the nuclear factor-Y (NF-Y) gene family. NF-YAs represent a kind of conservative transcription factor in plants and are involved in plant growth and development, as well as resistance to biotic and abiotic stress. In this study, 16 maize (Zea mays) NF-YA subunit genes were identified using bioinformatics methods, and they were divided into three categories by a phylogenetic analysis. A conserved domain analysis showed that most contained a CCAAT-binding transcription factor (CBFB) _NF-YA domain. Maize NF-YA subunit genes showed very obvious tissue expression characteristics. The expression level of the NF-YA subunit genes significantly changed under different abiotic stresses, including Fusarium graminearum infection and salicylic acid (SA) or jasmonic acid (JA) treatments. After inoculation with Setosphaeria turcica and Cochliobolus heterostrophus, the lesion areas of nfya01 and nfya06 were significantly larger than that of B73, indicating that ZmNFYA01 and ZmNFYA06 positively regulated maize disease resistance. ZmNFYA01 and ZmNFYA06 may regulated maize disease resistance by affecting the transcription levels of ZmPRs. Thus, NF-YA subunit genes played important roles in promoting maize growth and development and resistance to stress. The results laid a foundation for clarifying the functions and regulatory mechanisms of NF-YA subunit genes in maize.
Keywords	Maize ; NF-YA subunit gene ; Biological stress ; Abiotic stress ; Expression analysis ; Medicine ; R ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Release of legacy mercury and effect of aquaculture on mercury biogeochemical cycling in highly polluted Ya-Er Lake, China.

Chen, Lufeng / Zhang, Xing / Cao, Mengxi / Pan, Yu / Xiao, Cailing / Wang, Pu / Liang, Yong / Liu, Guangliang / Cai, Yong

Chemosphere

2021 Volume 275, Page(s) 130011

Abstract: ... the biogeochemical cycling and potential risk of Hg in the Ya-Er Lake, which was heavily contaminated by historical ... chlor-alkali production. Higher concentrations of total Hg (THg) in Ya-Er Lake water (16.8 ± 8.4 ng L ...

Abstract	Although global mercury (Hg) emission from chlor-alkali industry is decreasing, the legacy Hg may still have potential risks due to its environmental persistence. The objective of this work is to study the biogeochemical cycling and potential risk of Hg in the Ya-Er Lake, which was heavily contaminated by historical chlor-alkali production. Higher concentrations of total Hg (THg) in Ya-Er Lake water (16.8 ± 8.4 ng L
MeSH term(s)	Animals ; Aquaculture ; China ; Ecosystem ; Environmental Monitoring ; Geologic Sediments ; Lakes ; Mercury/analysis ; Methylmercury Compounds ; Water Pollutants, Chemical/analysis
Chemical Substances	Methylmercury Compounds ; Water Pollutants, Chemical ; Mercury (FXS1BY2PGL)
Language	English
Publishing date	2021-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2021.130011
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Article: Professor ya-ling han.

Zhang, He / Li, Lai-Fu

Journal of geriatric cardiology : JGC

2013 Volume 10, Issue 2, Page(s) 121–122

Language	English
Publishing date	2013-07-23
Publishing country	China
Document type	Journal Article
ZDB-ID	2421391-3
ISSN	1671-5411
ISSN	1671-5411
DOI	10.3969/j.issn.1671-5411.2013.02.015
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Article ; Online: Deep-sequence phylogenetics to quantify patterns of HIV transmission in the context of a universal testing and treatment trial - BCPP/Ya Tsie trial.

Magosi, Lerato E / Zhang, Yinfeng / Golubchik, Tanya / DeGruttola, Victor / Tchetgen Tchetgen, Eric / Novitsky, Vladimir / Moore, Janet / Bachanas, Pam / Segolodi, Tebogo / Lebelonyane, Refeletswe / Pretorius Holme, Molly / Moyo, Sikhulile / Makhema, Joseph / Lockman, Shahin / Fraser, Christophe / Essex, Myron Max / Lipsitch, Marc

eLife

2022 Volume 11

Abstract: ... in the 30-community Ya Tsie trial in Botswana. We sequenced HIV viral whole genomes from 5114 trial ...

Abstract	Background: Mathematical models predict that community-wide access to HIV testing-and-treatment can rapidly and substantially reduce new HIV infections. Yet several large universal test-and-treat HIV prevention trials in high-prevalence epidemics demonstrated variable reduction in population-level incidence. Methods: To elucidate patterns of HIV spread in universal test-and-treat trials, we quantified the contribution of geographic-location, gender, age, and randomized-HIV-intervention to HIV transmissions in the 30-community Ya Tsie trial in Botswana. We sequenced HIV viral whole genomes from 5114 trial participants among the 30 trial communities. Results: Deep-sequence phylogenetic analysis revealed that most inferred HIV transmissions within the trial occurred within the same or between neighboring communities, and between similarly aged partners. Transmissions into intervention communities from control communities were more common than the reverse post-baseline (30% [12.2 - 56.7] vs. 3% [0.1 - 27.3]) than at baseline (7% [1.5 - 25.3] vs. 5% [0.9 - 22.9]) compatible with a benefit from treatment-as-prevention. Conclusions: Our findings suggest that population mobility patterns are fundamental to HIV transmission dynamics and to the impact of HIV control strategies. Funding: This study was supported by the National Institute of General Medical Sciences (U54GM088558), the Fogarty International Center (FIC) of the U.S. National Institutes of Health (D43 TW009610), and the President's Emergency Plan for AIDS Relief through the Centers for Disease Control and Prevention (CDC) (Cooperative agreements U01 GH000447 and U2G GH001911).
MeSH term(s)	Epidemics ; Female ; HIV Infections/diagnosis ; HIV Infections/epidemiology ; HIV Infections/prevention & control ; Humans ; Incidence ; Male ; Phylogeny ; Prevalence
Language	English
Publishing date	2022-03-01
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.72657
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Article: Advances on plant miR169/NF-YA regulation modules.

Xu, Miao-yun / Zhu, Jia-xu / Zhang, Min / Wang, Lei

Yi chuan = Hereditas

2016 Volume 38, Issue 8, Page(s) 700–706

Abstract: ... and experimental analyses suggest that miR169 targets members of the transcription factor NF-YA gene ... In addition, a comprehensive understanding the regulatory functions of the miR169/NF-YA module in plant ...

Abstract	Plant microRNAs (miRNAs) are a class of small non-coding RNAs which target and regulate the expression of genes involved in several growth, development, and metabolism processes. The miR169 family is the largest and most conserved miRNA family in plants. Recent researches have shown involvement of miR169 members in the regulation of plant responding to abiotic stress and development. Computational prediction and experimental analyses suggest that miR169 targets members of the transcription factor NF-YA gene family. In this review, we summarize the origins, evolution and diversity of miR169 family members. In addition, a comprehensive understanding the regulatory functions of the miR169/NF-YA module in plant with particular emphasis on stress-induced flowering is discussed.
MeSH term(s)	Flowers/genetics ; Gene Expression Regulation, Plant/genetics ; Genes, Plant/genetics ; MicroRNAs/genetics ; RNA, Plant/genetics ; Stress, Physiological/genetics ; Transcription Factors/genetics
Chemical Substances	MicroRNAs ; RNA, Plant ; Transcription Factors
Language	English
Publishing date	2016
Publishing country	China
Document type	Journal Article ; Review
ISSN	0253-9772
ISSN	0253-9772
DOI	10.16288/j.yczz.15-526
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Article ; Online: NF-YA transcription factors suppress jasmonic acid-mediated antiviral defense and facilitate viral infection in rice.

Xiaoxiang Tan / Hehong Zhang / Zihang Yang / Zhongyan Wei / Yanjun Li / Jianping Chen / Zongtao Sun

PLoS Pathogens, Vol 18, Iss 5, p e

2022 Volume 1010548

Abstract	NF-Y transcription factors are known to play many diverse roles in the development and physiological responses of plants but little is known about their role in plant defense. Here, we demonstrate the negative roles of rice NF-YA family genes in antiviral defense against two different plant viruses, Rice stripe virus (RSV, Tenuivirus) and Southern rice black-streaked dwarf virus (SRBSDV, Fijivirus). RSV and SRBSDV both induced the expression of OsNF-YA family genes. Overexpression of OsNF-YAs enhanced rice susceptibility to virus infection, while OsNF-YAs RNAi mutants were more resistant. Transcriptome sequencing showed that the expression of jasmonic acid (JA)-related genes was significantly decreased in plants overexpressing OsNF-YA when they were infected by viruses. qRT-PCR and JA sensitivity assays confirmed that OsNF-YAs play negative roles in regulating the JA pathway. Further experiments showed that OsNF-YAs physically interact with JA signaling transcription factors OsMYC2/3 and interfere with JA signaling by dissociating the OsMYC2/3-OsMED25 complex, which inhibits the transcriptional activation activity of OsMYC2/3. Together, our results reveal that OsNF-YAs broadly inhibit plant antiviral defense by repressing JA signaling pathways, and provide new insight into how OsNF-YAs are directly associated with the JA pathway.
Keywords	Immunologic diseases. Allergy ; RC581-607 ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Theaflavoids A-C, new flavan-3-ols with potent α-glucosidase inhibitory activity from Yunnan black tea 'Jin-Ya'

Li, Na / Chen, Min / Zhu, Hong-Tao / Zhang, Man / Wang, Dong / Yang, Chong-Ren / Zhang, Ying-Jun

Lebensmittel-Wissenschaft + Technologie. 2022 Oct. 01, v. 168

2022

Abstract: ... The extensive investigation on the chemical constituents of Yunnan black tea 'Jin-Ya', produced from the leaf ... only moderate activities. The results indicated that Yunnan black tea 'Jin-Ya' is an ideal drink ...

Abstract	Black tea, rich in various and complex polyphenols, is one of the most popular beverages in the world due to its pleasant aroma and health benefits, such as alleviate hyperglycemia and antioxidant. The extensive investigation on the chemical constituents of Yunnan black tea 'Jin-Ya', produced from the leaf buds of Camellia sinensis var. assamica, led to the isolation and identification of 16 flavonoids including three new flavan-3-ols, namely theaflavoids A-C (1–3). Most of the isolates displayed obvious inhibitory activity on α-glucosidase with IC₅₀ values ranging from 1.11 to 24.7 μM. Notably, the new theaflavoids 1–3 showed much stronger inhibitory activity (IC₅₀ = 1.34, 1.11, and 4.57 μM, respectively) than those of the positive controls (acarbose and quercetin, IC₅₀ = 228 and 9.38 μM, respectively). In addition, the isolated flavonol glycosides 5–16 were evaluated for their antioxidant activities by DPPH and ABTS ⁺ radical scavenging assays. Those with galloyl group in molecular exhibited comparable free radical scavenging activities to the positive controls (ascorbic acid and Trolox), while most of the flavonol glycosides showed only moderate activities. The results indicated that Yunnan black tea 'Jin-Ya' is an ideal drink with hypoglycemic and antioxidant property, and is worthy of regular consumption.
Keywords	Camellia sinensis var. assamica ; acarbose ; antioxidant activity ; antioxidants ; ascorbic acid ; black tea ; flavanols ; free radicals ; glycosides ; hyperglycemia ; leaves ; odors ; polyphenols ; quercetin ; China
Language	English
Dates of publication	2022-1001
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	241369-3
ISSN	0460-1173 ; 0023-6438
ISSN	0460-1173 ; 0023-6438
DOI	10.1016/j.lwt.2022.113918
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: New Flavoalkaloids with Potent α-Glucosidase and Acetylcholinesterase Inhibitory Activities from Yunnan Black Tea 'Jin-Ya'.

Li, Na / Zhu, Hong-Tao / Wang, Dong / Zhang, Man / Yang, Chong-Ren / Zhang, Ying-Jun

Journal of agricultural and food chemistry

2020 Volume 68, Issue 30, Page(s) 7955–7963

Abstract: As a subgroup of flavoalkaloids, ...

Abstract	As a subgroup of flavoalkaloids,
MeSH term(s)	Acetylcholinesterase/chemistry ; Alkaloids/chemistry ; Camellia sinensis/chemistry ; China ; Enzyme Inhibitors/chemistry ; Glycosides/chemistry ; Humans ; Kinetics ; Molecular Structure ; Plant Extracts/chemistry ; Plant Leaves/chemistry ; alpha-Glucosidases/chemistry
Chemical Substances	Alkaloids ; Enzyme Inhibitors ; Glycosides ; Plant Extracts ; Acetylcholinesterase (EC 3.1.1.7) ; alpha-Glucosidases (EC 3.2.1.20)
Language	English
Publishing date	2020-07-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.0c02401
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Zs.A 1172: Show issues

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Article: Landslide Detection in the Linzhi–Ya’an Section along the Sichuan–Tibet Railway Based on InSAR and Hot Spot Analysis Methods

Zhang, Jinmin / Zhu, Wu / Cheng, Yiqing / Li, Zhenhong

Remote Sensing. 2021 Sept. 08, v. 13, no. 18

2021

Abstract: Construction of the 998.64-km Linzhi–Ya’an section of the Sichuan–Tibet Railway has been influenced ... images were collected to detect landslide disasters along the entire Linzhi–Ya’an section. Interferogram ... Finally, 517 landslide disasters along the Linzhi–Ya’an route were detected by integrating observed ...

Abstract	Construction of the 998.64-km Linzhi–Ya’an section of the Sichuan–Tibet Railway has been influenced by landslide disasters, threatening the safety of Sichuan–Tibet railway projects. Landslide identification and deformation analysis in this area are urgently needed. In this context, it was the first time that 164 advanced land-observing satellite-2 (ALOS-2) phased array type L-band synthetic aperture radar-2 (PALSAR-2) images were collected to detect landslide disasters along the entire Linzhi–Ya’an section. Interferogram stacking and small baseline interferometry methods were used to derive the deformation rate and time-series deformation from 2014–2020. After that, the hot spot analysis method was introduced to conduct spatial clustering analysis of the annual deformation rate, and the effective deformation area was quickly extracted. Finally, 517 landslide disasters along the Linzhi–Ya’an route were detected by integrating observed deformation, Google Earth optical images, and external geological data. The main factors controlling the spatial landslide distribution were analyzed. In the vertical direction, the spatial landslide distribution was mainly concentrated in the elevation range of 3000–5000 m, the slope range of 10–40°, and the aspect of northeast and east. In the horizontal direction, landslides were concentrated near rivers, and were also closely related to earthquake-prone areas, fault zones, and high-precipitation areas. In short, rainfall, freeze–thaw weathering, seismic activity, and fault zones are the main factors inducing landslides along this route. This research provides scientific support for the construction and operation of the Linzhi–Ya’an section of the Sichuan–Tibet Railway.
Keywords	Internet ; deformation ; freeze-thaw cycles ; geophysics ; interferometry ; landslides ; railroads ; rain ; time series analysis
Language	English
Dates of publication	2021-0908
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2513863-7
ISSN	2072-4292
ISSN	2072-4292
DOI	10.3390/rs13183566
Database	NAL-Catalogue (AGRICOLA)

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