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  1. Article ; Online: SARS-CoV-2 infection in a X-linked agammaglobulinemia adolescent: An immunological approach to treatment.

    Stracuzzi, Marta / Vanetti, Claudia / Clerici, Mario / Zuccotti, Gian Vincenzo / Trabattoni, Daria / Giacomet, Vania

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2023  Volume 34, Issue 3, Page(s) e13921

    MeSH term(s) Humans ; Adolescent ; COVID-19 ; SARS-CoV-2 ; Agammaglobulinemia/complications ; Agammaglobulinemia/diagnosis ; Agammaglobulinemia/therapy ; Genetic Diseases, X-Linked/complications ; Genetic Diseases, X-Linked/diagnosis ; Genetic Diseases, X-Linked/therapy
    Language English
    Publishing date 2023-03-28
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13921
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    Zs.A 3096: Show issues Location:
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  2. Article ; Online: Use of transcriptomics for diagnosis of infections and sepsis in children: A narrative review.

    Casini, Francesca / Valentino, Maria Sole / Lorenzo, Marc Garcia / Caiazzo, Roberta / Coppola, Crescenzo / David, Daniela / Di Tonno, Raffaella / Giacomet, Vania

    Acta paediatrica (Oslo, Norway : 1992)

    2024  Volume 113, Issue 4, Page(s) 670–676

    Abstract: Aim: The aim of this review was to summarise the most recent evidence about the use of omics-based techniques as an instrument for a more rapid and accurate characterisation of respiratory tract infections, neurological infections and sepsis in ... ...

    Abstract Aim: The aim of this review was to summarise the most recent evidence about the use of omics-based techniques as an instrument for a more rapid and accurate characterisation of respiratory tract infections, neurological infections and sepsis in paediatrics.
    Methods: We performed a narrative review using PubMed and a set of inclusion criteria: English language articles, clinical trials, meta-analysis and reviews including only paediatric population inherited to this topic in the last 15 years.
    Results: The examined studies suggest that host gene expression signatures are an effective method to characterise the different types of infections, to distinguish infection from colonisation and, in some cases, to assess the severity of the disease in children.
    Conclusions: 'Omics-based techniques' may help to define the aetiology of infections in paediatrics, representing a useful tool to choose the most appropriate therapies and limit antibiotic resistance.
    MeSH term(s) Child ; Humans ; Anti-Bacterial Agents/therapeutic use ; Sepsis/diagnosis ; Sepsis/genetics ; Sepsis/drug therapy ; Respiratory Tract Infections ; Gene Expression Profiling ; Language
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-19
    Publishing country Norway
    Document type Meta-Analysis ; Journal Article ; Review
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.17119
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  3. Article: Pediatric Lyme Disease in Northern Italy: An 18-Year Single-Center Case Series.

    Forlanini, Federica / Di Tonno, Raffaella / Caiazzo, Roberta / David, Daniela / Valentino, Maria Sole / Rimoldi, Sara Giordana / Zuccotti, Gian Vincenzo / Trevisan, Giusto / Basile, Francesca Wanda / Giacomet, Vania

    Microorganisms

    2024  Volume 12, Issue 3

    Abstract: Tracing the profile of pediatric Lyme borreliosis (LB) in Europe is difficult due to the interregional variation in its incidence and lack in notifications. Moreover, the identification of LB can be challenging. This study is an 18-year case series of ... ...

    Abstract Tracing the profile of pediatric Lyme borreliosis (LB) in Europe is difficult due to the interregional variation in its incidence and lack in notifications. Moreover, the identification of LB can be challenging. This study is an 18-year case series of 130 children and adolescents aged under 18 years referred to the Pediatric Infectious Diseases Unit at L. Sacco Hospital, Milan, with suspicion of LB, between January 2005 and July 2023. The routine serological workup consisted of a two-step process: an initial screening test followed by Western blot (WB). Forty-four (34%) patients were diagnosed with LB. The median age was six years, and 45% were females. Of the children with erythema migrans (EM), 33 (57%) were confirmed as having true EM, and, of these, 4 (12%) were atypical. Ten (23%) patients had early disseminated/late diseases, including facial nerve palsy (
    Language English
    Publishing date 2024-02-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12030455
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  4. Article ; Online: Immunophenotypes of Newborns From SARS-CoV-2-infected Mothers.

    Stracuzzi, Marta / Paradiso, Laura / Panelli, Simona / Amendola, Antonella / Tanzi, Elisabetta / Fappani, Clara / Zuccotti, Gianvincenzo / Giacomet, Vania

    The Pediatric infectious disease journal

    2023  Volume 43, Issue 5, Page(s) e164–e168

    Abstract: Background: Little is known about the neonatal immunologic response to a maternal SARS-CoV-2 infection present during childbirth. Here we analyze a cohort of 75 neonates from SARS-CoV-2-infected mothers.: Methods: The SARS-CoV-2 infection status was ... ...

    Abstract Background: Little is known about the neonatal immunologic response to a maternal SARS-CoV-2 infection present during childbirth. Here we analyze a cohort of 75 neonates from SARS-CoV-2-infected mothers.
    Methods: The SARS-CoV-2 infection status was laboratory assessed by real-time reverse transcription polymerase chain reaction on nasopharyngeal swabs (NPS) in both mothers during childbirth and neonates within 24 hours of life. Immunophenotypes of peripheral blood mononucleated cells and SARS-CoV-2 antispike IgA, IgM and IgG of the newborns were recorded. Ten (13.3%) of 75 neonates had positive NPS for SARS-CoV-2; 17 of 75 (23%) were SARS-CoV-2-IgG seropositive, of which one with positive NPS. All the newborns resulted seronegative for SARS-CoV-2 IgA and IgM and were asymptomatic. Our cohort of newborns was divided into groups according to IgG seropositivity (IgG+/-) and NPS results (NPS+/-).
    Results: The count and proportion of lymphocyte subsets (evaluated measuring CD3, CD4, CD8 and CD19 markers) and of natural killer cells (evaluated by measuring the CD3-/CD16+/CD56+ subset) were all in the normal range, with no statistical differences among groups. We found a significant expansion of the T cell (CD3+) subset in the IgG+ group interpreted as the result of immune effects triggered by trained immunity in these newborns, but a decrease in CD4+ T cells for NPS+ neonates. It is therefore difficult to conclude that the decrease in CD4 can certainly be caused by an infection.
    Conclusions: A maternal SARS-CoV-2 infection resulted in an expansive effect of CD3+ T cells in IgG+ newborns; nonetheless, it seems not to affect structural and functional development of the newborn immune system.
    MeSH term(s) Female ; Humans ; Infant, Newborn ; SARS-CoV-2 ; COVID-19 ; Mothers ; Immunoglobulin G ; Immunoglobulin M ; Immunoglobulin A
    Chemical Substances Immunoglobulin G ; Immunoglobulin M ; Immunoglobulin A
    Language English
    Publishing date 2023-12-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000004289
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    Zs.A 1852: Show issues Location:
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  5. Article ; Online: Humoral and cell-mediated immune responses in HIV-vertically infected young patients after three doses of the BNT162b2 mRNA SARS-CoV-2 vaccine.

    Vanetti, Claudia / Stracuzzi, Marta / Crivellaro, Elisa / Ciciliano, Federica / Garziano, Micaela / Fenizia, Claudio / Biasin, Mara / Rubinacci, Valeria / Amendola, Antonella / Tanzi, Elisabetta / Zuccotti, Gian Vincenzo / Clerici, Mario / Giacomet, Vania / Trabattoni, Daria

    Frontiers in immunology

    2024  Volume 14, Page(s) 1301766

    Abstract: Background: Data on the efficacy of three SARS-CoV-2 mRNA BNT162b2 vaccine doses and the role of previous SARS-CoV-2-infection in enhancing vaccine immunogenicity in HIV-vertically-infected people living with HIV (PLWH) are limited, as is the duration ... ...

    Abstract Background: Data on the efficacy of three SARS-CoV-2 mRNA BNT162b2 vaccine doses and the role of previous SARS-CoV-2-infection in enhancing vaccine immunogenicity in HIV-vertically-infected people living with HIV (PLWH) are limited, as is the duration of vaccine-induced responses.
    Methods: SARS-CoV-2 plasma neutralizing activity (NA) against the European (B.1), Delta (B.1.617.2) and Omicron (B.1.1.529) variants and cell-mediated immunity (CMI) were analyzed in 29 ART-treated young PLWH (mean age 27.9 years) and 30 healthy controls (HC) who received three BNT162b2 vaccine doses. Individuals were stratified based on the presence/absence of previous SARS-CoV-2 infection (infected and vaccinated -SIV-; uninfected and vaccinated -SV-). Analyses were performed before vaccination (T0), 25 days from the second dose (T1), the day the third dose was administered (T2), and 3 months after the third dose (T3).
    Results: In PLWH: i) NA against all variants was higher in SIV compared to SV at T2 and was increased at T3; ii) switched-memory plasmablasts were augmented in SIV alone at T2 and T3; iii) a SARS-CoV-2 specific T cell memory was generated; iv) IFN-γ-secreting CD4+ and CD8+ T lymphocytes were boosted at T3 mainly in SV. CMI magnitude was reduced in PLWH compared to HC. Notably, after the third dose of vaccine viremia was unmodified, but CD4 T cell counts were reduced>20% in 3/29 PHLW.
    Conclusion: A third dose of BNT162b2 vaccine induces strong humoral and CMI responses in young ART-treated PLWH independently from a previous SARS-CoV-2 natural infection. The lower magnitude of CMI responses should be considered when planning mRNA vaccine booster doses in PLWH.
    MeSH term(s) Humans ; Adult ; COVID-19 Vaccines ; BNT162 Vaccine ; COVID-19/prevention & control ; SARS-CoV-2 ; Immunity, Cellular ; RNA, Messenger ; HIV Infections
    Chemical Substances COVID-19 Vaccines ; BNT162 Vaccine ; RNA, Messenger
    Language English
    Publishing date 2024-01-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1301766
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  6. Article ; Online: Acute myocardial injury: a novel clinical pattern in children with COVID-19.

    Wolfler, Andrea / Mannarino, Savina / Giacomet, Vania / Camporesi, Anna / Zuccotti, Gianvincenzo

    The Lancet. Child & adolescent health

    2020  Volume 4, Issue 8, Page(s) e26–e27

    MeSH term(s) Arrhythmias, Cardiac/virology ; Betacoronavirus ; COVID-19 ; Child ; Child, Preschool ; Coronavirus Infections/complications ; Coronavirus Infections/physiopathology ; Epidemics ; Humans ; Infant ; Italy ; Mucocutaneous Lymph Node Syndrome/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/physiopathology ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome/virology
    Keywords covid19
    Language English
    Publishing date 2020-06-01
    Publishing country England
    Document type Letter
    ISSN 2352-4650
    ISSN (online) 2352-4650
    DOI 10.1016/S2352-4642(20)30168-1
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  7. Article ; Online: Ventricular septal defect and aortic hypoplasia in congenital cytomegalovirus infection: occasional finding or underdetected correlation?

    Gianolio, Laura / Fumagalli, Mara / Manfredini, Valeria / Mannarino, Savina / Giacomet, Vania / Zuccotti, Gian Vincenzo

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

    2021  Volume 35, Issue 25, Page(s) 6558–6560

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Pregnancy ; Infant, Newborn ; Female ; Child ; Humans ; Pregnancy Complications, Infectious/diagnosis ; DNA, Viral ; Cytomegalovirus Infections/complications ; Cytomegalovirus Infections/diagnosis ; Cytomegalovirus Infections/congenital ; Cytomegalovirus ; Fetal Diseases/diagnosis ; Heart Defects, Congenital ; Heart Septal Defects, Ventricular/complications
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2021-04-28
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2077261-0
    ISSN 1476-4954 ; 1057-0802 ; 1476-7058
    ISSN (online) 1476-4954
    ISSN 1057-0802 ; 1476-7058
    DOI 10.1080/14767058.2021.1918086
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    Zs.A 3510: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article: Congenital CMV, Lights and Shadows on Its Management: The Experience of a Reference Center in Northern Italy.

    Rubinacci, Valeria / Fumagalli, Mara / Meraviglia, Giulia / Gianolio, Laura / Sala, Anna / Stracuzzi, Marta / Dighera, Anna / Zuccotti, Gian Vincenzo / Giacomet, Vania

    Children (Basel, Switzerland)

    2022  Volume 9, Issue 5

    Abstract: Congenital cytomegalovirus infection (cCMV) is the most common congenital viral infection, with a consistent rate of morbidity, mortality, and long-term sequelae, especially in the case of late diagnosis. Nevertheless, a universal screening for CMV is ... ...

    Abstract Congenital cytomegalovirus infection (cCMV) is the most common congenital viral infection, with a consistent rate of morbidity, mortality, and long-term sequelae, especially in the case of late diagnosis. Nevertheless, a universal screening for CMV is not currently recommended, and global awareness about this infection, as well as accurate and shared indications on follow-up and treatment, are still lacking. We reviewed data about 59 suspect cCMV cases who referred to our center from 2014 to 2021. We report 41 cases of confirmed cCMV diagnosed at birth, with clinical or radiological abnormalities in 36.6% of them. Other five patients received a late diagnosis and all presented neurological impairment. Twelve patients received therapy with Valganciclovir within the first month of life, with favorable outcome in nine cases. Therapy after the first month of life was attempted in four patients, with improvement in one case. The overall awareness about cCMV infection was 32.6%. Considering our population, maternal serological screening followed by targeted testing of neonates could be an effective strategy. Some aspects of cCMV infection management should be further investigated, such as indication of treatment after the first month of life or in asymptomatic patients. Awareness about the infection should be improved to implement preventive strategies.
    Language English
    Publishing date 2022-05-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children9050655
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  9. Article ; Online: Acute myocardial injury

    Wolfler, Andrea / Mannarino, Savina / Giacomet, Vania / Camporesi, Anna / Zuccotti, Gianvincenzo

    The Lancet Child & Adolescent Health

    a novel clinical pattern in children with COVID-19

    2020  Volume 4, Issue 8, Page(s) e26–e27

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2352-4642
    DOI 10.1016/s2352-4642(20)30168-1
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Acute myocardial injury: a novel clinical pattern in children with COVID-19

    Wolfler, Andrea / Mannarino, Savina / Giacomet, Vania / Camporesi, Anna / Zuccotti, Gianvincenzo

    Lancet Child Adolesc Health

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #457007
    Database COVID19

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