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  1. Article ; Online: Cerebral Venous Thrombosis in COVID-19.

    Benny, Rajesh / Singh, Rakeshsingh K / Venkitachalam, Anil / Lalla, Rakesh S / Shah, Amit M / Bolegave, Vyankatesh / Shetty, Ashutosh N / Panchal, Keyur C / Choudhary, Jitendra / Mathew, Anita / Hunnur, Manoj / Shetty, Kishore V

    Neurology India

    2022  Volume 70, Issue 2, Page(s) 652–659

    Abstract: Background: COVID-19 causes a hypercoagulable state leading to thrombosis. Many of these thrombotic complications occur in those with severe disease and late in the disease course. COVID-19 has recently been associated with cerebral venous thrombosis ( ... ...

    Abstract Background: COVID-19 causes a hypercoagulable state leading to thrombosis. Many of these thrombotic complications occur in those with severe disease and late in the disease course. COVID-19 has recently been associated with cerebral venous thrombosis (CVT).
    Objective: To study the onset of CVT in relation to COVID-19 and compare their characteristics and outcomes with non-COVID CVT patients admitted during the same period.
    Materials and methods: This multicentric, retrospective study conducted between April 4 and October 15, 2020, included adult patients with CVT who were positive for the SARS-CoV-2 virus and compared them with CVT patients who were negative for the SARS-CoV-2 virus hospitalized during the same period. We studied their clinical profile, risk factors for CVT, and markers of COVID coagulopathy, imaging characteristics, and factors influencing their outcomes.
    Results: We included 18 COVID-19-infected patients and compared them with 43 non-COVID-19 CVT patients. Fourteen patients in the COVID-19 group presented with CVT without the other typical features of COVID-19. Thirteen patients had non-severe COVID-19 disease. Twelve patients had a good outcome (mRS ≤2). Mortality and disability outcomes were not significantly different between the two groups.
    Conclusion: Our study suggests a possible association between COVID-19 and CVT. CVT can be the presenting manifestation of an underlying COVID-19, occurring early in the course of COVID-19 and even in those with mild disease. Patients with worse GCS on admission, abnormal HRCT chest, severe COVID-19, and need for invasive ventilation had a poor outcome.
    MeSH term(s) Adult ; COVID-19/complications ; Humans ; Intracranial Thrombosis/complications ; Retrospective Studies ; SARS-CoV-2 ; Venous Thrombosis/etiology
    Language English
    Publishing date 2022-05-09
    Publishing country India
    Document type Journal Article ; Multicenter Study
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/0028-3886.344623
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 698: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Rare Complication of Carotid Stenting: New-Onset Refractory Status Epilepticus: A Study of Five Patients.

    Deshmukh, Narayan D / Singh, Rakeshsingh K / Lalla, Rakesh S / Karapurkar, Anil P / Khadilkar, Satish V

    Annals of Indian Academy of Neurology

    2019  Volume 22, Issue 2, Page(s) 210–212

    Abstract: Introduction: New-onset refractory status epilepticus (NORSE) is uncommon and almost 50% of cases are cryptogenic. We report the rare development of NORSE following carotid artery stenting (CAS), a procedure which is increasingly being used to treat the ...

    Abstract Introduction: New-onset refractory status epilepticus (NORSE) is uncommon and almost 50% of cases are cryptogenic. We report the rare development of NORSE following carotid artery stenting (CAS), a procedure which is increasingly being used to treat the carotid stenosis.
    Materials and methods: Patients who developed NORSE following CAS for the prevention of stroke over a period of 5 years were analyzed retrospectively. The degree of internal carotid artery stenosis (ICA) was estimated as per the NASCET criteria.
    Results: We analyzed five patients (age: 56-83 years). NORSE was reported within 30 min to 14 days post-CAS. Status epilepticus was focal in two patients, generalized in two, and one had nonconvulsive status epilepticus. All patients were treated with multiple antiepileptic drugs. Four patients recovered and survived and one succumbed. Two patients had comorbid hypertension and two had diabetes and hypertension. Four patients had hemiparesis due to the contralateral middle cerebral artery territory infarction and one patient had syncope. Two patients had postinfarction gliosis.
    Conclusions: We report a new cause of NORSE, following CAS. Stroke resulting in gliosis and cerebral hyperperfusion syndrome are the proposed mechanisms.
    Language English
    Publishing date 2019-02-02
    Publishing country India
    Document type Journal Article
    ZDB-ID 2240174-X
    ISSN 1998-3549 ; 0972-2327
    ISSN (online) 1998-3549
    ISSN 0972-2327
    DOI 10.4103/aian.AIAN_445_18
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-Associated CNS Demyelination: Clinical Spectrum and Comparison with Aquaporin-4 Antibody Positive Neuromyelitis Optica Spectrum Disorder.

    Ojha, Pawan T / Aglave, Vikram B / Soni, Girish / Jagiasi, Kamlesh A / Singh, Rakesh K / Singh, Rakeshsingh Kamleshsingh / Nagendra, Shashank

    Neurology India

    2020  Volume 68, Issue 5, Page(s) 1106–1114

    Abstract: Background: The clinical phenotypes of myelin oligodendrocyte glycoprotein (MOG) antibody disease, its disease course, and treatment are poorly understood and much work needs to be done towards this.: Objective: To characterize the clinico-radiologic ...

    Abstract Background: The clinical phenotypes of myelin oligodendrocyte glycoprotein (MOG) antibody disease, its disease course, and treatment are poorly understood and much work needs to be done towards this.
    Objective: To characterize the clinico-radiologic spectrum and treatment outcomes of MOG antibody disease and differentiate it from aquaporin-4 (AQP-4) antibody positive neuromyelitis optica spectrum disorders (NMO-SD).
    Methods: A single-center, observational study from Western India during 2017-2019, of 48 patients with either MOG antibody positive (21 patients) or AQP-4 antibody positive (27 patients) central nervous system demyelination.
    Results: MOG antibody group had median age 32.2 years, no gender bias, median disease duration 40 months, relapses in 9 patients (43%), and median 2.5 (1-16) episodes per patient. Onset phenotypes included isolated bilateral optic neuritis (ON) (43%), isolated unilateral ON (19%), acute brainstem syndrome (19%), simultaneous ON with myelitis (9%), isolated myelitis (5%), and acute disseminated encephalomyelitis optic neuritis (ADEM-ON) (5%). Characteristic neuroimaging abnormalities were anterior segment longitudinally extensive ON, upper brainstem, and thoracic cord involvement (both short and long segment lesions). Most patients (86%) responded well to steroids, only 3/21 required rescue immunotherapy. In total, 6 out of 46 eyes affected developed permanent visual disability, while one patient had motor disability. The features differentiating MOG from AQP-4 antibody group were: no female predilection, preferential optic nerve involvement, characteristic neuroimaging abnormalities, and favorable therapeutic response and outcome.
    Conclusions: MOG disease commonly presents as severe ON, myelitis, acute brainstem syndrome, ADEM or their combinations. Early identification, treatment, and maintenance immunosuppression are necessary. It can easily be differentiated from NMO-SD using clinico-radiological features and therapeutic response.
    MeSH term(s) Adult ; Aquaporin 4 ; Autoantibodies ; Disabled Persons ; Humans ; India ; Motor Disorders ; Myelin-Oligodendrocyte Glycoprotein/analysis ; Neuromyelitis Optica/diagnostic imaging
    Chemical Substances Aquaporin 4 ; Autoantibodies ; Myelin-Oligodendrocyte Glycoprotein
    Language English
    Publishing date 2020-10-24
    Publishing country India
    Document type Journal Article ; Observational Study
    ZDB-ID 415522-1
    ISSN 1998-4022 ; 0028-3886
    ISSN (online) 1998-4022
    ISSN 0028-3886
    DOI 10.4103/0028-3886.294831
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 698: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Characteristics and outcomes of 100 consecutive patients with acute stroke and COVID-19.

    Benny, Rajesh / Singh, Rakeshsingh K / Venkitachalam, Anil / Lalla, Rakesh Shyam / Pandit, Rahul A / Panchal, Keyur C / Pardasani, Vibhor / Chanchalani, Gunjan / Basle, Mheboob / Bolegave, Vyankatesh / Manoj, Hunnur / Shetty, Ashutosh N / Shah, Amit M / Pai, Pawan / Banthia, Nilesh M / Patil, Shekhar G / Chafale, Vishal / Pujara, Bhavin / Shah, Sanjay /
    Mehta, Naresh / Thakkar, Vicky V / Patel, Vikas / Shetty, Kishore V

    Journal of the neurological sciences

    2021  Volume 423, Page(s) 117348

    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Brain Ischemia/complications ; Brain Ischemia/drug therapy ; Brain Ischemia/therapy ; COVID-19/complications ; COVID-19 Testing ; Comorbidity ; Female ; Fibrinolytic Agents/therapeutic use ; Glasgow Coma Scale ; Headache/epidemiology ; Heart Disease Risk Factors ; Humans ; Male ; Mechanical Thrombolysis ; Middle Aged ; SARS-CoV-2 ; Sensation Disorders/epidemiology ; Stroke/complications ; Stroke/drug therapy ; Stroke/surgery ; Symptom Assessment ; Thrombolytic Therapy ; Time-to-Treatment ; Tissue Plasminogen Activator/therapeutic use ; Treatment Outcome
    Chemical Substances Fibrinolytic Agents ; Tissue Plasminogen Activator (EC 3.4.21.68)
    Language English
    Publishing date 2021-02-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2021.117348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 308: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Acute Ischemic Stroke Treatment Using Mechanical Thrombectomy: A Study of 137 Patients.

    Singh, Rakeshsingh K / Chafale, Vishal Annaji / Lalla, Rakesh Shyam / Panchal, Keyurkumar Chandrakantbhai / Karapurkar, Anil Pandurang / Khadilkar, Satish Vasant / Ojha, Pawan K / Godge, Yogesh / Singh, Rakesh K / Benny, Rajesh

    Annals of Indian Academy of Neurology

    2014  Volume 20, Issue 3, Page(s) 211–216

    Abstract: Background: Mechanical thrombectomy (MT) is the most effective treatment in large vessel occlusion (LVO). We have analyzed our initial experience of MT of 137 patients in anterior circulation (AC) and posterior circulation (PC) LVO using Solitaire stent ...

    Abstract Background: Mechanical thrombectomy (MT) is the most effective treatment in large vessel occlusion (LVO). We have analyzed our initial experience of MT of 137 patients in anterior circulation (AC) and posterior circulation (PC) LVO using Solitaire stent retriever device.
    Methods: Retrospective cohort analysis of 112 AC and 25 PC acute ischemic strokes was done considering various baseline characteristics, risk factors, National Institute of Health Stroke Scale (NIHSS) change, revascularization rate, complications, and functional outcome at 3 months using modified Rankin score.
    Results: Out of 137 patients, occlusion was found in M1 segment (44.5%), carotid T occlusion (37.2%), and basilar artery (18.2%). Atrial fibrillation was important risk factor for Carotid T occlusion. 50.4% patients received intravenous thrombolysis. Baseline mean NIHSS in AC was 15.5 (±4.32), and PC was 19 (±5.5). Tandem lesions were noted in 14.6%. There was significant difference in mean door-to-needle time for AC and PC (220 ± 80.6 and 326 ± 191.8 min, respectively). Mean time to revascularization for AC (39.5 ± 14.1) and PC (42.2 ± 19.4) was similar. Procedural success (modified thrombolysis in cerebral infarction ≥2b) observed in AC and PC was 92.9% and 84%, respectively (
    Conclusion: MT is safe treatment and equally effective for both AC and PC LVO. With careful patient selection, clinical outcome in PC was comparable to AC despite delayed presentation and higher baseline NIHSS.
    Language English
    Publishing date 2014-12-09
    Publishing country India
    Document type Journal Article
    ZDB-ID 2240174-X
    ISSN 1998-3549 ; 0972-2327
    ISSN (online) 1998-3549
    ISSN 0972-2327
    DOI 10.4103/aian.AIAN_158_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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