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  1. Book ; Online: KE-QI

    Ai, Chunhui / Wang, Derui / Yan, Xu / Xu, Yang / Xie, Wenrui / Cao, Ziqiang

    A Knowledge Enhanced Article Quality Identification Dataset

    2022  

    Abstract: ... entities to Baidu Encyclopedia, then propose Knowledge Enhanced article Quality Identification (KE-QI ... results on KE-QI show that with initialization of our pre-trained Node2Vec model, our model achieves ...

    Abstract With so many articles of varying qualities being produced every moment, it is a very urgent task to screen outstanding articles and commit them to social media. To our best knowledge, there is a lack of datasets and mature research works in identifying high-quality articles. Consequently, we conduct some surveys and finalize 7 objective indicators to annotate the quality of 10k articles. During annotation, we find that many characteristics of high-quality articles (e.g., background) rely more on extensive external knowledge than inner semantic information of articles. In response, we link extracted article entities to Baidu Encyclopedia, then propose Knowledge Enhanced article Quality Identification (KE-QI) dataset. To make better use of external knowledge, we propose a compound model which fuses the text and external knowledge information via a gate unit to classify the quality of an article. Our experimental results on KE-QI show that with initialization of our pre-trained Node2Vec model, our model achieves about 78\% $F_1$, outperforming other baselines.
    Keywords Computer Science - Computation and Language
    Subject code 306
    Publishing date 2022-06-15
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The San-Qi-Xue-Shang-Ning formula protects against ulcerative colitis by restoring the homeostasis of gut immunity and microbiota.

    Yu, Wei / Kang, Cai / Zhang, Yijia / Li, Qi / Zhang, Zhiqiang / Zheng, Yang / Liu, Xincheng / Yan, Jing

    Journal of ethnopharmacology

    2023  Volume 305, Page(s) 116125

    Abstract: ... associated cancer (CAC). The San-Qi-Xue-Shang-Ning (SQ) formula has been utilized in clinical practice ...

    Abstract Ethnopharmacological relevance: Ulcerative colitis (UC) is a major cause of morbidity and mortality due to repetitive remissions and relapses, and many severe complications, including colitis-associated cancer (CAC). The San-Qi-Xue-Shang-Ning (SQ) formula has been utilized in clinical practice to treat gut diseases, but its pharmacological evidence is limited and awaits elucidation.
    Aim of the study: Here, we elucidated the molecular mechanisms of the SQ formula.
    Materials and methods: Its therapeutic value in combating UC and CAC was predicted from network pharmacology and weighted gene co-expression network analysis (WGCNA). Experimental colitis models were established by feeding dextran sodium sulfate (DSS) to C57BL/6N mice for 7 days, and they were subjected to the SQ formula for 14 days. High-throughput technologies and biochemical investigations were executed to corroborate the anti-colitis effect.
    Results: Network pharmacology and WGCNA demonstrated that the targets of the SQ formula were associated with interleukin-17 (IL-17), tumor necrosis factor (TNF), IL-1b and peroxisome proliferators-activated receptor (PPAR) signaling pathways, and correlated with the survival in patients with colorectal cancer. In mice with colitis, the SQ treatment hindered colitis progression in a dose-dependent manner, as evidenced by the rescued colon length and weight loss, improved colonic epithelial integrity, and abolished crypt loss. In addition to the suppressed serum IL-17, TNFα, and IL-1b levels, the SQ-treated colitis mice exhibited decreased colonic protein abundance of hypoxia-inducible factor-1α (HIF-1 α), PPARα, and Caspase3 (Casp3) with an increased PPARγ expression. Concurrently, the high dose of SQ promoted the alternative activation of peritoneal macrophages by increasing Arg1 and inhibiting iNOS2, thereby facilitating the migration of NCM460 cells and controlling TNF-induced reactive oxygen species production and apoptosis in intestinal organoids. In colitis-accompanied dysbiosis, the SQ formula reversed the decreased microbiota diversity indexes and restored the microbiome profile in the murine colitis models.
    Conclusion: The SQ formula is a potent anti-colitis drug that facilitates inflammation resolution and restores gut microbiota homeostasis.
    MeSH term(s) Mice ; Animals ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/metabolism ; Interleukin-17/metabolism ; Mice, Inbred C57BL ; Colitis/chemically induced ; Colon ; Microbiota ; Homeostasis ; Dextran Sulfate/toxicity ; Disease Models, Animal
    Chemical Substances Interleukin-17 ; Dextran Sulfate (9042-14-2)
    Language English
    Publishing date 2023-01-02
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2022.116125
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Effects of Liqi Tongbian decoction on gut microbiota, SCFAs production, and 5-HT pathway in STC rats with Qi Stagnation Pattern.

    Liu, Qihong / Ke, Danfeng / Chen, Youqin / Shen, Aling / Liu, Liya / Hu, Lunan / Ren, Yan / Fang, Wenyi / Zhao, Peilin / Sferraf, Thomas J / Luo, Yunfeng / Ke, Xiao

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1337078

    Abstract: ... of Liqi Tongbian Decoction (LTD) in the treatment of STC, especially in cases involving the context of Qi ... short-chain fatty acids (SCFAs). We employed a rat model of STC with Qi Stagnation Pattern, established using ... into the management of STC with Qi Stagnation Pattern. ...

    Abstract Slow transit constipation (STC) is a common and debilitating condition characterized by delayed colonic transit and difficulty in fecal expulsion, significantly impacting patients' physical and mental wellbeing as well as their overall quality of life. This study investigates the therapeutic potential of Liqi Tongbian Decoction (LTD) in the treatment of STC, especially in cases involving the context of Qi stagnation, through a multifaceted approach involving the modulation of intestinal flora and short-chain fatty acids (SCFAs). We employed a rat model of STC with Qi Stagnation Pattern, established using the "loperamide + tail-clamping provocation method," to explore the effects of LTD on fecal characteristics, intestinal motility, and colonic pathology. Importantly, LTD exhibited the ability to increase the richness, diversity, and homogeneity of intestinal flora while also modulating the composition of microorganisms. It significantly increased the production of SCFAs, especially butyric acid. Moreover, LTD exerted a substantial influence on the synthesis of serotonin (5-HT) by modulating the expression of tryptophan hydroxylase (TPH) and interacting with the 5-HT4 receptor (5-HT4R), resulting in enhanced colonic motility. Correlation analyses revealed a positive correlation between certain bacterial genera, such as Lachnospiraceae_NK4A136 spp. and Clostridiales spp. and the concentrations of butyric acid and 5-HT. These results suggest a mechanistic link between microbiome composition, SCFAs production, and 5-HT synthesis. These findings highlight the potential of LTD to alleviate STC by facilitating a beneficial interplay among intestinal flora, SCFAs production, and 5-HT-mediated colonic motility, providing novel insights into the management of STC with Qi Stagnation Pattern.
    Language English
    Publishing date 2024-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1337078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Ba-Qi-Rougan formula alleviates hepatic fibrosis by suppressing hepatic stellate cell activation via the MSMP/CCR2/PI3K pathway.

    Xue, Yan / Zhu, Wanchun / Qiao, Fengjie / Yang, Yilan / Qiu, Jiaohao / Zou, Chen / Gao, Yating / Zhang, Xin / Li, Man / Shang, Zhi / Gao, Yueqiu / Huang, Lingying

    Journal of ethnopharmacology

    2024  Volume 329, Page(s) 118169

    Abstract: Ethnopharmacological relevance: The Ba-Qi-Rougan formula (BQRGF) is a traditional and effective ...

    Abstract Ethnopharmacological relevance: The Ba-Qi-Rougan formula (BQRGF) is a traditional and effective compound prescription from Traditional Chinese Medicine (TCM) utilized in treating hepatic fibrosis (HF).
    Aim of the study: We aimed to evaluate the therapeutic efficacy of BQRGF on HF and explore the underlying mechanisms of action.
    Materials and methods: UPLC-Q-TOF-MS technology was employed to identify the material basis of BQRGF. Mice with carbon tetrachloride (CCl
    Results: A total of 48 compounds were identified from BQRGF, with 12 compounds being absorbed into the bloodstream and 9 compounds being absorbed into the liver. Four weeks of BQRGF treatment in the HF mouse model led to significant improvements in biochemical and molecular assays and histopathology, particularly in the medium and high-dose groups. These improvements included a reduction in the level of liver injury and fibrosis-related factors. MSMP levels were elevated in human and mouse fibrotic liver tissues, and this increase was mitigated in HF mice treated with BQRGF. Moreover, primary cells and co-culture studies revealed that BQRGF reduced MSMP expression, decreased the expression of the hepatic stellate cell (HSC) activation markers, and suppressed critical phosphorylated protein levels in the CCR2/PI3K/AKT pathway. These findings were further validated using CCR2/PI3K/AKT signaling inhibitors and agonists in MSMP-activated LX2 cells.
    Conclusions: Collectively, our results suggest that BQRGF combats HF by diminishing MSMP levels and inhibiting MSMP-induced HSC activation through the CCR2/PI3K/AKT pathway.
    Language English
    Publishing date 2024-04-16
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2024.118169
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Network Meta-analysis of Qi-supplementing and Yin-nourishing Chinese patent medicines in treatment of early diabetic nephropathy].

    Wang, Wen-Ru / Zhang, Xu-Ming / Li, Ji-Xin / Yang, Jia-Yi / Yu, Ren-Huan / Xie, Yan-Ming

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2023  Volume 48, Issue 14, Page(s) 3949–3964

    Abstract: This study aimed to evaluate the efficacy of Qi-supplementing and Yin-nourishing Chinese patent ... of Qi-supplementing and Yin-nourishing Chinese patent medicines in the treatment of early DN. After ... to the large clinical heterogeneity, the quantitative analysis could not be performed. Overall, Qi ...

    Abstract This study aimed to evaluate the efficacy of Qi-supplementing and Yin-nourishing Chinese patent medicine in the treatment of early diabetic nephropathy(DN) by network Meta-analysis to explore the Chinese patent medicine with optimal efficacy and provide references for preventing renal deterioration and delaying the progression of early DN. Eight databases, including CNKI, Wanfang, VIP, SinoMed, PubMed, EMbase, Cochrane Library, and Web of Science, were searched for clinical randomized controlled trial(RCT) of Qi-supplementing and Yin-nourishing Chinese patent medicines in the treatment of early DN. After the literature mee-ting the inclusion criteria was screened, the quality of the literature was evaluated using the Cochrane risk-of-bias tool, and network Meta-analysis was performed using the BUGSnet package in R 4.2.1. Seventy-two research articles with a sample size of 6 344 cases were included, involving eight Chinese patent medicines and seven outcome indicators. The results of the network Meta-analysis showed that(1)in terms of improving urinary albumin excretion rate(UAER), Chinese patent medicines combined with conventional treatment were superior to conventional treatment, and Qiyao Xiaoke Capsules + conventional treatment was optimal.(2)In terms of reducing serum crea-tinine(Scr), Bailing Capsules + conventional treatment had superior efficacy.(3)In terms of reducing 24-hour urine total protein(24hUTP), Shenyan Kangfu Tablets + conventional treatment and Jinshuibao Capsules + conventional treatment had equivalent efficacy, and Shenyan Kangfu Tablets + conventional treatment was superior.(4)In terms of improving fasting blood glucose(FBG), Shenyan Kangfu Tablets + conventional treatment had superior efficacy.(5)In terms of improving total cholesterol(TC), Qiyao Xiaoke Capsules +conventional treatment had superior efficacy.(6)In terms of reducing triglyceride(TG), Bailing Capsules + conventional treatment had superior efficacy.(7)In terms of safety, the occurrence of adverse reactions was reported in seven interventions, but due to the large clinical heterogeneity, the quantitative analysis could not be performed. Overall, Qi-supplementing and Yin-nourishing Chinese patent medicines combined with conventional treatment were superior to conventional treatment alone in the treatment of early DN. The results showed that Qi-supplementing and Yin-nourishing Chinese patent medicines combined with conventional treatment had good clinical efficacy, and they could significantly reduce renal function indicators such as UAER, Scr, and 24hUTP, and reduce blood sugar and blood lipid, which can provide evidence-based support for the treatment of early DN. However, due to the differences in the quantity and quality of the included research articles, large-sample, multi-center, high-quality studies are still needed for further verification.
    MeSH term(s) Humans ; Diabetic Nephropathies/drug therapy ; Nonprescription Drugs/therapeutic use ; Qi ; Network Meta-Analysis ; Capsules ; Drugs, Chinese Herbal/therapeutic use ; Tablets ; Diabetes Mellitus/drug therapy
    Chemical Substances Nonprescription Drugs ; Capsules ; Drugs, Chinese Herbal ; Tablets
    Language Chinese
    Publishing date 2023-07-20
    Publishing country China
    Document type Meta-Analysis ; English Abstract ; Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20230314.501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Medication experience of TCM Master Academician Wang Qi in the treatment of premature ejaculation: Data mining and analysis].

    Fan, Xiao-Lei / Tang, Yi-Bo / Bai, Xue / Chen, Ya-Fei / Liu, Dan / Liu, Gui-Min / Liu, Zhe-Jun / Li, Ling-Ru / Zheng, Yan-Fei / Liu, Zhen-Quan

    Zhonghua nan ke xue = National journal of andrology

    2023  Volume 27, Issue 11, Page(s) 1017–1024

    Abstract: ... of Academician Wang Qi in the treatment of premature ejaculation (PE) using the TCM inheritance support platform ... Academician Wang Qi employs tranquilizing the mind and consolidating the kidney (An Zhi Gu Shen ... from Academician Wang Qi's Clinic. We established a database of medical records on the TCM inheritance support ...

    Abstract Objective: To analyze the academic thought, medication experience and prescription rules of Academician Wang Qi in the treatment of premature ejaculation (PE) using the TCM inheritance support platform (V2.5).
    Methods: We collected and sorted out the medical records on the treatment of PE from Academician Wang Qi's Clinic. We established a database of medical records on the TCM inheritance support platform, analyzed the drugs and prescriptions in the database and explored new prescriptions using "statistical reports" and "data analysis" systems on the platform.
    Results: A total of 91 effective prescriptions were recorded, involving 148 TCM drugs, with Phellodendron, Amomum Villosum, Polygala Tenuifolia, Tuckahoe, Lodestone, Oyster, Acanthopanax Senticosus, Uncaria, Tribulus, and Keel as the top 10 with the highest frequency of use, which were featured mainly by "warm" and "cold" concerning the four natures, "sweet", "bitter" and "pungent" relating to the five flavors, and acting on "kidney meridian", "liver meridian" and "heart meridian" in terms of the meridian tropisms. In addition, 5 new prescriptions were obtained through unsupervised entropy hierarchical clustering.
    Conclusions: In the treatment of PE, Academician Wang Qi employs tranquilizing the mind and consolidating the kidney (An Zhi Gu Shen) as the primary strategy, taking into account the three organs of heart, liver and kidneys, focusing on the phase of calming the mind or regulating the liver or clearing the kidney or controlling fire, and adding or reducing drugs according to different conditions and syndromes, which conforms to his diagnosis and treatment mode of "body differentiation-disease differentiation-syndrome differentiation". The analysis of the potential new prescriptions also accords with Academician Wang Qi's rules of medication, which can provide some ideas for the clinical treatment of and scientific researches on premature ejaculation in the future.
    Language Chinese
    Publishing date 2023-07-09
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2267480-9
    ISSN 1009-3591
    ISSN 1009-3591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Integrating Network Pharmacology and Component Analysis to Study the Potential Mechanisms of Qi-Fu-Yin Decoction in Treating Alzheimer's Disease.

    Lei, Xia / Xu, Hongdan / Wang, Yan / Gao, Hainan / Zhao, Deping / Zhang, Jinfeng / Zhu, Ziyue / Zuo, Kun / Liu, Ying / Li, Xiaoliang / Zhang, Ning

    Drug design, development and therapy

    2023  Volume 17, Page(s) 2841–2858

    Abstract: Purpose: To elucidate the potential mechanisms of QFY for the treatment of Alzheimer's Disease (AD), and explore the effective substances of QFY.: Materials and methods: UPLC-LTQ-Orbitrap-MS was used to identify the chemical constituents of the serum ...

    Abstract Purpose: To elucidate the potential mechanisms of QFY for the treatment of Alzheimer's Disease (AD), and explore the effective substances of QFY.
    Materials and methods: UPLC-LTQ-Orbitrap-MS was used to identify the chemical constituents of the serum samples and the cerebrospinal fluid samples of rats after QFY administration. Network pharmacology was used to predict potential targets and pathways of QFY against AD. The AD mice model was established by subcutaneous injection of D-gal for 8 consecutive weeks. New object recognition (NOR) and Morris water maze test (MWM) were used to evaluate the learning and memory abilities of mice. Moreover, the levels of TNF-α, IL-1β, and IL-18 in the brain hippocampus of mice were determined by ELISA. The expression of Bax, Bcl-2, Caspase-1, PSD95, SYP, ICAM-1 and MCP-1 proteins in the hippocampus was detected by Western blotting. Furthermore, qRT-PCR was used to detect the gene expressions of PSD95, SYP, M1 and M2 polarization markers of microglia, including iNOS, CD16, ARG-1, and IL-10 in the hippocampus.
    Results: A total of 51 prototype compounds were detected in rat serum and 15 prototype components were identified in rat cerebrospinal fluid. Behavioral experiments revealed that QFY significantly increased the recognition index, decreased the escape latency, increased the platform crossing times and increased the residence time in the target quadrant. QFY also could alleviate the ultrastructural pathological changes in the hippocampus of AD mice. Meanwhile, QFY treatment suppressed the expression of inflammatory factors, such as TNF-α, IL-1β, and IL-18. QFY improved the synaptic plasticity of the hippocampus in D-gal model mice by significantly increasing the expression of proteins and mRNAs of PSD95 and SYP.
    Conclusion: QFY could effectively improve the learning and memory impairment of D-gal-induced AD mice by inhibiting the excessive activation of microglia, enhancing the expression of M2 microglia, inhibiting the increase of inflammatory factors, cell adhesion factors and chemokines, anti-apoptosis, and improving synaptic plasticity.
    MeSH term(s) Mice ; Rats ; Animals ; Tumor Necrosis Factor-alpha ; Alzheimer Disease/drug therapy ; Interleukin-18 ; Network Pharmacology
    Chemical Substances Tumor Necrosis Factor-alpha ; qi-fu-yin ; Interleukin-18
    Language English
    Publishing date 2023-09-14
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2451346-5
    ISSN 1177-8881 ; 1177-8881
    ISSN (online) 1177-8881
    ISSN 1177-8881
    DOI 10.2147/DDDT.S402624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Xiang qi

    Shanghai qi yuan shi yan xiao xue bian

    shang

    2012  

    Title variant Xiangqi : shang ; Hsiang-ch'i
    Author's details Shanghai qi yuan shi yan xiao xue bian
    Keywords Chinesisches Schach
    Language Chinese
    Size 76, graph. Darst., Ill.
    Publisher Shanghai ren min chu ban she
    Publishing place Shanghai
    Document type Book
    Note In chines. Schr. ; Chin. Schach : Band 1
    ISBN 9787208110175 ; 7208110174
    Database Former special subject collection: coastal and deep sea fishing

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  9. Article ; Online: Protective effects of Da-cheng-qi decoction in rats with intracerebral hemorrhage.

    Zeng, Peng / Wang, Xiao-Ming / Su, Hong-Fei / Zhang, Teng / Ning, Lin-Na / Shi, Yan / Yang, Shu-Sheng / Lin, Li / Tian, Qing

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2021  Volume 90, Page(s) 153630

    Abstract: ... modifying treatment. Da-cheng-qi decoction (DCQ), composed of rhubarb, is one of the most commonly used ...

    Abstract Background: Intracerebral hemorrhage (ICH), the most fatal subtype of stroke, has no disease-modifying treatment. Da-cheng-qi decoction (DCQ), composed of rhubarb, is one of the most commonly used Chinese traditional decoctions in ICH treatment. But the mechanism is not clear. Emodin is an active compound found in rhubarb.
    Purpose: To study the protective effects of DCQ on ICH and its possible mechanisms of action.
    Methods: The ICH model was reproduced by injecting collagenase-VII into the left caudate putamen (CPu) of rats. DCQ and emodin were used to treat the ICH rats for 7 days. Behavior tests, proteomic analysis, morphological studies, and western blotting were performed.
    Results: The neurological deficits in the ICH rats recovered with DCQ and emodin on the 14
    Conclusion: The protective effects of DCQ on ICH were confirmed in this study, and its mechanism may be related to the inhibition of MAPK and activation of M2 microglia. These results are beneficial to the development of ICH therapeutic targets.
    MeSH term(s) Animals ; Cerebral Hemorrhage/drug therapy ; Drugs, Chinese Herbal/pharmacology ; Emodin/pharmacology ; Hippocampus/drug effects ; Proteomics ; Rats ; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors
    Chemical Substances Da-Cheng-Qi ; Drugs, Chinese Herbal ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Emodin (KA46RNI6HN)
    Language English
    Publishing date 2021-06-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2021.153630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Combined detection of urinary biomarkers noninvasively predicts extent of renal injury in patients with early diabetic kidney disease with kidney qi deficiency syndrome: A retrospective investigation.

    Wu, Wei / Meng, Xian-Jie / Wan, Bing-Ying / Fang, Qi-Jun / Liu, Ying-Lu / Wang, Jie / Fu, Yan / Yuan, Can-Can / Wang, Mei-Zi / Chong, Fee-Lan / Wan, Yi-Gang / Shen, Shan-Mei

    Anatomical record (Hoboken, N.J. : 2007)

    2021  Volume 306, Issue 12, Page(s) 2945–2957

    Abstract: ... biomarkers in noninvasively predicting the extent of renal damage in patients with early DKD with kidney qi ... with clinical manifestations of kidney qi deficiency syndrome. Therefore, the combined detection of UCysC, UNAG ... of renal injury in patients with early Type 2 DKD with kidney qi deficiency syndrome. UTBs may be one ...

    Abstract Incipient diagnosis and noninvasive forecasts using urinary biomarkers are important for preventing diabetic kidney disease (DKD) progression, but they are also controversial. Previous studies have shown a potential relationship between urinary tubular biomarkers (UTBs) and traditional Chinese medicine (TCM) syndrome in patients with DKD. Thus, we further evaluated the clinical significance of combined detection of urinary biomarkers in noninvasively predicting the extent of renal damage in patients with early DKD with kidney qi deficiency syndrome, and preliminarily explored the potential biological link between UTBs and TCM syndrome in DKD. We categorized 92 patients with Type 2 diabetes mellitus into three groups as follows: 20 patients with normoalbuminuria, 50 patients with microalbuminuria, and 22 patients with macroalbuminuria. We found that, in all groups, 24 hr urinary albumin (24hUAlb) and urinary albumin-to-creatinine ratio (UACR) showed stepwise and significant increases. Urinary cystatin C (UCysC), urinary N-acetyl-β-d-glucosaminidase (UNAG), and urinary retinol-binding protein (URBP) synchronously increased gradually, consistent with the degree of albuminuria in all groups. Moreover, 24hUAlb and UACR were positively correlated with UCysC, UNAG, and URBP, respectively. In 72 patients with Type 2 DKD with albuminuria, a positive correlation was observed between UNAG and URBP, UCysC was also positively correlated with UNAG and URBP, respectively. Additionally, TCM syndrome distributional characteristics in all patients were consistent with clinical manifestations of kidney qi deficiency syndrome. Therefore, the combined detection of UCysC, UNAG, URBP, and UAlb may be used as a practical clinical technique to noninvasively forecast the extent of renal injury in patients with early Type 2 DKD with kidney qi deficiency syndrome. UTBs may be one of the biological bases of the specific TCM syndromes in DKD.
    MeSH term(s) Humans ; Diabetic Nephropathies/diagnosis ; Albuminuria/diagnosis ; Albuminuria/urine ; Retrospective Studies ; Diabetes Mellitus, Type 2/complications ; Qi ; Acetylglucosaminidase/urine ; Kidney ; Biomarkers ; Albumins
    Chemical Substances Acetylglucosaminidase (EC 3.2.1.52) ; Biomarkers ; Albumins
    Language English
    Publishing date 2021-12-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2269667-2
    ISSN 1932-8494 ; 1932-8486
    ISSN (online) 1932-8494
    ISSN 1932-8486
    DOI 10.1002/ar.24835
    Database MEDical Literature Analysis and Retrieval System OnLINE

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