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  1. Article ; Online: Tribute to Lewis Landsberg: A Giant of Academic Medicine.

    Batlle, Daniel

    Hypertension (Dallas, Tex. : 1979)

    2021  Volume 79, Issue 1, Page(s) 291–292

    MeSH term(s) History, 20th Century ; History, 21st Century ; Humans ; Hypertension/history
    Language English
    Publishing date 2021-11-01
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.121.18484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Delayed Graft Function and the Renin-Angiotensin System.

    Yamani, Fatmah / Cianfarini, Cosimo / Batlle, Daniel

    Transplantation

    2024  

    Abstract: Delayed graft function (DGF) is a form of acute kidney injury (AKI) and a common complication following kidney transplantation. It adversely influences patient outcomes increases the financial burden of transplantation, and currently, no specific ... ...

    Abstract Delayed graft function (DGF) is a form of acute kidney injury (AKI) and a common complication following kidney transplantation. It adversely influences patient outcomes increases the financial burden of transplantation, and currently, no specific treatments are available. In developing this form of AKI, activation of the renin-angiotensin system (RAS) has been proposed to play an important role. In this review, we discuss the role of RAS activation and its contribution to the pathophysiology of DGF following the different stages of the transplantation process, from procurement and ischemia to transplantation into the recipient and including data from experimental animal models. Deceased kidney donors, whether during cardiac or brain death, may experience activation of the RAS. That may be continued or further potentiated during procurement and organ preservation. Additional evidence suggests that during implantation of the kidney graft and reperfusion in the recipient, the RAS is activated and may likely remain activated, extrapolating from other forms of AKI where RAS overactivity is well documented. Of particular interest in this setting is the status of angiotensin-converting enzyme 2, a key RAS enzyme essential for the metabolism of angiotensin II and abundantly present in the apical border of the proximal tubules, which is the site of predominant injury in AKI and DGF. Interventions aimed at safely downregulating the RAS using suitable shorter forms of angiotensin-converting enzyme 2 could be a way to offer protection against DGF.
    Language English
    Publishing date 2024-02-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004934
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 509: Show issues

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  3. Article ; Online: ACE2 in the Urine: Where Does It Come From?

    Wysocki, Jan / Batlle, Daniel

    Kidney360

    2022  Volume 3, Issue 12, Page(s) 2001–2004

    MeSH term(s) Angiotensin-Converting Enzyme 2 ; Renin-Angiotensin System ; Peptidyl-Dipeptidase A/metabolism
    Chemical Substances Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Peptidyl-Dipeptidase A (EC 3.4.15.1)
    Language English
    Publishing date 2022-12-29
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0005592022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Potential SARS-CoV-2 kidney infection and paths to injury.

    Hassler, Luise / Batlle, Daniel

    Nature reviews. Nephrology

    2022  Volume 18, Issue 5, Page(s) 275–276

    MeSH term(s) Acute Kidney Injury/etiology ; COVID-19 ; Female ; Humans ; Kidney ; Male ; SARS-CoV-2
    Language English
    Publishing date 2022-02-21
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-022-00551-6
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    Zs.A 6334: Show issues Location:
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    Zs.MG 107: Show issues

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  5. Article: COVID-19 and its impact on the kidney and the nephrology community.

    Soler, María José / Batlle, Daniel

    Clinical kidney journal

    2021  Volume 14, Issue Suppl 1, Page(s) i1–i5

    Language English
    Publishing date 2021-03-26
    Publishing country England
    Document type Editorial
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfab039
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    Zs.A 6587: Show issues Location:
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  6. Article ; Online: FSGS and COVID-19 in Non-African American Patients.

    Medina, Elba / Rueda, Carlos / Batlle, Daniel

    Kidney360

    2023  Volume 4, Issue 5, Page(s) 687–699

    Abstract: Collapsing Focal Segmental Glomerulosclerosis (FSGS) has been reported relatively frequently in African American (AA) patients with coronavirus disease 2019 (COVID-19), and it is associated almost always with Apolipoprotein L gen 1 (APOL1) high-risk ... ...

    Abstract Collapsing Focal Segmental Glomerulosclerosis (FSGS) has been reported relatively frequently in African American (AA) patients with coronavirus disease 2019 (COVID-19), and it is associated almost always with Apolipoprotein L gen 1 (APOL1) high-risk variants. We reviewed the published literature from April 2020 to November 2022 searching for non-African American (non-AA) patients with FSGS associated with COVID-19 (eight White patients, six Hispanic patients, three Asian patients, one Indian patient, and one Asian Indian patient). The following histologic patterns were found: collapsing (n=11), not otherwise specified (n=5), tip (n=2), and perihilar (n=1). Fifteen of the 19 patients had AKI. The APOL1 genotype was reported in only six of the 19 non-AA patients. Three of them (two Hispanic patients and one White patient) with collapsing FSGS had high-risk APOL1 variants. The other three patients (two White patients and one Hispanic patient with the collapsing variant, tip variant, and not otherwise specified) had low-risk APOL1 variants. Among 53 African American patients with collapsing FSGS associated with COVID-19, 48 had high-risk APOL1 variants and five had low-risk APOL1 variants. We conclude that in non-AA patients, FSGS is a rare complication of COVID-19. FSGS associated with COVID-19 can occur rarely with low-risk APOL1 variants in non-AA and AA patients. Non-AA patients reported to be associated with high-risk APOL1 variants possibly reflect inaccuracy of self-reported race with AA admixture because of unknown ancestry. Given the importance of APOL1 in the pathogenesis of FSGS associated with viral infection and to avoid racial bias, it seems appropriate that APOL1 testing be considered in patients with FSGS associated with COVID-19, regardless of self-reported race.
    MeSH term(s) Humans ; United States/epidemiology ; Glomerulosclerosis, Focal Segmental/genetics ; Glomerulosclerosis, Focal Segmental/pathology ; Apolipoprotein L1/genetics ; COVID-19/genetics ; Genotype
    Chemical Substances Apolipoprotein L1 ; APOL1 protein, human
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Review ; Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Revisiting the renin-angiotensin system.

    Soler, María José / Batlle, Daniel

    Molecular and cellular endocrinology

    2021  Volume 529, Page(s) 111268

    MeSH term(s) Angiotensin I/genetics ; Angiotensin I/metabolism ; Angiotensin II/genetics ; Angiotensin II/metabolism ; Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Angiotensinogen/genetics ; Angiotensinogen/metabolism ; Animals ; Blood Pressure/genetics ; Chymases/genetics ; Chymases/metabolism ; Diabetic Nephropathies/genetics ; Diabetic Nephropathies/metabolism ; Diabetic Nephropathies/pathology ; Gene Expression Regulation ; Humans ; Hypertension/genetics ; Hypertension/metabolism ; Hypertension/pathology ; Kidney/metabolism ; Kidney/pathology ; Peptide Fragments/genetics ; Peptide Fragments/metabolism ; Renin-Angiotensin System/genetics ; Signal Transduction ; Water-Electrolyte Balance/genetics
    Chemical Substances AGT protein, human ; Peptide Fragments ; angiotensin-(1-12), human ; Angiotensinogen (11002-13-4) ; Angiotensin II (11128-99-7) ; Angiotensin I (9041-90-1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; CMA1 protein, human (EC 3.4.21.39) ; Chymases (EC 3.4.21.39)
    Language English
    Publishing date 2021-04-02
    Publishing country Ireland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 187438-x
    ISSN 1872-8057 ; 0303-7207
    ISSN (online) 1872-8057
    ISSN 0303-7207
    DOI 10.1016/j.mce.2021.111268
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    Zs.A 1127: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: An Update on Kidney Ammonium Transport Along the Nephron.

    Harris, Autumn N / Skankar, Mythri / Melanmed, Michal / Batlle, Daniel

    Advances in kidney disease and health

    2023  Volume 30, Issue 2, Page(s) 189–196

    Abstract: Acid-base homeostasis is critical to the maintenance of normal health. The kidneys have a central role in bicarbonate generation, which occurs through the process of net acid excretion. Renal ammonia excretion is the predominant component of renal net ... ...

    Abstract Acid-base homeostasis is critical to the maintenance of normal health. The kidneys have a central role in bicarbonate generation, which occurs through the process of net acid excretion. Renal ammonia excretion is the predominant component of renal net acid excretion under basal conditions and in response to acid-base disturbances. Ammonia produced in the kidney is selectively transported into the urine or the renal vein. The amount of ammonia produced by the kidney that is excreted in the urine varies dramatically in response to physiological stimuli. Recent studies have advanced our understanding of ammonia metabolism's molecular mechanisms and regulation. Ammonia transport has been advanced by recognizing that the specific transport of NH3 and NH
    MeSH term(s) Ammonia ; Kidney ; Nephrons ; Renal Veins ; Ammonium Compounds
    Chemical Substances Ammonia (7664-41-7) ; Ammonium Compounds
    Language English
    Publishing date 2023-03-03
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ISSN 2949-8139
    ISSN (online) 2949-8139
    DOI 10.1053/j.akdh.2022.12.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Single-cell RNA profiling of glomerular cells in diabetic kidney: a step forward for understanding diabetic nephropathy.

    Soler, María José / Batlle, Daniel

    Annals of translational medicine

    2020  Volume 7, Issue Suppl 8, Page(s) S340

    Language English
    Publishing date 2020-01-22
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2019.09.104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: On the essentiality of the angiotensin converting enzyme 2 receptor for SARS-CoV-2 infection and the potential of soluble angiotensin converting enzyme 2 proteins as universal approach for variants causing COVID-19.

    Hassler, Luise / Penninger, Josef / Batlle, Daniel

    Clinical and translational medicine

    2022  Volume 12, Issue 10, Page(s) e1080

    MeSH term(s) Angiotensin-Converting Enzyme 2 ; Angiotensin-Converting Enzyme Inhibitors ; COVID-19 ; Humans ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/metabolism ; SARS-CoV-2/genetics
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2022-10-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.1080
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