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Book: Tao hong jing, zhi yi, ji zang, du shun

Shen, Qian / Li, Shijie / Huiyue

(Zhong guo li dai si xiang jia ; 7 ; 中國歷代思想家 ; 7)

1999

Author's details	shen qian, hui yue, li shi jie zhu
Series title	Zhong guo li dai si xiang jia ; 7 中國歷代思想家 ; 7
Language	Chinese
Size	330 p, ill, 21 cm
Edition	Geng xin ban
Publisher	Tai wan shang wu yin shu guan
Publishing place	Tai bei
Document type	Book
ISBN	9570515732 ; 9789570515732
Database	Former special subject collection: coastal and deep sea fishing

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Book: Zhong yi jie jing

Qian, Luotian

[Short cut to traditional Chinese medicine, by Qian Luotian et al.]

1962

Title translation	Short cut to traditional Chinese medicine, by Ch'ien Lo-t'ien et al.
MeSH term(s)	Medicine, East Asian Traditional
Language	Chinese
Size	16, 128 p.
Publisher	Tai ping shu ju
Publishing place	Hong Kong
Document type	Book
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Bioinformatic Analysis Identifying PSMB 1/2/3/4/6/8/9/10 as Prognostic Indicators in Clear Cell Renal Cell Carcinoma.

Guo, Jing-Yi / Jing, Zuo-Qian / Li, Xue-Jie / Liu, Li-Yuan

International journal of medical sciences

2022 Volume 19, Issue 5, Page(s) 796–812

Abstract: Renal cancer incidence has been increasing across the world, clear cell renal cell carcinoma (ccRCC) represents the major subtype of renal cancer. The proteasome is involved in onset, metabolism and survival of tumor and has been recognized as a ... ...

Abstract	Renal cancer incidence has been increasing across the world, clear cell renal cell carcinoma (ccRCC) represents the major subtype of renal cancer. The proteasome is involved in onset, metabolism and survival of tumor and has been recognized as a therapeutic target for various malignancies, while the role of β subunits of proteasome, PSMB gene family, in ccRCC has not been fully unveiled. Herein we investigated the expression and the prognostic role of PSMBs in ccRCC by analyzing a series of databases, including ONCOMINE, UALCAN, cBioPortal, STRING, GEPIA, GO and KEGG. Over-expressions of PSMB1/2/4/7/8/9/10 mRNA were found in ccRCC tissues compared to normal tissues, transcriptional levels of PSMB2/3/4/6/8/9/10 were significantly positively associated with patients' individual cancer stages and grades. Similar or higher levels of proteins encoded by PSMB1/2/3/7/8/9/10 were observed in tumor tissues compared to normal renal tissues. Further, high mRNA levels of PSMB1/2/3/4/6/10 were correlated with shorter overall survival in univariate analysis. Taken together, the results of our analysis implied that overexpression of PSMB1/2/3/4/6/8/9/10 were indicative of worse prognosis of ccRCC. However, further researches were required to validate our findings.
MeSH term(s)	Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Carcinoma, Renal Cell/pathology ; Computational Biology/methods ; Humans ; Kidney Neoplasms/pathology ; Prognosis ; Proteasome Endopeptidase Complex/genetics ; RNA, Messenger/genetics
Chemical Substances	Biomarkers, Tumor ; RNA, Messenger ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
Language	English
Publishing date	2022-05-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2151424-0
ISSN	1449-1907 ; 1449-1907
ISSN (online)	1449-1907
ISSN	1449-1907
DOI	10.7150/ijms.71152
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Sequential 2.5 mg letrozole/FSH therapy is more effective for promoting pregnancy in infertile women with PCOS: a pragmatic randomized controlled trial.

Chen, Li-Juan / Liu, Yi / Zhang, Ling / Li, Jing-Yi / Xiong, Wen-Qian / Li, Tao / Ding, Hui / Li, Bing-Jie

Frontiers in endocrinology

2024 Volume 14, Page(s) 1294339

Abstract: Study question: In infertile women with polycystic ovary syndrome (PCOS), is the sequential use of letrozole 2.5 mg/follicle stimulating hormone(FSH) more effective than letrozole 5 mg/FSH in stimulating ovulation and promoting pregnancy?: Research ... ...

Abstract	Study question: In infertile women with polycystic ovary syndrome (PCOS), is the sequential use of letrozole 2.5 mg/follicle stimulating hormone(FSH) more effective than letrozole 5 mg/FSH in stimulating ovulation and promoting pregnancy? Research design and methods: The study was designed as a prospective, single-center, randomized, controlled pragmatic clinical trial. 220 infertile women between the ages of 20 and 40, who matched the Rotterdam criteria for PCOS and had no other identified reasons for infertility were enrolled from April 2023 to July 2023.The participants were randomly assigned to two groups in a 1:1 ratio. One group received 2.5 mg of letrozole on cycle days 3-7 with a sequential injection of 75 IU FSH on cycle days 8-10 (n = 110), while the other group received 5 mg of letrozole on cycle days 3-7 with a sequential injection of 75 IU FSH on cycle days 8-10 (n = 110). The duration of FSH treatment varied depending on the follicular development stage. Each participant underwent one to three treatment cycles until achieving pregnancy.The primary outcome was the cumulative pregnancy rate of all the participants. Secondary outcomes included characteristics and clinical pregnancy rates of all the intervention cycles. Results: For all 220 participants, the sequential letrozole 2.5 mg/FSH treatment group had a significantly higher cumulative pregnancy rate compared to the letrozole 5 mg/FSH treatment group (72.7% versus 59.1%, RR (95%CI) = 1.23 (1.02, 1.49), P-value = 0.033). For all 468 intervention cycles, letrozole 2.5 mg/FSH group had a significantly higher clinical pregnancy rate than the letrozole 5 mg/FSH group (36.2% versus 26.3%, P-value = 0.021), no statistically significant differences were observed in ovulation rates or adverse effects. Conclusions: The data indicate that the sequential letrozole 2.5mg/FSH protocol may be more effective than the sequential letrozole 5mg/FSH protocol for promoting pregnancy in infertile women with PCOS. Clinical trial registration: www.chictr.org.cn, identifier ChiCTR2300069638.
MeSH term(s)	Pregnancy ; Female ; Humans ; Young Adult ; Adult ; Letrozole/therapeutic use ; Infertility, Female/complications ; Infertility, Female/drug therapy ; Polycystic Ovary Syndrome/complications ; Polycystic Ovary Syndrome/drug therapy ; Prospective Studies ; Fertility Agents, Female/therapeutic use ; Ovulation Induction/methods ; Follicle Stimulating Hormone/therapeutic use ; Follicle Stimulating Hormone, Human/therapeutic use
Chemical Substances	Letrozole (7LKK855W8I) ; Fertility Agents, Female ; Follicle Stimulating Hormone (9002-68-0) ; Follicle Stimulating Hormone, Human
Language	English
Publishing date	2024-01-15
Publishing country	Switzerland
Document type	Randomized Controlled Trial ; Pragmatic Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1294339
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: D Rhamnose β-hederin Reverses NAP1L5-mediated Adriamycin Resistance in Breast Cancer.

Xu, Ling-Yun / Qian, Qi / He, Xiao / Wang, Jing-Yi / Cheng, Lin

Alternative therapies in health and medicine

2023 Volume 29, Issue 3, Page(s) 127–133

Abstract: Context: The persistent use of anticancer medicines can cause multidrug resistance in many tumors and serious cytotoxicity for healthy cells, including adriamycin (ADR), a treatment for breast cancer (BC). Cell resistance to ADR in patients with ... ...

Abstract	Context: The persistent use of anticancer medicines can cause multidrug resistance in many tumors and serious cytotoxicity for healthy cells, including adriamycin (ADR), a treatment for breast cancer (BC). Cell resistance to ADR in patients with recurrent advanced BC can occur. Creating effective treatments that can grapple with multidrug resistance is still challenging. Traditional Chinese medicine (TCM) may offer a solution in D Rhamnose beta-hederin (DRβ-H), an oleanane type of triterpenoid saponin. Objective: The study intended to assess the ability of DRβ-H to inhibit the ADR resistance of two BC-lineage cell lines, MCF-7 and SUM-1315, and to explore the causal link between DRβ-H and the reversal of chemoresistance. Design: The research team performed a cell biology study. Setting: The study took place at laboratory in China. Outcome measures: The research team: (1) assessed cell viability and the migration and invasion the cell lines; (2) investigated the molecular mechanism and identified the downstream targets of DRβ-H, and (3) comprehensively examined the expression pattern, underlying functions, and evident prognostic significance of NAP1L5 in BC by gathering the online information available. Results: DRβ-H can inhibit the viability of the MCF-7/ADR and SUM-1315/ADR cancer cells in a dosage-dependent manner. NAP1L5 might be the main target of DRβ-H in reversing ADR resistance. Its expression decreased in BC cells, and the more advanced the BC was, the lower the NAP1L5 expression was. Conclusion: DRβ-H at nontoxic concentrations was related to ADR resistance in BC through its downstream target NAP1L5. NAP1L5 is potentially a preferable prognostic marker for BC.
MeSH term(s)	Humans ; Female ; Doxorubicin/pharmacology ; Doxorubicin/therapeutic use ; Breast Neoplasms/drug therapy ; Drug Resistance, Neoplasm ; Saponins/pharmacology ; Saponins/therapeutic use ; Nuclear Proteins/pharmacology ; Nuclear Proteins/therapeutic use
Chemical Substances	Doxorubicin (80168379AG) ; D rhamnose beta-hederin ; Saponins ; NAP1L5 protein, human ; Nuclear Proteins
Language	English
Publishing date	2023-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1225073-9
ISSN	1078-6791
ISSN	1078-6791
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4504: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Mechanosensitive channels TMEM63A and TMEM63B mediate lung inflation-induced surfactant secretion.

Chen, Gui-Lan / Li, Jing-Yi / Chen, Xin / Liu, Jia-Wei / Zhang, Qian / Liu, Jie-Yu / Wen, Jing / Wang, Na / Lei, Ming / Wei, Jun-Peng / Yi, Li / Li, Jia-Jia / Ling, Yu-Peng / Yi, He-Qiang / Hu, Zhenying / Duan, Jingjing / Zhang, Jin / Zeng, Bo

The Journal of clinical investigation

2024 Volume 134, Issue 5

Abstract: Pulmonary surfactant is a lipoprotein complex lining the alveolar surface to decrease the surface tension and facilitate inspiration. Surfactant deficiency is often seen in premature infants and in children and adults with respiratory distress syndrome. ... ...

Abstract	Pulmonary surfactant is a lipoprotein complex lining the alveolar surface to decrease the surface tension and facilitate inspiration. Surfactant deficiency is often seen in premature infants and in children and adults with respiratory distress syndrome. Mechanical stretch of alveolar type 2 epithelial (AT2) cells during lung expansion is the primary physiological factor that stimulates surfactant secretion; however, it is unclear whether there is a mechanosensor dedicated to this process. Here, we show that loss of the mechanosensitive channels TMEM63A and TMEM63B (TMEM63A/B) resulted in atelectasis and respiratory failure in mice due to a deficit of surfactant secretion. TMEM63A/B were predominantly localized at the limiting membrane of the lamellar body (LB), a lysosome-related organelle that stores pulmonary surfactant and ATP in AT2 cells. Activation of TMEM63A/B channels during cell stretch facilitated the release of surfactant and ATP from LBs fused with the plasma membrane. The released ATP evoked Ca2+ signaling in AT2 cells and potentiated exocytic fusion of more LBs. Our study uncovered a vital physiological function of TMEM63 mechanosensitive channels in preparing the lungs for the first breath at birth and maintaining respiration throughout life.
MeSH term(s)	Adult ; Animals ; Child ; Humans ; Infant ; Mice ; Adenosine Triphosphate ; Body Fluids ; Lung ; Pulmonary Surfactants ; Surface-Active Agents
Chemical Substances	Adenosine Triphosphate (8L70Q75FXE) ; Pulmonary Surfactants ; Surface-Active Agents ; Tmem64 protein, mouse
Language	English
Publishing date	2024-12-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI174508
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Early pheromone perception remodels neurodevelopment and accelerates neurodegeneration in adult C. elegans

Jing-Yi Peng / Xuqing Liu / Xian-Ting Zeng / Yue Hao / Jia-Hui Zhang / Qian Li / Xia-Jing Tong

Cell Reports, Vol 42, Iss 6, Pp 112598- (2023)

2023

Abstract: Summary: Age-associated neurodegenerative disorders such as Parkinson’s and Alzheimer’s diseases are mainly caused by protein aggregation. The etiologies of these neurodegenerative diseases share a chemical environment. However, how chemical cues ... ...

Abstract	Summary: Age-associated neurodegenerative disorders such as Parkinson’s and Alzheimer’s diseases are mainly caused by protein aggregation. The etiologies of these neurodegenerative diseases share a chemical environment. However, how chemical cues modulate neurodegeneration remains unclear. Here, we found that in Caenorhabditis elegans, exposure to pheromones in the L1 stage accelerates neurodegeneration in adults. Perception of pheromones ascr#3 and ascr#10 is mediated by chemosensory neurons ASK and ASI. ascr#3 perceived by G protein-coupled receptor (GPCR) DAF-38 in ASK activates glutamatergic transmission into AIA interneurons. ascr#10 perceived by GPCR STR-2 in ASI activates the secretion of neuropeptide NLP-1, which binds to the NPR-11 receptor in AIA. Activation of both ASI and ASK is required and sufficient to remodel neurodevelopment via AIA, which triggers insulin-like signaling and inhibits autophagy in adult neurons non-cell-autonomously. Our work reveals how pheromone perception at the early developmental stage modulates neurodegeneration in adults and provides insights into how the external environment impacts neurodegenerative diseases.
Keywords	CP: Neuroscience ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Characteristics of spatial and temporal variability in the distribution of biological soil crusts on the Loess Plateau, China.

Zhao, Yun-Ge / Ji, Jing-Yi / Zhang, Wan-Tao / Ming, Jiao / Huang, Wan-Yun / Gao, Li-Qian

Ying yong sheng tai xue bao = The journal of applied ecology

2024 Volume 35, Issue 3, Page(s) 739–748

Abstract: Biological soil crust (biocrust) is widely distributed on the Loess Plateau and plays multiple roles in regulating ecosystem stability and multifunctionality. Few reports are available on the distribution characteristics of biocrust in this region, which ...

Title translation	黄土高原生物土壤结皮分布时空分异特征.
Abstract	Biological soil crust (biocrust) is widely distributed on the Loess Plateau and plays multiple roles in regulating ecosystem stability and multifunctionality. Few reports are available on the distribution characteristics of biocrust in this region, which limits the assessment of its ecological functions. Based on 388 sampling points in different precipitation zones on the Loess Plateau from 2009 to 2020, we analyzed the coverage, composition, and influencing factors of biocrust across different durations since land abandonment, precipitation levels, topography (slope aspect and position), and utilization of abandoned slopelands (shrubland, forest, and grassland). On this base, with the assistance of machine learning and spatial modeling methods, we generated a distribution map of biocrust and its composition at a resolution of 250 m × 250 m, and analyzed the spatial distribution of biocrust on the Loess Plateau. The results showed that the average biocrust coverage in the woodlands and grasslands was 47.3%, of which cyanobacterial crust accounted for 25.5%, moss crust 19.7%, and lichen crust 2.1%. There were significant temporal and spatial variations. Temporally, the coverage of biocrust in specific regions fluctuated with the extension of the abandoned durations and coverage of cyanobacterial crust, while moss crust showed a reverse pattern. In addition, the coverage of biocrust in the wet season was slightly higher than that in the dry season within a year. Spatially, the coverage of biocrusts on the sandy lands area on the Loess Plateau was higher and dominated by cyanobacterial crusts, while the coverage was lower in the hilly and gully area. Precipitation and utilization of abandoned land were the major factors driving biocrust coverage and composition, while slope direction and position did not show obvious effect. In addition, soil organic carbon content, pH, and texture were related to the distribution of biocrust. This study uncovered the spatial and temporal variability of biocrust distribution, which might provide important data support for the research and management of biocrust in the Loess Plateau region.
MeSH term(s)	China ; Ecosystem ; Forests ; Soil/chemistry ; Spatio-Temporal Analysis ; Lichens/growth & development ; Grassland ; Cyanobacteria/growth & development ; Soil Microbiology ; Altitude ; Environmental Monitoring ; Bryophyta/growth & development ; Trees/growth & development
Chemical Substances	Soil
Language	English
Publishing date	2024-04-24
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2881809-X
ISSN	1001-9332
ISSN	1001-9332
DOI	10.13287/j.1001-9332.202403.011
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comprehensive analysis of phospholipid in milk and their biological roles as nutrients and biomarkers.

Gu, Jing-Yi / Li, Xia-Bing / Liao, Guang-Qin / Wang, Tian-Cai / Wang, Zi-Shuang / Jia, Qi / Qian, Yong-Zhong / Zhang, Xing-Lian / Qiu, Jing

Critical reviews in food science and nutrition

2024 , Page(s) 1–20

Abstract: Phospholipids (PL) have garnered significant attention due to their physiological activities. Milk and other dairy products are important dietary sources for humans and have been extensively used to analyze the presence of PL by various analytical ... ...

Abstract	Phospholipids (PL) have garnered significant attention due to their physiological activities. Milk and other dairy products are important dietary sources for humans and have been extensively used to analyze the presence of PL by various analytical techniques. In this paper, the analysis techniques of PL were reviewed with the eight trigrams of phospholipidomics and a comprehensive fingerprint of 1295 PLs covering 8 subclasses in milk and other dairy products, especially. Technology is the primary productive force. Based on phospholipidomics technology, we further review the relationship between the composition of PL and factors that may be involved in processing and experimental operation, and emphasized the significance of the biological role played by PL in dietary supplements and biomarkers (production, processing and clinical research), and providing the future research directions.
Language	English
Publishing date	2024-03-31
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1037504-1
ISSN	1549-7852 ; 1040-8398
ISSN (online)	1549-7852
ISSN	1040-8398
DOI	10.1080/10408398.2024.2330696
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1459: Show issues

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Article ; Online: Comprehensive assessment of the ecological risk of exposure to triphenyl phosphate in a bioindicator tadpole.

Ding, Guo-Hua / Wang, Zi-Ying / Chen, Jing-Yi / Wu, Qian-Qian / Zhou, Yi-Nan

Chemosphere

2022 Volume 308, Issue Pt 1, Page(s) 136242

Abstract: The toxicity of triphenyl phosphate (TPhP) to aquatic organisms in surface waters has been demonstrated; However, an understanding of toxicity profiles of TPhP in amphibians is limited. Therefore, the adverse effects and threshold concentrations of TPhP ... ...

Abstract	The toxicity of triphenyl phosphate (TPhP) to aquatic organisms in surface waters has been demonstrated; However, an understanding of toxicity profiles of TPhP in amphibians is limited. Therefore, the adverse effects and threshold concentrations of TPhP on metamorphosis, growth, locomotion, and hepatic antioxidants of Gosner stage 25 Polypedates megacephalus tadpoles under long-term (35 d) exposure to six TPhP concentrations until complete metamorphosis were assessed. Additionally, the overall effect of using integrated multiple biomarkers were determined to demonstrate the potential ecological risks of waterborne TPhP at environmentally relevant concentrations in amphibian tadpoles. With increasing TPhP concentrations, physical parameters (snout-vent length, body mass, condition factor, and hepatic somatic index), jumping distance, hepatic catalase, and superoxide dismutase activities decreased, whereas metamorphosis time and malondialdehyde content increased. The threshold concentration of TPhP that affected the tadpole biomarker, except for metamorphosis rate and jumping distance, was 50-400 μg/L. Furthermore, the standardized scores of the examined integrated biomarkers in the six TPhP concentrations were visualized using radar plots and calculated as the integrated biomarker responses (IBRs). The varying TPhP concentrations had different scores in the radar plots, and the threshold for affecting the IBR value was 10 μg/L, which was close to the TPhP concentration in surface waters. Additionally, IBR values were strongly positively correlated with the TPhP concentrations. These findings indicate that environmentally relevant exposure to waterborne TPhP can pose an ecological risk to amphibian tadpoles. This study can serve as a reference and assist in the formulation of relevant policies and strategies to control TPhP pollution in water bodies.
MeSH term(s)	Animals ; Antioxidants ; Catalase ; Environmental Biomarkers ; Larva ; Malondialdehyde ; Organophosphates/toxicity ; Superoxide Dismutase ; Water
Chemical Substances	Antioxidants ; Environmental Biomarkers ; Organophosphates ; Water (059QF0KO0R) ; Malondialdehyde (4Y8F71G49Q) ; Catalase (EC 1.11.1.6) ; Superoxide Dismutase (EC 1.15.1.1) ; triphenyl phosphate (YZE19Z66EA)
Language	English
Publishing date	2022-08-30
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2022.136242
Database	MEDical Literature Analysis and Retrieval System OnLINE

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