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Article ; Online: Systemic Lupus Induced by Messenger RNA Vaccination.

Voisin, Olivier / Priollet, Pascal

2022 Volume 97, Issue 7, Page(s) 1398–1399

MeSH term(s)	Humans ; Immunotherapy ; RNA, Messenger ; Vaccination/adverse effects
Chemical Substances	RNA, Messenger
Language	English
Publishing date	2022-07-04
Publishing country	England
Document type	Letter
ZDB-ID	124027-4
ISSN	1942-5546 ; 0025-6196
ISSN (online)	1942-5546
ISSN	0025-6196
DOI	10.1016/j.mayocp.2022.05.001
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Article ; Online: Elaboration of soft porous ultrasound insulators.

Poupart, Romain / Lacour, Thomas / Darnige, Pablo / Poncelet, Olivier / Aristégui, Christophe / Voisin, Thomas / Marre, Samuel / Brunet, Thomas / Mondain-Monval, Olivier

RSC advances

2020 Volume 10, Issue 68, Page(s) 41946–41953

Abstract: A simple and easy way is proposed for the fabrication of a highly attenuating composite material for underwater acoustics. The approach involves the introduction of porous polymer beads into a polyurethane matrix. The porous beads are prepared through an ...

Abstract	A simple and easy way is proposed for the fabrication of a highly attenuating composite material for underwater acoustics. The approach involves the introduction of porous polymer beads into a polyurethane matrix. The porous beads are prepared through an emulsion-templating approach, and two different processes are used. The first one uses microfluidics to synthesize beads of controlled diameter and porosity. The control over the bead size allows the selection of the frequency range where the material exhibits the highest acoustic attenuation. The second one uses a double emulsion approach and allows for the production of much larger quantities of beads. Both approaches yield materials exhibiting much higher acoustic absorption than the one obtained using the most commonly used micro-balloon inclusion. We present both the synthesis procedures and the structural and acoustic characterizations of the beads and the final acoustic materials.
Language	English
Publishing date	2020-11-17
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d0ra07269a
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Article ; Online: Infectious complications in patients treated with immune checkpoint inhibitors.

Karam, Jean-Denis / Noel, Nicolas / Voisin, Anne-Laure / Lanoy, Emilie / Michot, Jean-Marie / Lambotte, Olivier

European journal of cancer (Oxford, England : 1990)

2020 Volume 141, Page(s) 137–142

Abstract: Objective: Immune checkpoint inhibitor (ICI) antibodies constitute a new generation of cancer treatments, associated with immune-related adverse events (irAEs). A previous retrospective study of patients with metastatic melanoma (treated mostly with ... ...

Abstract	Objective: Immune checkpoint inhibitor (ICI) antibodies constitute a new generation of cancer treatments, associated with immune-related adverse events (irAEs). A previous retrospective study of patients with metastatic melanoma (treated mostly with anti-CTLA4 antibodies) reported a serious infection rate of 7.3%. The main risk factors were corticoids and infliximab use. We sought to describe infections and risk factors among patients receiving anti-PD-1/PD-L1 ICIs. Patients and methods: We reviewed 200 medical records sampled randomly from a French prospective registry, which collates patients treated with anti-PD-1/PD-L1 ICIs. We recorded demographic data, the occurrence of irAEs, immunosuppressant use, and the outcome. Results: Thirty-six patients (18%) experienced an infection by a median (interquartile range) of 47 (19.2-132) days after initiation of the ICI. Twenty-one patients (58.3%) had a lung infection, seven (19.4%) had a skin infection, seven (19.4%) had a urinary tract infection, and all of them received antibiotics. The infection was generally mild, and the patients were treated as outpatient. There were no infection-related deaths and no opportunistic infection. Sixty percent of the patients were being treated for metastatic melanoma and 35.5% for non-small cell lung cancer, and 106 irAEs (mostly grade II) were reported. Forty-seven patients received steroids for cancer symptoms or irAEs, and five received immunosuppressants during the immunotherapy. We did not observe any association between corticosteroid or immunosuppressant use and the occurrence of an infection. Conclusion: The infection rate in patients treated with an anti-PD-1/PD-L1 ICI was 18%, without any severe or opportunistic infection. The occurrence of an infection was not associated with corticosteroid or immunosuppressant use.
MeSH term(s)	Aged ; Antineoplastic Agents, Immunological/adverse effects ; Female ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Immunosuppressive Agents/therapeutic use ; Infections/chemically induced ; Infections/epidemiology ; Male ; Middle Aged ; Neoplasms/drug therapy ; Retrospective Studies
Chemical Substances	Antineoplastic Agents, Immunological ; Immune Checkpoint Inhibitors ; Immunosuppressive Agents
Language	English
Publishing date	2020-10-30
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	82061-1
ISSN	1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0277-5379 ; 0959-8049 ; 0964-1947
DOI	10.1016/j.ejca.2020.09.025
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Article ; Online: A typical babesiosis in an immunocompetent patient.

Voisin, Olivier / Monpierre, Lorra / Le Lorc'h, Erwan / Pilmis, Benoit / Le Monnier, Alban / Mourad, Jean-Jacques / Senghor, Yaye / Mizrahi, Assaf

Annales de biologie clinique

2021 Volume 79, Issue 5, Page(s) 456–459

Abstract: Babesiosis is a tick-borne infectious disease, caused by an intraerythrocytic parasite of the genus Babesia. It has clinical, biological and microbiological similarities with Plasmodium related infections. In rare cases, babesiosis may be complicated by ... ...

Abstract	Babesiosis is a tick-borne infectious disease, caused by an intraerythrocytic parasite of the genus Babesia. It has clinical, biological and microbiological similarities with Plasmodium related infections. In rare cases, babesiosis may be complicated by hemophagocytic lymphohistiocytosis, which occurs preferentially in the immunodeficient patient. We report here the case of a non-immunocompromised patient living in Manhattan, New York hospitalized for a complicated babesiosis of a hemophagocytic lymphohistiocytosis. After 7 days of hospitalization and treatment by azithromycin 500 mg/day and atovaquone 750 mg twice a day, the patient was discharged with an improvement in clinical symptoms and biological parameters.
MeSH term(s)	Atovaquone/therapeutic use ; Azithromycin/therapeutic use ; Babesia ; Babesiosis/complications ; Babesiosis/diagnosis ; Babesiosis/drug therapy ; Humans
Chemical Substances	Azithromycin (83905-01-5) ; Atovaquone (Y883P1Z2LT)
Language	English
Publishing date	2021-10-13
Publishing country	France
Document type	Case Reports ; Journal Article
ZDB-ID	418098-7
ISSN	1950-6112 ; 0003-3898
ISSN (online)	1950-6112
ISSN	0003-3898
DOI	10.1684/abc.2021.1675
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Article ; Online: Features of polymyalgia rheumatica-like syndrome after immune checkpoint inhibitor therapy.

Martin de Fremont, Gregoire / Belkhir, Rakiba / Henry, Julien / Voisin, Anne Laure / Lambotte, Olivier / Besson, Florent L / Mariette, Xavier / Nocturne, Gaetane

Annals of the rheumatic diseases

2020 Volume 81, Issue 3, Page(s) e52

MeSH term(s)	Giant Cell Arteritis ; Humans ; Immune Checkpoint Inhibitors ; Polymyalgia Rheumatica/drug therapy ; Syndrome
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2020-03-18
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/annrheumdis-2020-217225
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Uh III Zs.114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: No significant difference between ceftriaxone and cefotaxime in the emergence of antibiotic resistance in the gut microbiota of hospitalized patients: A pilot study.

Pilmis, Benoît / Jiang, Olivier / Mizrahi, Assaf / Nguyen Van, Jean-Claude / Lourtet-Hascoët, Julie / Voisin, Olivier / Le Lorc'h, Erwan / Hubert, Sidonie / Ménage, Elodie / Azria, Philippe / Borie, Marie-Françoise / Mahé, Annabelle / Mourad, Jean-Jacques / Trabattoni, Eloïse / Ganansia, Olivier / Zahar, Jean-Ralph / Le Monnier, Alban

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2021 Volume 104, Page(s) 617–623

Abstract: Background: Ceftriaxone and cefotaxime share a similar antibacterial spectrum and similar indications but have different pharmacokinetic characteristics. Ceftriaxone is administered once daily and 40% of its clearance is by biliary elimination, whereas ... ...

Abstract	Background: Ceftriaxone and cefotaxime share a similar antibacterial spectrum and similar indications but have different pharmacokinetic characteristics. Ceftriaxone is administered once daily and 40% of its clearance is by biliary elimination, whereas cefotaxime requires three administrations per day and shows less than 10% biliary elimination. The high biliary elimination of ceftriaxone suggests a greater impact of this antibiotic on the gut microbiota than cefotaxime. The objective of this study was to compare the impact of ceftriaxone and cefotaxime on the gut microbiota. Methods: A prospective clinical trial was performed that included 55 patients treated with intravenous ceftriaxone (1 g/24 h) or cefotaxime (1 g/8 h) for at least 3 days. Three fresh stool samples were collected from each patient (days 0, 3, and 7 or at the end of intravenous treatment) to assess the emergence of third-generation cephalosporin (3GC)-resistant Enterobacteriaceae, carbapenem-resistant Enterobacteriaceae, Pseudomonas aeruginosa, toxigenic Clostridioides difficile, and vancomycin-resistant enterococci. Results: The emergence of 3GC-resistant gram-negative enteric bacilli (Enterobacteriaceae) (5.9% vs 4.7%, p > 0.99), Enterococcus spp, and non-commensal microorganisms did not differ significantly between the groups. Both antibiotics reduced the counts of total gram-negative enteric bacilli and decreased the cultivable diversity of the microbiota, but the differences between the groups were not significant. Conclusion: No significant difference was observed between ceftriaxone and cefotaxime in terms of the emergence of resistance.
MeSH term(s)	Aged ; Aged, 80 and over ; Anti-Bacterial Agents/therapeutic use ; Cefotaxime/therapeutic use ; Ceftriaxone/therapeutic use ; Drug Resistance, Bacterial ; Feces/microbiology ; Female ; Gastrointestinal Microbiome/drug effects ; Gram-Negative Bacteria/drug effects ; Hospitalization ; Humans ; Male ; Microbial Sensitivity Tests ; Pilot Projects ; Prospective Studies
Chemical Substances	Anti-Bacterial Agents ; Ceftriaxone (75J73V1629) ; Cefotaxime (N2GI8B1GK7)
Language	English
Publishing date	2021-01-13
Publishing country	Canada
Document type	Clinical Trial ; Comparative Study ; Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2021.01.025
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Zs.A 4516: Show issues

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Article ; Online: Analysis of the association between prospectively collected immune-related adverse events and survival in patients with solid tumor treated with immune-checkpoint blockers, taking into account immortal-time bias.

Kfoury, Maria / Najean, Marie / Lappara, Ariane / Voisin, Anne-Laure / Champiat, Stéphane / Michot, Jean-Marie / Laghouati, Salim / Robert, Caroline / Besse, Benjamin / Soria, Jean-Charles / Lambotte, Olivier / Massard, Christophe / Marabelle, Aurélien / Texier, Matthieu

Cancer treatment reviews

2022 Volume 110, Page(s) 102452

Abstract: Background: Numerous retrospective studies and reviews have reported a positive association between immune-related adverse events (irAEs) and survival in non-small cell lung cancer (NSCLC) and melanoma patients treated with immune checkpoint blockers ( ... ...

Abstract	Background: Numerous retrospective studies and reviews have reported a positive association between immune-related adverse events (irAEs) and survival in non-small cell lung cancer (NSCLC) and melanoma patients treated with immune checkpoint blockers (ICBs). However, some results are controversial and the studies, whose results converge, should be interpreted cautiously because most of them do not deal appropriately with the immortal-time bias. Here, we report an observational real-life study of the association between prospectively collected irAEs and survival of patients treated with ICBs while dealing with the immortal-time bias. Methods: Data from patients treated at Gustave Roussy from June 2014 to October 2017 with anti-PD-(L)1 antibodies for a melanoma or NSCLC have been prospectively collected in the REISAMIC database, a pharmacovigilance registry dedicated to irAEs. Adverse events of grade 2 and higher were collected prospectively. To study the association between the occurrence of irAEs and survival, we used both a landmark analysis and a Cox regression model with time-dependent covariate. Results: 577 patients were treated with anti-PD-(L)1 antibodies for melanoma (60.3 %) or NSCLC (39.7 %). The occurrence of an irAE was significantly associated with improved overall survival (OS): HR 0.56, 95 % CI [0.41; 0.75], p = 0.0001 and progression-free survival (PFS): HR 0.63, 95 % CI [0.47; 0.83], p = 0.001 using a Cox regression model with time-dependent covariate. In a 12-week landmark analysis, median OS was 21.2 months (95 % CI, 12.2 to 35.7) and 16.4 months (95 % CI, 12.4 to 21.3) p = 0.26 and median PFS was 14.3 months (95 % CI, 9.5 to 24.6) and 13.4 months (95 % CI, 10.2 to 18.3) p = 0.66, for patients with and without irAEs, respectively. Conclusions: In our real-life study of patients with melanoma and NSCLC treated with anti-PD-(L)1 antibodies, we confirm that irAEs are associated with improved survival using a time-varying Cox regression model. Analysis with a landmark method showed no difference in OS or PFS between patients who experienced irAE during the first 12 weeks of treatment and those who did not. Retrospective analysis and reviews including studies that do not deal with the immortal-time bias and studies insufficiently powered for a landmark analysis should be interpreted with caution.
MeSH term(s)	Antineoplastic Agents, Immunological/adverse effects ; Carcinoma, Non-Small-Cell Lung/pathology ; Drug-Related Side Effects and Adverse Reactions ; Humans ; Immune Checkpoint Inhibitors ; Lung Neoplasms/pathology ; Melanoma/drug therapy ; Nivolumab/therapeutic use ; Retrospective Studies
Chemical Substances	Antineoplastic Agents, Immunological ; Immune Checkpoint Inhibitors ; Nivolumab (31YO63LBSN)
Language	English
Publishing date	2022-08-10
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	125102-8
ISSN	1532-1967 ; 0305-7372
ISSN (online)	1532-1967
ISSN	0305-7372
DOI	10.1016/j.ctrv.2022.102452
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Article: Elaboration of soft porous ultrasound insulators

Poupart, Romain / Lacour, Thomas / Darnige, Pablo / Poncelet, Olivier / Aristégui, Christophe / Voisin, Thomas / Marre, Samuel / Brunet, Thomas / Mondain-Monval, Olivier

RSC advances. 2020 Nov. 17, v. 10, no. 68

2020

Abstract	A simple and easy way is proposed for the fabrication of a highly attenuating composite material for underwater acoustics. The approach involves the introduction of porous polymer beads into a polyurethane matrix. The porous beads are prepared through an emulsion-templating approach, and two different processes are used. The first one uses microfluidics to synthesize beads of controlled diameter and porosity. The control over the bead size allows the selection of the frequency range where the material exhibits the highest acoustic attenuation. The second one uses a double emulsion approach and allows for the production of much larger quantities of beads. Both approaches yield materials exhibiting much higher acoustic absorption than the one obtained using the most commonly used micro-balloon inclusion. We present both the synthesis procedures and the structural and acoustic characterizations of the beads and the final acoustic materials.
Keywords	absorption ; acoustics ; composite materials ; diameter ; emulsions ; exhibitions ; frequency ; microfluidic technology ; polyurethanes ; porosity ; synthesis ; ultrasonics
Language	English
Dates of publication	2020-1117
Size	p. 41946-41953.
Publishing place	The Royal Society of Chemistry
Document type	Article
Note	NAL-light
ISSN	2046-2069
DOI	10.1039/d0ra07269a
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Diagnostic Advances in Childhood Tuberculosis—Improving Specimen Collection and Yield of Microbiological Diagnosis for Intrathoracic Tuberculosis

Eric Wobudeya / Maryline Bonnet / Elisabetta Ghimenton Walters / Pamela Nabeta / Rinn Song / Wilfred Murithi / Walter Mchembere / Bunnet Dim / Jean-Voisin Taguebue / Joanna Orne-Gliemann / Mark P. Nicol / Olivier Marcy

Pathogens, Vol 11, Iss 389, p

2022 Volume 389

Abstract: There is no microbiological gold standard for childhood tuberculosis (TB) diagnosis. The paucibacillary nature of the disease, challenges in sample collection in young children, and the limitations of currently available microbiological tests restrict ... ...

Abstract	There is no microbiological gold standard for childhood tuberculosis (TB) diagnosis. The paucibacillary nature of the disease, challenges in sample collection in young children, and the limitations of currently available microbiological tests restrict microbiological confirmation of intrathoracic TB to the minority of children. Recent WHO guidelines recommend the use of novel rapid molecular assays as initial diagnostic tests for TB and endorse alternative sample collection methods for children. However, the uptake of these tools in high-endemic settings remains low. In this review, we appraise historic and new microbiological tests and sample collection techniques that can be used for the diagnosis of intrathoracic TB in children. We explore challenges and possible ways to improve diagnostic yield despite limitations, and identify research gaps to address in order to improve the microbiological diagnosis of intrathoracic TB in children.
Keywords	tuberculosis ; children ; diagnosis ; microbiological tests ; sample collection methods ; Medicine ; R
Subject code	360
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Protective effect of obesity on survival in cancers treated with immunotherapy vanishes when controlling for type of cancer, weight loss and reduced skeletal muscle.

Antoun, Sami / Lanoy, Emilie / Ammari, Samy / Farhane, Siham / Martin, Lisa / Robert, Caroline / Planchard, David / Routier, Emilie / Voisin, Anne Laure / Messayke, Sabine / Champiat, Stephane / Michot, Jean Marie / Laghouati, Salim / Lambotte, Olivier / Marabelle, Aurélien / Baracos, Vickie

European journal of cancer (Oxford, England : 1990)

2022 Volume 178, Page(s) 49–59

Abstract: Introduction: Association of high body mass index (BMI) with longer survival has been reported in patients on immune checkpoint inhibitors (ICIs), but results are inconsistent. This 'obesity paradox' is potentially confounded by the effects of BMI ... ...

Abstract	Introduction: Association of high body mass index (BMI) with longer survival has been reported in patients on immune checkpoint inhibitors (ICIs), but results are inconsistent. This 'obesity paradox' is potentially confounded by the effects of BMI change over time and of skeletal muscle depletion. Methods: We conducted a secondary analysis of a prospective cohort, including consecutive patients receiving ICI treatment for melanoma (n = 411) and non-small cell lung cancer (NSCLC) (n = 389) in routine care. Results: In the univariable analysis of the entire population, overweight/obesity (BMI ≥ 25 kg/m Conclusions: The so-called 'obesity paradox', counterintuitive association between high BMI and longer survival, vanished when controlling for confounders, such as type of cancer, and manifestations of depletion (WL and reduced skeletal muscle mass).
MeSH term(s)	Humans ; Prospective Studies ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Lung Neoplasms/drug therapy ; Weight Loss ; Obesity/epidemiology ; Body Mass Index ; Muscle, Skeletal ; Melanoma/drug therapy ; Immunotherapy
Language	English
Publishing date	2022-10-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	82061-1
ISSN	1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0277-5379 ; 0959-8049 ; 0964-1947
DOI	10.1016/j.ejca.2022.10.013
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