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Article ; Online: Electrogastrography in patients with gastric motility disorders.

Al Kafee, Abdullah / Kayar, Yusuf

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine

2023 Volume 238, Issue 1, Page(s) 22–32

Abstract: Electrogastrography (EGG) is a novel diagnostic modality for assessing the gastrointestinal tract (GI) that generates spontaneous electrical activity and monitors gastric motility. The aim of this study was to compare patients with functional dyspepsia ( ... ...

Abstract	Electrogastrography (EGG) is a novel diagnostic modality for assessing the gastrointestinal tract (GI) that generates spontaneous electrical activity and monitors gastric motility. The aim of this study was to compare patients with functional dyspepsia (FD) and diabetic gastroparesis (D-GP) with healthy controls (CT) to use established findings on abnormalities of gastric motility based on EGG characteristics. In this study, 50 patients with FD, 50 D-GP patients, and 50 CT subjects were studied to compare EGG with discrete wavelet transform models (DWT) to extract signal characteristics using a variety of different qualitative and quantitative metrics from pre-prandial and postprandial states. As a result, higher statistically significant (
MeSH term(s)	Humans ; Electromyography ; Dyspepsia/diagnosis ; Postprandial Period/physiology ; Wavelet Analysis
Language	English
Publishing date	2023-11-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1065942-0
ISSN	2041-3033 ; 0046-2039 ; 0954-4119
ISSN (online)	2041-3033
ISSN	0046-2039 ; 0954-4119
DOI	10.1177/09544119231212269
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Article: Gallstone Frequency in Children With Celiac Disease.

Agin, Mehmet / Kayar, Yusuf

Cureus

2021 Volume 13, Issue 1, Page(s) e12767

Abstract: Introduction Celiac disease (CD) is a chronic autoimmune systemic disease caused by the T cell-driven immune mechanism, which is triggered by gluten in cereals such as wheat, barley, and rye in individuals who have a genetic predisposition. The purpose ... ...

Abstract	Introduction Celiac disease (CD) is a chronic autoimmune systemic disease caused by the T cell-driven immune mechanism, which is triggered by gluten in cereals such as wheat, barley, and rye in individuals who have a genetic predisposition. The purpose of the present study was to investigate the frequency of gallstones in children with CD. Methods A total of 120 patients who were diagnosed with CD and who were followed-up by the pediatric gastroenterology clinic of the hospital and 100 healthy children were included in the study. The age, gender, hemogram, biochemistry, and abdominal ultrasonography images of the patients were compared. Cases that had gallstones were evaluated in terms of fasting serum lipids, glucose-6-P dehydrogenase, and pyruvate kinase, osmotic fragility, hemoglobin electrophoresis, and peripheral smears. Cases diagnosed with a hematological or metabolic disease were excluded from the study. Celiac serology was examined in terms of CD diagnosis in cases who had gallstones for the first time. Results The median age of the patients with CD who were included in the study was eight years (5-12), and the median age of the control group was 10 years (6-13). A total of 48% of the Control Group was female, and 52% were male. No significant differences were detected between the age and gender distribution of the cases. There were no differences between hemogram and biochemical parameters. Gallstones were detected in six (5%) of CD-diagnosed cases, and in three (3%) of the cases in the control group. Two (2/160; 1.3%) of the patients who were referred to our clinic with the diagnosis of gallstones were diagnosed with CD. Conclusions: Early diagnosis and treatment of CD is important to avoid gallstone development because a gluten-free diet corrects enteropathy significantly in CD. CD must be considered in cases with gallstones.
Language	English
Publishing date	2021-01-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.12767
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Article ; Online: Amoxicillin, gemifloxacin and rabeprazole, as first-line Helicobacter pylori therapy in clinical practice: A pilot study.

Kilic, Guner / Kilic, Gulce Ecem / Özkahraman, Adnan / Konur, Sevki / Dertli, Ramazan / Kayar, Yusuf

Medicine

2024 Volume 103, Issue 18, Page(s) e38012

Abstract: Success in eradication of H. pylori is decreasing due to increasing resistant strains. In particular, side-effects due to 4-agent treatment multiple drug use are observed and treatment compliance decreases. The aim of this study was to evaluate the ... ...

Abstract	Success in eradication of H. pylori is decreasing due to increasing resistant strains. In particular, side-effects due to 4-agent treatment multiple drug use are observed and treatment compliance decreases. The aim of this study was to evaluate the efficacy, reliability, and side-effect profile of the combination of amoxicillin and rabeprazole with gemifloxacin, which is a new generation quinolone, in the treatment of H. pylori infection. This study was conducted on 71 naive patients who received H. pylori eradication. All the patients were administered treatment of Amoxicillin (1000 mg twice a day) + Gemifloxacin (320 mg once a day) + rabeprazole (20 mg twice a day) for 7 days. Drug compliance and treatment tolerance were evaluated after finishing the treatment. At 1 month after the end of the treatment, H. pylori eradication was evaluated in all the patients by examining H. pylori antigen in the feces. In the evaluation after treatment, H. pylori eradication was obtained in 63 (88.7%) patients and eradication was not obtained in 8 (11.3%) patients. The treatment was not completed by 2 patients because of side-effects and noncompliance, so after exclusion of these 2 patients, successful H. pylori eradication was obtained in 63 (91.3%) of 69 patients who completed the treatment. Side-effects were seen in a total of 9 (12.7%) patients. Diarrhea, bloating, abdominal pain, and nausea-vomiting were seen in some patients, but no reflux, constipation, skin rash, listlessness-fatigue, headache, dizziness, palpitations, dry mouth, or weight loss was seen in any patient. In regions with high resistance to clarithromycin and metronidazole in particular, the combination of gemifloxacin with amoxicillin and rabeprazole can be considered for use in first-stage treatment as both the efficacy and tolerability are high.
MeSH term(s)	Humans ; Rabeprazole/administration & dosage ; Rabeprazole/therapeutic use ; Amoxicillin/administration & dosage ; Amoxicillin/therapeutic use ; Helicobacter Infections/drug therapy ; Male ; Gemifloxacin ; Female ; Pilot Projects ; Helicobacter pylori/drug effects ; Drug Therapy, Combination ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/adverse effects ; Middle Aged ; Adult ; Fluoroquinolones/therapeutic use ; Fluoroquinolones/administration & dosage ; Treatment Outcome ; Aged
Chemical Substances	Rabeprazole (32828355LL) ; Amoxicillin (804826J2HU) ; Gemifloxacin (OKR68Y0E4T) ; Anti-Bacterial Agents ; Fluoroquinolones
Language	English
Publishing date	2024-05-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000038012
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Article: Demographic, Laboratory, and Clinical Comparison of Pediatric Brucella Cases With and Without Liver Involvement.

Agin, Mehmet / Kayar, Yusuf

Cureus

2020 Volume 12, Issue 10, Page(s) e10862

Abstract: Introduction In this study, the purpose was to compare the demographic, clinical, and laboratory results of ... ...

Abstract	Introduction In this study, the purpose was to compare the demographic, clinical, and laboratory results of pediatric
Language	English
Publishing date	2020-10-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.10862
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Article ; Online: The Effect of Primary Duodenogastric Bile Reflux on the Presence and Density of

Agin, Mehmet / Kayar, Yusuf

Medicina (Kaunas, Lithuania)

2019 Volume 55, Issue 12

Abstract: Background and Objectives: ...

Abstract	Background and Objectives:
MeSH term(s)	Adolescent ; Age Factors ; Bile Reflux/complications ; Bile Reflux/epidemiology ; Bile Reflux/pathology ; Biopsy ; Child ; Duodenogastric Reflux/complications ; Duodenogastric Reflux/epidemiology ; Duodenogastric Reflux/pathology ; Endoscopy, Digestive System/methods ; Female ; Gastritis/diagnostic imaging ; Gastritis/etiology ; Gastritis/microbiology ; Gastritis/pathology ; Helicobacter Infections/complications ; Helicobacter Infections/epidemiology ; Helicobacter Infections/microbiology ; Helicobacter Infections/pathology ; Helicobacter pylori/growth & development ; Helicobacter pylori/isolation & purification ; Humans ; Male ; Risk Factors ; Severity of Illness Index ; Turkey/epidemiology
Language	English
Publishing date	2019-12-05
Publishing country	Switzerland
Document type	Comparative Study ; Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina55120775
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Article: Diagnosis and Treatment of Fasciola Hepatica With Endoscopic Retrograde Cholangiopancreatography in a Child Patient: Case Report.

Agin, Mehmet / Kayar, Yusuf / Dertli, Ramazan

Cureus

2020 Volume 12, Issue 9, Page(s) e10486

Abstract: ... Fasciola ... ...

Abstract	Fasciola hepatica
Language	English
Publishing date	2020-09-16
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.10486
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Article ; Online: Electrogastrography in Patients with Functional Dyspepsia, Joint Hypermobility, and Diabetic Gastroparesis.

Al Kafee, Abdullah / Cilacı, Talar / Kayar, Yusuf / Akan, Aydın

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

2022 Volume 33, Issue 3, Page(s) 182–189

Abstract: Background: Transcutaneous electrogastrography is a novel modality to assess the human stomach's gastric myoelectrical activity. The purpose of this study was to compare functional dyspepsia, joint hypermobility, and diabetic gastroparesis patients with ...

Abstract	Background: Transcutaneous electrogastrography is a novel modality to assess the human stomach's gastric myoelectrical activity. The purpose of this study was to compare functional dyspepsia, joint hypermobility, and diabetic gastroparesis patients with healthy control subjects in terms of gastric motility abnormalities through electrogastrography evaluations, and to then evaluate the correlation among variations in their blood parameters. Methods: This study analyzed 120 subjects with functional dyspepsia (n = 30), joint hypermobility (n = 30), diabetic gastroparesis (n = 30), and control subjects (n = 30). The electrogastrography parameters included the dominant frequency, dominant power, power ratio, and instability coefficient, which were analyzed preprandially and postprandially. Although there are similar studies in the literature, there is no other study in which all groups have been studied together, as in our study. Results: The electrogastrography results showed that preprandial dominant frequency (P = .031), dominant power (P = .047), and instability coefficient (P = .043), and postprandial dominant frequency (P = .041) and dominant power (P = .035) results were statistically significant among the functional dyspepsia, joint hypermobility, diabetic gastroparesis, and control groups. There was no significant difference found in terms of power ratio (P = .114) values. However, only glucose (P = .04) and calcium (P = .04) levels showed statistical significance. Several blood tests including hemoglobin (P = .032), creatinine (P= .045), calcium (P = .037), potassium (P= .041), white blood cells (P = .038), and alanine aminotransferase (P = .031) also showed correlation with the dominant frequency, power ratio, and instability coefficient parameters. Conclusions:* This joint methodology demonstrated that it is possible to differentiate between functional dyspepsia, joint hypermobility, and diabetic gastroparesis patients from healthy subjects by using electrogastrography. Moreover, the majority of patients showed adequate gastric motility in response to food.
MeSH term(s)	Calcium ; Diabetes Mellitus ; Dyspepsia/etiology ; Gastric Emptying ; Gastroparesis/diagnosis ; Gastroparesis/etiology ; Humans ; Joint Instability ; Stomach
Chemical Substances	Calcium (SY7Q814VUP)
Language	English
Publishing date	2022-02-01
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	1340275-4
ISSN	2148-5607 ; 1300-4948
ISSN (online)	2148-5607
ISSN	1300-4948
DOI	10.5152/tjg.2021.20853
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Article: Chronic hepatitis C infection: how much are physicians aware of?

Kayar, Yusuf / Kayar, Nuket Bayram / Agin, Mehmet

Przeglad gastroenterologiczny

2019 Volume 14, Issue 2, Page(s) 112–120

Abstract: Aim: The purpose of our study is to measure the awareness of hepatitis C among physicians employed in Istanbul, and investigate the relationship between awareness and the specialization field, age and presence of chronic hepatitis/positive family ... ...

Abstract	Aim: The purpose of our study is to measure the awareness of hepatitis C among physicians employed in Istanbul, and investigate the relationship between awareness and the specialization field, age and presence of chronic hepatitis/positive family history. Material and methods: Level of awareness of 125 family physicians and 76 internal medicine physicians, employed within Istanbul Province, on hepatitis C infection were evaluated using standard questionnaire. Relationship between their awareness and age, specialization, presence of any chronic hepatitis and chronic hepatitis C in any relatives were investigated. Results: The mean age of the physicians was 30.9 ±7.1 years (range: 23-45 years) and 58% of them were women. Seventy-five (37.3%) physicians were between ages of 23-28, 67 (33.3%) physicians were between ages of 29-32, and 59 (29.4%) physicians ages was greater than 32. Twenty-one (10.4%) physicians had hepatitis or a first-or second-degree relative with hepatitis. Physicians were found to be insufficient in answering the questions on hepatitis C virus transmission routes and who should be screened. When examined based on transmission routes, there were no significant differences between physicians' specializations and positive familial history, but physicians aged 23-28 had significantly poorer awareness at some points. Internal medicine specialists had better awareness on screening tests compared to family physicians but there were no significant differences between positive familial history and physicians' age. Conclusions: Physicians' awareness should be improved to prevent hepatitis C virus transmission and to identify existing conditions.
Language	English
Publishing date	2019-07-05
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2596134-2
ISSN	1897-4317 ; 1895-5770
ISSN (online)	1897-4317
ISSN	1895-5770
DOI	10.5114/pg.2019.85895
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Article: Association of autoimmune diseases with celiac disease and its risk factors.

Kayar, Yusuf / Dertli, Ramazan

Pakistan journal of medical sciences

2019 Volume 35, Issue 6, Page(s) 1548–1553

Abstract: Objectives: Autoimmune Diseases (AIDs) are detected in celiac patients. Our purpose was to determine the AIDs that are associated with celiac disease and related risk factors in the Turkish population.: Methods: The study included 230 celiac patients ...

Abstract	Objectives: Autoimmune Diseases (AIDs) are detected in celiac patients. Our purpose was to determine the AIDs that are associated with celiac disease and related risk factors in the Turkish population. Methods: The study included 230 celiac patients who were diagnosed and followed-up in our clinics between 2015-2019. All AIDs that accompanied the celiac disease were recorded, and their association with risk factors was analyzed. Results: The mean age of the patients was 35.6±10.6 years (age range:18-72). A total of 58(25.2%) patients were male and the mean age at onset of disease was 29.1±6.5 years. The duration of disease follow-up was 6.5±4.6 years. One hundred and twenty two (53%) patients were on a strict diet, and 72(31.3%) patients had accompanying AID. Hashimoto thyroiditis was found in 39(17%) patients, asthma in 16(7%) patients as the most common comorbidities. There was a significant relation between AID and female gender, age of diagnosis being <40 years, duration of disease, non-GIS symptoms at the time of admission, and non-employment status. Conclusion: Screening other AIDs in celiac patients are important, especially in individuals who have risk factors. Considering that many AIDs may develop in the future despite dietary compliance, patients should be followed with a multidisciplinary approach.
Language	English
Publishing date	2019-11-04
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	2032827-8
ISSN	1681-715X ; 1682-024X ; 1017-4699
ISSN (online)	1681-715X
ISSN	1682-024X ; 1017-4699
DOI	10.12669/pjms.35.6.821
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Article ; Online: Chronic hepatitis C infection

Yusuf Kayar / Nuket Bayram Kayar / Mehmet Agin

Gastroenterology Review, Vol 14, Iss 2, Pp 112-

how much are physicians aware of?

2019 Volume 120

Keywords	awareness ; hepatitis c ; familial physicians ; internal medicine ; Medicine ; R
Language	English
Publishing date	2019-07-01T00:00:00Z
Publisher	Termedia Publishing House
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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