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  1. Article ; Online: An Extensive Review on Lung Cancer Therapeutics Using Machine Learning Techniques: State-of-the-art and Perspectives.

    Ahmad, Shaban / Raza, Khalid

    Journal of drug targeting

    2024  , Page(s) 1–15

    Abstract: Lung cancer starts when lung cells grow uncontrollably, forming tumours that make breathing difficult. There are more than 100 types of human cancer, and in most cases, it is untreatable due to the unavailability of medico-infrastructure and facilities, ... ...

    Abstract Lung cancer starts when lung cells grow uncontrollably, forming tumours that make breathing difficult. There are more than 100 types of human cancer, and in most cases, it is untreatable due to the unavailability of medico-infrastructure and facilities, even though the USFDA approved 57 anticancer drugs in 2020 alone. WHO reported more than 10 million cancer-related deaths yearly, and lung cancer alone accounts for more than 1.80 million deaths and a few studies suggest lung cancer incidence and deaths may surpass 3.8 million and 3.2 million by 2050, which demands rapid drug designing and repurposing and the role of artificial intelligence (AI) found to be the best solutions. AI in lung cancer therapeutics has emerged as a significant area of research in recent years. This state-of-the-art review aims to explore the various applications of AI in lung cancer treatment and its potential to revolutionise patient care, and predictive models can analyse large datasets, including clinical data, genetic information, and treatment outcomes, for novel drug design and to generate personalised treatment recommendations, having the potential to optimise therapeutic strategies, enhance treatment efficacy, and minimise adverse effects.
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1187110-6
    ISSN 1029-2330 ; 1061-186X
    ISSN (online) 1029-2330
    ISSN 1061-186X
    DOI 10.1080/1061186X.2024.2347358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Computing the Laplacian spectrum and Wiener index of pentagonal-derivation cylinder/Möbius network.

    Ali, Umar / Li, Junxiang / Ahmad, Yasir / Raza, Zahid

    Heliyon

    2024  Volume 10, Issue 2, Page(s) e24182

    Abstract: The Laplacian spectrum significantly contributes the study of the structural features of non-regular networks. Actually, it emphasizes the interaction among the network eigenvalues and their structural properties. ... ...

    Abstract The Laplacian spectrum significantly contributes the study of the structural features of non-regular networks. Actually, it emphasizes the interaction among the network eigenvalues and their structural properties. Let
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e24182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Identification of 5-nitroindazole as a multitargeted inhibitor for CDK and transferase kinase in lung cancer: a multisampling algorithm-based structural study.

    Ahmad, Shaban / Raza, Khalid

    Molecular diversity

    2023  

    Abstract: Lung cancer is the second most common cancer, which is the leading cause of cancer death worldwide. The FDA has approved almost 100 drugs against lung cancer, but it is still not curable as most drugs target a single protein and block a single pathway. ... ...

    Abstract Lung cancer is the second most common cancer, which is the leading cause of cancer death worldwide. The FDA has approved almost 100 drugs against lung cancer, but it is still not curable as most drugs target a single protein and block a single pathway. In this study, we screened the Drug Bank library against three major proteins- ribosomal protein S6 kinase alpha-6 (6G77), cyclic-dependent protein kinase 2 (1AQ1), and insulin-like growth factor 1 (1K3A) of lung cancer and identified the compound 5-nitroindazole (DB04534) as a multitargeted inhibitor that potentially can treat lung cancer. For the screening, we deployed multisampling algorithms such as HTVS, SP and XP, followed by the MM\GBSA calculation, and the study was extended to molecular fingerprinting analysis, pharmacokinetics prediction, and Molecular Dynamics simulation to understand the complex's stability. The docking scores against the proteins 6G77, 1AQ1, and 1K3A were - 6.884 kcal/mol, - 7.515 kcal/mol, and - 6.754 kcal/mol, respectively. Also, the compound has shown all the values satisfying the ADMET criteria, and the fingerprint analysis has shown wide similarities and the water WaterMap analysis that helped justify the compound's suitability. The molecular dynamics of each complex have shown a cumulative deviation of less than 2 Å, which is considered best for the biomolecules, especially for the protein-ligand complexes. The best feature of the identified drug candidate is that it targets multiple proteins that control cell division and growth hormone mediates simultaneously, reducing the burden of the pharmaceutical industry by reducing the resistance chance.
    Language English
    Publishing date 2023-04-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1376507-3
    ISSN 1573-501X ; 1381-1991
    ISSN (online) 1573-501X
    ISSN 1381-1991
    DOI 10.1007/s11030-023-10648-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Editorial: The practical implication of clinical pharmacokinetics in drug development, pharmaceutical analysis, and clinical research.

    Khan, Abad / Ahmad, Lateef / Raza, Faisal / Khan, Saeed Ahmad / Ali, Tahir

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1252030

    Language English
    Publishing date 2023-07-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1252030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Aflatoxins in Wheat Grains: Detection and Detoxification through Chemical, Physical, and Biological Means.

    Ismail, Ahmed Mahmoud / Raza, Muhammad Hassan / Zahra, Naseem / Ahmad, Rafiq / Sajjad, Yasar / Khan, Sabaz Ali

    Life (Basel, Switzerland)

    2024  Volume 14, Issue 4

    Abstract: Wheat ( ...

    Abstract Wheat (
    Language English
    Publishing date 2024-04-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14040535
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Clinical Audit: A Necessity Or A Formality?

    Ajaz, Sami / Ahmad, Muhammad / Sarfraz, Muhammad Raza

    JPMA. The Journal of the Pakistan Medical Association

    2023  Volume 73, Issue 11, Page(s) 2312–2313

    MeSH term(s) Humans ; Clinical Audit ; Medical Audit
    Language English
    Publishing date 2023-11-27
    Publishing country Pakistan
    Document type Journal Article
    ZDB-ID 603873-6
    ISSN 0030-9982
    ISSN 0030-9982
    DOI 10.47391/JPMA.9310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Comparative genomic assessment of members of genus Tenacibaculum: an exploratory study.

    Satyam, Rohit / Ahmad, Shaban / Raza, Khalid

    Molecular genetics and genomics : MGG

    2023  Volume 298, Issue 5, Page(s) 979–993

    Abstract: Tenacibaculosis is an ulcerative skin disorder that affects finfish. It is caused by members of the genus Tenacibaculum, resulting in eccentric behavioural changes, including anorexia, lethargy, and abnormal swimming patterns that often result in ... ...

    Abstract Tenacibaculosis is an ulcerative skin disorder that affects finfish. It is caused by members of the genus Tenacibaculum, resulting in eccentric behavioural changes, including anorexia, lethargy, and abnormal swimming patterns that often result in mortality. Currently, species suspected of causing fish mortality include T. ovolyticum, T. gallaicum, T. discolor, T. finnmarkense, T. mesophilum, T. soleae, T. dicentrarchi, and T. maritimum. However, pathogenic members and the mechanisms involved in disease causation, progression, and transmission are limited due to the inadequate sequencing efforts in the past decade. In this study, we use a comparative genomics approach to investigate the characteristic features of 26 publicly available genomes of Tenacibaculum and report our observations. We propose the reclassification of "T. litoreum HSC 22" to the singaporense species and assignment of "T. sp. 4G03" to the species discolor (species with quotation marks have not been appropriately named). We also report the co-occurrence of several antimicrobial resistance/virulence genes and genes private to a few members. Finally, we mine several non-B DNA forming regions, operons, tandem repeats, high-confidence putative effector proteins, and sortase that might play a pivotal role in bacterial evolution, transcription, and pathogenesis.
    MeSH term(s) Animals ; Tenacibaculum/genetics ; Fish Diseases/microbiology ; Flavobacteriaceae Infections/genetics ; Flavobacteriaceae Infections/microbiology ; Genomics ; Fishes
    Language English
    Publishing date 2023-05-24
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2044817-X
    ISSN 1617-4623 ; 1617-4615
    ISSN (online) 1617-4623
    ISSN 1617-4615
    DOI 10.1007/s00438-023-02031-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Retraction Note: The non-linear relationship between carbon dioxide emissions, financial development and energy consumption in developing European and Central Asian economies.

    Chunyu, Leng / Zain-Ul-Abidin, Syed / Majeed, Wajeeha / Raza, Syed Muhammad Faraz / Ahmad, Ishtiaq

    Environmental science and pollution research international

    2024  Volume 31, Issue 15, Page(s) 23286

    Language English
    Publishing date 2024-03-11
    Publishing country Germany
    Document type Retraction of Publication
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-024-32870-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Structural-functional analysis and molecular characterization of arsenate reductase from

    Bhati, Reeta / Nigam, Arti / Ahmad, Shaban / Raza, Khalid / Singh, Rajni

    3 Biotech

    2023  Volume 13, Issue 9, Page(s) 305

    Abstract: Enterobacter cloacae: Supplementary information: The online version contains supplementary material available at 10.1007/s13205-023-03730-9. ...

    Abstract Enterobacter cloacae
    Supplementary information: The online version contains supplementary material available at 10.1007/s13205-023-03730-9.
    Language English
    Publishing date 2023-08-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2600522-0
    ISSN 2190-5738 ; 2190-572X
    ISSN (online) 2190-5738
    ISSN 2190-572X
    DOI 10.1007/s13205-023-03730-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Computational screening and MM/GBSA-based MD simulation studies reveal the high binding potential of FDA-approved drugs against

    Singh, Akash Pratap / Ahmad, Shaban / Raza, Khalid / Gautam, Hemant K

    Journal of biomolecular structure & dynamics

    2023  , Page(s) 1–11

    Abstract: Cutibacterium ... ...

    Abstract Cutibacterium acnes
    Language English
    Publishing date 2023-08-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2023.2242950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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