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  1. Article ; Online: Racial discrimination and parenting perceptions among low-income Black couples.

    Perry, Nicholas S / Dieujuste, Nathalie / Parsons, Aleja / Stanley, Scott M / Rhoades, Galena K

    Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)

    2024  

    Abstract: Racism affects Black individuals in the United States through multiple institutional, social, and economic injustices. Relationship scientists have called for greater attention to the potentially harmful effects racism might exert on Black families. A ... ...

    Abstract Racism affects Black individuals in the United States through multiple institutional, social, and economic injustices. Relationship scientists have called for greater attention to the potentially harmful effects racism might exert on Black families. A small literature has begun to document negative associations between experiences of racism and romantic relationship functioning. However, even less empirical work has focused on a central relationship domain for many Black couples: parenting. The present study used cross-sectional data (
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 619328-6
    ISSN 1939-1293 ; 0893-3200
    ISSN (online) 1939-1293
    ISSN 0893-3200
    DOI 10.1037/fam0001207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Infant diarrheal disease in rhesus macaques impedes microbiome maturation and is linked to uncultured Campylobacter species.

    Rhoades, Nicholas S / Cinco, Isaac R / Hendrickson, Sara M / Prongay, Kamm / Haertel, Andrew J / Flores, Gilberto E / Slifka, Mark K / Messaoudi, Ilhem

    Communications biology

    2024  Volume 7, Issue 1, Page(s) 37

    Abstract: Diarrheal diseases remain one of the leading causes of death for children under 5 globally, disproportionately impacting those living in low- and middle-income countries (LMIC). Campylobacter spp., a zoonotic pathogen, is one of the leading causes of ... ...

    Abstract Diarrheal diseases remain one of the leading causes of death for children under 5 globally, disproportionately impacting those living in low- and middle-income countries (LMIC). Campylobacter spp., a zoonotic pathogen, is one of the leading causes of food-borne infection in humans. Yet to be cultured Campylobacter spp. contribute to the total burden in diarrheal disease in children living in LMIC thus hampering interventions. We performed microbiome profiling and metagenomic genome assembly on samples collected from over 100 infant rhesus macaques longitudinally and during cases of clinical diarrhea within the first year of life. Acute diarrhea was associated with long-lasting taxonomic and functional shifts of the infant gut microbiome indicative of microbiome immaturity. We constructed 36 Campylobacter metagenomic assembled genomes (MAGs), many of which fell within 4 yet to be cultured species. Finally, we compared the uncultured Campylobacter MAGs assembled from infant macaques with publicly available human metagenomes to show that these uncultured species are also found in human fecal samples from LMIC. These data highlight the importance of unculturable Campylobacter spp. as an important target for reducing disease burden in LMIC children.
    MeSH term(s) Child ; Infant ; Animals ; Humans ; Macaca mulatta ; Campylobacter/genetics ; Microbiota ; Metagenome ; Diarrhea
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-023-05695-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Chitin and laminarin additively trigger wheat reactive oxygen species but not resistance to Fusarium head blight.

    Hao, Guixia / Rhoades, Nicholas A / McCormick, Susan

    Plant direct

    2023  Volume 7, Issue 10, Page(s) e538

    Abstract: Plants respond to fungal infections by activating defense genes including producing reactive oxygen species (ROS). The ... ...

    Abstract Plants respond to fungal infections by activating defense genes including producing reactive oxygen species (ROS). The fungus
    Language English
    Publishing date 2023-10-17
    Publishing country England
    Document type Journal Article
    ISSN 2475-4455
    ISSN (online) 2475-4455
    DOI 10.1002/pld3.538
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  4. Article ; Online: Taxonomic and Functional Shifts in the Perinatal Gut Microbiome of Rhesus Macaques.

    Rhoades, Nicholas S / Cinco, Isaac R / Hendrickson, Sara M / Slifka, Mark K / Messaoudi, Ilhem

    Microbiology spectrum

    2022  Volume 10, Issue 4, Page(s) e0081422

    Abstract: Pregnancy and the postpartum period result in some of the most dramatic metabolic, hormonal, and physiological changes that can be experienced by an otherwise healthy adult. The timing and magnitude of these changes is key for both maternal and fetal ... ...

    Abstract Pregnancy and the postpartum period result in some of the most dramatic metabolic, hormonal, and physiological changes that can be experienced by an otherwise healthy adult. The timing and magnitude of these changes is key for both maternal and fetal health. One of the factors believed to critically modulate these physiological changes is the maternal gut microbiome. However, the dynamic changes in this community during the perinatal period remain understudied. Clinical studies can be complicated by confounding variables like diet and other drivers of heterogeneity in the human microbiome. Therefore, in this study, we conducted a longitudinal analysis of the fecal microbiome obtained during the pregnancy and postpartum periods in 26 captive rhesus macaques using 16S rRNA gene amplicon sequencing and shotgun metagenomics. Shifts at both the taxonomic and functional potential level were detected when comparing pregnancy to postpartum samples. Taxonomically, Alloprevotella, Actinobacillus, and Anaerovibrio were enriched in the gut microbiome during pregnancy, while Treponema,
    MeSH term(s) Adult ; Animals ; Butyrates ; Feces ; Female ; Folic Acid ; Gastrointestinal Microbiome/physiology ; Humans ; Infant, Newborn ; Macaca mulatta/genetics ; Macaca mulatta/metabolism ; Pregnancy ; RNA, Ribosomal, 16S/genetics ; Starch
    Chemical Substances Butyrates ; RNA, Ribosomal, 16S ; Starch (9005-25-8) ; Folic Acid (935E97BOY8)
    Language English
    Publishing date 2022-07-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.00814-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Infant diarrheal disease in rhesus macaques impedes microbiome maturation and is linked to uncultured Campylobacter species

    Nicholas S. Rhoades / Isaac R. Cinco / Sara M. Hendrickson / Kamm Prongay / Andrew J. Haertel / Gilberto E. Flores / Mark K. Slifka / Ilhem Messaoudi

    Communications Biology, Vol 7, Iss 1, Pp 1-

    2024  Volume 14

    Abstract: Abstract Diarrheal diseases remain one of the leading causes of death for children under 5 globally, disproportionately impacting those living in low- and middle-income countries (LMIC). Campylobacter spp., a zoonotic pathogen, is one of the leading ... ...

    Abstract Abstract Diarrheal diseases remain one of the leading causes of death for children under 5 globally, disproportionately impacting those living in low- and middle-income countries (LMIC). Campylobacter spp., a zoonotic pathogen, is one of the leading causes of food-borne infection in humans. Yet to be cultured Campylobacter spp. contribute to the total burden in diarrheal disease in children living in LMIC thus hampering interventions. We performed microbiome profiling and metagenomic genome assembly on samples collected from over 100 infant rhesus macaques longitudinally and during cases of clinical diarrhea within the first year of life. Acute diarrhea was associated with long-lasting taxonomic and functional shifts of the infant gut microbiome indicative of microbiome immaturity. We constructed 36 Campylobacter metagenomic assembled genomes (MAGs), many of which fell within 4 yet to be cultured species. Finally, we compared the uncultured Campylobacter MAGs assembled from infant macaques with publicly available human metagenomes to show that these uncultured species are also found in human fecal samples from LMIC. These data highlight the importance of unculturable Campylobacter spp. as an important target for reducing disease burden in LMIC children.
    Keywords Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article: Longitudinal Profiling of the Macaque Vaginal Microbiome Reveals Similarities to Diverse Human Vaginal Communities.

    Rhoades, Nicholas S / Hendrickson, Sara M / Gerken, Danielle R / Martinez, Kassandra / Slayden, Ov D / Slifka, Mark K / Messaoudi, Ilhem

    mSystems

    2021  Volume 6, Issue 2

    Abstract: The vaginal microbiota plays an important role in women's reproductive and urogenital health. It is now well accepted that a "healthy" vaginal microbiome is dominated ... ...

    Abstract The vaginal microbiota plays an important role in women's reproductive and urogenital health. It is now well accepted that a "healthy" vaginal microbiome is dominated by
    Language English
    Publishing date 2021-04-27
    Publishing country United States
    Document type Journal Article
    ISSN 2379-5077
    ISSN 2379-5077
    DOI 10.1128/mSystems.01322-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Campylobacter vaccination reduces diarrheal disease and infant growth stunting among rhesus macaques.

    Hendrickson, Sara M / Thomas, Archana / Raué, Hans-Peter / Prongay, Kamm / Haertel, Andrew J / Rhoades, Nicholas S / Slifka, Jacob F / Gao, Lina / Quintel, Benjamin K / Amanna, Ian J / Messaoudi, Ilhem / Slifka, Mark K

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 3806

    Abstract: Campylobacter-associated enteric disease is estimated to be responsible for more than 160 million cases of gastroenteritis each year and is linked to growth stunting of infants living under conditions of poor sanitation and hygiene. Here, we examine ... ...

    Abstract Campylobacter-associated enteric disease is estimated to be responsible for more than 160 million cases of gastroenteritis each year and is linked to growth stunting of infants living under conditions of poor sanitation and hygiene. Here, we examine naturally occurring Campylobacter-associated diarrhea among rhesus macaques as a model to determine if vaccination could reduce severe diarrheal disease and infant growth stunting. Compared to unvaccinated controls, there are no Campylobacter diarrhea-associated deaths observed among vaccinated infant macaques and all-cause diarrhea-associated infant mortality is decreased by 76% (P = 0.03). By 9 months of age, there is a 1.3 cm increase in dorsal length that equaled a significant 1.28 LAZ (Length-for-Age Z score) improvement in linear growth among vaccinated infants compared to their unvaccinated counterparts (P = 0.001). In this work, we show that Campylobacter vaccination not only reduces diarrheal disease but also potentially serves as an effective intervention that improves infant growth trajectories.
    MeSH term(s) Animals ; Campylobacter ; Macaca mulatta ; Diarrhea/prevention & control ; Growth Disorders/prevention & control ; Campylobacter Infections/prevention & control
    Language English
    Publishing date 2023-06-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-39433-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Acute SARS-CoV-2 infection is associated with an expansion of bacteria pathogens in the nose including

    Rhoades, Nicholas S / Pinski, Amanda / Monsibais, Alisha N / Jankeel, Allen / Doratt, Brianna M / Cinco, Isaac R / Ibraim, Izabela / Messaoudi, Ilhem

    bioRxiv : the preprint server for biology

    2021  

    Abstract: Much of the research conducted on SARS-CoV-2 and COVID-19 has focused on the systemic host response, especially that generated by severely ill patients. Very few studies have investigated the impact of acute SARS-CoV-2 within the nasopharynx, the site of ...

    Abstract Much of the research conducted on SARS-CoV-2 and COVID-19 has focused on the systemic host response, especially that generated by severely ill patients. Very few studies have investigated the impact of acute SARS-CoV-2 within the nasopharynx, the site of initial infection and viral replication. In this study we profiled changes in the nasal microbial communities as well as in host transcriptional profile during acute SARS-CoV-2 infection using 16S amplicon sequencing and RNA sequencing. These analyses were coupled to viral genome sequencing. Our microbiome analysis revealed that the nasal microbiome of COVID patients was unique and was marked by an expansion of bacterial pathogens. Some of these microbes (i.e.
    Language English
    Publishing date 2021-05-20
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2021.05.20.445008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Acute SARS-CoV-2 infection is associated with an increased abundance of bacterial pathogens, including Pseudomonas aeruginosa in the nose.

    Rhoades, Nicholas S / Pinski, Amanda N / Monsibais, Alisha N / Jankeel, Allen / Doratt, Brianna M / Cinco, Isaac R / Ibraim, Izabela / Messaoudi, Ilhem

    Cell reports

    2021  Volume 36, Issue 9, Page(s) 109637

    Abstract: Research conducted on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis and coronavirus disease 2019 (COVID-19) generally focuses on the systemic host response, especially that generated by severely ill patients, with few studies ... ...

    Abstract Research conducted on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis and coronavirus disease 2019 (COVID-19) generally focuses on the systemic host response, especially that generated by severely ill patients, with few studies investigating the impact of acute SARS-CoV-2 at the site of infection. We show that the nasal microbiome of SARS-CoV-2-positive patients (CoV
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Bacteria/classification ; Bacteria/isolation & purification ; Bacterial Infections/microbiology ; COVID-19/complications ; COVID-19/immunology ; COVID-19/microbiology ; Coinfection/microbiology ; Coinfection/virology ; Cross-Sectional Studies ; DNA, Bacterial/genetics ; Female ; Humans ; Immunity, Innate ; Inflammation ; Male ; Microbiota ; Middle Aged ; Nose/microbiology ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/isolation & purification ; RNA, Ribosomal, 16S/genetics ; RNA, Viral/genetics ; RNA-Seq ; Transcriptome ; Viral Load ; Young Adult
    Chemical Substances DNA, Bacterial ; RNA, Ribosomal, 16S ; RNA, Viral
    Language English
    Publishing date 2021-08-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2021.109637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Growth faltering regardless of chronic diarrhea is associated with mucosal immune dysfunction and microbial dysbiosis in the gut lumen.

    Rhoades, Nicholas S / Hendrickson, Sara M / Prongay, Kamm / Haertel, Andrew / Gill, Leanne / Edwards, Robert A / Garzel, Laura / Slifka, Mark K / Messaoudi, Ilhem

    Mucosal immunology

    2021  Volume 14, Issue 5, Page(s) 1113–1126

    Abstract: Despite the impact of childhood diarrhea on morbidity and mortality, our understanding of its sequelae has been significantly hampered by the lack of studies that examine samples across the entire intestinal tract. Infant rhesus macaques are naturally ... ...

    Abstract Despite the impact of childhood diarrhea on morbidity and mortality, our understanding of its sequelae has been significantly hampered by the lack of studies that examine samples across the entire intestinal tract. Infant rhesus macaques are naturally susceptible to human enteric pathogens and recapitulate the hallmarks of diarrheal disease such as intestinal inflammation and growth faltering. Here, we examined intestinal biopsies, lamina propria leukocytes, luminal contents, and fecal samples from healthy infants and those experiencing growth faltering with distant acute or chronic active diarrhea. We show that growth faltering in the presence or absence of active diarrhea is associated with a heightened systemic and mucosal pro-inflammatory state centered in the colon. Moreover, polyclonal stimulation of colonic lamina propria leukocytes resulted in a dampened cytokine response, indicative of immune exhaustion. We also detected a functional and taxonomic shift in the luminal microbiome across multiple gut sites including the migration of Streptococcus and Prevotella species between the small and large intestine, suggesting a decompartmentalization of gut microbial communities. Our studies provide valuable insight into the outcomes of diarrheal diseases and growth faltering not attainable in humans and lays the groundwork to test interventions in a controlled and reproducible setting.
    MeSH term(s) Animals ; Biodiversity ; Biomarkers ; Biopsy ; Chronic Disease ; Diarrhea/complications ; Diarrhea/etiology ; Diarrhea/metabolism ; Diarrhea/pathology ; Disease Models, Animal ; Disease Susceptibility ; Dysbiosis/complications ; Dysbiosis/immunology ; Gastrointestinal Microbiome/immunology ; Growth Disorders/etiology ; Growth Disorders/metabolism ; Immunity, Mucosal/genetics ; Immunohistochemistry ; Intestinal Mucosa/immunology ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Lymphocyte Count ; Macaca mulatta ; Metagenome ; Metagenomics/methods ; Transcriptome
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-06-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2411370-0
    ISSN 1935-3456 ; 1933-0219
    ISSN (online) 1935-3456
    ISSN 1933-0219
    DOI 10.1038/s41385-021-00418-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6796: Show issues Location:
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