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  1. Article ; Online: Influenza evolution with little host selection.

    Braun, Katarina M / Friedrich, Thomas C

    Nature ecology & evolution

    2019  Volume 3, Issue 2, Page(s) 159–160

    MeSH term(s) Humans ; Influenza, Human/immunology ; Orthomyxoviridae ; Seasons ; Selection, Genetic
    Language English
    Publishing date 2019-01-07
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2397-334X
    ISSN (online) 2397-334X
    DOI 10.1038/s41559-018-0782-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Luteinizing Hormone Effect on Luteal Cells Is Dependent on the Corpus Luteum Stage in Felids.

    Hryciuk, Michał M / Jewgenow, Katarina / Braun, Beate C

    Animals : an open access journal from MDPI

    2021  Volume 11, Issue 1

    Abstract: The objective of this study was to investigate the effect of luteinizing hormone (LH) on steroidogenic luteal cells obtained from corpora lutea (CL) of the domestic cat and selected wild felids. Luteal cells were isolated enzymatically from CL at ... ...

    Abstract The objective of this study was to investigate the effect of luteinizing hormone (LH) on steroidogenic luteal cells obtained from corpora lutea (CL) of the domestic cat and selected wild felids. Luteal cells were isolated enzymatically from CL at different developmental stages and cultured for two days in the presence and absence of 100 ng/mL LH, respectively. Functionality was assessed by progesterone (P4) accumulation in cell culture media determined by ELISA. In addition, steroidogenic function was confirmed using immunohistochemistry for 3β-hydroxysteroid dehydrogenase (HSD3B). The enzymatic method allowed for the isolation of mostly small luteal cells in all investigated felids. Treatment with LH resulted in an increase in P4 secretion of cultured luteal cells obtained from CL in the formation stage (African lion) and development/maintenance stage (domestic cat (
    Language English
    Publishing date 2021-01-14
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani11010179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cloprostenol, a synthetic analog of prostaglandin F2α induces functional regression in cultured luteal cells of felids†.

    Hryciuk, Michał M / Jewgenow, Katarina / Braun, Beate C

    Biology of reproduction

    2021  Volume 105, Issue 1, Page(s) 137–147

    Abstract: In the present study, we investigated the effect of the synthetic analog of prostaglandin F2α (PGF2α)-cloprostenol-on cultured steroidogenic luteal cells of selected felid species over a 2-day culture period. The changes induced by cloprostenol were ... ...

    Abstract In the present study, we investigated the effect of the synthetic analog of prostaglandin F2α (PGF2α)-cloprostenol-on cultured steroidogenic luteal cells of selected felid species over a 2-day culture period. The changes induced by cloprostenol were measured based on progesterone concentration and mRNA expression analysis of selected genes. Cloprostenol significantly reduced concentration of progesterone in cell culture medium of small luteal cells isolated from domestic cat corpora lutea (CL) at the development/maintenance stage (P < 0.05), but did not influence progesterone production in cultured cells from the regression stage. A decrease or complete silencing of progesterone production was also measured in cultured luteal cells of African lion (formation stage) and Javan leopard (development/maintenance stage). Gene-expression analysis by real-time PCR revealed that treatment with cloprostenol did not have an influence on expression of selected genes coding for enzymes of steroidogenesis (StAR, HSD3B, CYP11A1) or prostaglandin synthesis (PTGS2, PGES), nor did it effect hormone receptors (AR, ESR1, PGR, PTGER2), an anti-oxidative enzyme (SOD1) or factors of cell apoptosis (FAS, CASP3, TNFRSF1B, BCL2) over the studied period. Significant changes were measured only for expressions of luteinizing hormone (P < 0.05), prolactin (P < 0.05) and PGF2α receptors (P < 0.005) (LHCGR, PRLR, and PTGFR). The obtained results confirm that PGF2α/cloprostenol is a luteolytic agent in CL of felids and its impact on progesterone production depends on the developmental stage of the CL. Cloprostenol short-term treatment on luteal cells was associated only with functional but not structural changes related to luteal regression.
    MeSH term(s) Animals ; Cats/physiology ; Cells, Cultured ; Cloprostenol/pharmacology ; Female ; Lions/physiology ; Luteal Cells/drug effects ; Luteolysis/psychology ; Luteolytic Agents/pharmacology ; Panthera/physiology
    Chemical Substances Luteolytic Agents ; Cloprostenol (4208238832)
    Language English
    Publishing date 2021-04-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1118-6
    ISSN 1529-7268 ; 0006-3363
    ISSN (online) 1529-7268
    ISSN 0006-3363
    DOI 10.1093/biolre/ioab070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 551: Show issues Location:
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  4. Book ; Online: gagekmoreno/SARS-CoV-2-in-Southern-Wisconsin

    Gage Moreno / Katarina Braun / m-a-martin

    SARS-CoV-2 in Southern Wisconsin

    2020  

    Abstract: This is the first release to accompany our manuscript "Revealing fine-scale spatiotemporal differences in SARS-CoV-2 introduction and spread" ...

    Abstract This is the first release to accompany our manuscript "Revealing fine-scale spatiotemporal differences in SARS-CoV-2 introduction and spread"
    Keywords covid19
    Publishing date 2020-09-21
    Publishing country eu
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Luteinizing Hormone Effect on Luteal Cells Is Dependent on the Corpus Luteum Stage in Felids

    Michał M. Hryciuk / Katarina Jewgenow / Beate C. Braun

    Animals, Vol 11, Iss 1, p

    2021  Volume 179

    Abstract: The objective of this study was to investigate the effect of luteinizing hormone (LH) on steroidogenic luteal cells obtained from corpora lutea (CL) of the domestic cat and selected wild felids. Luteal cells were isolated enzymatically from CL at ... ...

    Abstract The objective of this study was to investigate the effect of luteinizing hormone (LH) on steroidogenic luteal cells obtained from corpora lutea (CL) of the domestic cat and selected wild felids. Luteal cells were isolated enzymatically from CL at different developmental stages and cultured for two days in the presence and absence of 100 ng/mL LH, respectively. Functionality was assessed by progesterone (P4) accumulation in cell culture media determined by ELISA. In addition, steroidogenic function was confirmed using immunohistochemistry for 3β-hydroxysteroid dehydrogenase (HSD3B). The enzymatic method allowed for the isolation of mostly small luteal cells in all investigated felids. Treatment with LH resulted in an increase in P4 secretion of cultured luteal cells obtained from CL in the formation stage (African lion) and development/maintenance stage (domestic cat ( p < 0.05), Javan leopard), whereas luteal cells from more advanced stages of luteal development (regression) responded moderately or not at all to LH stimulation (domestic cat, Asiatic golden cat, Asiatic lion). The protein signal for HSD3B on CL was visible until development/maintenance. In conclusion, this study shows that LH promotes P4 production in luteal cells only until the onset of regression, when morphological signs are visible on the CL of felids and HSD3B is no longer detectable.
    Keywords felids ; luteal cells ; steroidogenic activity ; luteinizing hormone ; domestic cat ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
    Subject code 630
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Functional and Morphological Characterization of Small and Large Steroidogenic Luteal Cells From Domestic Cats Before and During Culture.

    Hryciuk, Michał M / Braun, Beate C / Bailey, Liam D / Jewgenow, Katarina

    Frontiers in endocrinology

    2019  Volume 10, Page(s) 724

    Abstract: The current study aimed to isolate, culture and characterize small (SLC) and large (LLC) steroidogenic cells from ... ...

    Abstract The current study aimed to isolate, culture and characterize small (SLC) and large (LLC) steroidogenic cells from the
    Language English
    Publishing date 2019-11-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2019.00724
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Correction for Riemersma et al., "Rapid Evolution of Enhanced Zika Virus Virulence during Direct Vertebrate Transmission Chains".

    Riemersma, Kasen K / Jaeger, Anna S / Crooks, Chelsea M / Braun, Katarina M / Weger-Lucarelli, James / Ebel, Gregory D / Friedrich, Thomas C / Aliota, Matthew T

    Journal of virology

    2022  Volume 96, Issue 10, Page(s) e0050122

    Language English
    Publishing date 2022-05-02
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.00501-22
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 609: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Avian H7N9 influenza viruses are evolutionarily constrained by stochastic processes during replication and transmission in mammals.

    Braun, Katarina M / Haddock Iii, Luis A / Crooks, Chelsea M / Barry, Gabrielle L / Lalli, Joseph / Neumann, Gabriele / Watanabe, Tokiko / Imai, Masaki / Yamayoshi, Seiya / Ito, Mutsumi / Moncla, Louise H / Koelle, Katia / Kawaoka, Yoshihiro / Friedrich, Thomas C

    Virus evolution

    2023  Volume 9, Issue 1, Page(s) vead004

    Abstract: H7N9 avian influenza viruses (AIVs) have caused over 1,500 documented human infections since emerging in 2013. Although wild-type H7N9 AIVs can be transmitted by respiratory droplets in ferrets, they have not yet caused widespread outbreaks in humans. ... ...

    Abstract H7N9 avian influenza viruses (AIVs) have caused over 1,500 documented human infections since emerging in 2013. Although wild-type H7N9 AIVs can be transmitted by respiratory droplets in ferrets, they have not yet caused widespread outbreaks in humans. Previous studies have revealed molecular determinants of H7N9 AIV host switching, but little is known about potential evolutionary constraints on this process. Here, we compare patterns of sequence evolution for H7N9 AIV and mammalian H1N1 viruses during replication and transmission in ferrets. We show that three main factors-purifying selection, stochasticity, and very narrow transmission bottlenecks-combine to severely constrain the ability of H7N9 AIV to effectively adapt to mammalian hosts in isolated, acute spillover events. We find rare evidence of natural selection favoring new, potentially mammal-adapting mutations within ferrets but no evidence of natural selection acting during transmission. We conclude that human-adapted H7N9 viruses are unlikely to emerge during typical spillover infections. Our findings are instead consistent with a model in which the emergence of a human-transmissible virus would be a rare and unpredictable, though highly consequential, 'jackpot' event. Strategies to control the total number of spillover infections will limit opportunities for the virus to win this evolutionary lottery.
    Language English
    Publishing date 2023-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2818949-8
    ISSN 2057-1577
    ISSN 2057-1577
    DOI 10.1093/ve/vead004
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  9. Article: Determining the source of transmission of SARS-CoV-2 infection in a healthcare worker.

    Safdar, Nasia / Moreno, Gage K / Braun, Katarina M / Friedrich, Thomas C / O'Connor, David H

    medRxiv : the preprint server for health sciences

    2020  

    Abstract: Healthcare workers (HCWs) are at the frontlines of the COVID-19 pandemic and are at risk of exposure to SARS-CoV-2 infection from their interactions with patients and in the community. Limited availability of recommended personal protective equipment ( ... ...

    Abstract Healthcare workers (HCWs) are at the frontlines of the COVID-19 pandemic and are at risk of exposure to SARS-CoV-2 infection from their interactions with patients and in the community. Limited availability of recommended personal protective equipment (PPE), in particular N95 respirators, has fueled concerns about whether HCWs are adequately protected from exposure while caring for patients. Understanding the source of SARS-CoV-2 infection in a HCW - the community or the healthcare system - is critical for understanding the effectiveness of hospital infection control and PPE practices. In Dane County, Wisconsin, community prevalence of SARS-CoV-2 is relatively low (cumulative prevalence of ~0.06% - positive cases / total population in Dane county as of April 17). Although SARS-CoV-2 infections in HCWs are often presumed to be acquired during the course of patient care, there are few reports unambiguously identifying the source of acquisition. The objective of this brief report was to determine the source of transmission of SARS-CoV-2 in a healthcare worker.
    Keywords covid19
    Language English
    Publishing date 2020-05-01
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2020.04.27.20077016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Using Virus Sequencing to Determine Source of SARS-CoV-2 Transmission for Healthcare Worker.

    Safdar, Nasia / Moreno, Gage K / Braun, Katarina M / Friedrich, Thomas C / O'Connor, David H

    Emerging infectious diseases

    2020  Volume 26, Issue 10, Page(s) 2489–2491

    Abstract: Whether a healthcare worker's severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is community or hospital acquired affects prevention practices. We used virus sequencing to determine that infection of a healthcare worker who cared for ...

    Abstract Whether a healthcare worker's severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is community or hospital acquired affects prevention practices. We used virus sequencing to determine that infection of a healthcare worker who cared for 2 SARS-CoV-2-infected patients was probably community acquired. Appropriate personal protective equipment may have protected against hospital-acquired infection.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Community-Acquired Infections/virology ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Health Personnel ; Humans ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Occupational Diseases/prevention & control ; Pandemics ; Personal Protective Equipment ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; RNA, Viral/analysis ; SARS-CoV-2 ; Sequence Analysis, RNA
    Chemical Substances RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-08-06
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2610.202322
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4778: Show issues Location:
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