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  1. Article ; Online: Mild coronary artery dilatation developed in some children with mild COVID-19 but completely regressed within 3 months.

    Rouva, Glykeria / Vergadi, Eleni / Hatzidaki, Eleftheria / Germanakis, Ioannis

    Acta paediatrica (Oslo, Norway : 1992)

    2022  Volume 111, Issue 9, Page(s) 1764–1770

    Abstract: Aim: We studied the incidence and time course of any coronary artery changes in children up to 2 years of age who were hospitalised with mild COVID-19.: Methods: This was a single-centre prospective study of 29 children (19 males) with a median age ... ...

    Abstract Aim: We studied the incidence and time course of any coronary artery changes in children up to 2 years of age who were hospitalised with mild COVID-19.
    Methods: This was a single-centre prospective study of 29 children (19 males) with a median age of 3 months and interquartile range (IQR) of 1.6-4.3 months. They were admitted to a Greek University hospital for mild COVID-19 from 1 March to 30 December 2021. Three echocardiographic evaluations were performed at a median (IQR) of 19 (16-24) days, 82 (75-89) days and 172 (163-197) after the first symptoms. The prevalence of coronary artery dilation, regression, and changes was documented.
    Results: Coronary artery dilation was present in 3 (10.3%) cases at the first evaluation, with complete regression at the second. Regression was observed in 18/24 (75%) cases with follow-up data and 9 (31%) demonstrated significant z-score changes of >2. Coronary artery changes in any segment at any time were documented in 18/29 (62%) of the patients.
    Conclusion: Cases of transient and very mild coronary artery dilatation following mild COVID-19 completely regressed within 3 months. Large-scale studies are needed to document the extent and time course of coronary artery dilation following paediatric COVID-19.
    MeSH term(s) COVID-19 ; Child ; Coronary Aneurysm/etiology ; Coronary Vessels ; Dilatation/adverse effects ; Humans ; Infant ; Male ; Mucocutaneous Lymph Node Syndrome/epidemiology ; Prospective Studies ; Retrospective Studies
    Language English
    Publishing date 2022-07-04
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.16465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Infectious Diseases Associated with Desert Dust Outbreaks: A Systematic Review.

    Vergadi, Eleni / Rouva, Glykeria / Angeli, Maria / Galanakis, Emmanouil

    International journal of environmental research and public health

    2022  Volume 19, Issue 11

    Abstract: Background: Desert dust outbreaks and dust storms are the major source of particulate matter globally and pose a major threat to human health. We investigated the microorganisms transported with desert dust particles and evaluated their potential impact ...

    Abstract Background: Desert dust outbreaks and dust storms are the major source of particulate matter globally and pose a major threat to human health. We investigated the microorganisms transported with desert dust particles and evaluated their potential impact on human health.
    Methods: A systematic review of all reports on the association between non-anthropogenic desert dust pollution, dust microorganisms and human health is conducted.
    Results: In total, 51 articles were included in this review. The affected regions studied were Asia (32/51, 62.7%) followed by Europe (9/51, 17.6%), America (6/51, 11.8%), Africa (4/51, 7.8%) and Australia (1/51, 2.0%). The Sahara Desert was the most frequent source of dust, followed by Asian and American deserts. In 39/51 studies the dust-related microbiome was analyzed, while, in 12/51 reports, the association of desert dust with infectious disease outbreaks was examined. Pathogenic and opportunistic agents were isolated from dust in 24/39 (61.5%) and 29/39 (74.4%) of the studies, respectively. A significant association of dust events with infectious disease outbreaks was found in 10/12 (83.3%) reports. The infectious diseases that were mostly investigated with dust outbreaks were pneumonia, respiratory tract infections, COVID-19, pulmonary tuberculosis and coccidioidomycosis.
    Conclusions: Desert dust outbreaks are vehicles of a significant number of pathogenic or opportunistic microorganisms and limited data indicate an association between dust events and infectious disease outbreaks. Further research is required to strengthen the correlation between dust events and infectious diseases and subsequently guide preventive public health measures.
    MeSH term(s) Air Pollutants/analysis ; Air Pollution/analysis ; COVID-19 ; Communicable Diseases/epidemiology ; Desert Climate ; Disease Outbreaks ; Dust/analysis ; Humans ; Particulate Matter
    Chemical Substances Air Pollutants ; Dust ; Particulate Matter
    Language English
    Publishing date 2022-06-05
    Publishing country Switzerland
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19116907
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The role of the autonomic nervous system in nocturnal enuresis.

    Angeli, Maria / Bitsori, Maria / Rouva, Glykeria / Galanakis, Emmanouil

    Journal of pediatric urology

    2022  Volume 19, Issue 1, Page(s) 6–18

    Abstract: Introduction: Nocturnal enuresis (NE) is common in children, but its pathophysiology is still not fully understood. Despite the recognition of three major pathways, nocturnal polyuria, nocturnal bladder dysfunction and sleep disorders, their inter- ... ...

    Abstract Introduction: Nocturnal enuresis (NE) is common in children, but its pathophysiology is still not fully understood. Despite the recognition of three major pathways, nocturnal polyuria, nocturnal bladder dysfunction and sleep disorders, their inter-relations remain elusive. The autonomic nervous system (ANS) which is greatly involved in both diuresis and sleep might have an important role in NE.
    Methods: A comprehensive electronic search of Medline database was performed, to identify articles reporting on the role of the autonomic nervous system (ANS) in enuretic children regarding sleep regulation, cardiovascular function and diuresis-related hormones and neurotransmitters.
    Results: Of an initial total of 646 articles, 45 studies were finally selected for data extraction according to inclusion criteria, published between 1960 and 2022. Of these studies 26 reported on sleep regulation, 10 on cardiovascular functions and 12 on ANS-associated hormones and neurotransmitters. Evidence on parasympathetic or sympathetic overstimulation in enuretic individuals is suggesting that NE could be attributed to a dysregulation of ANS. Sleep studies have shown increased rapid eye movement sleep time in polyuric enuretic children pointing to sympathetic overactivity, whereas patients with overactive bladder have non-rapid eye movement related enuretic episodes, potentially associated with parasympathetic stimulation. Twenty-four-hour blood pressure monitoring demonstrated "non-dipping" phenomenon, suggesting sympathetic involvement, whereas heart-rate analysis showed parasympathetic hyperfunction. Nocturnal lower levels of arginine-vasopressin, angiotensin II and aldosterone in polyuric children with NE as compared to non-polyuric and controls and potential involvement of dopamine and serotonin in sleep and micturition suggest that ANS-associated hormones and neurotransmitters have a role in the pathogenesis of NE.
    Conclusion: Summarizing the existing data we suggest that ANS dysregulation related either with sympathetic or parasympathetic overactivity may provide a unifying model in understanding the pathogenesis of NE in different enuretic subpopulations. This observation provides new insights in future research and new potential treatment options.
    MeSH term(s) Child ; Humans ; Nocturnal Enuresis ; Autonomic Nervous System ; Primary Dysautonomias ; Polyuria ; Sleep
    Language English
    Publishing date 2022-10-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2237683-5
    ISSN 1873-4898 ; 1477-5131
    ISSN (online) 1873-4898
    ISSN 1477-5131
    DOI 10.1016/j.jpurol.2022.10.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6387: Show issues Location:
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  4. Article ; Online: Infectious Diseases Associated with Desert Dust Outbreaks

    Eleni Vergadi / Glykeria Rouva / Maria Angeli / Emmanouil Galanakis

    International Journal of Environmental Research and Public Health, Vol 19, Iss 6907, p

    A Systematic Review

    2022  Volume 6907

    Abstract: Background: Desert dust outbreaks and dust storms are the major source of particulate matter globally and pose a major threat to human health. We investigated the microorganisms transported with desert dust particles and evaluated their potential impact ... ...

    Abstract Background: Desert dust outbreaks and dust storms are the major source of particulate matter globally and pose a major threat to human health. We investigated the microorganisms transported with desert dust particles and evaluated their potential impact on human health. Methods: A systematic review of all reports on the association between non-anthropogenic desert dust pollution, dust microorganisms and human health is conducted. Results: In total, 51 articles were included in this review. The affected regions studied were Asia (32/51, 62.7%) followed by Europe (9/51, 17.6%), America (6/51, 11.8%), Africa (4/51, 7.8%) and Australia (1/51, 2.0%). The Sahara Desert was the most frequent source of dust, followed by Asian and American deserts. In 39/51 studies the dust-related microbiome was analyzed, while, in 12/51 reports, the association of desert dust with infectious disease outbreaks was examined. Pathogenic and opportunistic agents were isolated from dust in 24/39 (61.5%) and 29/39 (74.4%) of the studies, respectively. A significant association of dust events with infectious disease outbreaks was found in 10/12 (83.3%) reports. The infectious diseases that were mostly investigated with dust outbreaks were pneumonia, respiratory tract infections, COVID-19, pulmonary tuberculosis and coccidioidomycosis. Conclusions: Desert dust outbreaks are vehicles of a significant number of pathogenic or opportunistic microorganisms and limited data indicate an association between dust events and infectious disease outbreaks. Further research is required to strengthen the correlation between dust events and infectious diseases and subsequently guide preventive public health measures.
    Keywords airborne pathogens ; climate change ; desert dust ; ecosystem and public health ; global warming ; pollution ; Medicine ; R
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Acute abdomen in multisystem inflammatory syndrome in children: A systematic review.

    Rouva, Glykeria / Vergadi, Eleni / Galanakis, Emmanouil

    Acta paediatrica (Oslo, Norway : 1992)

    2021  Volume 111, Issue 3, Page(s) 467–472

    Abstract: Aim: Multisystem inflammatory syndrome in children (MIS-C), a rare severe complication of SARS-CoV-2 infection, has been recently reported to mimic acute abdomen and lead to surgical interventions, posing challenges for clinicians. In this systematic ... ...

    Abstract Aim: Multisystem inflammatory syndrome in children (MIS-C), a rare severe complication of SARS-CoV-2 infection, has been recently reported to mimic acute abdomen and lead to surgical interventions, posing challenges for clinicians. In this systematic review, we evaluated the rate of acute abdomen and abdominal surgical emergencies in children with MIS-C.
    Methods: Systematic review of all MIS-C cases presented with acute abdomen.
    Results: A total of 385 patients with MIS-C, from 38 studies, were included. Gastrointestinal manifestations were prominent in 233/385 (60.5%) children. Acute abdomen was noted in 72/385 (18.7%) of MIS-C cases and in 72/233 (30.9%) of MIS-C cases with gastrointestinal symptoms. Final diagnoses were mostly non-surgical (55/72, 76.4%), such as mesenteric lymphadenitis (23/72, 31.9%), terminal ileitis/ileocolitis (19/72, 26.4%), free abdominal fluid/ascites (8/72, 11.1%) and paralytic ileus (3/72, 4.2%). Laparotomy was performed in 35/72 (48.6%) of children with MIS-C, and acute abdomen and was proven unnecessary in 18/35 (51.4%) cases. True abdominal surgical emergencies, such as appendicitis and obstructive ileus, were confirmed in 17/72 (23.6%) cases.
    Conclusion: MIS-C often presents with acute abdomen, mostly due to non-surgical intestinal inflammatory pathology. However, surgical complications occur in patients with MIS-C; therefore, a high index of suspicion should remain.
    MeSH term(s) Abdomen, Acute/diagnosis ; Abdomen, Acute/etiology ; COVID-19/complications ; Child ; Humans ; Intestinal Obstruction ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome
    Language English
    Publishing date 2021-12-03
    Publishing country Norway
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 203487-6
    ISSN 1651-2227 ; 0365-1436 ; 0803-5253
    ISSN (online) 1651-2227
    ISSN 0365-1436 ; 0803-5253
    DOI 10.1111/apa.16178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Mesenteric Lymphadenitis Presenting as Acute Abdomen in a Child with Multisystem Inflammatory Syndrome.

    Blevrakis, Evangelos / Vergadi, Eleni / Stefanaki, Maria / Alexiadi-Oikonomou, Iris / Rouva, Glykeria / Germanakis, Ioannis / Galanakis, Emmanouil

    Infectious disease reports

    2022  Volume 14, Issue 3, Page(s) 428–432

    Abstract: Multisystem inflammatory syndrome in children (MIS-C) may develop as a rare complication following COVID-19. MIS-C presentation varies substantially, but fever and gastrointestinal symptoms are the most prominent. Indeed, gastrointestinal involvement may ...

    Abstract Multisystem inflammatory syndrome in children (MIS-C) may develop as a rare complication following COVID-19. MIS-C presentation varies substantially, but fever and gastrointestinal symptoms are the most prominent. Indeed, gastrointestinal involvement may be severe enough to present as acute abdomen, posing challenges to clinicians. We present herein the case of a healthy five-year-old male who presented with fever, vomiting, and abdominal pain, resembling acute abdomen. The patient had no history of SARS-CoV-2 infection or exposure, and MIS-C diagnosis was initially surpassed unnoticed. The patient underwent exploratory laparotomy that only revealed mesenteric lymphadenitis. Postoperatively, the patient met the clinical and laboratory diagnostic criteria of MIS-C. SARS-CoV-2 exposure was serologically confirmed and MIS-C treatment was commenced, resulting in defervescence and a satisfactory outcome. In young patients presenting with acute abdomen, surgeons should be aware of MIS-C, so that earlier diagnosis and appropriate treatment are made prior to surgical interventions.
    Language English
    Publishing date 2022-06-06
    Publishing country Switzerland
    Document type Case Reports
    ISSN 2036-7430
    ISSN 2036-7430
    DOI 10.3390/idr14030046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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