Article ; Online: Autonomic nervous system involvement in chronic inflammatory demyelinating polyradiculoneuropathy: a literature review.
2023 Volume 44, Issue 9, Page(s) 3071–3082
Abstract: ... may indicate the presence of a comorbid disease (e.g., diabetes) and facilitate the differentiation of CIDP ... from other neuropathies (e.g., amyloid neuropathy). Five studies performed quantitative assessment of autonomic function ...
| Abstract | Background and aims: Although dysautonomia is a well-recognized complication of acute demyelinating polyradiculoneuropathy, it is rarely reported and evaluated in chronic demyelinating neuropathies. The purpose of this review is to search and synthesize the current literature on the prevalence and type of autonomic dysfunction (AD) in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Methods: PubMed and Web of Science were searched for studies reporting AD in CIDP. Results: Twelve studies, including 346 patients with CIDP, were found eligible for the review. Seven studies used autonomic tests only as an additional component of the comprehensive clinical evaluation, and found that dysautonomia in CIDP may indicate the presence of a comorbid disease (e.g., diabetes) and facilitate the differentiation of CIDP from other neuropathies (e.g., amyloid neuropathy). Five studies performed quantitative assessment of autonomic function in CIDP as a primary goal. Two studies have used the Composite Autonomic Severity Score (CASS) to assess severity and distribution of dysautonomia. The reported prevalence of dysautonomia in CIDP during quantitative assessment of autonomic function ranged from 25 to 89%, depending on the battery of tests used, with CASS not exceeding 4 points. The abnormalities in autonomic tests indicated both sympathetic and parasympathetic dysfunction and did not correlate with the duration, severity and variant of CIDP. Conclusions: Clinical or subclinical involvement of the ANS has been shown to be common and relatively mild in CIDP. The impact of autonomic impairment on disability and of its possible response to therapy in CIDP needs to be further investigated. |
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| MeSH term(s) | Humans ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/complications ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/diagnosis ; Autonomic Nervous System ; Diabetes Mellitus ; Primary Dysautonomias/diagnosis ; Primary Dysautonomias/epidemiology ; Primary Dysautonomias/etiology |
| Chemical Substances | 6-chloropenicillanic acid S-sulfoxide (97729-66-3) |
| Language | English |
| Publishing date | 2023-04-21 |
| Publishing country | Italy |
| Document type | Journal Article ; Review |
| ZDB-ID | 2016546-8 |
| ISSN | 1590-3478 ; 1590-1874 |
| ISSN (online) | 1590-3478 |
| ISSN | 1590-1874 |
| DOI | 10.1007/s10072-023-06802-z |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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