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Article ; Online: Unique Structure and Distinctive Properties of the Ancient and Ubiquitous Gamma-Type Envelope Glycoprotein.

Hogan, Victoria / Johnson, Welkin E

2023 Volume 15, Issue 2

Abstract: After the onset of the AIDS pandemic, HIV-1 ( ... ...

Abstract	After the onset of the AIDS pandemic, HIV-1 (genus
MeSH term(s)	Female ; Pregnancy ; Animals ; Humans ; Mice ; Placenta ; Gammaretrovirus ; Alpharetrovirus ; Leukemia Virus, Murine ; Ebolavirus ; Endogenous Retroviruses ; HIV Seropositivity ; Glycoproteins/genetics ; Mammals
Chemical Substances	Glycoproteins
Language	English
Publishing date	2023-01-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15020274
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Article ; Online: Test Yourself Answer: 48-year-old female with paresthesias to the left posterior ankle.

Adams, Luke W / Van Demark, Robert E / Durkin, Victoria / Johnson, Joshua D / Erie, Andrew J

Skeletal radiology

2023 Volume 53, Issue 5, Page(s) 1023–1025

MeSH term(s)	Female ; Humans ; Middle Aged ; Ankle ; Paresthesia ; Ankle Joint ; Lower Extremity
Language	English
Publishing date	2023-11-07
Publishing country	Germany
Document type	Case Reports ; Editorial
ZDB-ID	527592-1
ISSN	1432-2161 ; 0364-2348
ISSN (online)	1432-2161
ISSN	0364-2348
DOI	10.1007/s00256-023-04489-z
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Article ; Online: Test yourself question: 48-year-old female with paresthesias to the left posterior ankle.

Adams, Luke W / Van Demark, Robert E / Durkin, Victoria / Johnson, Joshua D / Erie, Andrew J

Skeletal radiology

2023 Volume 53, Issue 5, Page(s) 977–978

MeSH term(s)	Female ; Humans ; Middle Aged ; Ankle ; Paresthesia ; Ankle Joint ; Lower Extremity
Language	English
Publishing date	2023-11-06
Publishing country	Germany
Document type	Case Reports ; Editorial
ZDB-ID	527592-1
ISSN	1432-2161 ; 0364-2348
ISSN (online)	1432-2161
ISSN	0364-2348
DOI	10.1007/s00256-023-04488-0
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Article ; Online: Structural disconnection relates to functional changes after temporal lobe epilepsy surgery.

Sainburg, Lucas E / Janson, Andrew P / Johnson, Graham W / Jiang, Jasmine W / Rogers, Baxter P / Chang, Catie / Englot, Dario J / Morgan, Victoria L

Brain : a journal of neurology

2024 Volume 146, Issue 9, Page(s) 3913–3922

Abstract: Epilepsy surgery consists of surgical resection of the epileptic focus and is recommended for patients with drug-resistant focal epilepsy. However, focal brain lesions can lead to effects in distant brain regions. Similarly, the focal resection in ... ...

Abstract	Epilepsy surgery consists of surgical resection of the epileptic focus and is recommended for patients with drug-resistant focal epilepsy. However, focal brain lesions can lead to effects in distant brain regions. Similarly, the focal resection in temporal lobe epilepsy surgery has been shown to lead to functional changes distant from the resection. Here we hypothesize that there are changes in brain function caused by temporal lobe epilepsy surgery in regions distant from the resection that are due to their structural disconnection from the resected epileptic focus. Therefore, the goal of this study was to localize changes in brain function caused by temporal lobe epilepsy surgery and relate them to the disconnection from the resected epileptic focus. This study takes advantage of the unique opportunity that epilepsy surgery provides to investigate the effects of focal disconnections on brain function in humans, which has implications in epilepsy and broader neuroscience. Changes in brain function from pre- to post-epilepsy surgery were quantified in a group of temporal lobe epilepsy patients (n = 36) using a measure of resting state functional MRI activity fluctuations. We identified regions with significant functional MRI changes that had high structural connectivity to the resected region in healthy controls (n = 96) and patients based on diffusion MRI. The structural disconnection from the resected epileptic focus was then estimated using presurgical diffusion MRI and related to the functional MRI changes from pre- to post-surgery in these regions. Functional MRI activity fluctuations increased from pre- to post-surgery in temporal lobe epilepsy in the two regions most highly structurally connected to the resected epileptic focus in healthy controls and patients-the thalamus and the fusiform gyrus ipsilateral to the side of surgery (PFWE < 0.05). Broader surgeries led to larger functional MRI changes in the thalamus than more selective surgeries (P < 0.05), but no other clinical variables were related to functional MRI changes in either the thalamus or fusiform. The magnitude of the functional MRI changes in both the thalamus and fusiform increased with a higher estimated structural disconnection from the resected epileptic focus when controlling for the type of surgery (P < 0.05). These results suggest that the structural disconnection from the resected epileptic focus may contribute to the functional changes seen after epilepsy surgery. Broadly, this study provides a novel link between focal disconnections in the structural brain network and downstream effects on function in distant brain regions.
MeSH term(s)	Humans ; Epilepsy, Temporal Lobe/diagnostic imaging ; Epilepsy, Temporal Lobe/surgery ; Epilepsy, Temporal Lobe/pathology ; Brain/diagnostic imaging ; Brain/surgery ; Brain/pathology ; Magnetic Resonance Imaging ; Diffusion Magnetic Resonance Imaging ; Temporal Lobe/pathology ; Drug Resistant Epilepsy/diagnostic imaging ; Drug Resistant Epilepsy/surgery ; Drug Resistant Epilepsy/pathology
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80072-7
ISSN	1460-2156 ; 0006-8950
ISSN (online)	1460-2156
ISSN	0006-8950
DOI	10.1093/brain/awad117
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Article: Dual DNA/RNA-binding factor regulates dynamics of hnRNP splicing condensates.

Ray, Mukulika / Zaborowsky, Julia / Mahableshwarkar, Pranav / Vaidyanathan, Smriti / Shum, Jasmine / Viswanathan, Renjith / Huang, Annie / Wang, Szu-Huan / Johnson, Victoria / Wake, Noah / Conard, Ashley M / Conicella, Alexander E / Puterbaugh, Ryan / Fawzi, Nicolas L / Larschan, Erica

bioRxiv : the preprint server for biology

2024

Abstract: Despite decades of research, mechanisms by which co-transcriptional alternative splicing events are targeted to the correct genomic locations to drive cell fate decisions remain unknown. By combining structural and molecular approaches, we define a new ... ...

Abstract	Despite decades of research, mechanisms by which co-transcriptional alternative splicing events are targeted to the correct genomic locations to drive cell fate decisions remain unknown. By combining structural and molecular approaches, we define a new mechanism by which an essential transcription factor (TF) targets co-transcriptional splicing through physical and functional interaction with RNA and RNA binding proteins (RBPs). We show that an essential TF co-transcriptionally regulates sex-specific alternative splicing by directly interacting with a subset of target RNAs on chromatin and modulating the dynamics of hnRNPA2 homolog nuclear splicing condensates.
Language	English
Publishing date	2024-01-12
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.11.575216
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Article ; Online: A scoping review to inform the development of dementia care competencies.

Kay, Kelly / Metersky, Kateryna / Smye, Victoria / McGrath, Colleen / Johnson, Karen / Astell, Arlene / Sun, Winnie / Bartfay, Emma

Dementia (London, England)

2023 Volume 22, Issue 5, Page(s) 1138–1163

Abstract: ... of the core knowledge, skills, and abilities, (i.e., competencies) that should underpin dementia-related ...

Abstract	Health professionals and care partners of persons living with dementia have expressed that learning needs related to dementia care are a priority. There are currently a variety of training programs available in Ontario (Canada) to address aspects of dementia care, but no commonly accepted description of the core knowledge, skills, and abilities, (i.e., competencies) that should underpin dementia-related training and education in the province. The aim of this study was to review current evidence to inform the later development of competency statements describing the knowledge, skills and actions required for dementia care among care providers ranging from laypersons to health professionals. We also sought to validate existing dementia care principles and align new concepts to provide a useful organizing framework for future competency development. We distinguished between micro-, meso- and macro-level concepts to clarify the competencies required by individuals situated in different locations across the healthcare system, linking competency development in dementia care to broader system transformation. This review precedes the co-development of a holistic competency framework to guide approaches to dementia care training in Ontario.
MeSH term(s)	Humans ; Clinical Competence ; Dementia/therapy ; Health Personnel/education ; Curriculum ; Ontario
Language	English
Publishing date	2023-03-28
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	2084045-7
ISSN	1741-2684 ; 1471-3012
ISSN (online)	1741-2684
ISSN	1471-3012
DOI	10.1177/14713012231165568
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Article ; Online: Nitrogen isotopes reveal independent origins of N

Kipp, Michael A / Stüeken, Eva E / Strömberg, Caroline A E / Brightly, William H / Arbour, Victoria M / Erdei, Boglárka / Hill, Robert S / Johnson, Kirk R / Kvaček, Jiří / McElwain, Jennifer C / Miller, Ian M / Slodownik, Miriam / Vajda, Vivi / Buick, Roger

Nature ecology & evolution

2023 Volume 8, Issue 1, Page(s) 57–69

Abstract: Cycads are ancient seed plants (gymnosperms) that emerged by the early Permian. Although they were common understory flora and food for dinosaurs in the Mesozoic, their abundance declined markedly in the Cenozoic. Extant cycads persist in restricted ... ...

Abstract	Cycads are ancient seed plants (gymnosperms) that emerged by the early Permian. Although they were common understory flora and food for dinosaurs in the Mesozoic, their abundance declined markedly in the Cenozoic. Extant cycads persist in restricted populations in tropical and subtropical habitats and, with their conserved morphology, are often called 'living fossils.' All surviving taxa receive nitrogen from symbiotic N
MeSH term(s)	Nitrogen Isotopes ; Symbiosis ; Cycadopsida ; Nitrogen ; Fossils ; Cyanobacteria
Chemical Substances	Nitrogen Isotopes ; Nitrogen (N762921K75)
Language	English
Publishing date	2023-11-16
Publishing country	England
Document type	Journal Article
ISSN	2397-334X
ISSN (online)	2397-334X
DOI	10.1038/s41559-023-02251-1
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Article ; Online: Face-to-face bullying in and outside of schools and cyberbullying are associated with suicidality in Kenyan high school students: a public health issue.

Ndetei, David M / Mutiso, Victoria / Shanley, Jenelle R / Musyimi, Christine / Nyamai, Pascalyne / Munyua, Timothy / Osborn, Tom L / Johnson, Natalie E / Gilbert, Sonja / Abio, Anne / Javed, Afzal / Sourander, Andre

BMC psychiatry

2024 Volume 24, Issue 1, Page(s) 277

Abstract: Background: Childhood bullying has been classified as a major public health concern by WHO, with negative effects on the health education and social outcomes of both bullies and victims. There is no current Kenyan data on the prevalence of face-to-face ... ...

Abstract	Background: Childhood bullying has been classified as a major public health concern by WHO, with negative effects on the health education and social outcomes of both bullies and victims. There is no current Kenyan data on the prevalence of face-to-face bullying and cyberbullying co-occurring in the same cohort of youth and how they are associated with different aspects of suicidality and socio-demographic characteristics. This study aims to fill these gaps in the Kenyan situation so as to inform current policy and practice. Methodology: This cross-sectional study involved 2,652 students from ten secondary schools in Kenya, selected from three regions representing different levels of public funded schools and socioeconomic spaces. The outcome variable was derived from the questionnaire which asked students questions related to self-harm, suicide thoughts, plans, and attempts. Predictor variables were based on response on experience of bullying in school, out of school, at home, and cyberbullying. Other variables such as gender, age, family background, and class were also collected from the self-reported questions. Data were analyzed using SPSS version 25, with descriptive summary statistics and chi-square tests used to examine variables, and logistic regression analysis used to determine the associations between suicidality and experience of bullying. Results: The mean age was 16.13 years. More than half of the participants were male, with the largest proportion living in rural areas. Face-to-face bullying was more prevalent than cyberbullying, with 82% of participants experiencing bullying and 68% experiencing it almost daily in the past six months. Both face-to-face bullying and cyberbullying were associated with suicidal thoughts, plans, and attempts. Predictors of suicidal attempts included being bullied outside of school and being a victim of group bullying, while being bullied every day and being bullied by adult men were predictors of suicidal attempts in cyberbullying. Conclusion: There is a high prevalence of face-to-face bullying both in and outside schools. There is also a high prevalence of cyberbullying. Both face-to-face and cyberbullying are associated with suicidality in Kenyan high school students.
MeSH term(s)	Adult ; Adolescent ; Humans ; Male ; Child ; Female ; Cyberbullying ; Kenya/epidemiology ; Suicidal Ideation ; Cross-Sectional Studies ; Suicide ; Bullying ; Schools ; Students ; Self Report
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2050438-X
ISSN	1471-244X ; 1471-244X
ISSN (online)	1471-244X
ISSN	1471-244X
DOI	10.1186/s12888-024-05739-7
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Article ; Online: Real-world outcomes in patients with KRAS G12C-mutated advanced non-small cell lung cancer treated with docetaxel in second-line or beyond.

Gray, Jhanelle E / Hsu, Hil / Younan, Diana / Suri, Gaurav / Chia, Victoria / Spira, Alexander / Johnson, Melissa

Lung cancer (Amsterdam, Netherlands)

2023 Volume 181, Page(s) 107260

Abstract: Introduction: The KRAS G12C mutation has recently become a druggable target in non-small cell lung cancer (NSCLC). In this observational study, we present real-world clinicopathological characteristics, treatment patterns, and survival outcomes data in ... ...

Abstract	Introduction: The KRAS G12C mutation has recently become a druggable target in non-small cell lung cancer (NSCLC). In this observational study, we present real-world clinicopathological characteristics, treatment patterns, and survival outcomes data in patients with KRAS mutation-positive advanced NSCLC (aNSCLC), including those with KRAS G12C and KRAS non-G12C mutations, who received docetaxel as standard-of-care treatment in the second-line and beyond (2L+). Methods: US-based electronic health record-derived de-identified databases were used to assess clinicopathological characteristics and outcomes in adult aNSCLC patients with KRAS mutations treated with 2L+ docetaxel between January 1, 2011, and March 31, 2021. The primary endpoints were median real-world overall survival OS (rwOS) and median real-world progression-free survival (rwPFS), which were estimated in 2L, third-line, fourth-line, and 2L+ analysis sets among patients who had a 6-month minimum opportunity for follow-up and were not taking a clinical trial drug. Results: Of the 677 patients with KRAS-mutant aNSCLC (KRAS mutant cohort) treated with 2L+ docetaxel, 295 (43.6%) had KRAS G12C mutation (KRAS G12C cohort) and 382 (56.4%) had KRAS non-G12C mutation (KRAS non-G12C cohort). Across all cohorts, approximately 47%, 35%, 14-15%, and 6-9% of patients received 2L, third-line, fourth-line, and fifth- or later-line docetaxel, respectively. In the KRAS G12C cohort, ∼68% of patients were treated with a PD-1/PD-L1 inhibitor prior to 2L+ docetaxel. Most 2L+ docetaxel regimens in the KRAS G12C cohort were combinations (59.5%), primarily with ramucirumab (45.2%). In the KRAS G12C cohort, the median rwOS and median rwPFS after 2L+ docetaxel were 6.0 (95% CI, 4.9-7.1) and 3.4 (95% CI, 2.7-4.2) months, respectively, with similar trends observed in other cohorts and lines of therapy. Conclusions: Real-world outcomes were poor in patients with KRAS G12C-mutated aNSCLC treated with 2L+ docetaxel. Targeted and more efficacious treatment options in these patients are warranted.
MeSH term(s)	Adult ; Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Docetaxel/therapeutic use ; Proto-Oncogene Proteins p21(ras)/genetics ; Lung Neoplasms/drug therapy ; Taxoids ; Mutation
Chemical Substances	Docetaxel (15H5577CQD) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; Taxoids ; KRAS protein, human
Language	English
Publishing date	2023-05-25
Publishing country	Ireland
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632771-0
ISSN	1872-8332 ; 0169-5002
ISSN (online)	1872-8332
ISSN	0169-5002
DOI	10.1016/j.lungcan.2023.107260
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Zs.A 2135: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Modeling traumatic brain injury with human brain organoids.

Jgamadze, Dennis / Johnson, Victoria E / Wolf, John A / Cullen, D Kacy / Song, Hongjun / Ming, Guo-Li / Smith, Douglas H / Chen, H Isaac

Current opinion in biomedical engineering

2022 Volume 14, Page(s) 52–58

Abstract: Traumatic brain injury (TBI) remains a prominent public health concern despite several decades of attempts to develop therapies for the associated neurological and cognitive deficits. Effective models of this condition are imperative for better defining ... ...

Abstract	Traumatic brain injury (TBI) remains a prominent public health concern despite several decades of attempts to develop therapies for the associated neurological and cognitive deficits. Effective models of this condition are imperative for better defining its pathophysiology and testing therapeutics. Human brain organoids are stem cell-derived neural tissues that recapitulate many of the steps of normal neurodevelopment, resulting in the reproduction of a substantial degree of brain architecture. Organoids are highly relevant to clinical conditions because of their human nature and three-dimensional tissue structure, yet they are easier to manipulate and interrogate experimentally than animals. Thus, they have the potential to serve as a novel platform for studying TBI. In this article, we discuss available
Language	English
Publishing date	2022-03-30
Publishing country	England
Document type	Journal Article
ISSN	2468-4511
ISSN	2468-4511
DOI	10.1016/j.cobme.2020.05.004
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