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Book: Schizo-obsessive disorder

Poyurovsky, Michael

(Cambridge Medicine)

2013

Author's details	Michael Poyurovsky
Series title	Cambridge Medicine
Keywords	Schizophrenia / complications ; Obsessive-Compulsive Disorder / complications ; Schizophrenic Psychology
Language	English
Size	XI, 236 S. : Ill., graph. Darst., 24 cm
Publisher	Cambridge Univ. Press
Publishing place	Cambridge u.a.
Publishing country	Great Britain
Document type	Book
Note	Includes bibliographical references and index
HBZ-ID	HT018469220
ISBN	978-1-107-00012-4 ; 1-107-00012-2
Database	Catalogue ZB MED Medicine, Health

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2014 A 4455	available for loan (reading room)	Lesesaal EG

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Article ; Online: Beneficial Effect of Quetiapine on Sleep, Anxiety, Depression and Myalgia Symptoms in a Patient With Post-COVID-19 Condition.

Poyurovsky, Michael / Weizman, Abraham

Journal of clinical psychopharmacology

2023 Volume 43, Issue 4, Page(s) 381–382

MeSH term(s)	Humans ; Quetiapine Fumarate ; Depression/drug therapy ; Myalgia/chemically induced ; Myalgia/drug therapy ; COVID-19 ; Anxiety/drug therapy ; Sleep
Chemical Substances	Quetiapine Fumarate (2S3PL1B6UJ)
Language	English
Publishing date	2023-05-29
Publishing country	United States
Document type	Letter
ZDB-ID	604631-9
ISSN	1533-712X ; 0271-0749
ISSN (online)	1533-712X
ISSN	0271-0749
DOI	10.1097/JCP.0000000000001706
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Article ; Online: Low-Dose Quetiapine Fumarate (50 mg) for Obsessive-Compulsive Disorder Patients With Comorbid Bipolar Depression.

Poyurovsky, Michael / Weizman, Abraham

Clinical neuropharmacology

2021 Volume 44, Issue 5, Page(s) 196–197

MeSH term(s)	Antipsychotic Agents/therapeutic use ; Bipolar Disorder/complications ; Bipolar Disorder/drug therapy ; Bipolar Disorder/epidemiology ; Comorbidity ; Dibenzothiazepines/therapeutic use ; Humans ; Obsessive-Compulsive Disorder/complications ; Obsessive-Compulsive Disorder/drug therapy ; Obsessive-Compulsive Disorder/epidemiology ; Quetiapine Fumarate/therapeutic use
Chemical Substances	Antipsychotic Agents ; Dibenzothiazepines ; Quetiapine Fumarate (2S3PL1B6UJ)
Language	English
Publishing date	2021-08-21
Publishing country	United States
Document type	Letter
ZDB-ID	199293-4
ISSN	1537-162X ; 0362-5664
ISSN (online)	1537-162X
ISSN	0362-5664
DOI	10.1097/WNF.0000000000000474
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Article ; Online: Quetiapine for Bipolar Depressive Episode in Obsessive-Compulsive Disorder Patients Maintained on Selective Serotonin Reuptake Inhibitor Treatment.

Poyurovsky, Michael / Weizman, Abraham

Clinical neuropharmacology

2021 Volume 44, Issue 4, Page(s) 123–125

Abstract: Objectives: A meaningful proportion of patients with obsessive-compulsive disorder (OCD) develop symptoms of bipolar depression (BP-D). In the present investigation, we aimed to determine whether quetiapine is efficacious in OCD patients who despite ... ...

Abstract	Objectives: A meaningful proportion of patients with obsessive-compulsive disorder (OCD) develop symptoms of bipolar depression (BP-D). In the present investigation, we aimed to determine whether quetiapine is efficacious in OCD patients who despite continuous treatment with a selective serotonin reuptake inhibitor developed an acute episode of BP-D. Methods: We analyzed 68 charts of Diagnostic and Statistical Manual of Mental Disorders Fifth Edition OCD patients from our outpatient clinic and identified 15 patients who in addition met Diagnostic and Statistical Manual of Mental Disorders Fifth Edition criteria for bipolar II disorder, depressive episode. Eleven (7 men and 4 women, aged 24-54 years) patients for whom quetiapine was added to treat the index episode of BP-D were included. Treatment response was assessed retrospectively and defined as a score of "much improved" or "very much improved" on the Clinical Global Impression-Improvement scale. Results: Quetiapine was added for treatment of BP-D in a dose range of 150 to 400 mg (mean, 273 mg). Eight (73%) of the 11 study patients fulfilled the criterion of response, that is a score of "much improve" (4 patients) and "very much improved" (4 patients) on the Clinical Global Impression-Improvement scale. Notably, quetiapine was associated with additional improvement of OCD symptoms in 6 of 8 study responders. Quetiapine was well tolerated. The most frequently detected side effects were drowsiness (5 patients), constipation (4 patients), and orthostatic hypotension (2 patients). Conclusions: The revealed beneficial effect of quetiapine addition for acute episode of BP-D in OCD patients maintained on selective serotonin reuptake inhibitor treatment merits further controlled investigation.
MeSH term(s)	Antipsychotic Agents/therapeutic use ; Bipolar Disorder/drug therapy ; Dibenzothiazepines/adverse effects ; Drug Therapy, Combination ; Female ; Humans ; Male ; Obsessive-Compulsive Disorder/drug therapy ; Quetiapine Fumarate/therapeutic use ; Retrospective Studies ; Serotonin Uptake Inhibitors/therapeutic use ; Treatment Outcome
Chemical Substances	Antipsychotic Agents ; Dibenzothiazepines ; Serotonin Uptake Inhibitors ; Quetiapine Fumarate (2S3PL1B6UJ)
Language	English
Publishing date	2021-03-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	199293-4
ISSN	1537-162X ; 0362-5664
ISSN (online)	1537-162X
ISSN	0362-5664
DOI	10.1097/WNF.0000000000000456
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Article ; Online: Treatment of Antipsychotic-Induced Akathisia: Role of Serotonin 5-HT

Poyurovsky, Michael / Weizman, Abraham

Drugs

2020 Volume 80, Issue 9, Page(s) 871–882

Abstract: Akathisia is one of the most prevalent and distressing adverse effects associated with antipsychotic drug treatment. Propranolol, a non-selective beta-adrenergic receptor antagonist, is currently considered a first-line treatment for antipsychotic- ... ...

Abstract	Akathisia is one of the most prevalent and distressing adverse effects associated with antipsychotic drug treatment. Propranolol, a non-selective beta-adrenergic receptor antagonist, is currently considered a first-line treatment for antipsychotic-induced akathisia (AIA). Surprisingly, the evidence for its anti-akathisia effect is modest. Propranolol's side effects (e.g. orthostatic hypotension, bradycardia), contraindications (e.g. asthma) and increased complexity in titration schedules limit its use in some patients. Anticholinergic agents and benzodiazepines merely provide symptomatic relief in patients with AIA. Effective and well-tolerated treatment remains a major unmet need in akathisia and warrants a search for new anti-akathisia agents. Accumulating evidence during the last two decades indicates that agents with marked postsynaptic serotonin 5-HT
MeSH term(s)	Akathisia, Drug-Induced/drug therapy ; Algorithms ; Antipsychotic Agents/adverse effects ; Humans ; Propranolol/adverse effects ; Psychomotor Agitation/etiology ; Receptor, Serotonin, 5-HT2A/metabolism ; Serotonin 5-HT2 Receptor Antagonists/therapeutic use ; Serotonin Receptor Agonists/adverse effects
Chemical Substances	Antipsychotic Agents ; Receptor, Serotonin, 5-HT2A ; Serotonin 5-HT2 Receptor Antagonists ; Serotonin Receptor Agonists ; Propranolol (9Y8NXQ24VQ)
Language	English
Publishing date	2020-05-08
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	120316-2
ISSN	1179-1950 ; 0012-6667
ISSN (online)	1179-1950
ISSN	0012-6667
DOI	10.1007/s40265-020-01312-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Beneficial Effect of Betahistine, a Structural Analog of Histamine, in Clozapine-Related Sedation.

Poyurovsky, Michael / Weizman, Abraham

Clinical neuropharmacology

2019 Volume 42, Issue 4, Page(s) 145

MeSH term(s)	Betahistine/therapeutic use ; Clozapine/adverse effects ; Conscious Sedation ; Humans
Chemical Substances	Clozapine (J60AR2IKIC) ; Betahistine (X32KK4201D)
Language	English
Publishing date	2019-05-28
Publishing country	United States
Document type	Letter
ZDB-ID	199293-4
ISSN	1537-162X ; 0362-5664
ISSN (online)	1537-162X
ISSN	0362-5664
DOI	10.1097/WNF.0000000000000346
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Article ; Online: Rate of OCD and sub-threshold OCD in bipolar disorder patients with first depressive episode.

Braverman, Leonid / Fuchs, Camil / Weizman, Abraham / Poyurovsky, Michael

Psychiatry research

2021 Volume 302, Page(s) 114010

Abstract: Evidence indicates that obsessive-compulsive disorder (OCD) co-occurs with bipolar disorder (BD) at a higher rate than in the general population. Although there is a preliminary indication of a predominant aggregation of OCD in BD patients with bipolar ... ...

Abstract	Evidence indicates that obsessive-compulsive disorder (OCD) co-occurs with bipolar disorder (BD) at a higher rate than in the general population. Although there is a preliminary indication of a predominant aggregation of OCD in BD patients with bipolar depression (BP-D), no explicit evaluation has previously been undertaken. Using the Structured Clinical Interview for DSM-5 Axis-I disorders and appropriate rating scales, seventy-three BD patients experiencing their first depressive episode were screened for OCD and subthreshold OCD. Nineteen (26%) of the 73 participants in addition to BP-D also met DSM-5 criteria for OCD and 17 (23.2%) patients met criteria for sub-threshold OCD. No differences in demographic and clinical variables evaluated in the study were found between the BP-D patients with and without OCD. Limitations of the study included a relatively small sample size, cross-sectional design and inclusion of only hospitalized BP-D patients. Additional studies are warranted to better define the longitudinal course of comorbid BP-D/OCD, treatment approaches and outcomes of this challenging patient population. Explicit prospective comparison of the rate of DSM-5 OCD and subthreshold OCD in depressive versus manic episodes of bipolar disorder within the same patient is justified.
MeSH term(s)	Bipolar Disorder/complications ; Bipolar Disorder/epidemiology ; Comorbidity ; Cross-Sectional Studies ; Humans ; Obsessive-Compulsive Disorder/complications ; Obsessive-Compulsive Disorder/epidemiology ; Prospective Studies
Language	English
Publishing date	2021-05-15
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2021.114010
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Article ; Online: Beneficial Effect of a Relatively Low Dose of Clozapine in a Bipolar Depression Patient With Comorbid Obsessive-Compulsive Disorder and Severe Suicidality.

Poyurovsky, Michael / Papach, Pavlo / Weizman, Abraham

Clinical neuropharmacology

2020 Volume 43, Issue 5, Page(s) 169–170

MeSH term(s)	Adult ; Antipsychotic Agents/therapeutic use ; Bipolar Disorder/complications ; Bipolar Disorder/drug therapy ; Clozapine/therapeutic use ; Depressive Disorder/complications ; Depressive Disorder/drug therapy ; Female ; Humans ; Obsessive-Compulsive Disorder/complications ; Suicidal Ideation ; Suicide, Attempted
Chemical Substances	Antipsychotic Agents ; Clozapine (J60AR2IKIC)
Language	English
Publishing date	2020-09-18
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	199293-4
ISSN	1537-162X ; 0362-5664
ISSN (online)	1537-162X
ISSN	0362-5664
DOI	10.1097/WNF.0000000000000406
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Article ; Online: Very Low-Dose Mirtazapine (7.5 mg) in Treatment of Acute Antipsychotic-Associated Akathisia.

Poyurovsky, Michael / Weizman, Abraham

Journal of clinical psychopharmacology

2018 Volume 38, Issue 6, Page(s) 609–611

Abstract: Background: Some evidence suggests that off-label use of mirtazapine (15 mg) is effective in treatment of acute antipsychotic-associated akathisia (AAA). We analyzed whether a lower dose of mirtazapine (7.5 mg) maintained its antiakathisia properties ... ...

Abstract	Background: Some evidence suggests that off-label use of mirtazapine (15 mg) is effective in treatment of acute antipsychotic-associated akathisia (AAA). We analyzed whether a lower dose of mirtazapine (7.5 mg) maintained its antiakathisia properties while exhibiting better tolerability in patients with schizophrenia and mood disorders who developed acute AAA. Methods: Medical charts were retrospectively evaluated for 12 patients with AAA. All scored at least 2 (mild akathisia) on the Barnes Akathisia Rating Scale (BARS) and were treated with mirtazapine (7.5 mg) for a mean of 10.3 days. Results: There was a statistically significant decrease in the BARS subjective, distress, and global (P < 0.01 to P < 0.001), but not objective (P = 0.63), subscales. Five participants (41.6%) fulfilled the predefined criterion of response, a decrease of at least 2 points on the BARS global subscale. The positive antiakathisia effect of mirtazapine was observed predominantly in aripiprazole-treated patients. Mirtazapine (7.5 mg) was well tolerated, and no clinically significant adverse effects, primarily drowsiness or increased appetite, were reported. Conclusions: A large-scale controlled evaluation is warranted to substantiate clinical utility of off-label use of mirtazapine (7.5 mg) for patients with AAA.
MeSH term(s)	Adult ; Akathisia, Drug-Induced/drug therapy ; Akathisia, Drug-Induced/etiology ; Antipsychotic Agents/adverse effects ; Female ; Humans ; Male ; Mental Disorders/drug therapy ; Middle Aged ; Mirtazapine/administration & dosage ; Mirtazapine/pharmacology ; Off-Label Use ; Outcome Assessment (Health Care) ; Serotonin 5-HT2 Receptor Antagonists/administration & dosage ; Serotonin 5-HT2 Receptor Antagonists/pharmacology ; Young Adult
Chemical Substances	Antipsychotic Agents ; Serotonin 5-HT2 Receptor Antagonists ; Mirtazapine (A051Q2099Q)
Language	English
Publishing date	2018-10-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	604631-9
ISSN	1533-712X ; 0271-0749
ISSN (online)	1533-712X
ISSN	0271-0749
DOI	10.1097/JCP.0000000000000972
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Article ; Online: Beneficial effect of quetiapine monotherapy in patients with bipolar depression and comorbid obsessive-compulsive disorder.

Poyurovsky, Michael / Braverman, Leonid / Weizman, Abraham

International clinical psychopharmacology

2020 Volume 36, Issue 1, Page(s) 50–53

Abstract: Obsessive-compulsive disorder (OCD) is a prevalent and clinically significant comorbid condition in patients with bipolar disorder. Treatment of bipolar disorder/OCD patients is challenging. We report the results of an open-label, short-term, prospective ...

Abstract	Obsessive-compulsive disorder (OCD) is a prevalent and clinically significant comorbid condition in patients with bipolar disorder. Treatment of bipolar disorder/OCD patients is challenging. We report the results of an open-label, short-term, prospective investigation of quetiapine monotherapy in 16 patients (three men and 13 women, aged 18-56 years) hospitalized for acute bipolar depression who in addition met Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria for OCD. The participants were treated with quetiapine in a dose range of 150-600 mg (mean 347 mg) for a mean duration of 4.3 ± 1.4 weeks (range 3-7 weeks). Eleven (68.8%) of the 16 study participants fulfilled the predefined criteria for response, namely a score of 'very much improved' (four patients) and 'much improved' (seven patients) on the Clinical Global Impression - Improvement scale. Treatment with quetiapine was associated with a statistically significant decrease from baseline in the relevant rating scales for the assessment of depressive, manic and OCD symptoms. Quetiapine was well tolerated. The most frequently reported side effects were sedation, orthostatic hypotension and constipation. Durability of the positive therapeutic effect of quetiapine monotherapy in patients with bipolar disorder/OCD comorbidity and the necessity for subsequent augmentation with anti-OCD agents need to be addressed in future controlled studies.
MeSH term(s)	Adolescent ; Adult ; Bipolar Disorder/drug therapy ; Bipolar Disorder/epidemiology ; Comorbidity ; Female ; Humans ; Male ; Middle Aged ; Obsessive-Compulsive Disorder/drug therapy ; Obsessive-Compulsive Disorder/epidemiology ; Prospective Studies ; Quetiapine Fumarate/therapeutic use ; Treatment Outcome ; Young Adult
Chemical Substances	Quetiapine Fumarate (2S3PL1B6UJ)
Language	English
Publishing date	2020-08-08
Publishing country	England
Document type	Journal Article
ZDB-ID	632837-4
ISSN	1473-5857 ; 0268-1315
ISSN (online)	1473-5857
ISSN	0268-1315
DOI	10.1097/YIC.0000000000000325
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