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Article ; Online: Cerebral Arteriopathies, Venous Thrombosis, and Migraine.

Camargo, Erica C S / Singhal, Aneesh B

2017 Volume 37, Issue 3, Page(s) 339–350

MeSH term(s)	Cerebral Arterial Diseases/complications ; Humans ; Migraine Disorders/complications ; Stroke/etiology ; Stroke/prevention & control ; Venous Thrombosis/complications
Language	English
Publishing date	2017-07-31
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	603165-1
ISSN	1098-9021 ; 0271-8235
ISSN (online)	1098-9021
ISSN	0271-8235
DOI	10.1055/s-0037-1603914
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Article ; Online: Case 39-2021: A 26-Year-Old Woman with Respiratory Failure and Altered Mental Status.

Kadar, Aran / Shah, Viral S / Mendoza, Dexter P / Lai, Peggy S / Aghajan, Yasmin / Piazza, Gregory / Camargo, Erica C / Viswanathan, Kartik

The New England journal of medicine

2021 Volume 385, Issue 26, Page(s) 2464–2474

MeSH term(s)	Adult ; Brain/diagnostic imaging ; Brain/pathology ; Brain Diseases/complications ; Brain Diseases/diagnosis ; Bronchoalveolar Lavage Fluid/cytology ; Diagnosis, Differential ; Embolism, Fat/complications ; Embolism, Fat/diagnosis ; Female ; Humans ; Lipoabdominoplasty/adverse effects ; Lung/drug effects ; Lung/pathology ; Mental Disorders ; Respiratory Insufficiency ; Tomography, X-Ray Computed
Language	English
Publishing date	2021-12-22
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMcpc2107355
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Article: Other cerebrovascular occlusive disease.

Camargo, Erica C S / Schaefer, Pamela W / Singhal, Aneesh B

Handbook of clinical neurology

2016 Volume 135, Page(s) 317–350

Abstract: In this chapter we review the optimal imaging modalities for subacute and chronic stroke. We discuss the utility of computed tomography (CT) and multimodal CT imaging. Further, we analyze the importance of specific magnetic resonance imaging sequences, ... ...

Abstract	In this chapter we review the optimal imaging modalities for subacute and chronic stroke. We discuss the utility of computed tomography (CT) and multimodal CT imaging. Further, we analyze the importance of specific magnetic resonance imaging sequences, such as diffusion-weighted imaging for acute ischemic stroke, T2/fluid-attenuated inversion recovery for subacute and chronic stroke, and susceptibility imaging for detection of intracranial hemorrhages. Different ischemic stroke mechanisms are reviewed, and how these imaging modalities may aid in the determination of such. Further, we analyze how topographic patterns in ischemic stroke may provide important clues to the diagnosis, in addition to the temporal evolution of the stroke. Lastly, specific cerebrovascular occlusive diseases are reviewed, with emphasis on the optimal imaging modalities and their findings in each condition.
MeSH term(s)	Cerebrovascular Disorders/diagnostic imaging ; Humans ; Image Processing, Computer-Assisted ; Neuroimaging
Language	English
Publishing date	2016
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	0072-9752
ISSN	0072-9752
DOI	10.1016/B978-0-444-53485-9.00017-9
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Article: Cerebral Arteriopathies, Venous Thrombosis, and Migraine

Camargo, Erica C. S. / Singhal, Aneesh B.

Seminars in Neurology

(Stroke Prevention)

2017 Volume 37, Issue 03, Page(s) 339–350

Abstract: In this article, the authors review stroke preventive strategies in a diverse group of conditions, namely the nonatherosclerotic cerebral arteriopathies, migraine-associated or migraine-induced stroke, and cerebral venous sinus thrombosis. Although these ...

Series title	Stroke Prevention
Abstract	In this article, the authors review stroke preventive strategies in a diverse group of conditions, namely the nonatherosclerotic cerebral arteriopathies, migraine-associated or migraine-induced stroke, and cerebral venous sinus thrombosis. Although these conditions are less common causes of stroke in the aggregate, they are frequent causes of stroke in teenagers and young adults. Aside from posing unique diagnostic challenges, their management is limited by the absence of randomized clinical trials or high-level evidence that is specific to these conditions. Therapeutic decision-making is largely based on expert opinion, clinical experience, and retrospective studies; it is often empiric. It remains uncertain whether otherwise routine secondary stroke-preventive strategies, such as long-term antiplatelet treatment, lipid-lowering medications, and antihypertensive agents, are applicable to patients with stroke from a cerebral arteriopathy or migraine-associated stroke.
Keywords	ischemic stroke ; migraine ; cerebral arteritis ; cerebral venous thrombosis ; stroke prevention
Language	English
Publishing date	2017-06-01
Publisher	Thieme Medical Publishers
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	603165-1
ISSN	1098-9021 ; 0271-8235
ISSN (online)	1098-9021
ISSN	0271-8235
DOI	10.1055/s-0037-1603914
Database	Thieme publisher's database

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Article ; Online: Human topoisomerase inhibition and DNA/BSA binding of Ru(II)-SCAR complexes as potential anticancer candidates for oral application.

De Grandis, Rone A / de Camargo, Mariana S / da Silva, Monize M / Lopes, Érica O / Padilha, Elias C / Resende, Flávia A / Peccinini, Rosângela G / Pavan, Fernando R / Desideri, Alessandro / Batista, Alzir A / Varanda, Eliana A

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine

2017 Volume 30, Issue 3, Page(s) 321–334

Abstract: Three ruthenium(II) phosphine/diimine/picolinate complexes were selected aimed at investigating anticancer activity against several cancer cell lines and the capacity of inhibiting the supercoiled DNA relaxation mediated by human topoisomerase IB (Top 1). ...

Abstract	Three ruthenium(II) phosphine/diimine/picolinate complexes were selected aimed at investigating anticancer activity against several cancer cell lines and the capacity of inhibiting the supercoiled DNA relaxation mediated by human topoisomerase IB (Top 1). The structure-lipophilicity relationship in membrane permeability using the Caco-2 cells have also been evaluated in this study. SCAR 5 was found to present 45 times more cytotoxicity against breast cancer cell when compared to cisplatin. SCAR 4 and 5 were both found to be capable of inhibiting the supercoiled DNA relaxation mediated by Top 1. Interaction studies showed that SCAR 4 and 5 can bind to DNA through electrostatic interactions while SCAR 6 is able to bind covalently to DNA. The complexes SCAR were found to interact differently with bovine serum albumin (BSA) suggesting hydrophobic interactions with albumin. The permeability of all complexes was seen to be dependent on their lipophilicity. SCAR 4 and 5 exhibited high membrane permeability (P
MeSH term(s)	Administration, Oral ; Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Binding Sites/drug effects ; Cattle ; Cell Line, Tumor ; Cell Proliferation/drug effects ; DNA/antagonists & inhibitors ; DNA/chemistry ; DNA Topoisomerases, Type I/metabolism ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Organometallic Compounds/administration & dosage ; Organometallic Compounds/chemical synthesis ; Organometallic Compounds/chemistry ; Organometallic Compounds/pharmacology ; Ruthenium/administration & dosage ; Ruthenium/chemistry ; Ruthenium/pharmacology ; Serum Albumin, Bovine/antagonists & inhibitors ; Serum Albumin, Bovine/chemistry ; Structure-Activity Relationship ; Topoisomerase Inhibitors/administration & dosage ; Topoisomerase Inhibitors/chemical synthesis ; Topoisomerase Inhibitors/chemistry ; Topoisomerase Inhibitors/pharmacology
Chemical Substances	Antineoplastic Agents ; Organometallic Compounds ; Topoisomerase Inhibitors ; Serum Albumin, Bovine (27432CM55Q) ; Ruthenium (7UI0TKC3U5) ; DNA (9007-49-2) ; DNA Topoisomerases, Type I (EC 5.99.1.2) ; TOP1 protein, human (EC 5.99.1.2)
Language	English
Publishing date	2017-03-16
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1112688-7
ISSN	1572-8773 ; 0966-0844
ISSN (online)	1572-8773
ISSN	0966-0844
DOI	10.1007/s10534-017-0008-z
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Zs.A 2515: Show issues

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Article: Regional CBF changes in Parkinson's disease: the importance of functional neuroimaging analyses.

Amorim, Bárbara J / Camargo, Erica C S / Etchebehere, Elba C S C

European journal of nuclear medicine and molecular imaging

2007 Volume 34, Issue 9, Page(s) 1455–1457

MeSH term(s)	Aged ; Brain/pathology ; Cerebrovascular Circulation ; Diagnostic Imaging/methods ; Humans ; Models, Statistical ; Parkinson Disease/diagnosis ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Perfusion ; Radiopharmaceuticals/pharmacology ; Reproducibility of Results ; Technetium Tc 99m Exametazime/pharmacology ; Tomography, Emission-Computed, Single-Photon/methods ; Treatment Outcome
Chemical Substances	Radiopharmaceuticals ; Technetium Tc 99m Exametazime (3B744AG22N)
Language	English
Publishing date	2007-09
Publishing country	Germany
Document type	Comment ; Editorial
ZDB-ID	8236-3
ISSN	1619-7089 ; 1619-7070 ; 0340-6997
ISSN (online)	1619-7089
ISSN	1619-7070 ; 0340-6997
DOI	10.1007/s00259-007-0411-8
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Zs.A 1227: Show issues

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Article ; Online: Field Assessment Stroke Triage for Emergency Destination: A Simple and Accurate Prehospital Scale to Detect Large Vessel Occlusion Strokes.

Lima, Fabricio O / Silva, Gisele S / Furie, Karen L / Frankel, Michael R / Lev, Michael H / Camargo, Érica C S / Haussen, Diogo C / Singhal, Aneesh B / Koroshetz, Walter J / Smith, Wade S / Nogueira, Raul G

Stroke

2016 Volume 47, Issue 8, Page(s) 1997–2002

Abstract: Background and purpose: Patients with large vessel occlusion strokes (LVOS) may be better served by direct transfer to endovascular capable centers avoiding hazardous delays between primary and comprehensive stroke centers. However, accurate stroke ... ...

Abstract	Background and purpose: Patients with large vessel occlusion strokes (LVOS) may be better served by direct transfer to endovascular capable centers avoiding hazardous delays between primary and comprehensive stroke centers. However, accurate stroke field triage remains challenging. We aimed to develop a simple field scale to identify LVOS. Methods: The Field Assessment Stroke Triage for Emergency Destination (FAST-ED) scale was based on items of the National Institutes of Health Stroke Scale (NIHSS) with higher predictive value for LVOS and tested in the Screening Technology and Outcomes Project in Stroke (STOPStroke) cohort, in which patients underwent computed tomographic angiography within the first 24 hours of stroke onset. LVOS were defined by total occlusions involving the intracranial internal carotid artery, middle cerebral artery-M1, middle cerebral artery-2, or basilar arteries. Patients with partial, bihemispheric, and anterior+posterior circulation occlusions were excluded. Receiver operating characteristic curve, sensitivity, specificity, positive predictive value, and negative predictive value of FAST-ED were compared with the NIHSS, Rapid Arterial Occlusion Evaluation (RACE) scale, and Cincinnati Prehospital Stroke Severity (CPSS) scale. Results: LVO was detected in 240 of the 727 qualifying patients (33%). FAST-ED had comparable accuracy to predict LVO to the NIHSS and higher accuracy than RACE and CPSS (area under the receiver operating characteristic curve: FAST-ED=0.81 as reference; NIHSS=0.80, P=0.28; RACE=0.77, P=0.02; and CPSS=0.75, P=0.002). A FAST-ED ≥4 had sensitivity of 0.60, specificity of 0.89, positive predictive value of 0.72, and negative predictive value of 0.82 versus RACE ≥5 of 0.55, 0.87, 0.68, and 0.79, and CPSS ≥2 of 0.56, 0.85, 0.65, and 0.78, respectively. Conclusions: FAST-ED is a simple scale that if successfully validated in the field, it may be used by medical emergency professionals to identify LVOS in the prehospital setting enabling rapid triage of patients.
MeSH term(s)	Aged ; Aged, 80 and over ; Arterial Occlusive Diseases/diagnosis ; Arterial Occlusive Diseases/diagnostic imaging ; Brain/diagnostic imaging ; Brain Ischemia/diagnosis ; Brain Ischemia/diagnostic imaging ; Computed Tomography Angiography ; Emergency Medical Services ; Female ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Sensitivity and Specificity ; Severity of Illness Index ; Stroke/diagnosis ; Stroke/diagnostic imaging ; Triage/methods
Language	English
Publishing date	2016-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.116.013301
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Zs.A 448: Show issues

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Article ; Online: Association of Physical Function with Clinical and Subclinical Brain Disease: The Framingham Offspring Study.

Camargo, Erica C / Weinstein, Galit / Beiser, Alexa S / Tan, Zaldy S / DeCarli, Charles / Kelly-Hayes, Margaret / Kase, Carlos / Murabito, Joanne M / Seshadri, Sudha

Journal of Alzheimer's disease : JAD

2016 Volume 53, Issue 4, Page(s) 1597–1608

Abstract: Background: Handgrip strength and gait speed are simple measures of physical capability and have been associated with current and future health outcomes. However, studies on their associations with brain structure and function in middle-aged adults are ... ...

Abstract	Background: Handgrip strength and gait speed are simple measures of physical capability and have been associated with current and future health outcomes. However, studies on their associations with brain structure and function in middle-aged adults are lacking. Objective: To assess the relationship of fast-paced walking speed and handgrip strength with risk of dementia, Alzheimer's disease (AD), and stroke, as well as the cross-sectional associations with cognitive and brain magnetic resonance imaging (MRI) measures in a middle-aged community sample. Methods: Framingham Offspring (n = 2,176; mean age 62, 54% female) had physical function, brain MRI, and cognitive evaluations between 1999 and 2005 and were followed-up for incident dementia AD and stroke until 11 years later. We related walking speed and handgrip strength to incident dementia, AD, and stroke using Cox models, and to brain and cognitive measures using multivariable linear and logistic regression. Models were adjusted for age, sex, education, and vascular risk factors. Results: Slow walking and weak handgrip were associated with more than 2.5-fold increase in risk of AD. Weaker handgrip was associated with an increased risk of incident stroke (HR 1.74, 95% CI: 1.12-2.70/SDU, p = 0.01) in persons ≥65 years. Both measures were associated with lower total brain volume and poorer performance on tests of visual memory, language, executive function, and visuoperceptual function. Slower gait was also related to poorer verbal memory, and weaker handgrip to poorer abstraction. Conclusion: Tests of walking speed and handgrip strength may serve as clinical markers of brain structure and function and may improve dementia risk prediction.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Alzheimer Disease/complications ; Brain Diseases/diagnostic imaging ; Brain Diseases/physiopathology ; Cognition Disorders/diagnosis ; Cognition Disorders/etiology ; Cohort Studies ; Cross-Sectional Studies ; Dementia/complications ; Female ; Hand Strength/physiology ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neuropsychological Tests ; Residence Characteristics ; Risk Factors ; Stroke/complications ; Walking/physiology
Language	English
Publishing date	2016-08-18
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1440127-7
ISSN	1875-8908 ; 1387-2877
ISSN (online)	1875-8908
ISSN	1387-2877
DOI	10.3233/JAD-160229
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Zs.A 6084: Show issues

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Article: Stroke in Latin America.

Camargo, Erica C S / Bacheschi, Luiz A / Massaro, Ayrton R

Neuroimaging clinics of North America

2005 Volume 15, Issue 2, Page(s) 283–96, x

Abstract: Stroke is one of the leading causes of mortality in Latin America, with variable incidence and prevalence throughout the continent reflecting regional socioeconomic differences. In Latin America, uncontrolled hypertension is one of the major causes of ... ...

Abstract	Stroke is one of the leading causes of mortality in Latin America, with variable incidence and prevalence throughout the continent reflecting regional socioeconomic differences. In Latin America, uncontrolled hypertension is one of the major causes of stroke, but other modifiable risk factors also play a role, such as heavy alcohol consumption and smoking. Intracerebral hemorrhage and lacunar stroke are more frequent in Latin America than in North America and Europe. There are multiple causes of stroke that are endemic to Latin America, including neurocysticercosis, Chagas' disease, sickle cell anemia, malaria, hemorrhagic fever, and snake bites.
MeSH term(s)	Cost of Illness ; Humans ; Latin America/epidemiology ; Risk Factors ; Socioeconomic Factors ; Stroke/diagnosis ; Stroke/epidemiology ; Stroke/etiology
Language	English
Publishing date	2005-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1314594-0
ISSN	1052-5149
ISSN	1052-5149
DOI	10.1016/j.nic.2005.07.002
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Article ; Online: Generalized periodic EEG activity in two cases of neurosyphilis

Anghinah Renato / Camargo Érica C.S. / Braga Nádia I. / Waksman Simone / Nitrini Ricardo

Arquivos de Neuro-Psiquiatria, Vol 64, Iss 1, Pp 122-

2006 Volume 124

Abstract: Neurosyphilis is a recognized cause of epileptic seizures and cognitive impairment, but is not usually associated with the finding of generalized periodic activity in the EEG. We report two similar cases characterized by progressive cognitive impairment ... ...

Abstract	Neurosyphilis is a recognized cause of epileptic seizures and cognitive impairment, but is not usually associated with the finding of generalized periodic activity in the EEG. We report two similar cases characterized by progressive cognitive impairment followed by partial complex seizures, in whom the EEG showed generalized periodic activity. Both cerebrospinal fluid and the response to penicillin therapy confirmed the diagnoses of neurosyphilis in the two cases. The finding of EEG generalized periodic activity in patients with cognitive or behavioral disorders is usually associated with Creutzfeldt-Jakob disease, although there are other conditions, some of them potentially reversible, which may also present this EEG abnormality. Neurosyphilis has tended not to be included among them, and our present findings support the importance of first ruling out neurosyphilis in those patients with cognitive or behavioral disorders associated with generalized periodic epileptiform discharges.
Keywords	neurosyphilis ; EEG ; generalized periodic activity ; cognitive impairment ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Neurology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	515
Language	English
Publishing date	2006-01-01T00:00:00Z
Publisher	Academia Brasileira de Neurologia - ABNEURO
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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