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  1. Book ; Online ; E-Book: Hodson and Geddes' Cystic Fibrosis

    Bush, Andrew

    2024  

    Author's details edited by Andrew Bush [and five others]
    Keywords Pediatrics
    Subject code 410.5
    Language English
    Size 1 online resource (747 pages)
    Edition Fifth edition.
    Publisher CRC Press
    Publishing place Boca Raton, FL
    Document type Book ; Online ; E-Book
    Note Includes index.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 9781000988536 ; 9781032202211 ; 1000988538 ; 1032202211
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Kendig and Wilmott's disorders of the respiratory tract in children

    Wilmott, Robert W. / Kendig, Edwin L. / Bush, Andrew

    2024  

    Abstract: Extensively revised from cover to cover, Kendig and Wilmott's Disorders of the Respiratory Tract in Children, 10th Edition, continues to be your #1 choice for reliable, up-to-date information on all aspects of pediatric respiratory disorders. This highly ...

    Title variant Disorders of the respiratory tract in children
    Author's details Andrew Bush [und viele weitere]
    Abstract Extensively revised from cover to cover, Kendig and Wilmott's Disorders of the Respiratory Tract in Children, 10th Edition, continues to be your #1 choice for reliable, up-to-date information on all aspects of pediatric respiratory disorders. This highly respected reference is accessible to specialists and primary care providers alike, with coverage of both common and less common respiratory problems found in the newborn and child. Detailed and thorough, this edition covers basic science and its relevance to today's clinical issues as well as treatment, management, and outcomes information, making it an ideal resource for day-to-day practice as well as certification or recertification review and other professional examinations such as pHERMES. - Offers an international perspective on the whole spectrum of the specialty, including a robust video library with demonstrations of key procedures and bronchoscopic views. - Uses a consistent format with succinct, bulleted text, and contains abundant tables and figures, chapter summaries, and more than 500 full-color images to convey key information in an easy-to-digest manner. - Contains eleven new chapters and discusses timely topics such as big data and -omics in respiratory disease, COVID-19, obesity and its consequences, and vaping and nicotine addiction among children and young people. - Provides up-to-date instruction on key procedures, such as bronchoscopy and pulmonary function testing. - Highlights the knowledge and expertise of nearly 90 new authors who are global experts in the fields of pediatrics, pulmonology, neurology, microbiology, cardiology, physiology, diagnostic imaging, critical care, otolaryngology, allergy, and surgery. - An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
    Keywords Medicine ; Pediatrics ; Pädiatrie, Neonatologie ; Peds ; Speciality Medicine ; Single-item retail product ; Pneumologie, Atmung, Asthma
    Language English
    Size Illustrationen, Diagramme, xxii, 1202 Seiten
    Edition Tenth edition
    Publisher Elsevier
    Publishing place Philadelphia, PA ; © 2024
    Publishing country United States
    Document type Book
    Accompanying material Zugang zur Online-Ausgabe über Code
    HBZ-ID HT030071454
    ISBN 9780323829151 ; 0323829155
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Going Down, Dooby Doo Down, Down: Identifying Rapid Spirometry Decline.

    Bush, Andrew

    American journal of respiratory and critical care medicine

    2023  Volume 208, Issue 10, Page(s) 1014–1015

    MeSH term(s) Humans ; Adult ; Spirometry ; Airway Obstruction ; Respiratory Physiological Phenomena ; Lung
    Language English
    Publishing date 2023-08-06
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202307-1212ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Differing effects of mepolizumab across the life course.

    Bush, Andrew

    The Lancet. Respiratory medicine

    2023  Volume 11, Issue 2, Page(s) 123–125

    MeSH term(s) Humans ; Life Change Events ; Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antibodies, Monoclonal, Humanized/pharmacology ; Eosinophils
    Chemical Substances mepolizumab (90Z2UF0E52) ; Anti-Asthmatic Agents ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(23)00004-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Basic clinical management of preschool wheeze.

    Bush, Andrew

    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology

    2023  Volume 34, Issue 7, Page(s) e13988

    Abstract: Preschool wheeze is very common and often difficult to treat. Most children do not require any investigations; only a detailed history and physical examination to ensure an alternative diagnosis is not being missed; and the differential diagnosis, and ... ...

    Abstract Preschool wheeze is very common and often difficult to treat. Most children do not require any investigations; only a detailed history and physical examination to ensure an alternative diagnosis is not being missed; and the differential diagnosis, and hence investigation protocols for the child in whom a major illness is suspected, shows geographical variation. The pattern of symptoms may be divided into episodic viral and multiple trigger to guide treatment, but the pattern of symptoms must be re-assessed regularly. However, symptom patterns are a poor guide to underlying pathology. Attention to the proper use of spacers, and adverse environmental exposures such as tobacco smoke exposure, is essential. There are no disease-modifying therapies, so therapy is symptomatic. This paper reviews recent advances in treatment, including new data on the place of leukotriene receptor antagonists, prednisolone for acute attacks of wheeze, and antibiotics, based on new attempts to understand the underlying pathology in a way that is clinically practical.
    MeSH term(s) Child ; Child, Preschool ; Humans ; Prednisolone ; Leukotriene Antagonists/therapeutic use ; Schools ; Respiratory Sounds/diagnosis ; Diagnosis, Differential
    Chemical Substances Prednisolone (9PHQ9Y1OLM) ; Leukotriene Antagonists
    Language English
    Publishing date 2023-07-22
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1057059-7
    ISSN 1399-3038 ; 0905-6157 ; 0906-5784
    ISSN (online) 1399-3038
    ISSN 0905-6157 ; 0906-5784
    DOI 10.1111/pai.13988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Learning from cystic fibrosis: How can we start to personalise treatment of Children's Interstitial Lung Disease (chILD)?

    Bush, Andrew

    Paediatric respiratory reviews

    2023  

    Abstract: Cystic fibrosis (CF) is a monogenic disorder cause by mutations in the CF Transmembrane Regulator (CFTR) gene. The prognosis of cystic fibrosis has been transformed by the discovery of highly effective modulator therapies (HEMT). Treatment has changed ... ...

    Abstract Cystic fibrosis (CF) is a monogenic disorder cause by mutations in the CF Transmembrane Regulator (CFTR) gene. The prognosis of cystic fibrosis has been transformed by the discovery of highly effective modulator therapies (HEMT). Treatment has changed from reactive therapy dealing with complications of the disease to pro-active correction of the underlying molecular functional abnormality. This has come about by discovering the detailed biology of the different CF molecular sub-endotypes; the development of biomarkers to assess response even in mild disease or young children; the performance of definitive large randomised controlled trials in patients with a common mutation and the development of in vitro testing systems to test efficacy in those patients with rare CFTR mutations. As a result, CF is now an umbrella term, rather than a specific diagnostic label; we have moved from clinical phenotypes to molecular subendotypes. Children's Interstitial Lung Diseases (chILDs) comprise more than 200 entities, and are a diverse group of diseases, for an increasing number of which an underlying gene mutation has been discovered. Many of these entities are umbrella terms, such as pulmonary alveolar proteinosis or hypersensitivity pneumonitis, for each of which there are multiple and very different endotypes. Even those chILDs for which a specific gene mutation has been discovered comprise, as with CF, different molecular subendotypes likely mandating different therapies. For most chILDs, current treatment is non-specific (corticosteroids, azithromycin, hydroxychloroquine). The variability of the different entities means that there is little evidence for the efficacy of any treatment. This review considers how some of the lessons of the success story of CF are being applied to chILD, thus opening the opportunities for truly personalised medicine in these conditions. Advances in knowledge in the molecular biology of surfactant protein C and Adenosine triphosphate binding cassette subfamily A member 3 (ABCA3), and the possibilities of discovering novel therapies by in vitro studies will especially be highlighted.
    Language English
    Publishing date 2023-11-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2147664-0
    ISSN 1526-0550 ; 1526-0542
    ISSN (online) 1526-0550
    ISSN 1526-0542
    DOI 10.1016/j.prrv.2023.11.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online ; E-Book: Forensic geropsychology

    Bush, Shane S. / Heck, Andrew L.

    practice essentials

    2018  

    Author's details edited by Shane S. Bush and Andrew L. Heck
    Keywords Forensic psychology ; Older people/Psychology
    Subject code 614.150846
    Language English
    Size 1 Online-Ressource (304 Seiten)
    Publisher American Psychological Association
    Publishing place Washington, DC
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019688509
    ISBN 978-1-4338-2893-5 ; 9781433828928 ; 1-4338-2893-6 ; 1433828928
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: Too Little, Too Late: Adult Lung Disease Cannot Be Prevented by Interventions in Adult Life.

    Bush, Andrew

    American journal of respiratory and critical care medicine

    2022  Volume 207, Issue 2, Page(s) 124–126

    MeSH term(s) Humans ; Child ; Adult ; Adolescent ; Tobacco Smoke Pollution ; Incidence ; Lung Neoplasms ; Lung ; Nicotiana
    Chemical Substances Tobacco Smoke Pollution
    Language English
    Publishing date 2022-08-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202208-1537ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Collection: Paediatric respiratory disease

    Bush, Andrew

    (An atlas of investigation and management)

    2011  

    Author's details ed. by Andrew Bush
    Series title An atlas of investigation and management
    Language English
    Dates of publication 2011-9999
    Publisher Clinical Publ
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Collection (display volumes)
    HBZ-ID HT017031819
    Database Catalogue ZB MED Medicine, Health

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  10. Article: How to Choose the Correct Drug in Severe Pediatric Asthma.

    Bush, Andrew

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 902168

    Abstract: When a child with severe asthma (asthma defined clinically for the purposes of this review as wheeze, breathlessness, and chest tightness sometimes with cough) does not respond to treatment, it is important to be sure that an alternative or additional ... ...

    Abstract When a child with severe asthma (asthma defined clinically for the purposes of this review as wheeze, breathlessness, and chest tightness sometimes with cough) does not respond to treatment, it is important to be sure that an alternative or additional diagnosis is not being missed. In school age children, the next step is a detailed protocolized assessment to determine the nature of the problem, whether within the airway or related to co-morbidities or social/environmental factors, in order to personalize the treatment. For example, those with refractory difficult asthma due to persistent non-adherence may benefit from using budesonide and formoterol combined in a single inhaler [single maintenance and reliever treatment (SMART)] as both a reliever and preventer. For those with steroid-resistant Type 2 airway inflammation, the use of biologicals such as omalizumab and mepolizumab should be considered, but for mepolizumab at least, there is a paucity of pediatric data. Protocols are less well developed in preschool asthma, where steroid insensitive disease is much more common, but the use of two simple measurements, aeroallergen sensitization, and peripheral blood eosinophil count, allows the targeted use of inhaled corticosteroids (ICSs). There is also increasing evidence that chronic airway infection may be important in preschool wheeze, increasing the possibility that targeted antibiotics may be beneficial. Asthma in the first year of life is not driven by Type 2 inflammation, so beyond avoiding prescribing ICSs, no evidence based recommendations can be made. In the future, we urgently need to develop objective biomarkers, especially of risk, so that treatment can be targeted effectively; we need to address the scandal of the lack of data in children compared with adults, precluding making evidence-based therapeutic decisions and move from guiding treatment by phenotypes, which will change as the environment changes, to endotype based therapy.
    Language English
    Publishing date 2022-06-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.902168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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