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  1. Article ; Online: How Irritating! Electronic Cigarettes Not "95% Safer" Than Combustible Cigarettes: Recent Mechanistic Insights Into Endothelial Dysfunction.

    Conklin, Daniel J

    Arteriosclerosis, thrombosis, and vascular biology

    2022  Volume 42, Issue 11, Page(s) 1351–1354

    MeSH term(s) Electronic Nicotine Delivery Systems ; Tobacco Products ; Nicotine/adverse effects
    Chemical Substances Nicotine (6M3C89ZY6R)
    Language English
    Publishing date 2022-10-26
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.122.318468
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1705: Show issues Location:
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  2. Article ; Online: Recent advances in the cardiotoxicity of anti-cancer drugs: Navigating the landscape of anthracycline-induced cardiotoxicity.

    Chandy, Mark / Conklin, Daniel J

    Toxicology and applied pharmacology

    2023  Volume 482, Page(s) 116791

    MeSH term(s) Humans ; Cardiotoxicity ; Anthracyclines/adverse effects ; Antineoplastic Agents/adverse effects ; Antibiotics, Antineoplastic
    Chemical Substances Anthracyclines ; Antineoplastic Agents ; Antibiotics, Antineoplastic
    Language English
    Publishing date 2023-12-14
    Publishing country United States
    Document type Editorial
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2023.116791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A novel evaluation of endothelial dysfunction ex vivo: "Teaching an Old Drug a New Trick".

    Jin, Lexiao / Conklin, Daniel J

    Physiological reports

    2021  Volume 9, Issue 21, Page(s) e15120

    Abstract: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Many CVDs begin with endothelium dysfunction (ED), including hypertension, thrombosis, and atherosclerosis. Our assay evaluated ED in isolated murine aorta by ... ...

    Abstract Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Many CVDs begin with endothelium dysfunction (ED), including hypertension, thrombosis, and atherosclerosis. Our assay evaluated ED in isolated murine aorta by quantifying phenylephrine-induced contractions (PE) in the presence of L-NAME, which blocked acetylcholine-induced relaxation (ACh %; >99%). The "L-NAME PE Contraction Ratio" (PECR) was defined as: "PE Tension post-L-NAME" divided by "PE Tension pre-L-NAME." We hypothesized that our novel PE Contraction Ratio would strongly correlate with alterations in endothelium function. Validation 1: PECR and ACh % values of naïve aortas were strongly and positively correlated (PECR vs. ACh %, r
    MeSH term(s) Acetaldehyde/toxicity ; Acetylcholine/pharmacology ; Animals ; Aorta/drug effects ; Aorta/metabolism ; Aorta/physiology ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/physiopathology ; Enzyme Inhibitors/pharmacology ; Female ; Formaldehyde/toxicity ; Male ; Mice ; Mice, Inbred C57BL ; NG-Nitroarginine Methyl Ester/pharmacology ; Vasoconstriction
    Chemical Substances Enzyme Inhibitors ; Formaldehyde (1HG84L3525) ; Acetaldehyde (GO1N1ZPR3B) ; Acetylcholine (N9YNS0M02X) ; NG-Nitroarginine Methyl Ester (V55S2QJN2X)
    Language English
    Publishing date 2021-11-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2724325-4
    ISSN 2051-817X ; 2051-817X
    ISSN (online) 2051-817X
    ISSN 2051-817X
    DOI 10.14814/phy2.15120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Exposure to Fine Particulate Matter Air Pollution Disrupts Erythrocyte Turnover.

    Asplund, Haley / Dreyer, Hector H / Singhal, Richa / Rouchka, Eric C / O'Toole, Timothy E / Haberzettl, Petra / Conklin, Daniel J / Sansbury, Brian E

    Circulation research

    2024  Volume 134, Issue 9, Page(s) 1224–1227

    MeSH term(s) Particulate Matter/adverse effects ; Erythrocytes/metabolism ; Erythrocytes/drug effects ; Humans ; Air Pollution/adverse effects ; Male ; Air Pollutants/adverse effects ; Air Pollutants/toxicity ; Female
    Chemical Substances Particulate Matter ; Air Pollutants
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Research Support, Non-U.S. Gov't ; Letter ; Research Support, N.I.H., Extramural
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.124.324411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.70: Show issues Location:
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  5. Article ; Online: Fine particulate matter (PM

    Ribble, Amanda / Hellmann, Jason / Conklin, Daniel J / Bhatnagar, Aruni / Haberzettl, Petra

    The Science of the total environment

    2023  Volume 877, Page(s) 162934

    Abstract: Results of human and animal studies independently suggest that either ambient fine particulate matter ( ... ...

    Abstract Results of human and animal studies independently suggest that either ambient fine particulate matter (PM
    MeSH term(s) Humans ; Male ; Female ; Mice ; Animals ; Particulate Matter/toxicity ; Particulate Matter/metabolism ; Insulin Resistance ; Glucose Intolerance/chemically induced ; Lung ; Oxidative Stress ; Glucose/metabolism ; Air Pollutants/toxicity ; Air Pollutants/metabolism
    Chemical Substances Particulate Matter ; Glucose (IY9XDZ35W2) ; Air Pollutants
    Language English
    Publishing date 2023-03-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.162934
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 949: Show issues Location:
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  6. Article ; Online: Environmental Determinants of Hypertension and Diabetes Mellitus: Sounding Off About the Effects of Noise.

    Basner, Mathias / Riggs, Daniel W / Conklin, Daniel J

    Journal of the American Heart Association

    2020  Volume 9, Issue 6, Page(s) e016048

    MeSH term(s) Canada ; Cohort Studies ; Diabetes Mellitus/epidemiology ; Humans ; Hypertension/epidemiology ; Hypertension/etiology ; Incidence ; Noise, Transportation
    Language English
    Publishing date 2020-03-09
    Publishing country England
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.120.016048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Acute cardiopulmonary toxicity of inhaled aldehydes: role of TRPA1.

    Conklin, Daniel J

    Annals of the New York Academy of Sciences

    2016  Volume 1374, Issue 1, Page(s) 59–67

    Abstract: Inhalation of high-level volatile aldehydes, as present in smoke from wildfires and in tobacco smoke, is associated with both acute and chronic cardiopulmonary morbidity and mortality, but the underlying mechanisms are unclear. The transient receptor ... ...

    Abstract Inhalation of high-level volatile aldehydes, as present in smoke from wildfires and in tobacco smoke, is associated with both acute and chronic cardiopulmonary morbidity and mortality, but the underlying mechanisms are unclear. The transient receptor potential ankyrin 1 (TRPA1) protein forms a cation channel (irritant receptor) that mediates tobacco smoke-induced airway and lung injury, yet the role of TRPA1 in the cardiovascular toxicity of aldehyde exposure is unclear. Physiologically, airway-located TRPA1 activation triggers an irritant response (e.g., coughing and "respiratory braking") that alters the rate and depth of breathing to reduce exposure. Acrolein (2-propenal), a volatile, unsaturated aldehyde, activates TRPA1. Acrolein was used as a chemical weapon in World War I and is present at high levels in wildfires and tobacco smoke. Acrolein is thought to contribute to pulmonary and cardiovascular injury caused by tobacco smoke exposure, although the role of TRPA1 in cardiovascular toxicity is unclear. This minireview addresses this gap in our knowledge by exploring literature and recent data indicating a connection between TRPA1 and cardiovascular as well as pulmonary injury due to inhaled aldehydes.
    MeSH term(s) Aldehydes/toxicity ; Animals ; Heart/drug effects ; Heart/physiopathology ; Humans ; Inhalation Exposure/analysis ; Lung/drug effects ; Lung/physiopathology ; Transient Receptor Potential Channels/antagonists & inhibitors ; Transient Receptor Potential Channels/metabolism
    Chemical Substances Aldehydes ; Transient Receptor Potential Channels
    Language English
    Publishing date 2016-05-06
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/nyas.13055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Se 110: Show issues Location:
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  8. Article: Aldose Reductase (AR) Mediates and Perivascular Adipose Tissue (PVAT) Modulates Endothelial Dysfunction of Short-Term High-Fat Diet Feeding in Mice.

    Conklin, Daniel J / Haberzettl, Petra / MacKinlay, Kenneth G / Murphy, Daniel / Jin, Lexiao / Yuan, Fangping / Srivastava, Sanjay / Bhatnagar, Aruni

    Metabolites

    2023  Volume 13, Issue 12

    Abstract: Increased adiposity of both visceral and perivascular adipose tissue (PVAT) depots is associated with an increased risk of diabetes and cardiovascular disease (CVD). Under healthy conditions, PVAT modulates vascular tone via the release of PVAT-derived ... ...

    Abstract Increased adiposity of both visceral and perivascular adipose tissue (PVAT) depots is associated with an increased risk of diabetes and cardiovascular disease (CVD). Under healthy conditions, PVAT modulates vascular tone via the release of PVAT-derived relaxing factors, including adiponectin and leptin. However, when PVAT expands with high-fat diet (HFD) feeding, it appears to contribute to the development of endothelial dysfunction (ED). Yet, the mechanisms by which PVAT alters vascular health are unclear. Aldose reductase (AR) catalyzes glucose reduction in the first step of the polyol pathway and has been long implicated in diabetic complications including neuropathy, retinopathy, nephropathy, and vascular diseases. To better understand the roles of both PVAT and AR in HFD-induced ED, we studied structural and functional changes in aortic PVAT induced by short-term HFD (60% kcal fat) feeding in wild type (WT) and aldose reductase-null (AR-null) mice. Although 4 weeks of HFD feeding significantly increased body fat and PVAT mass in both WT and AR-null mice, HFD feeding induced ED in the aortas of WT mice but not of AR-null mice. Moreover, HFD feeding augmented endothelial-dependent relaxation in aortas with intact PVAT only in WT and not in AR-null mice. These data indicate that AR mediates ED associated with short-term HFD feeding and that ED appears to provoke 'compensatory changes' in PVAT induced by HFD. As these data support that the ED of HFD feeding is AR-dependent, vascular-localized AR remains a potential target of temporally selective intervention.
    Language English
    Publishing date 2023-11-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo13121172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Emerging technology and platforms for cardiotoxicity testing.

    Mohamed, Tamer M A / Conklin, Daniel J

    Toxicology and applied pharmacology

    2020  Volume 408, Page(s) 115262

    MeSH term(s) Animals ; Antineoplastic Agents/toxicity ; Cardiotoxicity ; Environmental Pollutants/toxicity ; Humans ; Technology ; Toxicity Tests
    Chemical Substances Antineoplastic Agents ; Environmental Pollutants
    Language English
    Publishing date 2020-10-02
    Publishing country United States
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2020.115262
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  10. Article ; Online: Recent developments in vascular biology.

    Conklin, Daniel J

    Circulation research

    2014  Volume 115, Issue 12, Page(s) e79–82

    MeSH term(s) Animals ; Biomedical Research/trends ; Blood Vessels/metabolism ; Blood Vessels/pathology ; Blood Vessels/physiopathology ; Genetic Predisposition to Disease ; Humans ; Vascular Diseases/genetics ; Vascular Diseases/metabolism ; Vascular Diseases/pathology ; Vascular Diseases/physiopathology ; Vascular Diseases/therapy ; Vascular Remodeling ; Vasodilation
    Language English
    Publishing date 2014-12-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.114.305639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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