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  1. Article ; Online: m

    Karandashov, Ivan / Kachanov, Artyom / Dukich, Maria / Ponomareva, Natalia / Brezgin, Sergey / Lukashev, Alexander / Pokrovsky, Vadim S / Chulanov, Vladimir / Kostyusheva, Anastasiya / Kostyushev, Dmitry

    Viruses

    2024  Volume 16, Issue 4

    Abstract: The epitranscriptomic modification m ...

    Abstract The epitranscriptomic modification m
    MeSH term(s) Immunity, Innate ; Humans ; Virus Diseases/immunology ; Virus Diseases/virology ; Methylation ; Virus Replication ; Viruses/immunology ; Viruses/genetics ; Animals ; RNA, Viral/genetics ; RNA, Viral/immunology ; Signal Transduction ; Host-Pathogen Interactions/immunology
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2024-04-13
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v16040601
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: M

    Mantei, Andrej / Meyer, Tim / Schürmann, Mariana / Beßler, Christiane / Bias, Harald / Krieger, David / Bauer, Torsten / Bacher, Petra / Helmuth, Johannes / Volk, Hans-Dieter / Schürmann, Dirk / Scheffold, Alexander / Meisel, Christian

    The European respiratory journal

    2022  Volume 60, Issue 1

    Abstract: Background: Rapid and reliable diagnostic work-up of tuberculosis (TB) remains a major healthcare goal. In particular, discrimination of TB infection from TB disease with currently available diagnostic tools is challenging and time consuming. This study ...

    Abstract Background: Rapid and reliable diagnostic work-up of tuberculosis (TB) remains a major healthcare goal. In particular, discrimination of TB infection from TB disease with currently available diagnostic tools is challenging and time consuming. This study aimed at establishing a standardised blood-based assay that rapidly and reliably discriminates TB infection from TB disease based on multiparameter analysis of TB antigen-reactive CD4
    Methods: 157 HIV-negative subjects with suspected TB infection or TB disease were recruited from local tertiary care hospitals in Berlin (Germany). Peripheral blood mononuclear cells were analysed for CD4
    Results: Using the scoring system, our assay (TB-Flow Assay) allowed reliable discrimination of TB infection from both pulmonary and extrapulmonary TB disease with high sensitivity (90.9%) and specificity (93.3%) as was confirmed by Monte-Carlo cross-validation.
    Conclusion: With low time requirement, ease of sample collection, and high sensitivity and specificity both for pulmonary and extrapulmonary TB disease, we believe this novel standardised TB-Flow Assay will improve the work-up of patients with suspected TB disease, supporting rapid TB diagnosis and facilitating treatment decisions.
    MeSH term(s) Antigens, Bacterial ; CD4-Positive T-Lymphocytes ; Humans ; Latent Tuberculosis ; Leukocytes, Mononuclear ; Mycobacterium tuberculosis ; Tuberculosis/diagnosis
    Chemical Substances Antigens, Bacterial
    Language English
    Publishing date 2022-07-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01780-2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2322: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 292: Show issues

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  3. Book ; Thesis: Etablierung des M-ANNHEIM-AiP-Aktivitätsscores zur Erfasssung der Krankheitsaktivität bei autoimmuner Pankreatitis

    Münch, Markus / Schneider, Alexander

    2019  

    Institution Universität Heidelberg
    Author's details vorgelegt von Markus Münch ; Referent: Priv.-Doz. Dr. med. Alexander Schneider
    Language German
    Size 70 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität zu Heidelberg, 2020
    HBZ-ID HT020688835
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 E 132 order for loan Magazin

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  4. Article ; Online: Ca(II) and Yb(II) complexes featuring M(C≡C)

    Lyubov, Dmitry M / Zakaria, Hamza / Nelyubina, Yulia V / Aysin, Rinat R / Bukalov, Sergey S / Trifonov, Alexander A

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2024  Volume 30, Issue 12, Page(s) e202303533

    Abstract: Bis(carbazolide) complexes M[3,6-tBu ...

    Abstract Bis(carbazolide) complexes M[3,6-tBu
    Language English
    Publishing date 2024-01-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202303533
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  5. Article ; Online: Au → M bonds promote catalytic alkyne hydrofunctionalisation.

    Eltester, M Alexander / Gildenast, Hans / Rabatinová, Kristína / Pütz, Christopher / Cremer, Christopher / Lanzerath, Patrick / Schroers, Julian P / Tauchert, Michael E

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 36, Page(s) 5459–5462

    Abstract: ... PMP-type ligands (M = Cu ...

    Abstract The impact of metalloligands on Au catalysed alkyne hydrofunctionalisation is studied. Ambiphilic PMP-type ligands (M = Cu
    Language English
    Publishing date 2023-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc01008b
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  6. Article ; Online: Systematic expression analysis of m

    Gundert, Larissa / Strick, Alexander / von Hagen, Felix / Schmidt, Doris / Klümper, Niklas / Tolkach, Yuri / Toma, Marieta / Kristiansen, Glen / Ritter, Manuel / Ellinger, Jörg

    BJUI compass

    2021  Volume 2, Issue 6, Page(s) 402–411

    Abstract: Objectives: To investigate the regulation of the N-6-methyladenosine (m: Patients and methods ... expression of the m: Results: The expression of all m: Conclusion: In conclusion, m ...

    Abstract Objectives: To investigate the regulation of the N-6-methyladenosine (m
    Patients and methods: Tissue samples were collected within the framework of the Biobank at the Center for Integrated Oncology Bonn. The expression of the methyltransferases was systematically determined in clear cell renal carcinoma (ccRCC) on the RNA (real-time PCR) and protein level (immunohistochemistry). Additionally, protein expression of the m
    Results: The expression of all m
    Conclusion: In conclusion, m
    Language English
    Publishing date 2021-05-03
    Publishing country United States
    Document type Journal Article
    ISSN 2688-4526
    ISSN (online) 2688-4526
    DOI 10.1002/bco2.89
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Heterogeneity in the M. tuberculosis β-Lactamase Inhibition by Sulbactam.

    Schmidt, Marius / Malla, Tek Narsingh / Zielinski, Kara / Aldama, Luis / Bajt, Sasa / Feliz, Denisse / Hayes, Brandon / Hunter, Mark / Kupitz, Christopher / Lisova, Stella / Knoska, Juraj / Martin-Garcia, Jose / Mariani, Valerio / Pandey, Suraj / Poudyal, Ishwor / Sierra, Raymond / Tolstikova, Alexandra / Yefanov, Oleksandr / Yoon, Ching Hong /
    Ourmazd, Abbas / Fromme, Petra / Schwander, Peter / Barty, Anton / Chapman, Henry / Stojković, Emina / Batyuk, Alexander / Boutet, Sébastien / Phillips, George / Pollack, Lois

    Research square

    2023  

    Abstract: For decades, researchers have been determined to elucidate essential enzymatic functions on the atomic lengths scale by tracing atomic positions in real time. Our work builds on new possibilities unleashed by mix-and-inject serial crystallography (MISC) ...

    Abstract For decades, researchers have been determined to elucidate essential enzymatic functions on the atomic lengths scale by tracing atomic positions in real time. Our work builds on new possibilities unleashed by mix-and-inject serial crystallography (MISC)
    Language English
    Publishing date 2023-01-10
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-2334665/v1
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  8. Article ; Online: Heterogeneity in M. tuberculosis β-lactamase inhibition by Sulbactam.

    Malla, Tek Narsingh / Zielinski, Kara / Aldama, Luis / Bajt, Sasa / Feliz, Denisse / Hayes, Brendon / Hunter, Mark / Kupitz, Christopher / Lisova, Stella / Knoska, Juraj / Martin-Garcia, Jose Manuel / Mariani, Valerio / Pandey, Suraj / Poudyal, Ishwor / Sierra, Raymond G / Tolstikova, Alexandra / Yefanov, Oleksandr / Yoon, Chung Hong / Ourmazd, Abbas /
    Fromme, Petra / Schwander, Peter / Barty, Anton / Chapman, Henry N / Stojkovic, Emina A / Batyuk, Alexander / Boutet, Sébastien / Phillips, George N / Pollack, Lois / Schmidt, Marius

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 5507

    Abstract: For decades, researchers have elucidated essential enzymatic functions on the atomic length scale by tracing atomic positions in real-time. Our work builds on possibilities unleashed by mix-and-inject serial crystallography (MISC) at X-ray free electron ... ...

    Abstract For decades, researchers have elucidated essential enzymatic functions on the atomic length scale by tracing atomic positions in real-time. Our work builds on possibilities unleashed by mix-and-inject serial crystallography (MISC) at X-ray free electron laser facilities. In this approach, enzymatic reactions are triggered by mixing substrate or ligand solutions with enzyme microcrystals. Here, we report in atomic detail (between 2.2 and 2.7 Å resolution) by room-temperature, time-resolved crystallography with millisecond time-resolution (with timepoints between 3 ms and 700 ms) how the Mycobacterium tuberculosis enzyme BlaC is inhibited by sulbactam (SUB). Our results reveal ligand binding heterogeneity, ligand gating, cooperativity, induced fit, and conformational selection all from the same set of MISC data, detailing how SUB approaches the catalytic clefts and binds to the enzyme noncovalently before reacting to a trans-enamine. This was made possible in part by the application of singular value decomposition to the MISC data using a program that remains functional even if unit cell parameters change up to 3 Å during the reaction.
    MeSH term(s) Humans ; Ligands ; Mycobacterium tuberculosis ; Sulbactam/pharmacology ; beta-Lactamases ; Tuberculosis
    Chemical Substances Ligands ; Sulbactam (S4TF6I2330) ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2023-09-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-41246-1
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  9. Article ; Online: Mettl14-mediated m

    Li, Liang / Sun, Yue / Davis, Alexander E / Shah, Sahil H / Hamed, Lobna K / Wu, Man-Ru / Lin, Cheng-Hui / Ding, Jun B / Wang, Sui

    Cell reports

    2023  Volume 42, Issue 6, Page(s) 112596

    Abstract: Neural progenitor cells lengthen their cell cycle to prime themselves for differentiation as development proceeds. It is currently not clear how they counter this lengthening and avoid being halted in the cell cycle. We show that ... ...

    Abstract Neural progenitor cells lengthen their cell cycle to prime themselves for differentiation as development proceeds. It is currently not clear how they counter this lengthening and avoid being halted in the cell cycle. We show that N
    MeSH term(s) Retina/metabolism ; Cell Differentiation ; Neural Stem Cells ; Cell Division ; Organogenesis
    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2023.112596
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  10. Article ; Online: Deciphering the "m

    Garcia-Campos, Miguel Angel / Edelheit, Sarit / Toth, Ursula / Safra, Modi / Shachar, Ran / Viukov, Sergey / Winkler, Roni / Nir, Ronit / Lasman, Lior / Brandis, Alexander / Hanna, Jacob H / Rossmanith, Walter / Schwartz, Schraga

    Cell

    2019  Volume 178, Issue 3, Page(s) 731–747.e16

    Abstract: N6-methyladenosine (m ...

    Abstract N6-methyladenosine (m
    MeSH term(s) Adenosine/analogs & derivatives ; Adenosine/analysis ; Adenosine/immunology ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO/metabolism ; Animals ; Antibodies/immunology ; Chromatography, High Pressure Liquid ; Embryoid Bodies/metabolism ; Embryonic Stem Cells ; Endoribonucleases/metabolism ; Humans ; Meiosis ; Methylation ; Mice ; Nucleotide Motifs ; RNA, Messenger/chemistry ; RNA, Messenger/metabolism ; Saccharomyces cerevisiae/genetics ; Sequence Analysis, RNA/methods ; Tandem Mass Spectrometry
    Chemical Substances Antibodies ; RNA, Messenger ; N-methyladenosine (CLE6G00625) ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO (EC 1.14.11.33) ; FTO protein, human (EC 1.14.11.33) ; Endoribonucleases (EC 3.1.-) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2019-06-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2019.06.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1167: Show issues Location:
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    Zs.MG 58: Show issues

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