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  1. Article ; Online: Air pollution, weather and positive airway pressure treatment adherence in adults with sleep apnea: a retrospective community-based repeated-measures longitudinal study.

    Kendzerska, Tetyana / Szyszkowicz, Mieczysław / Saymeh, Mouaz / Mallick, Ranjeeta / Carlsten, Christopher / Ayas, Najib T / Laratta, Cheryl R / Orach, Juma / Dales, Robert

    Journal of sleep research

    2024  , Page(s) e14183

    Abstract: We assessed the relation between air pollution, weather, and adherence to positive airway pressure (PAP) therapy in a retrospective community-based repeated-measures study of adults with obstructive sleep apnea who purchased PAP devices from a registered ...

    Abstract We assessed the relation between air pollution, weather, and adherence to positive airway pressure (PAP) therapy in a retrospective community-based repeated-measures study of adults with obstructive sleep apnea who purchased PAP devices from a registered provider between 2013 and 2017 (Ottawa, Ontario, Canada) and had at least one day of data. Daily PAP-derived data, air pollution, and weather databases were linked using postal code. The exposures were mean nocturnal (8:00 p.m. to 8:00 a.m.) (i) residential concentrations of nitrogen dioxide (NO
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1122722-9
    ISSN 1365-2869 ; 0962-1105
    ISSN (online) 1365-2869
    ISSN 0962-1105
    DOI 10.1111/jsr.14183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Acceptance of and adherence with long-term positive airway pressure treatment in adults with chronic obstructive pulmonary disease: A systematic review protocol.

    Laratta, Cheryl R / Moore, Linn E / Jen, Rachel / Campbell, Sandra M / MacLean, Joanna E / Pendharkar, Sachin R / Rowe, Brian H

    PloS one

    2023  Volume 18, Issue 7, Page(s) e0287887

    Abstract: Background: Long-term noninvasive positive airway pressure (PAP) treatment is effective treatment for sleep-related breathing disorders and chronic hypercarbic respiratory failure secondary to chronic obstructive pulmonary disease (COPD). PAP treatment ... ...

    Abstract Background: Long-term noninvasive positive airway pressure (PAP) treatment is effective treatment for sleep-related breathing disorders and chronic hypercarbic respiratory failure secondary to chronic obstructive pulmonary disease (COPD). PAP treatment may be delivered as continuous positive airway pressure or noninvasive ventilation. Success in initiating PAP treatment and barriers to its use in adult patients with COPD are largely unknown. This systematic review aims to identify the acceptance of and adherence to PAP treatment prescribed for long-term use in adult patients with COPD and to summarize variables associated with these measures.
    Methods: Seven online electronic databases will be searched by an experienced medical librarian to identify records containing the concepts "obstructive airways disease" and "noninvasive positive airway pressure" and "acceptance" or "adherence". Randomized and non-randomized studies of interventions will be included. Citation lists from relevant articles will be reviewed, and experts will be contacted regarding unpublished studies. Abstracts from key conferences between 2018-2023 and Google Scholar search results will be reviewed for inclusion. Titles, abstracts and full texts will be reviewed independently for inclusion by two reviewers. Data extraction will be completed by one author using a pre-established form and primary outcomes confirmed by a second author. Methodological quality will be evaluated. If sufficient data are available for meta-analysis, a pooled summary statistic for the primary outcome will be calculated using a random-effects generic inverse-variance meta-analysis, weighted proportion or weighted medians-based approach. Subgroup analysis will explore clinically meaningful sources of heterogeneity. Variables that are associated with acceptance and adherence will be described.
    Discussion: Long-term PAP treatment is a complex intervention prescribed to patients with COPD for several indications. Synthesis of the evidence on success with PAP treatment and variables associated with acceptance or adherence will inform program and policy development for supporting patients with COPD who are prescribed this therapy.
    Trial registration: Systematic review registration: This protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) on July 13, 2021 (registration number CRD42021259262), with revisions submitted on April 17, 2023.
    MeSH term(s) Humans ; Adult ; Systematic Reviews as Topic ; Pulmonary Disease, Chronic Obstructive/therapy ; Noninvasive Ventilation ; Hypercapnia ; Respiration ; Meta-Analysis as Topic
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0287887
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  3. Article ; Online: Temporal and Regional Trends in Obstructive Sleep Apnea Using Administrative Health Data in Alberta, Canada.

    Pendharkar, Sachin R / Sharpe, Heather / Rosychuk, Rhonda J / Laratta, Cheryl R / Fong, Andrew / Duan, Qiuli M / Ronksley, Paul E / MacLean, Joanna E

    Annals of the American Thoracic Society

    2022  Volume 20, Issue 3, Page(s) 433–439

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Female ; Male ; Child ; Humans ; Aged ; Child, Preschool ; Alberta/epidemiology ; Sleep Apnea, Obstructive/diagnosis ; Databases, Factual ; Prevalence
    Language English
    Publishing date 2022-12-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202209-789OC
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Addressing challenges with current therapies for obstructive sleep apnea.

    Laratta, Cheryl R / Ayas, Najib T / Povitz, Marcus / Pendharkar, Sachin R

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2018  Volume 190, Issue 18, Page(s) E573

    MeSH term(s) Adult ; Humans ; Risk Factors ; Sleep Apnea, Obstructive
    Language English
    Publishing date 2018-04-30
    Publishing country Canada
    Document type Letter ; Comment
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.69278
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  5. Article ; Online: Treatment outcomes among rural and urban patients with obstructive sleep apnea: a prospective cohort study.

    Corrigan, Jennifer / Tsai, Willis H / Ip-Buting, Ada / Ng, Christopher / Ogah, Imhokhai / Peller, Peter / Sharpe, Heather / Laratta, Cheryl / Pendharkar, Sachin R

    Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

    2021  Volume 18, Issue 4, Page(s) 1013–1020

    Abstract: Study objectives: To determine whether adherence to continuous positive airway pressure (CPAP) in adults with uncomplicated obstructive sleep apnea differs by rural vs urban residential address.: Methods: In this prospective cohort study, we ... ...

    Abstract Study objectives: To determine whether adherence to continuous positive airway pressure (CPAP) in adults with uncomplicated obstructive sleep apnea differs by rural vs urban residential address.
    Methods: In this prospective cohort study, we recruited adults who initiated CPAP for uncomplicated obstructive sleep apnea that was diagnosed by a physician using sleep specialist-interpreted diagnostic testing. Participants were classified as urban (community size > 100,000) or rural (community size < 100,000) by translating residential postal code into geographic census area. The primary outcome was mean daily hours of CPAP use compared between rural and urban patients. Secondary outcomes included the proportion of patients who were adherent to CPAP, change in Epworth Sleepiness Scale score, change in EuroQOL-5D visual analog score, and Visit-Specific Satisfaction Instrument score. All outcomes were measured 3 months after CPAP initiation.
    Results: We enrolled 242 patients (100 rural) with a mean (standard deviation) age of 51 (13) years and a respiratory event index of 24 (18) events/h. The mean (95% confidence interval) CPAP use was 3.19 (2.8-3.58) hours/night and 35% were CPAP-adherent, with no difference between urban and rural patients. Among the 65% of patients who were using CPAP at 3 months, the mean CPAP use was 4.89 (4.51-5.28) hours/night and was not different between rural and urban patients. Improvement in the Epworth Sleepiness Scale score and patient satisfaction was similar between groups, but the EuroQOL-5D score improved to a greater extent in rural patients. Urban or rural residence was not associated with CPAP adherence according to multivariable regression analysis.
    Conclusions: Rural vs urban residence was not associated with differences in CPAP adherence among patients with uncomplicated OSA diagnosed by a physician using specialist-interpreted sleep diagnostic testing.
    Citation: Corrigan J, Tsai WH, Ip-Buting A, et al. Treatment outcomes among rural and urban patients with obstructive sleep apnea: a prospective cohort study.
    MeSH term(s) Adult ; Continuous Positive Airway Pressure ; Humans ; Middle Aged ; Patient Compliance ; Patient Satisfaction ; Prospective Studies ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/therapy ; Treatment Outcome
    Language English
    Publishing date 2021-11-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2397213-0
    ISSN 1550-9397 ; 1550-9389
    ISSN (online) 1550-9397
    ISSN 1550-9389
    DOI 10.5664/jcsm.9776
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Acceptance of and adherence with long-term positive airway pressure treatment in adults with chronic obstructive pulmonary disease

    Cheryl R Laratta / Linn E Moore / Rachel Jen / Sandra M Campbell / Joanna E MacLean / Sachin R Pendharkar / Brian H Rowe

    PLoS ONE, Vol 18, Iss 7, p e

    A systematic review protocol.

    2023  Volume 0287887

    Abstract: Background Long-term noninvasive positive airway pressure (PAP) treatment is effective treatment for sleep-related breathing disorders and chronic hypercarbic respiratory failure secondary to chronic obstructive pulmonary disease (COPD). PAP treatment ... ...

    Abstract Background Long-term noninvasive positive airway pressure (PAP) treatment is effective treatment for sleep-related breathing disorders and chronic hypercarbic respiratory failure secondary to chronic obstructive pulmonary disease (COPD). PAP treatment may be delivered as continuous positive airway pressure or noninvasive ventilation. Success in initiating PAP treatment and barriers to its use in adult patients with COPD are largely unknown. This systematic review aims to identify the acceptance of and adherence to PAP treatment prescribed for long-term use in adult patients with COPD and to summarize variables associated with these measures. Methods Seven online electronic databases will be searched by an experienced medical librarian to identify records containing the concepts "obstructive airways disease" and "noninvasive positive airway pressure" and "acceptance" or "adherence". Randomized and non-randomized studies of interventions will be included. Citation lists from relevant articles will be reviewed, and experts will be contacted regarding unpublished studies. Abstracts from key conferences between 2018-2023 and Google Scholar search results will be reviewed for inclusion. Titles, abstracts and full texts will be reviewed independently for inclusion by two reviewers. Data extraction will be completed by one author using a pre-established form and primary outcomes confirmed by a second author. Methodological quality will be evaluated. If sufficient data are available for meta-analysis, a pooled summary statistic for the primary outcome will be calculated using a random-effects generic inverse-variance meta-analysis, weighted proportion or weighted medians-based approach. Subgroup analysis will explore clinically meaningful sources of heterogeneity. Variables that are associated with acceptance and adherence will be described. Discussion Long-term PAP treatment is a complex intervention prescribed to patients with COPD for several indications. Synthesis of the evidence on success with PAP treatment and ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Acceptance of and adherence with long-term positive airway pressure treatment in adults with chronic obstructive pulmonary disease

    Cheryl R. Laratta / Linn E. Moore / Rachel Jen / Sandra M. Campbell / Joanna E. MacLean / Sachin R. Pendharkar / Brian H. Rowe

    PLoS ONE, Vol 18, Iss

    A systematic review protocol

    2023  Volume 7

    Abstract: Background Long-term noninvasive positive airway pressure (PAP) treatment is effective treatment for sleep-related breathing disorders and chronic hypercarbic respiratory failure secondary to chronic obstructive pulmonary disease (COPD). PAP treatment ... ...

    Abstract Background Long-term noninvasive positive airway pressure (PAP) treatment is effective treatment for sleep-related breathing disorders and chronic hypercarbic respiratory failure secondary to chronic obstructive pulmonary disease (COPD). PAP treatment may be delivered as continuous positive airway pressure or noninvasive ventilation. Success in initiating PAP treatment and barriers to its use in adult patients with COPD are largely unknown. This systematic review aims to identify the acceptance of and adherence to PAP treatment prescribed for long-term use in adult patients with COPD and to summarize variables associated with these measures. Methods Seven online electronic databases will be searched by an experienced medical librarian to identify records containing the concepts “obstructive airways disease” and “noninvasive positive airway pressure” and “acceptance” or “adherence”. Randomized and non-randomized studies of interventions will be included. Citation lists from relevant articles will be reviewed, and experts will be contacted regarding unpublished studies. Abstracts from key conferences between 2018–2023 and Google Scholar search results will be reviewed for inclusion. Titles, abstracts and full texts will be reviewed independently for inclusion by two reviewers. Data extraction will be completed by one author using a pre-established form and primary outcomes confirmed by a second author. Methodological quality will be evaluated. If sufficient data are available for meta-analysis, a pooled summary statistic for the primary outcome will be calculated using a random-effects generic inverse-variance meta-analysis, weighted proportion or weighted medians-based approach. Subgroup analysis will explore clinically meaningful sources of heterogeneity. Variables that are associated with acceptance and adherence will be described. Discussion Long-term PAP treatment is a complex intervention prescribed to patients with COPD for several indications. Synthesis of the evidence on success with PAP treatment and ...
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Diagnosis and treatment of obstructive sleep apnea in adults.

    Laratta, Cheryl R / Ayas, Najib T / Povitz, Marcus / Pendharkar, Sachin R

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2017  Volume 189, Issue 48, Page(s) E1481–E1488

    MeSH term(s) Adult ; Continuous Positive Airway Pressure ; Humans ; Polysomnography ; Risk Factors ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/etiology ; Sleep Apnea, Obstructive/therapy
    Language English
    Publishing date 2017-12-04
    Publishing country Canada
    Document type Journal Article ; Review
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.170296
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  9. Article ; Online: Air Pollution and the Effectiveness of Positive Airway Pressure Therapy in Individuals With Sleep Apnea: A Retrospective Community-Based Repeated-Measures Longitudinal Study.

    Kendzerska, Tetyana / Szyszkowicz, Mieczysław / Alvarez, Jonathan Villa / Mallick, Ranjeeta / Carlsten, Christopher / Ayas, Najib / Laratta, Cheryl R / Jovic, Branka / Orach, Juma / Smith-Doiron, Marc / Dales, Robert

    Chest

    2022  Volume 162, Issue 5, Page(s) 1176–1187

    Abstract: Background: Ambient air pollution may affect the severity of untreated OSA, but it is unknown whether air pollution adversely impacts the effectiveness of positive airway pressure (PAP) therapy.: Research question: Do short-term changes in outdoor ... ...

    Abstract Background: Ambient air pollution may affect the severity of untreated OSA, but it is unknown whether air pollution adversely impacts the effectiveness of positive airway pressure (PAP) therapy.
    Research question: Do short-term changes in outdoor air pollution adversely impact adults with OSA using PAP therapy?
    Study design and methods: We conducted a retrospective community-based repeated-measures longitudinal study of adults with OSA who purchased a PAP device from a registered equipment provider between 2013 and 2017 (Ontario, Canada) and had data on the daily device-derived residual apnea-hypopnea index (AHI
    Results: Eight thousand one hundred forty-eight adults were analyzed with a median of 89 days (interquartile range [IQR], 29-302 days) of observation during which PAP was used for ≥ 4 h. The median daily AHI
    Interpretation: We demonstrated a modest but statistically significant increase in residual respiratory events during PAP therapy associated with an increase in air pollution concentrations.
    MeSH term(s) Adult ; Humans ; Air Pollutants/analysis ; Longitudinal Studies ; Retrospective Studies ; Environmental Exposure/analysis ; Air Pollution/adverse effects ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; Nitrogen Dioxide/analysis ; Sleep Apnea Syndromes ; Sleep Apnea, Obstructive/therapy ; Ontario
    Chemical Substances Air Pollutants ; Particulate Matter ; Nitrogen Dioxide (S7G510RUBH)
    Language English
    Publishing date 2022-08-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2022.07.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Reliability and validity of the post COVID-19 condition stigma questionnaire: A prospective cohort study.

    Damant, Ronald W / Rourke, Liam / Cui, Ying / Lam, Grace Y / Smith, Maeve P / Fuhr, Desi P / Tay, Jaqueline K / Varughese, Rhea A / Laratta, Cheryl R / Lau, Angela / Wong, Eric Y / Stickland, Michael K / Ferrara, Giovanni

    EClinicalMedicine

    2022  Volume 55, Page(s) 101755

    Abstract: Background: Many of the 10-20% percent of COVID-19 survivors who develop Post COVID-19 Condition (PCC, or Long COVID) describe experiences suggestive of stigmatization, a known social determinant of health. Our objective was to develop an instrument, ... ...

    Abstract Background: Many of the 10-20% percent of COVID-19 survivors who develop Post COVID-19 Condition (PCC, or Long COVID) describe experiences suggestive of stigmatization, a known social determinant of health. Our objective was to develop an instrument, the Post COVID-19 Condition Stigma Questionnaire (PCCSQ), with which to quantify and characterise PCC-related stigma.
    Methods: We conducted a prospective cohort study to assess the reliability and validity of the PCCSQ. Patients referred to our Post COVID-19 Clinic in the Canadian City of Edmonton, Alberta between May 29, 2021 and May 24, 2022 who met inclusion criteria (attending an academic post COVID-19 clinic; age ≥18 years; persistent symptoms and impairment at ≥ 12 weeks since PCR positive acute COVID-19 infection; English-speaking; internet access; consenting) were invited to complete online questionnaires, including the PCCSQ. Analyses were conducted to estimate the instrument's reliability, construct validity, and association with relevant instruments and defined health outcomes.
    Findings: Of the 198 patients invited, 145 (73%) met inclusion criteria and completed usable questionnaires. Total Stigma Score (TSS) on the PCCSQ ranged from 40 to 174/200. The mean (SD) was 103.9 (31.3). Cronbach's alpha was 0.97. Test-retest reliability was 0.92. Factor analysis supported a 6-factor latent construct. Subtest reliabilities were >0.75. Individuals reporting increased TSS occurred across all demographic groups. Increased risk categories included women, white ethnicity, and limited educational opportunities. TSS was positively correlated with symptoms, depression, anxiety, loneliness, reduced self-esteem, thoughts of self-harm, post-COVID functional status, frailty, EQ5D5L score, and number of ED visits. It was negatively correlated with perceived social support, 6-min walk distance, and EQ5D5L global rating. Stigma scores were significantly increased among participants reporting employment status as disabled.
    Interpretation: Our findings suggested that the PCCSQ is a valid, reliable tool with which to estimate PCC-related stigma. It allows for the identification of patients reporting increased stigma and offers insights into their experiences.
    Funding: The Edmonton Post COVID-19 Clinic is supported by the University of Alberta and Alberta Health Services. No additional sources of funding were involved in the execution of this research study.
    Language English
    Publishing date 2022-11-25
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2022.101755
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