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Article ; Online: Climatério e menopausa

Poliana Ferreira Campos / Maria Eduarda Almeida Marçal / Luanna dos Santos Rocha / Valdirene Pereira da Silva Carvalho / Jovânia Marques de Oliveira e Silva

Revista de Enfermagem da Universidade Federal de Santa Maria, Vol

conhecimento e condutas de enfermeiras que atuam na Atenção Primária à Saúde

2022 Volume 12

Abstract: Objetivo: identificar o conhecimento e as condutas de enfermeiras na Atenção Primária à Saúde sobre climatério e menopausa. Método: estudo descritivo exploratório, de abordagem qualitativa, realizado junto a 15 enfermeiras do município de Pesqueira, ... ...

Abstract	Objetivo: identificar o conhecimento e as condutas de enfermeiras na Atenção Primária à Saúde sobre climatério e menopausa. Método: estudo descritivo exploratório, de abordagem qualitativa, realizado junto a 15 enfermeiras do município de Pesqueira, Pernambuco, Brasil. Os dados foram coletados por meio de entrevista semiestruturada e analisados pelo método de Bardin. Resultados: foi identificado conhecimento limitado em relação a definição de climatério, menopausa e de sinais e sintomas característicos, como também referente à terapia de reposição hormonal vaginal. A captação destas mulheres para as consultas de enfermagem se dava por demanda espontânea e ao realizar exame do colpocitopatológico. Conclusão: o conhecimento acerca do climatério é limitado nas práticas das enfermeiras na abordagem às mulheres que estão passando por esta fase. Na busca de minimizar as lacunas relacionadas ao desconhecimento profissional, é relevante a continuidade de estudos sobre a assistência a esse público.
Keywords	Climatério ; Terapia de Reposição Hormonal ; Saúde da Mulher ; Cuidados de Enfermagem ; Atenção Primária à Saúde ; Medicine ; R ; Nursing ; RT1-120
Language	Portuguese
Publishing date	2022-08-01T00:00:00Z
Publisher	Universidade Federal de Santa Maria
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: E-Volve

Vitor Pimentel Dos Santos / André Rodrigues / Gabriel Dutra / Luana Bastos / Diego Mariano / José Gutembergue Mendonça / Yan Jerônimo Gomes Lobo / Eduardo Mendes / Giovana Maia / Karina dos Santos Machado / Adriano Velasque Werhli / Gerd Rocha / Leonardo Henrique França de Lima / Raquel de Melo-Minardi

PeerJ, Vol 10, p e

understanding the impact of mutations in SARS-CoV-2 variants spike protein on antibodies and ACE2 affinity through patterns of chemical interactions at protein interfaces

2022 Volume 13099

Abstract: ... measuring of the impacts caused by variant strains in such complexes, we implemented E-Volve, a tool ... strain, as pointed by E-Volve, as well as an intensification of this effect by changes ... Moreover, E-Volve can depict the main alterations in important biological structures, as shown in the SARS ...

Abstract	Background The SARS-CoV-2 pandemic reverberated, posing health and social hygiene obstacles throughout the globe. Mutant lineages of the virus have concerned scientists because of convergent amino acid alterations, mainly on the viral spike protein. Studies have shown that mutants have diminished activity of neutralizing antibodies and enhanced affinity with its human cell receptor, the ACE2 protein. Methods Hence, for real-time measuring of the impacts caused by variant strains in such complexes, we implemented E-Volve, a tool designed to model a structure with a list of mutations requested by users and return analyses of the variant protein. As a proof of concept, we scrutinized the spike-antibody and spike-ACE2 complexes formed in the variants of concern, B.1.1.7 (Alpha), B.1.351 (Beta), and P.1 (Gamma), by using contact maps depicting the interactions made amid them, along with heat maps to quantify these major interactions. Results The results found in this study depict the highly frequent interface changes made by the entire set of mutations, mainly conducted by N501Y and E484K. In the spike-Antibody complex, we have noticed alterations concerning electrostatic surface complementarity, breaching essential sites in the P17 and BD-368-2 antibodies. Alongside, the spike-ACE2 complex has presented new hydrophobic bonds. Discussion Molecular dynamics simulations followed by Poisson-Boltzmann calculations corroborate the higher complementarity to the receptor and lower to the antibodies for the K417T/E484K/N501Y (Gamma) mutant compared to the wild-type strain, as pointed by E-Volve, as well as an intensification of this effect by changes at the protein conformational equilibrium in solution. A local disorder of the loop α1′/β1′, as well its possible effects on the affinity to the BD-368-2 antibody were also incorporated to the final conclusions after this analysis. Moreover, E-Volve can depict the main alterations in important biological structures, as shown in the SARS-CoV-2 complexes, marking a major step in ...
Keywords	SARS-CoV-2 ; Antibody ; Variant ; Vaccine ; ACE2 ; Chemical interactions ; Medicine ; R
Subject code	612
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	PeerJ Inc.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Opportunistic pneumonia caused by E. cuniculi in mice immunosuppressed with cyclophosphamide.

Figuerêdo Moreira, Iramirton / Marcelino Alvares-Saraiva, Anuska / Cristina Pérez, Elizabeth / Guilherme Xavier, José / Denelle Spadacci-Morena, Diva / Silva de Araújo, Ronalda / Ricardo Dell'Armelina Rocha, Paulo / Anete Lallo, Maria

Immunobiology

2022 Volume 227, Issue 3, Page(s) 152194

Abstract: ... the microsporidia called Encephalitozoon cuniculi. This study aimed to evaluate pneumonia caused by E. cuniculi ... the immune cells associated with the microsporidial pneumonia. C57BL/6 mice were infected intravenously with E ...

Abstract	Opportunistic fungal pneumonia is a cause of concern in immunocompromised patients due to its high morbidity and mortality rates. One such opportunistic agent affecting immunocompromised patients is the microsporidia called Encephalitozoon cuniculi. This study aimed to evaluate pneumonia caused by E. cuniculi in mice treated with the immunosuppressive agent cyclophosphamide (Cy). This study also aimed to describe the immune cells associated with the microsporidial pneumonia. C57BL/6 mice were infected intravenously with E. cuniculi spores and treated with Cy (75 mg/kg/week, intraperitoneally). Thirty days post-infection, the fungal burden (qPCR), histopathological lesions, cytokine production, and the phenotype of the immune cells in the lung parenchyma were evaluated. Histologically, interstitial pneumonia with lymphocytic infiltrate was observed in the infected animals. The infiltrate mainly consisted of CD8
MeSH term(s)	Animals ; Cuniculidae ; Cyclophosphamide/adverse effects ; Encephalitozoonosis ; Humans ; Immunocompromised Host ; Mice ; Mice, Inbred C57BL ; Pneumonia/drug therapy
Chemical Substances	Cyclophosphamide (8N3DW7272P)
Language	English
Publishing date	2022-03-06
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	563292-4
ISSN	1878-3279 ; 0171-2985
ISSN (online)	1878-3279
ISSN	0171-2985
DOI	10.1016/j.imbio.2022.152194
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Article ; Online: Using Digital Tools to Study the Health of Adults Born Preterm at a Large Scale: e-Cohort Pilot Study.

Lorthe, Elsa / Santos, Carolina / Ornelas, José Pedro / Doetsch, Julia Nadine / Marques, Sandra C S / Teixeira, Raquel / Santos, Ana Cristina / Rodrigues, Carina / Gonçalves, Gonçalo / Ferreira Sousa, Pedro / Correia Lopes, João / Rocha, Artur / Barros, Henrique

Journal of medical Internet research

2023 Volume 25, Page(s) e39854

Abstract: ... Objective: This study aimed to assess the feasibility of recruiting and following up an e-cohort of adults ... observational, and international e-cohort pilot study (Health of Adult People Born Preterm-an e-Cohort ... Pilot Study [HAPP-e]). Inclusion criteria were being an adult (aged ≥18 years), born preterm (<37 weeks ...

Abstract	Background: Preterm birth is a global health concern. Its adverse consequences may persist throughout the life course, exerting a potentially heavy burden on families, health systems, and societies. In high-income countries, the first children who benefited from improved care are now adults entering middle age. However, there is a clear gap in the knowledge regarding the long-term outcomes of individuals born preterm. Objective: This study aimed to assess the feasibility of recruiting and following up an e-cohort of adults born preterm worldwide and provide estimations of participation, characteristics of participants, the acceptability of questions, and the quality of data collected. Methods: We implemented a prospective, open, observational, and international e-cohort pilot study (Health of Adult People Born Preterm-an e-Cohort Pilot Study [HAPP-e]). Inclusion criteria were being an adult (aged ≥18 years), born preterm (<37 weeks of gestation), having internet access and an email address, and understanding at least 1 of the available languages. A large, multifaceted, and multilingual communication strategy was established. Between December 2019 and June 2021, inclusion and repeated data collection were performed using a secured web platform. We provided descriptive statistics regarding participation in the e-cohort, namely, the number of persons who registered on the platform, signed the consent form, initiated and completed the baseline questionnaire, and initiated and completed the follow-up questionnaire. We also described the main characteristics of the HAPP-e participants and provided an assessment of the quality of the data and the acceptability of sensitive questions. Results: As of December 31, 2020, a total of 1004 persons had registered on the platform, leading to 527 accounts with a confirmed email and 333 signed consent forms. A total of 333 participants initiated the baseline questionnaire. All participants were invited to follow-up, and 35.7% (119/333) consented to participate, of whom 97.5% (116/119) initiated the follow-up questionnaire. Completion rates were very high both at baseline (296/333, 88.9%) and at follow-up (112/116, 96.6%). This sample of adults born preterm in 34 countries covered a wide range of sociodemographic and health characteristics. The gestational age at birth ranged from 23+6 to 36+6 weeks (median 32, IQR 29-35 weeks). Only 2.1% (7/333) of the participants had previously participated in a cohort of individuals born preterm. Women (252/333, 75.7%) and highly educated participants (235/327, 71.9%) were also overrepresented. Good quality data were collected thanks to validation controls implemented on the web platform. The acceptability of potentially sensitive questions was excellent, as very few participants chose the "I prefer not to say" option when available. Conclusions: Although we identified room for improvement in specific procedures, this pilot study confirmed the great potential for recruiting a large and diverse sample of adults born preterm worldwide, thereby advancing research on adults born preterm.
MeSH term(s)	Pregnancy ; Middle Aged ; Child ; Infant, Newborn ; Adult ; Humans ; Female ; Adolescent ; Infant ; Premature Birth ; Pilot Projects ; Prospective Studies ; Parturition ; Gestational Age
Language	English
Publishing date	2023-05-15
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2028830-X
ISSN	1438-8871 ; 1438-8871
ISSN (online)	1438-8871
ISSN	1438-8871
DOI	10.2196/39854
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Article ; Online: Inter/multiculturalismo e diversidade musical

Paulo Roberto de Oliveira Coutinho / Inês de Almeida Rocha

Caminhos da Educação, Vol 3, Iss

algumas narrativas acadêmicas

2022 Volume 3

Abstract: O artigo apresenta uma análise da produção acadêmica a partir de perspectivas teóricas e conceituais inter/multiculturais publicadas em dois periódicos especializados - a Revista da ABEM e o International Journal of Music Education - na última década. O ... ...

Abstract	O artigo apresenta uma análise da produção acadêmica a partir de perspectivas teóricas e conceituais inter/multiculturais publicadas em dois periódicos especializados - a Revista da ABEM e o International Journal of Music Education - na última década. O principal foco de análise foi à consideração desse quadro teórico/conceitual como mote de diálogo interdisciplinar para discutir questões relacionadas às formas como a diversidade musical se manifesta nos discursos da referida produção. O levantamento das produções compreende o período de 2009 a 2019[1] nos respectivos periódicos. Os resultados desta análise mostram que a diversidade musical/cultural se materializa de diferentes maneiras, resultando em diferentes respostas ao tratamento das diferenças culturais. Nas considerações, o estudo destaca a importância de construção de debates e reflexões sobre uma concepção de diversidade musical para além da perspectiva da pluralidade. Nessa ótica, este estudo aponta a necessidade de se considerar as interações e tensões culturais como fenômenos inerentes às ressignificações de saberes e conhecimentos a partir de diferentes expressões culturais. Palavras-chave: Educação Musical; Diversidade Musical; Inter/multiculturalismo. [1] O período citado decorre do fato deste levantamento bibliográfico ser material constitutivo de um recorte de um dos capítulos de tese de doutorado defendida em 2019.
Keywords	Educação Musical ; Diversidade em música ; Multiculturalismo ; Interculturalidade ; Education ; L ; Social sciences (General) ; H1-99
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Universidade Federal do Piauí
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Educação estatística e transdisciplinaridade

Alessandra de Abreu Corrêa / João Bernardes da Rocha Filho

Alexandria, Vol 14, Iss

aproximações nas práticas docentes nos anos finais do ensino fundamental

2021 Volume 1

Abstract: Aproximações entre a Educação Estatística e os estudos transdisciplinares, existentes nas práticas docentes, nos anos finais do ensino fundamental constituíram os objetos de pesquisa, buscando-se descrevê-los e analisá-los. Assim, a questão de estudo foi: ...

Abstract	Aproximações entre a Educação Estatística e os estudos transdisciplinares, existentes nas práticas docentes, nos anos finais do ensino fundamental constituíram os objetos de pesquisa, buscando-se descrevê-los e analisá-los. Assim, a questão de estudo foi: como os elementos indicadores transdisciplinares e as concepções da Educação Estatística se articulam nas práticas docentes nos anos finais do ensino fundamental? Percebeu-se que assuntos ligados a elementos transdisciplinares nas práticas docentes tendem a ser secundarizados, assim como há omissão dos indicadores provenientes da transdisciplinaridade produzidos nessas condições. A análise dos dados foi baseada nos pressupostos e procedimentos da Análise Textual Discursiva, e caracteriza uma abordagem qualitativa, analítica e compreensiva. A partir, das respostas da entrevista episódica de duas docentes, nota-se que existem vínculos entre as atitudes de transdisciplinaridade e as práticas docentes que perpassam a dimensão profissional e alcançam atitudes transdisciplinares que pode ocorrer por meio dos indicadores nomeados como respeito pelo outro e cooperação.
Keywords	Educação estatística ; Transdisciplinaridade ; Indicadores transdisciplinares ; Ensino fundamental ; Special aspects of education ; LC8-6691 ; Science (General) ; Q1-390
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Universidade Federal de Santa Catarina
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Antiproliferative Activity of Two Unusual Dimeric Flavonoids, Brachydin E and Brachydin F, Isolated from

de Lima, Carolina A / Cubero, Mayra C Z / Franco, Yollanda E M / Rodrigues, Carla D P / do Nascimento, Jessyane R / Vendramini-Costa, Débora B / Sciani, Juliana M / da Rocha, Cláudia Q / Longato, Giovanna B

BioMed research international

2022 Volume 2022, Page(s) 3319203

Abstract: Despite the breakthrough in the development of anticancer therapies, plant-derived chemotherapeutics continue to be the basis of treatment for most types of cancers. ...

Abstract	Despite the breakthrough in the development of anticancer therapies, plant-derived chemotherapeutics continue to be the basis of treatment for most types of cancers.
MeSH term(s)	Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Bignoniaceae/chemistry ; Brazil ; Cell Line, Tumor ; Flavonoids/pharmacology ; Humans ; Molecular Docking Simulation ; Plant Extracts/chemistry ; Plant Roots/chemistry
Chemical Substances	Antineoplastic Agents ; Flavonoids ; Plant Extracts
Language	English
Publishing date	2022-02-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2022/3319203
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Article ; Online: Inter e intra-variability of the best ranked teams

Augusto Cezar Rodrigues Rocha / Lorenzo Laporta / Geovana Pires Rodrigues / Juracy da Silva Guimarães / Marcos Henrique do Nascimento / Marcelo Couto Jorge Rodrigues / Thiago José Leonardi / Claudio Andre Barbosa de Lira / Henrique de Oliveira Castro / Gustavo De Conti Teixeira Costa

PLoS ONE, Vol 18, Iss 2, p e

A network analysis in male high-level volleyball.

2023 Volume 0280365

Abstract: ... volleyball teams in a macro- and micro-level view, through the inter e intra-team variability analysis ...

Abstract	The present research objective was to analyze the offensive phase from Complex I in high-level male volleyball teams in a macro- and micro-level view, through the inter e intra-team variability analysis of eight best teams of the 2018 Men's Volleyball World Championship over the social network analysis and eigenvector centrality. The sample consisted of 22 matches and 2,743 offensive actions, resulting in 8 sub-networks with 368 nodes and 6221 edges. The results showed from macro view the variables that presented highest centrality values were Attack Zone 4 (range 0.56-0.90), Attack Tempo 2 (0.65-0.87), Power Attack (0.62-0.94), No Touch Block (0.61-1), Attack Effect Continuity (0.59-0.94), and Middle Blocker Centralized (0.60-0.95). In a micro view, Reception Effect, Play Position, Reception Zone, and Block Composition showed high variability in each sub-network. The intra- and inter-team variability presented the importance of to respect each team idiosyncrasies and to consider the different approaches to the game and success.
Keywords	Medicine ; R ; Science ; Q
Subject code	796
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Alberto J. Mimenza-Alvarado / Oscar Arrieta / Miguel A. Celis / Judith DomÃnguez-Cherit / Sergio Islas-Andrade / Alberto Lifshitz / Armando Mansilla / Iris MartÃnez / Mucio Moreno / Alejandro A. Reyes-SÃ¡nchez / Luisa L. Rocha-Arrieta / Guillermo J. Ruiz-ArgÃ¼elles / Julio Sotelo / Emma VerÃ¡stegui / Diana Vilar-Compte / Sonia Toussaint

Gaceta Médica de México, Vol 159, Iss

2023 Volume 2

Abstract: En México, como en el resto del mundo, la investigación clínica por instituciones académicas y farmacéuticas ha seguido la tendencia general de la globalización y se ha movido inexorablemente a niveles de países de medianos y bajos ingresos. ...

Abstract	En México, como en el resto del mundo, la investigación clínica por instituciones académicas y farmacéuticas ha seguido la tendencia general de la globalización y se ha movido inexorablemente a niveles de países de medianos y bajos ingresos.
Keywords	Public aspects of medicine ; RA1-1270 ; Internal medicine ; RC31-1245
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Permanyer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Juventude e trauma geracional

Carla Baiense Felix / Victor Nascimento Rocha / Patrícia Fernandes Viana Franco Castro / Larissa de Morais Ribeiro Mendes / Helen Pinto de Britto Fontes

Liinc em Revista, Vol 17, Iss

como os jovens brasileiros respondem à pandemia e à infodemia da Covid-19

2021 Volume 1

Abstract: A partir da compreensão da pandemia de Covid-19 como trauma global, investigamos como jovens das cinco regiões brasileiras lidam com a crise sanitária e suas consequências, a partir de suas interações com o noticiário. Em um ambiente marcado por perdas ... ...

Abstract	A partir da compreensão da pandemia de Covid-19 como trauma global, investigamos como jovens das cinco regiões brasileiras lidam com a crise sanitária e suas consequências, a partir de suas interações com o noticiário. Em um ambiente marcado por perdas materiais e simbólicas, e atravessado pelo excesso de informações e desinformação, buscamos entender de que maneira nossos informantes reagem à exposição midiática ao evento traumático e que sentidos produzem para o que consideramos um trauma geracional (Edmunds, Turner, 2005). Para isto, realizamos uma revisão bibliográfica sobre mídia e trauma, letramento midiático e infodemia, e apresentamos os resultados de uma pesquisa online, conduzida nos dois últimos meses de 2020, com a participação de 855 pessoas, entre 15 e 29 anos
Keywords	Juventude ; Noticiário ; Covid-19 ; Infodemia ; Trauma ; Bibliography. Library science. Information resources ; Z ; Information resources (General) ; ZA3040-5185
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Programa de Pós-Graduação em Ciência da Informação Ibict/UFRJ
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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