Article ; Online: Podophyllotoxin Cytological Effects on the Epidermis in Condyloma Acuminatum.
The American Journal of dermatopathology
2022 Volume 44, Issue 1, Page(s) 70–72
Abstract: Abstract: Podophyllotoxin (PPT) is used to treat condylomata acuminata and works by destabilizing microtubules within epithelial cells, leading to mitotic arrest in metaphase. PPT-induced changes to the epidermis can cause histological findings ... ...
Abstract | Abstract: Podophyllotoxin (PPT) is used to treat condylomata acuminata and works by destabilizing microtubules within epithelial cells, leading to mitotic arrest in metaphase. PPT-induced changes to the epidermis can cause histological findings mimicking dysplasia. Here, we present a case of vulvar condyloma acuminatum treated with PPT, showing ballooning degeneration, necrotic keratinocytes, and mitotic figures. PPT-treated skin may resemble dysplasia or squamous cell carcinoma in situ due to dyskeratosis and frequent mitoses; however, the synchronicity of mitotic figures in early phases of mitosis, as well as the absence of cellular pleomorphism and atypical mitotic figures, allows for distinction from malignancy. This case demonstrates the importance of understanding the histological changes caused by PPT to prevent misdiagnosis and potential overtreatment. |
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MeSH term(s) | Adult ; Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Agents, Phytogenic/adverse effects ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/pathology ; Condylomata Acuminata/diagnosis ; Condylomata Acuminata/drug therapy ; Condylomata Acuminata/pathology ; Diagnostic Errors ; Epidermis/pathology ; Female ; Humans ; Overtreatment ; Podophyllotoxin/administration & dosage ; Podophyllotoxin/adverse effects ; Vulvar Neoplasms/diagnosis ; Vulvar Neoplasms/pathology |
Chemical Substances | Antineoplastic Agents, Phytogenic ; Podophyllotoxin (L36H50F353) |
Language | English |
Publishing date | 2022-03-18 |
Publishing country | United States |
Document type | Case Reports ; Journal Article |
ZDB-ID | 448469-1 |
ISSN | 1533-0311 ; 0193-1091 |
ISSN (online) | 1533-0311 |
ISSN | 0193-1091 |
DOI | 10.1097/DAD.0000000000002050 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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