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  1. Article ; Online: Podophyllotoxin Cytological Effects on the Epidermis in Condyloma Acuminatum.

    Leung, Bonnie / Enos, Tyler / Vandergriff, Travis

    The American Journal of dermatopathology

    2022  Volume 44, Issue 1, Page(s) 70–72

    Abstract: Abstract: Podophyllotoxin (PPT) is used to treat condylomata acuminata and works by destabilizing microtubules within epithelial cells, leading to mitotic arrest in metaphase. PPT-induced changes to the epidermis can cause histological findings ... ...

    Abstract Abstract: Podophyllotoxin (PPT) is used to treat condylomata acuminata and works by destabilizing microtubules within epithelial cells, leading to mitotic arrest in metaphase. PPT-induced changes to the epidermis can cause histological findings mimicking dysplasia. Here, we present a case of vulvar condyloma acuminatum treated with PPT, showing ballooning degeneration, necrotic keratinocytes, and mitotic figures. PPT-treated skin may resemble dysplasia or squamous cell carcinoma in situ due to dyskeratosis and frequent mitoses; however, the synchronicity of mitotic figures in early phases of mitosis, as well as the absence of cellular pleomorphism and atypical mitotic figures, allows for distinction from malignancy. This case demonstrates the importance of understanding the histological changes caused by PPT to prevent misdiagnosis and potential overtreatment.
    MeSH term(s) Adult ; Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Agents, Phytogenic/adverse effects ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/pathology ; Condylomata Acuminata/diagnosis ; Condylomata Acuminata/drug therapy ; Condylomata Acuminata/pathology ; Diagnostic Errors ; Epidermis/pathology ; Female ; Humans ; Overtreatment ; Podophyllotoxin/administration & dosage ; Podophyllotoxin/adverse effects ; Vulvar Neoplasms/diagnosis ; Vulvar Neoplasms/pathology
    Chemical Substances Antineoplastic Agents, Phytogenic ; Podophyllotoxin (L36H50F353)
    Language English
    Publishing date 2022-03-18
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 448469-1
    ISSN 1533-0311 ; 0193-1091
    ISSN (online) 1533-0311
    ISSN 0193-1091
    DOI 10.1097/DAD.0000000000002050
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Intradermal nevus with osteoclast-like giant cell melanocytes.

    Enos, Tyler / Vandergriff, Travis

    Journal of cutaneous pathology

    2019  Volume 46, Issue 11, Page(s) 888–891

    MeSH term(s) Female ; Humans ; Melanocytes/pathology ; Middle Aged ; Nevus, Intradermal/pathology ; Nose Neoplasms/pathology ; Skin Neoplasms/pathology
    Language English
    Publishing date 2019-07-09
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 187078-6
    ISSN 1600-0560 ; 0303-6987
    ISSN (online) 1600-0560
    ISSN 0303-6987
    DOI 10.1111/cup.13519
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Microreticular perineurioma: A new morphological subtype of a rare entity.

    Salah, Haneen T / D'ardis, Julieta A / Enos, Tyler / Klimas, Natasha / Gerber, Howard B

    Journal of cutaneous pathology

    2023  Volume 50, Issue 5, Page(s) 396–399

    Abstract: Perineurioma is a benign peripheral nerve sheath tumor. Several subtypes have been described, including plexiform, reticular, and sclerosing. The reticular variant has been previously described as having a net or lace-like growth pattern consisting of ... ...

    Abstract Perineurioma is a benign peripheral nerve sheath tumor. Several subtypes have been described, including plexiform, reticular, and sclerosing. The reticular variant has been previously described as having a net or lace-like growth pattern consisting of large anastomosing cords of spindle-shaped cells. We report a case of an 11-year-old male who presented with a 2-year history of a slowly enlarging, tan-white lesion on the finger. Microscopically, the lesion consisted of cells with ovoid nuclei and delicate, elongate cytoplasmic processes, arranged in a microreticular pattern. The lesional cells were markedly positive for epithelial membrane antigen and claudin-1. Based on these features and the unusual morphology, the case was called a microreticular perineuroma. The patient underwent complete excision of the lesion with no recurrence 9 months after follow-up. To our knowledge, this is the first reported case of this morphologic variant. Awareness of this entity is important to avoid inappropriate management.
    MeSH term(s) Male ; Humans ; Child ; Biomarkers, Tumor ; Immunohistochemistry ; Nerve Sheath Neoplasms/pathology ; Fingers/pathology ; Cell Proliferation
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2023-03-12
    Publishing country United States
    Document type Case Reports
    ZDB-ID 187078-6
    ISSN 1600-0560 ; 0303-6987
    ISSN (online) 1600-0560
    ISSN 0303-6987
    DOI 10.1111/cup.14418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Treatment of extensive elastosis perforans serpiginosa with acitretin in a man with Down syndrome.

    Enos, Tyler / Vasquez, Rebecca / Vandergriff, Travis / Wang, Richard / Rainwater, Yevgeniya

    International journal of dermatology

    2020  Volume 60, Issue 5, Page(s) 611–612

    MeSH term(s) Acitretin/therapeutic use ; Down Syndrome/complications ; Down Syndrome/drug therapy ; Elastic Tissue ; Humans ; Male ; Skin Diseases/drug therapy
    Chemical Substances Acitretin (LCH760E9T7)
    Language English
    Publishing date 2020-11-23
    Publishing country England
    Document type Case Reports
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.15321
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A Subtle Historical Clue Unlocks a Contact Puzzle.

    DeBord, Logan / Enos, Tyler / Cruz, Ponciano

    Dermatitis : contact, atopic, occupational, drug

    2018  Volume 30, Issue 1, Page(s) 77

    MeSH term(s) Conjunctivitis, Allergic/chemically induced ; Dermatitis, Allergic Contact/etiology ; Facial Dermatoses/chemically induced ; Female ; Histamine H1 Antagonists/adverse effects ; Humans ; Ketotifen/adverse effects ; Middle Aged ; Ophthalmic Solutions/adverse effects ; Patch Tests
    Chemical Substances Histamine H1 Antagonists ; Ophthalmic Solutions ; Ketotifen (X49220T18G)
    Language English
    Publishing date 2018-12-20
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2144723-8
    ISSN 2162-5220 ; 1532-8163 ; 1710-3568
    ISSN (online) 2162-5220 ; 1532-8163
    ISSN 1710-3568
    DOI 10.1097/DER.0000000000000424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Assessing comfort level with pediatric skin specimens among dermatopathologists and pediatric pathologists: A national cross-sectional survey.

    Enos, Tyler / Hughes, Connor / Kelley, Shannon / Mir, Adnan / Rakheja, Dinesh / Vandergriff, Travis

    Journal of cutaneous pathology

    2021  Volume 48, Issue 9, Page(s) 1109–1114

    Abstract: Background: Cutaneous histopathologic diagnoses in children often differ from those in adults. Depending on practice setting, these specimens may be evaluated by dermatopathologists or pediatric pathologists. We sought to determine whether comfort level ...

    Abstract Background: Cutaneous histopathologic diagnoses in children often differ from those in adults. Depending on practice setting, these specimens may be evaluated by dermatopathologists or pediatric pathologists. We sought to determine whether comfort level with pediatric dermatopathology is associated with prior training, pediatric dermatopathology exposure during fellowship, career duration, or specimen subtype.
    Methods: We surveyed dermatopathologists and pediatric pathologists practicing in the United States. Training and practice variables were evaluated by multivariable regression for association with comfort level.
    Results: Of the 156 respondents, 72% were dermatopathologists (response rate 11.6%) and 28% were pediatric pathologists (response rate 9.3%). Dermatopathologists reported higher comfort overall (P < .001); this was also true for inflammatory dermatoses and melanocytic neoplasms (P < .001). Thirty-four percent and 75% of dermatopathologists and pediatric pathologists, respectively, reported lower comfort with pediatric skin specimens than their usual cases. Pediatric pathologists were 28% more likely to refer these cases to colleagues. Among dermatopathologists, dermatology-trained were more comfortable than pathology-trained colleagues interpreting inflammatory dermatoses (P < .001).
    Conclusions: Pathologists' comfort with pediatric dermatopathology varied significantly based upon prior training, career duration, and specimen subtype. These results suggest opportunities for improving education in this domain.
    MeSH term(s) Child ; Clinical Competence/statistics & numerical data ; Cross-Sectional Studies ; Dermatologists/statistics & numerical data ; Fellowships and Scholarships ; Humans ; Melanocytes/pathology ; Melanoma/pathology ; Pathologists/statistics & numerical data ; Pediatrics/trends ; Referral and Consultation ; Self Efficacy ; Skin/pathology ; Skin Diseases/diagnosis ; Skin Diseases/pathology ; Skin Neoplasms/pathology ; Specimen Handling/psychology ; Surveys and Questionnaires ; United States
    Language English
    Publishing date 2021-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187078-6
    ISSN 1600-0560 ; 0303-6987
    ISSN (online) 1600-0560
    ISSN 0303-6987
    DOI 10.1111/cup.13997
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Acute generalized exanthematous pustulosis induced by empiric hydroxychloroquine for presumed COVID-19.

    Enos, Tyler / Jeong, Haneol S / Vandergriff, Travis / Jacobe, Heidi T / Chong, Benjamin F

    Dermatologic therapy

    2020  Volume 33, Issue 6, Page(s) e13834

    MeSH term(s) Acute Generalized Exanthematous Pustulosis/diagnosis ; Acute Generalized Exanthematous Pustulosis/drug therapy ; Acute Generalized Exanthematous Pustulosis/etiology ; Adult ; Antiviral Agents/adverse effects ; COVID-19/diagnosis ; COVID-19/drug therapy ; Drug Tapering ; Female ; Glucocorticoids/administration & dosage ; Humans ; Hydroxychloroquine/adverse effects ; Skin/drug effects ; Skin/pathology ; Treatment Outcome
    Chemical Substances Antiviral Agents ; Glucocorticoids ; Hydroxychloroquine (4QWG6N8QKH)
    Keywords covid19
    Language English
    Publishing date 2020-07-08
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 1354801-3
    ISSN 1529-8019 ; 1396-0296
    ISSN (online) 1529-8019
    ISSN 1396-0296
    DOI 10.1111/dth.13834
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Opportunities for education during the COVID-19 pandemic.

    Nguyen, Khang D / Enos, Tyler / Vandergriff, Travis / Vasquez, Rebecca / Cruz, Ponciano D / Jacobe, Heidi T / Mauskar, Melissa M

    JAAD international

    2020  Volume 1, Issue 1, Page(s) 21–22

    Language English
    Publishing date 2020-05-04
    Document type Editorial
    ISSN 2666-3287
    ISSN (online) 2666-3287
    DOI 10.1016/j.jdin.2020.04.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Brentuximab vedotin in CD30

    Enos, Tyler H / Feigenbaum, Lawrence S / Wickless, Heather W

    International journal of dermatology

    2017  Volume 56, Issue 12, Page(s) 1400–1405

    Abstract: Background: The utility of brentuximab vedotin (BV) in CD30: Methods: A literature review was conducted, and we analyzed data from published trials and case reports obtained via search of Ovid-MEDLINE: Results: Mean age at BV initiation was 60.8 ... ...

    Abstract Background: The utility of brentuximab vedotin (BV) in CD30
    Methods: A literature review was conducted, and we analyzed data from published trials and case reports obtained via search of Ovid-MEDLINE
    Results: Mean age at BV initiation was 60.8 years (67 - PC-ALCL; 60.1 - MF), and 4.1 therapies were attempted prior to BV (3.1 - PC-ALCL; 4.2 - MF). The overall response rate was 67.7% (100% - PC-ALCL; 63.9% - MF), with 16.2% of patients experiencing complete response (100% - PC-ALCL; 6.6% - MF). Mean time to clinical response was 5.3 and 9.3 weeks for PC-ALCL and MF, respectively. Mean response duration for patients with PC-ALCL was 7.6 and 7.8 months for MF. Peripheral neuropathy (57.2%) and fatigue (35.6%) were the most commonly reported adverse effects.
    Conclusions: This analysis summates the current evidence regarding the use of BV in treating CD30
    MeSH term(s) Antineoplastic Agents, Immunological/adverse effects ; Antineoplastic Agents, Immunological/therapeutic use ; Fatigue/chemically induced ; Humans ; Immunoconjugates/adverse effects ; Immunoconjugates/therapeutic use ; Ki-1 Antigen/metabolism ; Lymphoma, Primary Cutaneous Anaplastic Large Cell/drug therapy ; Lymphoma, Primary Cutaneous Anaplastic Large Cell/metabolism ; Mycosis Fungoides/drug therapy ; Mycosis Fungoides/metabolism ; Peripheral Nervous System Diseases/chemically induced ; Retreatment ; Skin Neoplasms/drug therapy ; Skin Neoplasms/metabolism
    Chemical Substances Antineoplastic Agents, Immunological ; Immunoconjugates ; Ki-1 Antigen ; brentuximab vedotin (7XL5ISS668)
    Language English
    Publishing date 2017-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 412254-9
    ISSN 1365-4632 ; 0011-9059 ; 1461-1244
    ISSN (online) 1365-4632
    ISSN 0011-9059 ; 1461-1244
    DOI 10.1111/ijd.13696
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Acute generalized exanthematous pustulosis induced by empiric hydroxychloroquine for presumed COVID-19

    Enos, Tyler / Jeong, Haneol S / Vandergriff, Travis / Jacobe, Heidi T / Chong, Benjamin F

    Dermatol Ther

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #600024
    Database COVID19

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