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  1. Book ; Thesis: Über den Einfluss genetischer Modifikatoren der Hämoglobin F-Synthese auf den Verlauf der Sichelzellkrankheit

    Allard, Pierre Nicolas / Kulozik, Andreas

    2022  

    Institution Universität Heidelberg
    Author's details vorgelegt von Pierre Nicolas Allard ; Doktorvater: Herr Prof. Dr. med. A. Kulozik, PhD
    Language German
    Size 165 Blätter, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2022
    HBZ-ID HT030043540
    Database Catalogue ZB MED Medicine, Health

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    2023 E 958 order for loan Magazin

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  2. Article ; Online: Gapless Superfluidity and Neutron Star Cooling

    Valentin Allard / Nicolas Chamel

    Physical Sciences Forum, Vol 7, Iss 9, p

    2023  Volume 9

    Abstract: The presence of currents in the interior of cold neutron stars can lead to a state in which nucleons remain superfluid while the quasiparticle energy spectrum has no gap. We show within the self-consistent time-dependent nuclear energy density functional ...

    Abstract The presence of currents in the interior of cold neutron stars can lead to a state in which nucleons remain superfluid while the quasiparticle energy spectrum has no gap. We show within the self-consistent time-dependent nuclear energy density functional theory that the nucleon specific heat is then comparable to that in the normal phase, contrasting with the classical BCS result in the absence of super flows. This dynamical, gapless superfluid state has important implications for the cooling of neutron stars.
    Keywords neutron star ; superfluidity ; cooling ; pairing gap ; specific heat ; Mechanical drawing. Engineering graphics ; T351-385 ; Physical and theoretical chemistry ; QD450-801
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Complex Hepatectomy Under Total Vascular Exclusion of the Liver Preserving the Caval Flow with Portal Hypothermic Perfusion and Temporary Portacaval Shunt: A Proof of Concept.

    Azoulay, Daniel / Salloum, Chady / Allard, Marc-Antoine / Serrablo, Alejandro / Moussa, Maya / Romano, Pierluigi / Pietraz, Daniel / Golse, Nicolas / Lim, Chetana

    Annals of surgical oncology

    2024  

    Abstract: Background: Hypothermic liver perfusion decreases ischemia/reperfusion injury during hepatectomy under standard total vascular exclusion (TVE) of the liver. This surgery needs venovenous bypass and is hampered by high morbi-mortality. TVE preserving the ...

    Abstract Background: Hypothermic liver perfusion decreases ischemia/reperfusion injury during hepatectomy under standard total vascular exclusion (TVE) of the liver. This surgery needs venovenous bypass and is hampered by high morbi-mortality. TVE preserving the inferior vena cava (IVC) flow is hemodynamically well tolerated but remains limited in duration when performed under liver normothermia. The objective of this study was to report the results of TVE preserving the caval flow, modified to allow hypothermic liver perfusion and obviate splanchnic congestion.
    Patients and methods: The technique, indicated for tumors abutting large tributaries of the hepatic veins but sparing their roots in IVC and the latter, was applied when TVE was anticipated to last for ≥ 60 min. It combines continuous TVE preserving the IVC flow with hypothermic liver perfusion and temporary portacaval shunt (PCS). Results are given as median (range).
    Results: Vascular control was achieved in 13 patients with excellent hemodynamical tolerance. PCS was direct or via an interposed synthetic graft (five and eight cases, respectively). Liver temperature dropped to 16.5 (6-24) °C under perfusion of 2 (2-4) L of cold perfusate. TVE lasted 67 (54-125) min and 4.5 (0-8) blood units were transfused. Resection was major in nine cases and was complete in all cases. Five complications occurred in four patients, and the 90-day mortality rate was zero.
    Conclusions: This technique maintains stable hemodynamics and combines the advantages of in situ or ex situ standard TVE with hypothermic liver perfusion, without their inherent prolongation of ischemia time and need for venovenous bypass.
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-024-15227-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Acute hypothermia in Covid 19: A case report.

    Allard, Nicolas / Maruani, Ari / Cret, Corina / Ameri, Alain

    eNeurologicalSci

    2020  Volume 20, Page(s) 100248

    Keywords covid19
    Language English
    Publishing date 2020-06-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2838045-9
    ISSN 2405-6502 ; 2405-6502
    ISSN (online) 2405-6502
    ISSN 2405-6502
    DOI 10.1016/j.ensci.2020.100248
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  5. Article ; Online: Adipocyte hypertrophy associates with

    Ye, Run Zhou / Montastier, Emilie / Frisch, Frédérique / Noll, Christophe / Allard-Chamard, Hugues / Gévry, Nicolas / Tchernof, André / Carpentier, André C

    iScience

    2023  Volume 27, Issue 1, Page(s) 108692

    Abstract: Adipocyte hypertrophy is associated with metabolic complications independent of obesity. We aimed to determine: 1) the association between adipocyte size and postprandial fatty acid metabolism; 2) the potential mechanisms driving the obesity-independent, ...

    Abstract Adipocyte hypertrophy is associated with metabolic complications independent of obesity. We aimed to determine: 1) the association between adipocyte size and postprandial fatty acid metabolism; 2) the potential mechanisms driving the obesity-independent, hypertrophy-associated dysmetabolism
    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.108692
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Influence of arylalkyl amines on the formation of hybrid CsPbBr

    Ruby, Ernest / Levy-Falk, Hugo / Trippé-Allard, Gaëlle / Fossard, Frédéric / Vallet, Maxime / Guiblin, Nicolas / Lauret, Jean-Sébastien / Deleporte, Emmanuelle / Mayer, Cédric R

    Nanoscale advances

    2024  Volume 6, Issue 6, Page(s) 1704–1719

    Abstract: Perovskite nanocrystals have attracted much attention in the last ten years due to their different applications, especially in the photovoltaic domain and LED performance. In this large family of perovskite nanocrystals, ... ...

    Abstract Perovskite nanocrystals have attracted much attention in the last ten years due to their different applications, especially in the photovoltaic domain and LED performance. In this large family of perovskite nanocrystals, CsPbBr
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article
    ISSN 2516-0230
    ISSN (online) 2516-0230
    DOI 10.1039/d3na01105d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: [No title information]

    Gautier, Nicolas / Ficheux, Maxence / Henri, Patrick / Lanot, Antoine / Béchade, Clémence / Allard, Bénédicte

    Nephrologie & therapeutique

    2022  Volume 18, Issue 5S1, Page(s) 5S2–5S11

    Abstract: Dialysis is a restrictive treatment with a significant impact on the quality of life of patients. Home hemodialysis (HHD) allows to maintain quality of life while improving the conditions of purification, in particular with the daily or even nocturnal ... ...

    Title translation Innovations en hémodialyse à domicile: Innovations in home hemodialysis.
    Abstract Dialysis is a restrictive treatment with a significant impact on the quality of life of patients. Home hemodialysis (HHD) allows to maintain quality of life while improving the conditions of purification, in particular with the daily or even nocturnal practice of hemodialysis. The arrival of systems with a cycler in the 2010s for home hemodialysis brings a new dynamism for this type of technique. The practice with dialysate low flow with the optimization of storage space, the simplification of the use of generators and the emmergence of telemonitoring tools increases the accessibility of this dialysis technique, so that we can hope in the coming years to be able to offer this dialysis modality to any patient with chronic renal failure requiring extra-renal purification. ©2022 Société francophone de néphrologie, dialyse et transplantation. Published by Elsevier Masson SAS. All rights reserved.
    MeSH term(s) Humans ; Hemodialysis, Home/methods ; Quality of Life ; Kidney Failure, Chronic/therapy ; Renal Dialysis ; Renal Insufficiency, Chronic/therapy
    Language French
    Publishing date 2022-11-14
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1016/S1769-7255(23)00004-4
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    Zs.A 6298: Show issues Location:
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  8. Article ; Online: Branched pegylated linker-auristatin to control hydrophobicity for the production of homogeneous minibody-drug conjugate against HER2-positive breast cancer.

    Douez, Emmanuel / Allard-Vannier, Emilie / Amar, Imène Ait Mohamed / Jolivet, Louis / Boursin, Fanny / Maisonial-Besset, Aurélie / Witkowski, Tiffany / Chezal, Jean-Michel / Colas, Cyril / Letast, Stéphanie / Auvert, Etienne / Denevault-Sabourin, Caroline / Aubrey, Nicolas / Joubert, Nicolas

    Journal of controlled release : official journal of the Controlled Release Society

    2024  Volume 366, Page(s) 567–584

    Abstract: Trastuzumab emtansine (Kadcyla®) was the first antibody-drug conjugate (ADC) approved by the Food and Drug Administration in 2013 against a solid tumor, and the first ADC to treat human epidermal growth factor receptor 2 positive (HER2+) breast cancer. ... ...

    Abstract Trastuzumab emtansine (Kadcyla®) was the first antibody-drug conjugate (ADC) approved by the Food and Drug Administration in 2013 against a solid tumor, and the first ADC to treat human epidermal growth factor receptor 2 positive (HER2+) breast cancer. However, this second generation ADC is burden by several limitations included heterogeneity, limited activity against heterogeneous tumor (regarding antigen expression) and suboptimal tumor penetration. To address this, different development strategies are oriented towards homogeneous conjugation, new drugs, optimized linkers and/or smaller antibody formats. To reach better developed next generation ADCs, a key parameter to consider is the management of the hydrophobicity associated with the linker-drug, increasing with and limiting the drug-to-antibody ratio (DAR) of the ADC. Here, an innovative branched pegylated linker was developed, to control the hydrophobicity of the monomethyl auristatin E (MMAE) and its cathepsin B-sensitive trigger. This branched pegylated linker-MMAE was then used for the efficient generation of internalizing homogeneous ADC of DAR 8 and minibody-drug conjugate of DAR 4, targeting HER2. Both immunoconjugates were then evaluated in vitro and in vivo on breast cancer models. Interestingly, this study highlighted that the minibody-MMAE conjugate of DAR 4 was the best immunoconjugate regarding in vitro cellular internalization and cytotoxicity, gamma imaging, ex vivo biodistribution profile in mice and efficient reduction of tumor size in vivo. These results are very promising and encourage us to explore further fragment-drug conjugate development.
    MeSH term(s) United States ; Mice ; Humans ; Animals ; Female ; Breast Neoplasms/drug therapy ; Pharmaceutical Preparations ; Tissue Distribution ; Cell Line, Tumor ; Immunoconjugates/therapeutic use ; Ado-Trastuzumab Emtansine ; Hydrophobic and Hydrophilic Interactions ; Polyethylene Glycols ; Oligopeptides ; Aminobenzoates
    Chemical Substances Pharmaceutical Preparations ; auristatin ; Immunoconjugates ; Ado-Trastuzumab Emtansine (SE2KH7T06F) ; Polyethylene Glycols (3WJQ0SDW1A) ; Oligopeptides ; Aminobenzoates
    Language English
    Publishing date 2024-01-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 632533-6
    ISSN 1873-4995 ; 0168-3659
    ISSN (online) 1873-4995
    ISSN 0168-3659
    DOI 10.1016/j.jconrel.2024.01.012
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    Zs.A 2055: Show issues Location:
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  9. Article ; Online: Acute hypothermia in Covid 19

    Nicolas Allard / Ari Maruani / Corina Cret / Alain Ameri

    eNeurologicalSci, Vol 20, Iss , Pp 100248- (2020)

    A case report

    2020  

    Keywords Neurology. Diseases of the nervous system ; RC346-429 ; covid19
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Using risk factors and markers to predict bacterial respiratory co-/superinfections in COVID-19 patients: is the antibiotic steward's toolbox full or empty?

    Van Laethem, Johan / Pierreux, Jan / Wuyts, Stephanie Cm / De Geyter, Deborah / Allard, Sabine D / Dauby, Nicolas

    Acta clinica Belgica

    2023  Volume 78, Issue 5, Page(s) 418–430

    Abstract: Background: Adequate diagnosis of bacterial respiratory tract co-/superinfection (bRTI) in coronavirus disease (COVID-19) patients is challenging, as there is insufficient knowledge about the role of risk factors and (para)clinical parameters in the ... ...

    Abstract Background: Adequate diagnosis of bacterial respiratory tract co-/superinfection (bRTI) in coronavirus disease (COVID-19) patients is challenging, as there is insufficient knowledge about the role of risk factors and (para)clinical parameters in the identification of bacterial co-/superinfection in the COVID-19 setting. Empirical antibiotic therapy is mainly based on COVID-19 severity and expert opinion, rather than on scientific evidence generated since the start of the pandemic.
    Purpose: We report the best available evidence regarding the predictive value of risk factors and (para)clinical markers in the diagnosis of bRTI in COVID-19 patients.
    Methods: A multidisciplinary team identified different potential risk factors and (para)clinical predictors of bRTI in COVID-19 and formulated one or two research questions per topic. After a thorough literature search, research gaps were identified, and suggestions concerning further research were formulated. The quality of this narrative review was ensured by following the Scale for the Assessment of Narrative Review Articles.
    Results: Taking into account the scarcity of scientific evidence for markers and risk factors of bRTI in COVID-19 patients, to date, COVID-19 severity is the only parameter which can be associated with higher risk of developing bRTI.
    Conclusions: Evidence on the usefulness of risk factors and (para)clinical factors as predictors of bRTI in COVID-19 patients is scarce. Robust studies are needed to optimise antibiotic prescribing and stewardship activities in the context of COVID-19.
    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Superinfection/drug therapy ; COVID-19/epidemiology ; SARS-CoV-2 ; Risk Factors
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-02-01
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 390201-8
    ISSN 2295-3337 ; 0001-5512 ; 1784-3286
    ISSN (online) 2295-3337
    ISSN 0001-5512 ; 1784-3286
    DOI 10.1080/17843286.2023.2167328
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