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Article ; Online: Erratum for Zheng et al., "Characterization of the First Cultured Representative of '

Zheng, Rikuan / Cai, Ruining / Wang, Chong / Liu, Rui / Sun, Chaomin

2022 Volume 13, Issue 2, Page(s) e0065722

Language	English
Publishing date	2022-03-21
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.00657-22
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Correction: Zheng et al. Geniposide Ameliorated Dexamethasone-Induced Cholesterol Accumulation in Osteoblasts by Mediating the GLP-1R/ABCA1 Axis.

Zheng, Yizhou / Xiao, Yaosheng / Zhang, Di / Zhang, Shanshan / Ouyang, Jing / Li, Linfu / Shi, Weimei / Zhang, Rui / Liu, Hai / Jin, Qi / Chen, Zhixi / Xu, Daohua / Wu, Longhuo

Cells

2022 Volume 11, Issue 23

Abstract: The authors wish to make the following changes to their paper [ ... ]. ...

Abstract	The authors wish to make the following changes to their paper [...].
Language	English
Publishing date	2022-11-30
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11233838
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Article ; Online: Letter by Zheng et al Regarding Article, "Impact of Initial Imaging Protocol on Likelihood of Endovascular Stroke Therapy".

Zheng, Feng / Zhou, Jianfeng / Liu, Chubin / Wang, Cui'e / Li, Yasong / Hu, Weipeng / Krischek, Boris

Stroke

2021 Volume 52, Issue 2, Page(s) e87–e88

MeSH term(s)	Brain Ischemia/diagnostic imaging ; Brain Ischemia/therapy ; Humans ; Probability ; Stroke/diagnostic imaging ; Stroke/therapy
Language	English
Publishing date	2021-01-25
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	80381-9
ISSN	1524-4628 ; 0039-2499 ; 0749-7954
ISSN (online)	1524-4628
ISSN	0039-2499 ; 0749-7954
DOI	10.1161/STROKEAHA.120.032586
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Zs.A 448: Show issues

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Article: Qing-Re-Xiao-Zheng Formula Modulates Gut Microbiota and Inhibits Inflammation in Mice With Diabetic Kidney Disease.

Gao, Yabin / Yang, Ruibing / Guo, Lan / Wang, Yaoxian / Liu, Wei Jing / Ai, Sinan / Woon, Ting Hui / Wang, Zheng / Zhai, Yuanyuan / Wang, Zhen / Peng, Liang

Frontiers in medicine

2021 Volume 8, Page(s) 719950

Abstract: ... and protect the renal function in DKD. Qing-Re-Xiao-Zheng formula (QRXZF) is ...

Abstract	Evidence indicates that the metabolic inflammation induced by gut microbiota dysbiosis contributes to diabetic kidney disease. Prebiotic supplementations to prevent gut microbiota dysbiosis, inhibit inflammatory responses, and protect the renal function in DKD. Qing-Re-Xiao-Zheng formula (QRXZF) is a Traditional Chinese Medicine (TCM) formula that has been used for DKD treatment in China. Recently, there are growing studies show that regulation of gut microbiota is a potential therapeutic strategy for DKD as it is able to reduce metabolic inflammation associated with DKD. However, it is unknown whether QRXZF is effective for DKD by regulating of gut microbiota. In this study, we investigated the reno-protective effect of QRXZF by exploring its potential mechanism between gut microbiota and downstream inflammatory pathways mediated by gut-derived lipopolysaccharide (LPS) in the kidney. High-fat diet (HFD) and streptozotocin injection-induced DKD mice model was established to assess the QRXZF effect
Language	English
Publishing date	2021-09-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2021.719950
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Article ; Online: Hu-Qi-Zheng-Xiao Decoction Inhibits the Metastasis of Hepatocellular Carcinoma Cells by Suppressing the HIF-1α Signaling Pathway to Inhibit EMT, LCSC, and Angiogenic Process.

Wang, Xuejing / Yin, Ling / Chai, Mengyin / Kou, Buxin / Liu, Xiaoni / Wang, Xiaojun

Integrative cancer therapies

2024 Volume 23, Page(s) 15347354231226126

Abstract: ... of the digestive system. Hu-Qi-Zheng-Xiao (HQZX) decoction has been clinically found to prolong the survival of patients ...

Abstract	Background: Hepatocellular carcinoma (HCC) is a common clinical malignant tumor of the digestive system. Hu-Qi-Zheng-Xiao (HQZX) decoction has been clinically found to prolong the survival of patients with hepatocellular carcinoma and improve the quality of patients' survival, but its antitumor biological mechanism is still unclear. Methods: A nude mouse hollow fiber hepatocellular carcinoma model was constructed to analyze the in vivo efficacy of HQZX decoction against 7 different hepatocellular carcinoma cells. The subcutaneous graft tumor model was again validated. In vitro, the effect of HQZX decoction on the growth and metastasis of the cell line with the highest growth inhibition was evaluated. The cell line with the best efficacy response screened was again used to construct a hollow fiber hepatocellular carcinoma model and hollow fiber conduit cells were extracted to detect the expression of HIF-1α, VEGF, EMT-related molecules, LCSCs-related molecules, and to observe the density of the subcutaneous vascular network of hollow fiber conduits. The liver metastasis model of splenic injection was constructed to observe the effect of HQZX decoction on tumor metastasis. Results: The hollow fiber hepatocellular carcinoma model was evaluated for the efficacy of HQZX decoction, and it was found to have the highest growth inhibition of LM3-luc cells. In vitro, the CCK8 assay revealed that HQZX decoction could inhibit tumor migration and invasion and promote apoptosis. In addition, the mechanism study of extracting cells from hollow fiber tubes found that HQZX decoction could inhibit metastasis-associated HIF-1α, VEGF, EMT-related molecules, and LCSCs-related molecules expression. capillary network around subcutaneous fiber tubes was reduced in the HQZX decoction gavage group of mice. It inhibited tumor metastasis in nude mice. Conclusions: HQZX decoction inhibited the growth of a variety of hepatocellular carcinoma cells. HQZX decoction suppressed the expression of metastasis-associated VEGF, EMT-related molecules, and LCSCs-related molecules and inhibited tumor angiogenesis and growth and metastasis, which may be related to the inhibition of the HIF-1α signaling pathway. It reveals that HQZX decoction may be a promising herbal compound for anti-HCC therapy, and also reveals the accurate feasibility of the hollow fiber hepatocellular carcinoma model for in vivo pharmacodynamic evaluation and mechanism study.
MeSH term(s)	Humans ; Mice ; Animals ; Carcinoma, Hepatocellular/metabolism ; Liver Neoplasms/metabolism ; Mice, Nude ; Vascular Endothelial Growth Factor A/metabolism ; Cell Line, Tumor ; Signal Transduction ; Cell Proliferation
Chemical Substances	Vascular Endothelial Growth Factor A
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2182320-0
ISSN	1552-695X ; 1534-7354
ISSN (online)	1552-695X
ISSN	1534-7354
DOI	10.1177/15347354231226126
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Zs.A 6026: Show issues

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Article ; Online: Applying latent tree analysis to classify Traditional Chinese Medicine syndromes (Zheng) in patients with psoriasis vulgari.

Xu, Wen-Jie / Zhang, Nevin-L / Li, Ping / Wang, Tian-Fang / Chen, Wei-Wen / Liu, April-H / Mohler-Kuo, Meichun

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

2022 Volume 42, Issue 1, Page(s) 132–139

Abstract: ... must stratify patients into subtypes (known as TCM syndromes or Zheng) and apply appropriate TCM treatments ... to different subtypes. However, no unified symptom-based classification scheme of subtypes (Zheng) exists ... of the analysis divided patients into three subtype groups with clear TCM Zheng connotations: 'blood deficiency ...

Abstract	Objective: To treat patients with psoriasis vulgaris using Traditional Chinese Medicine (TCM), one must stratify patients into subtypes (known as TCM syndromes or Zheng) and apply appropriate TCM treatments to different subtypes. However, no unified symptom-based classification scheme of subtypes (Zheng) exists for psoriasis vulgaris. The present paper aims to classify patients with psoriasis vulgaris into different subtypes via the analysis of clinical TCM symptom and sign data. Methods: A cross-sectional survey was carried out in Beijing from 2005-2008, collecting clinical TCM symptom and sign data from 2764 patients with psoriasis vulgaris. Roughly 108 symptoms and signs were initially analyzed using latent tree analysis, with a selection of the resulting latent variables then used as features to cluster patients into subtypes. Results: The initial latent tree analysis yielded a model with 43 latent variables. The second phase of the analysis divided patients into three subtype groups with clear TCM Zheng connotations: 'blood deficiency and wind dryness'; 'blood heat'; and 'blood stasis'. Conclusions: Via two-phase analysis of clinic symptom and sign data, three different Zheng subtypes were identified for psoriasis vulgaris. Statistical characteristics of the three subtypes are presented. This constitutes an evidence-based solution to the syndromedifferentiation problem that exists with psoriasis vulgaris.
MeSH term(s)	Cross-Sectional Studies ; Hot Temperature ; Humans ; Medicine, Chinese Traditional/methods ; Psoriasis/diagnosis ; Psoriasis/therapy ; Syndrome
Language	English
Publishing date	2022-03-19
Publishing country	China
Document type	Journal Article
ZDB-ID	603186-9
ISSN	2589-451X ; 0254-6272 ; 0255-2922
ISSN (online)	2589-451X ; 0254-6272
ISSN	0255-2922
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Zs.B 2564: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Qing-Re-Xiao-Zheng Formula Modulates Gut Microbiota and Inhibits Inflammation in Mice With Diabetic Kidney Disease

Yabin Gao / Ruibing Yang / Lan Guo / Yaoxian Wang / Wei Jing Liu / Sinan Ai / Ting Hui Woon / Zheng Wang / Yuanyuan Zhai / Zhen Wang / Liang Peng

Frontiers in Medicine, Vol

2021 Volume 8

Abstract: ... and protect the renal function in DKD. Qing-Re-Xiao-Zheng formula (QRXZF) is ...

Abstract	Evidence indicates that the metabolic inflammation induced by gut microbiota dysbiosis contributes to diabetic kidney disease. Prebiotic supplementations to prevent gut microbiota dysbiosis, inhibit inflammatory responses, and protect the renal function in DKD. Qing-Re-Xiao-Zheng formula (QRXZF) is a Traditional Chinese Medicine (TCM) formula that has been used for DKD treatment in China. Recently, there are growing studies show that regulation of gut microbiota is a potential therapeutic strategy for DKD as it is able to reduce metabolic inflammation associated with DKD. However, it is unknown whether QRXZF is effective for DKD by regulating of gut microbiota. In this study, we investigated the reno-protective effect of QRXZF by exploring its potential mechanism between gut microbiota and downstream inflammatory pathways mediated by gut-derived lipopolysaccharide (LPS) in the kidney. High-fat diet (HFD) and streptozotocin injection-induced DKD mice model was established to assess the QRXZF effect in vivo. Mice treated with QRXZF for 8 weeks had significantly lower levels of urinary albumin, serum cholesterol and triglycerides. The renal injuries observed through histological analysis were attenuated as well. Also, mice in the QRXZF group had higher levels of Zonula occludens protein-1 (ZO-1) expression, lower levels of serum fluorescein-isothiocyanate (FITC)-dextran and less-damaged colonic mucosa as compared to the DKD group, implying the benefit role for the gut barrier integrity. QRXZF treatment also reversed gut dysbiosis and reduced levels of gut-derived LPS. Notably, the expression of toll-like receptor 4 (TLR4) and nuclear factor-κB (NF-κB), which are important inflammation pathways in DKD, were suppressed in the QRXZF groups. In conclusion, our results indicated that the reno-protective effects of QRXZF was probably associated with modulating gut microbiota and inhibiting inflammatory responses in the kidney.
Keywords	Qing-Re-Xiao-Zheng formula ; gut microbiota ; inflammation ; diabetic kidney disease ; TLR4/NF-κB pathway ; Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Can a model be evaluated by a single fictitious data point in a real-world study case? Further comments on Zheng et al. (2022).

Xu, Hanqiu / Liu, Fenfen / Li, Chunqiang

The Science of the total environment

2022 Volume 858, Issue Pt 2, Page(s) 159911

Language	English
Publishing date	2022-11-03
Publishing country	Netherlands
Document type	Letter
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.159911
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 949: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Fu-Zheng-Tong-Luo formula promotes autophagy and alleviates idiopathic pulmonary fibrosis by controlling the Janus kinase 2/signal transducer and activator of transcription 3 pathway.

Zhang, Xing / Su, Jie / Lin, Jiacheng / Liu, Lujiong / Wu, Jiamin / Yuan, Wenli / Zhang, Yibao / Chen, Qi / Su, Zi Jian / Xu, Guihua / Sun, Meng / Zhang, Yile / Chen, Xuan / Zhang, Wei

Journal of ethnopharmacology

2023 Volume 314, Page(s) 116633

Abstract: Ethnopharmacological relevance: Fu-Zheng-Tong-Luo (FZTL) formula is a Chinese herbal prescription ...

Abstract	Ethnopharmacological relevance: Fu-Zheng-Tong-Luo (FZTL) formula is a Chinese herbal prescription which is used to treat idiopathic pulmonary fibrosis (IPF). We previously reported that the FZTL formula could improve IPF injury in rats; however, the mechanism remains unelucidated. Aim of the study: To elucidate the effects and mechanisms of the FZTL formula on IPF. Materials and methods: The bleomycin-induced pulmonary fibrosis rat model and transforming growth factor-β-induced lung fibroblast model were used. Histological changes and fibrosis formation were detected in the rat model after treatment with the FZTL formula. Furthermore, the effects of the FZTL formula on autophagy and lung fibroblast activation were determined. Moreover, the mechanism of FZTL was explored using transcriptomics analysis. Results: We observed that FZTL alleviated IPF injury in rats and inhibited inflammatory responses and fibrosis formation in rats. Moreover, it promoted autophagy and inhibited lung fibroblast activation in vitro. Transcriptomics analysis revealed that FZTL regulates the Janus kinase 2 (JAK)/signal transducer and activator of the transcription 3 (STAT) signaling pathway. The JAK2/STAT3 signaling activator interleukin 6 inhibited the anti-fibroblast activation effect of the FZTL formula. Combined treatment with the JAK2 inhibitor (AZD1480) and autophagy inhibitor (3-methyladenine) did not enhance the antifibrotic effect of FZTL. Conclusions: The FZTL formula can inhibit IPF injury and lung fibroblast activation. Its effects are mediated via the JAK2/STAT3 signaling pathway. The FZTL formula may be a potential complementary therapy for pulmonary fibrosis.
MeSH term(s)	Rats ; Animals ; Janus Kinase 2/metabolism ; STAT3 Transcription Factor/metabolism ; Idiopathic Pulmonary Fibrosis/chemically induced ; Idiopathic Pulmonary Fibrosis/drug therapy ; Idiopathic Pulmonary Fibrosis/pathology ; Signal Transduction ; Fibrosis ; Bleomycin ; Fluorouracil/pharmacology
Chemical Substances	Janus Kinase 2 (EC 2.7.10.2) ; STAT3 Transcription Factor ; Bleomycin (11056-06-7) ; Fluorouracil (U3P01618RT)
Language	English
Publishing date	2023-05-17
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116633
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Zs.A 1494: Show issues

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Article: Phytochemical and chemotaxonomic investigations on the whole herbs of Bidens procera L.C.Xu ex X.W.Zheng

Cai, Fu-Jie / Wang, Lu / Zhao, Wei / Tian, Jin-Li / Kong, De-Gang / Liu, Qing / Sun, Xiao-Hui / Zhou, Hong-Lei

Biochemical systematics and ecology. 2022 Apr., v. 101

2022

Abstract: Bidens procera L.C.Xu ex X.W.Zheng (B. procera) as a new species was firstly investigated ...

Abstract	Bidens procera L.C.Xu ex X.W.Zheng (B. procera) as a new species was firstly investigated by phytochemical method, resulting in the isolation of sixteen compounds including eight flavonoids (7–14), four caffeoyl derivatives (3–6), two coumarins (1–2), one alkaloid (15), and one aliphatic (16). Their structures were elucidated by analyses of their NMR and MS spectroscopic data as well as by comparison of these data with those published in the literature. Compounds 2, 9, 15, 16 were reported from the Compositae family for the first time. Chemotaxonomic studies indicated that there were close relationships between species B. procera and Bidens pilosa L. (B. pilosa), as well as genera Bidens and Chrysanthemum.
Keywords	Bidens pilosa ; Chrysanthemum ; alkaloids ; chemotaxonomy ; coumarins ; ecology ; flavonoids ; new species ; spectral analysis
Language	English
Dates of publication	2022-04
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0305-1978
DOI	10.1016/j.bse.2022.104395
Database	NAL-Catalogue (AGRICOLA)

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