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Book ; Online ; Thesis: In-vitro-Studie zur Blutkompatibilität von modifizierten Oberflächen kleinkalibriger Gefäßprothesen aus bakterieller Nanocellulose

Kießwetter, Viktoria [Verfasser] / Scherner, Maximilian Philipp [Gutachter] / Akhyari, Payam [Gutachter]

2023

Author's details	Viktoria Kießwetter ; Gutachter: Maximilian Philipp Scherner, Payam Akhyari
Keywords	Medizin, Gesundheit ; Medicine, Health
Subject code	sg610
Language	German
Publisher	Universitätsbibliothek Otto-von-Guericke-Universität
Publishing place	Magdeburg
Document type	Book ; Online ; Thesis
Database	Digital theses on the web

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Book ; Thesis: Der makrophagenspezifische Insulinrezeptorknockout und seine Auswirkungen auf die Atherogenese in vitro und in vivo

Scherner, Maximilian Philipp / Brüning, Jens Claus / Krone, Wilhelm

2009

Institution	Universitätsklinikum Köln / Klinik II für Innere Medizin
Author's details	vorgelegt von Maximilian Philipp Scherner ; 1. Berichterstatterin / Berichterstatter: Universitätsprofessor Dr. med. J.C. Brüning, 2. Berichterstatterin / Berichterstatter: Universitätsprofessor Dr. med. W. Krone ; aus dem Zentrum für Innere Medizin der Universität zu Köln, Klinik II und Poliklinik für Innere Medizin
Language	German
Size	115 S. : Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Köln, Univ., Diss., 2009
HBZ-ID	HT016102790
Database	Catalogue ZB MED Medicine, Health

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Book ; Online ; Thesis: Der makrophagenspezifische Insulinrezeptorknockout und seine Auswirkungen auf die Atherogenese in vitro und in vivo

Scherner, Maximilian Philipp / Brüning, Jens Claus / Krone, Wilhelm

2009

Institution	Universitätsklinikum Köln / Klinik II für Innere Medizin
Author's details	vorgelegt von Maximilian Philipp Scherner ; 1. Berichterstatterin / Berichterstatter: Universitätsprofessor Dr. med. J.C. Brüning, 2. Berichterstatterin / Berichterstatter: Universitätsprofessor Dr. med. W. Krone ; aus dem Zentrum für Innere Medizin der Universität zu Köln, Klinik II und Poliklinik für Innere Medizin
Subject code	610
Language	German
Publishing country	Germany
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	Köln, Univ., Diss., 2009
Note	Open Access
HBZ-ID	HT016034203
DOI	10.4126/38m-000000097
Database	Repository for Life Sciences

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Article ; Online: Delicate Role of PD-L1/PD-1 Axis in Blood Vessel Inflammatory Diseases: Current Insight and Future Significance.

Veluswamy, Priya / Wacker, Max / Scherner, Maximilian / Wippermann, Jens

International journal of molecular sciences

2020 Volume 21, Issue 21

Abstract: Immune checkpoint molecules are the antigen-independent generator of secondary signals that aid in maintaining the homeostasis of the immune system. The programmed death ligand-1 (PD-L1)/PD-1 axis is one among the most extensively studied immune- ... ...

Abstract	Immune checkpoint molecules are the antigen-independent generator of secondary signals that aid in maintaining the homeostasis of the immune system. The programmed death ligand-1 (PD-L1)/PD-1 axis is one among the most extensively studied immune-inhibitory checkpoint molecules, which delivers a negative signal for T cell activation by binding to the PD-1 receptor. The general attributes of PD-L1's immune-suppressive qualities and novel mechanisms on the barrier functions of vascular endothelium to regulate blood vessel-related inflammatory diseases are concisely reviewed. Though targeting the PD-1/PD-L1 axis has received immense recognition-the Nobel Prize in clinical oncology was awarded in the year 2018 for this discovery-the use of therapeutic modulating strategies for the PD-L1/PD-1 pathway in chronic inflammatory blood vessel diseases is still limited to experimental models. However, studies using clinical specimens that support the role of PD-1 and PD-L1 in patients with underlying atherosclerosis are also detailed. Of note, delicate balances in the expression levels of PD-L1 that are needed to preserve T cell immunity and to curtail acute as well as chronic infections in underlying blood vessel diseases are discussed. A significant link exists between altered lipid and glucose metabolism in different cells and the expression of PD-1/PD-L1 molecules, and its possible implications on vascular inflammation are justified. This review summarizes the most recent insights concerning the role of the PD-L1/PD-1 axis in vascular inflammation and, in addition, provides an overview exploring the novel therapeutic approaches and challenges of manipulating these immune checkpoint proteins, PD-1 and PD-L1, for suppressing blood vessel inflammation.
MeSH term(s)	B7-H1 Antigen/antagonists & inhibitors ; B7-H1 Antigen/immunology ; B7-H1 Antigen/metabolism ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Programmed Cell Death 1 Receptor/antagonists & inhibitors ; Programmed Cell Death 1 Receptor/immunology ; Programmed Cell Death 1 Receptor/metabolism ; Vasculitis/drug therapy ; Vasculitis/immunology ; Vasculitis/metabolism ; Vasculitis/pathology
Chemical Substances	B7-H1 Antigen ; CD274 protein, human ; Immune Checkpoint Inhibitors ; PDCD1 protein, human ; Programmed Cell Death 1 Receptor
Keywords	covid19
Language	English
Publishing date	2020-10-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms21218159
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Clinical and hemodynamic outcomes of the Perceval sutureless aortic valve from a real-world registry.

Concistré, Giovanni / Baghai, Max / Santarpino, Giuseppe / Royse, Alistair / Scherner, Maximilian / Troise, Giovanni / Glauber, Mattia / Solinas, Marco

Interdisciplinary cardiovascular and thoracic surgery

2023 Volume 36, Issue 6

Abstract: ... while paravalvular leak ≥2 in only 0.1%. At a maximum follow-up of 8 years, 1.9% of cardiovascular deaths and 0.8 ...

Abstract	Objectives: Perceval sutureless valve has been in clinical use for >15 years. The aim of this study is to report the real-word clinical and haemodynamic performance from the SURE-aortic valve replacement international prospective registry in patients who underwent aortic valve replacement with Perceval valve. Methods: From 2011 to 2021, patients from 55 institutions received a Perceval valve. Postoperative, follow-up, and echocardiographic outcomes were analysed. Results: A total of 1652 patients were included; mean age was 75.3 ± 7.0 years (53.9% female); mean EuroSCORE II was 4.1 ± 6.3. Minimally invasive approach was performed in 45.3% of patients; concomitant procedures were done in 35.9% of cases. Within 30 days, 0.3 and 0.7% valve-related reinterventions were reported. Transient ischaemic attack, disabling and non-disabling strokes were limited (0.4%, 0.4% and 0.7%, respectively). Pacemaker implant was required in 5.7% of patients. Intra-prosthetic regurgitation ≥2 was present in 0.2% of cases, while paravalvular leak ≥2 in only 0.1%. At a maximum follow-up of 8 years, 1.9% of cardiovascular deaths and 0.8% of valve-related reintervention occurred. Among the 10 cases of structural valve deterioration (mean 5.6 ± 1.4 years after implant; range: 2.6-7.3 years), 9 were treated with a transcatheter vale-in-valve implantation and 1 with explant. Mean pressure gradient decreased from 45.8 ± 16.5 mmHg preoperatively to 13.3 ± 5.2 mmHg at discharge and remained stable during follow-up. Conclusions: This experience represents the largest prospective real-world cohort of patients treated with Perceval showing that Perceval is a safe and effective alternative to conventional surgical aortic valve replacement, providing favourable clinical and haemodynamic results also at mid-term follow-up.
Language	English
Publishing date	2023-06-12
Publishing country	England
Document type	Journal Article
ISSN	2753-670X
ISSN (online)	2753-670X
DOI	10.1093/icvts/ivad103
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Delicate Role of PD-L1/PD-1 Axis in Blood Vessel Inflammatory Diseases

Priya Veluswamy / Max Wacker / Maximilian Scherner / Jens Wippermann

International Journal of Molecular Sciences, Vol 21, Iss 8159, p

Current Insight and Future Significance

2020 Volume 8159

Abstract	Immune checkpoint molecules are the antigen-independent generator of secondary signals that aid in maintaining the homeostasis of the immune system. The programmed death ligand-1 (PD-L1)/PD-1 axis is one among the most extensively studied immune-inhibitory checkpoint molecules, which delivers a negative signal for T cell activation by binding to the PD-1 receptor. The general attributes of PD-L1’s immune-suppressive qualities and novel mechanisms on the barrier functions of vascular endothelium to regulate blood vessel-related inflammatory diseases are concisely reviewed. Though targeting the PD-1/PD-L1 axis has received immense recognition—the Nobel Prize in clinical oncology was awarded in the year 2018 for this discovery—the use of therapeutic modulating strategies for the PD-L1/PD-1 pathway in chronic inflammatory blood vessel diseases is still limited to experimental models. However, studies using clinical specimens that support the role of PD-1 and PD-L1 in patients with underlying atherosclerosis are also detailed. Of note, delicate balances in the expression levels of PD-L1 that are needed to preserve T cell immunity and to curtail acute as well as chronic infections in underlying blood vessel diseases are discussed. A significant link exists between altered lipid and glucose metabolism in different cells and the expression of PD-1/PD-L1 molecules, and its possible implications on vascular inflammation are justified. This review summarizes the most recent insights concerning the role of the PD-L1/PD-1 axis in vascular inflammation and, in addition, provides an overview exploring the novel therapeutic approaches and challenges of manipulating these immune checkpoint proteins, PD-1 and PD-L1, for suppressing blood vessel inflammation.
Keywords	programmed death-1 (PD-1) ; PD-L1 ; PD-L2 ; coronary artery disease ; atherosclerosis and blood vessel inflammatory diseases ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2020-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Bacterial Nanocellulose-Based Grafts for Cell Colonization Studies: An In Vitro Bioreactor Perfusion Model.

Wacker, Max / Riedel, Jan / Veluswamy, Priya / Scherner, Maximilian / Wippermann, Jens / Walles, Heike / Hülsmann, Jörn

Methods in molecular biology (Clifton, N.J.)

2021 Volume 2436, Page(s) 205–222

Abstract: With the aging population, the demand for artificial small diameter vascular grafts is constantly increasing, as the availability of autologous grafts is limited due to vascular diseases. A confluent lining with endothelial cells is considered to be a ... ...

Abstract	With the aging population, the demand for artificial small diameter vascular grafts is constantly increasing, as the availability of autologous grafts is limited due to vascular diseases. A confluent lining with endothelial cells is considered to be a cornerstone for long-term patency of artificial small diameter grafts. We use bacterial nanocellulose off-the-shelf grafts and describe a detailed methodology to study the ability of these grafts to re-colonize with endothelial cells in an in vitro bioreactor model. The viability of the constructs generated in this process was investigated using established cell culture and tissue engineering methods, which includes WST-1 proliferation assay, AcLDL uptake assay, lactate balancing and histological characterization. The data generated this straight forward methodology allow an initial assessment of the principal prospects of success in forming a stable endothelium in artificial vascular prostheses.
MeSH term(s)	Bioreactors ; Blood Vessel Prosthesis ; Endothelial Cells ; Perfusion ; Tissue Engineering/methods
Language	English
Publishing date	2021-09-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/7651_2021_417
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Activation of the stress response among the cardiac surgical residents: comparison of teaching procedures and other (daily) medical activities.

Awad, George / Pohl, Robert / Darius, Sabine / Thielmann, Beatrice / Varghese, Sam / Wacker, Max / Schmidt, Hendrik / Wippermann, Jens / Scherner, Maximilian / Böckelmann, Irina

Journal of cardiothoracic surgery

2022 Volume 17, Issue 1, Page(s) 112

Abstract: Background: The aim of this Pilot study was to investigate the cardiac surgical residents' workload during different surgical teaching interventions and to compare their stress levels with other working time spent in the intensive care unit or normal ... ...

Abstract	Background: The aim of this Pilot study was to investigate the cardiac surgical residents' workload during different surgical teaching interventions and to compare their stress levels with other working time spent in the intensive care unit or normal ward. Methods: The objective stress was assessed using two cardiac surgical residents' heart rate variability (HRV) both during surgical activities (32 selected teaching operations (coronary artery bypass graft n = 26 and transcatheter aortic valve implantation n = 6), and during non-surgical periods. Heart rate, time and frequency domains as well as non-linear parameters were analyzed using the Wilcoxon test. Results: The parasympathetic activity was significantly reduced during the surgical phase, compared to the non-surgical phase: Mean RR (675.7 ms vs. 777.3 ms), RMSSD (23.1 ms vs. 34.0 ms) and pNN50 (4.7% vs. 10.6%). This indicates that the residents had a higher stress level during surgical activities in comparison to the non-surgical times. The evaluation of the Stress Index during the operations and outside the operating room (8.07 vs. 10.6) and the parasympathetic nervous system index (- 1.75 to - 0.91) as well as the sympathetic nervous system index (1.84 vs. 0.65) confirm the higher stress level during surgery. This can be seen too used the FFT Analysis with higher intraoperative LF/HF ratio (6.7 vs. 3.8). Conclusion: HRV proved to be a good, objective method of identifying stress among physicians both in and outside the operating room. Our results show that residents are exposed to high psychological workloads during surgical activities, especially as the operating surgeon.
MeSH term(s)	Cardiac Surgical Procedures ; Heart Rate/physiology ; Humans ; Internship and Residency ; Pilot Projects
Language	English
Publishing date	2022-05-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-022-01873-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Acute kidney injury after transcatheter aortic valve implantation.

Scherner, Maximilian / Wahlers, Thorsten

Journal of thoracic disease

2015 Volume 7, Issue 9, Page(s) 1527–1535

Abstract: Even though experience and techniques have constantly improved over the last years, peri- and postprocedural complications in high risk TAVI-collectives remain a major issue affecting outcome and survival. Acute kidney injury (AKI) is a frequent ... ...

Abstract	Even though experience and techniques have constantly improved over the last years, peri- and postprocedural complications in high risk TAVI-collectives remain a major issue affecting outcome and survival. Acute kidney injury (AKI) is a frequent complication after transcatheter aortic valve implantation (TAVI) and effects outcome and survival. However, the definition of AKI in published studies dealing with the phenomenon of AKI after TAVI varies widely and lacks standardization. This Review aims to present an overview over the current literature concerning AKI after TAVI with regard to the definition of AKI, the impact of AKI on mortality and potential risk factors for renal impairment after TAVI.
Language	English
Publishing date	2015-11-04
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.3978/j.issn.2072-1439.2015.06.14
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Immunophenotyping of Monocyte Migration Markers and Therapeutic Effects of Selenium on IL-6 and IL-1β Cytokine Axes of Blood Mononuclear Cells in Preoperative and Postoperative Coronary Artery Disease Patients.

Wacker, Max / Ball, Anna / Beer, Hans-Dietmar / Schmitz, Ingo / Borucki, Katrin / Azizzadeh, Faranak / Scherner, Maximilian / Awad, George / Wippermann, Jens / Veluswamy, Priya

International journal of molecular sciences

2023 Volume 24, Issue 8

Abstract: Multivessel coronary artery disease (CAD) is characterized by underlying chronic vascular inflammation and occlusion in the coronary arteries, where these patients undergo coronary artery bypass grafting (CABG). Since post-cardiotomy inflammation is a ... ...

Abstract	Multivessel coronary artery disease (CAD) is characterized by underlying chronic vascular inflammation and occlusion in the coronary arteries, where these patients undergo coronary artery bypass grafting (CABG). Since post-cardiotomy inflammation is a well known phenomenon after CABG, attenuation of this inflammation is required to reduce perioperative morbidity and mortality. In this study, we aimed to phenotype circulating frequencies and intensities of monocyte subsets and monocyte migration markers, respectively, and to investigate the plasma level of inflammatory cytokines and chemokines between preoperative and postoperative CAD patients and later, to intervene the inflammation with sodium selenite. We found a higher amplitude of inflammation, postoperatively, in terms of CCR1
MeSH term(s)	Humans ; Coronary Artery Disease/drug therapy ; Coronary Artery Disease/surgery ; Cytokines/genetics ; Immunophenotyping ; Inflammation ; Interleukin-6/pharmacology ; Monocytes ; Selenium/pharmacology ; Selenium/therapeutic use ; Tumor Necrosis Factor-alpha/pharmacology ; Interleukin-1beta/metabolism
Chemical Substances	Cytokines ; Interleukin-6 ; Selenium (H6241UJ22B) ; Tumor Necrosis Factor-alpha ; Interleukin-1beta
Language	English
Publishing date	2023-04-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24087198
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