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  1. Book: Chronic kidney disease and hypertension

    Weir, Matthew R.

    (Clinical hypertension and vascular diseases)

    2015  

    Author's details Matthew R. Weir ; Edgar V. Lerma ed
    Series title Clinical hypertension and vascular diseases
    Language English
    Size XIII, 257 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT018516747
    ISBN 978-1-4939-1981-9 ; 9781493919826 ; 1-4939-1981-4 ; 1493919822
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 276 available for loan (reading room) Lesesaal EG

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  2. Book: Evidence based management of hypertension

    Weir, Matthew R.

    2010  

    Title variant Evidence-based management of hypertension
    Author's details Matthew R. Weir
    Language English
    Size X, 232 S. : graph. Darst.
    Edition 1. ed.
    Publisher tfm Publ
    Publishing place Harley
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT015867058
    ISBN 978-1-903378-72-4 ; 1-903378-72-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 3460 order for loan Magazin

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  3. Article ; Online: Decision Points in the Management of Patients with Diabetic Kidney Disease.

    Weir, Matthew R

    The Journal of family practice

    2021  Volume 70, Issue 6S, Page(s) S7–S12

    Abstract: Learning objectives: At the end of the activity, participants will be able to: • Identify the risks of kidney disease and their consequences in patients with type 2 diabetes (T2D). • Appropriately screen for the presence of chronic kidney disease (CKD) ... ...

    Abstract Learning objectives: At the end of the activity, participants will be able to: • Identify the risks of kidney disease and their consequences in patients with type 2 diabetes (T2D). • Appropriately screen for the presence of chronic kidney disease (CKD) in patients with T2D. • Initiate evidence-based therapy to slow the progression of kidney disease in patients with T2D and CKD. • Describe the benefits and limitations of the steroidal and nonsteroidal mineralocorticoid receptor antagonists in the treatment of patients with DKD.
    MeSH term(s) Clinical Decision-Making ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Disease Management ; Disease Progression ; Humans ; Medication Adherence ; Mineralocorticoid Receptor Antagonists/therapeutic use ; Referral and Consultation ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/etiology ; Renal Insufficiency, Chronic/therapy
    Chemical Substances Mineralocorticoid Receptor Antagonists
    Language English
    Publishing date 2021-08-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 197883-4
    ISSN 1533-7294 ; 0094-3509
    ISSN (online) 1533-7294
    ISSN 0094-3509
    DOI 10.12788/jfp.0217
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1274: Show issues Location:
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    Zs.MO 444: Show issues

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  4. Article ; Online: Managing Anemia across the Stages of Kidney Disease in Those Hyporesponsive to Erythropoiesis-Stimulating Agents.

    Weir, Matthew R

    American journal of nephrology

    2021  Volume 52, Issue 6, Page(s) 450–466

    Abstract: Background: Patients with CKD frequently have anemia that results from iron-restricted erythropoiesis and inflammation. Anemia of CKD is currently managed with iron supplements and erythropoiesis-stimulating agents (ESAs) to promote erythropoiesis and ... ...

    Abstract Background: Patients with CKD frequently have anemia that results from iron-restricted erythropoiesis and inflammation. Anemia of CKD is currently managed with iron supplements and erythropoiesis-stimulating agents (ESAs) to promote erythropoiesis and with RBC transfusion in severe cases. Hyporesponse to ESAs, or the need for larger than usual doses to attain a given hemoglobin (Hb) level, is associated with increased morbidity and mortality and presents a pressing clinical challenge, particularly for patients on dialysis. This paper reviews ESA hyporesponse and potential new therapeutic options in the management of anemia of CKD.
    Summary: The most common causes of ESA hyporesponse include iron deficiency and inflammation, and to a lesser degree, secondary hyperparathyroidism, inadequate dialysis, malnutrition, and concomitant medications. Management of ESA hyporesponse is multipronged and involves treating low level infections, ensuring adequate nutrition, and optimizing iron status and dialysis modality, although some patients can remain refractory. Inflammation directly increases production and secretion of hepcidin, contributes to an impaired response to hypoxia, and suppresses proliferation of erythroid progenitors. Coordination of renal and hepatic erythropoietin (EPO) production and iron metabolism is under the control of hypoxia-inducible factors (HIF), which are in turn regulated by HIF-prolyl hydroxylases (HIF-PHs). HIF-PHs and hepcidin are therefore attractive potential drug targets particularly in patients with ESA hyporesponse. Several oral HIF-PH inhibitors have been evaluated in patients with anemia of CKD and have been shown to increase Hb and reduce hepcidin regardless of inflammation, iron status, or dialysis modality. These sustained effects are achieved through more modest increases in endogenous EPO compared with ESAs. Key Messages: Treatments that address ESA hyporesponse remain a significant unmet clinical need in patients with anemia of CKD. New therapies such as HIF-PH inhibitors have the potential to address fundamental aspects of ESA hyporesponse and provide a new therapeutic option in these patients.
    MeSH term(s) Anemia/etiology ; Anemia/therapy ; Enzyme Inhibitors/therapeutic use ; Hematinics/therapeutic use ; Hemoglobins/metabolism ; Hepcidins/antagonists & inhibitors ; Humans ; Hyperparathyroidism, Secondary/complications ; Hypoxia-Inducible Factor-Proline Dioxygenases/antagonists & inhibitors ; Infections/complications ; Infections/drug therapy ; Inflammation/complications ; Iron/therapeutic use ; Iron Deficiencies/complications ; Iron Deficiencies/drug therapy ; Nutritional Status ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/therapy
    Chemical Substances Enzyme Inhibitors ; Hematinics ; Hemoglobins ; Hepcidins ; Iron (E1UOL152H7) ; Hypoxia-Inducible Factor-Proline Dioxygenases (EC 1.14.11.29)
    Language English
    Publishing date 2021-07-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 604540-6
    ISSN 1421-9670 ; 0250-8095
    ISSN (online) 1421-9670
    ISSN 0250-8095
    DOI 10.1159/000516901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Multimodal efforts to slow the progression of chronic kidney disease in patients with type 2 diabetes mellitus.

    Rastogi, Anjay / Weir, Matthew R

    Journal of diabetes and its complications

    2023  Volume 37, Issue 8, Page(s) 108515

    Abstract: In patients with chronic kidney disease (CKD) associated with type 2 diabetes mellitus (T2DM), slowing kidney disease progression is an important therapeutic goal. Many patients with T2DM and CKD also have cardiovascular (CV) comorbidities. Renin- ... ...

    Abstract In patients with chronic kidney disease (CKD) associated with type 2 diabetes mellitus (T2DM), slowing kidney disease progression is an important therapeutic goal. Many patients with T2DM and CKD also have cardiovascular (CV) comorbidities. Renin-angiotensin-aldosterone system inhibitors (RAASis), which include angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs), are drugs with known antihypertensive effects as well as CV and kidney protective effects in patients with CKD. Studies have shown that adding a sodium-glucose cotransporter-2 (SGLT2) inhibitor to ACEI or ARB therapy has additive benefits in terms of kidney and CV protection in patients with CKD (with/without T2DM). For patients with CKD associated with T2DM who have persistent albuminuria despite taking the maximum tolerated dose of a RAASi, adding a nonsteroidal mineralocorticoid receptor antagonist (finerenone) has demonstrated CV and kidney benefits in clinical trials. In this article, we review the use of ACEIs and ARBs for their kidney and CV protective effects when used alone or in combination with a drug with a different mechanism of action. From reviewing the available evidence, it seems clear that a multimodal drug effort is needed to achieve maximum kidney and CV protective effects for patients with CKD associated with T2DM.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Angiotensin Receptor Antagonists/therapeutic use ; Renal Insufficiency, Chronic ; Antihypertensive Agents/therapeutic use ; Renin-Angiotensin System
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors ; Angiotensin Receptor Antagonists ; Antihypertensive Agents
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1105840-7
    ISSN 1873-460X ; 1056-8727
    ISSN (online) 1873-460X
    ISSN 1056-8727
    DOI 10.1016/j.jdiacomp.2023.108515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2225: Show issues Location:
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  6. Article ; Online: Reserpine: A New Consideration of and Old Drug for Refractory Hypertension.

    Weir, Matthew R

    American journal of hypertension

    2020  Volume 33, Issue 8, Page(s) 708–710

    MeSH term(s) Blood Pressure ; Diuretics ; Humans ; Hypertension ; Hypotension ; Reserpine
    Chemical Substances Diuretics ; Reserpine (8B1QWR724A)
    Language English
    Publishing date 2020-04-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 639383-4
    ISSN 1941-7225 ; 1879-1905 ; 0895-7061
    ISSN (online) 1941-7225 ; 1879-1905
    ISSN 0895-7061
    DOI 10.1093/ajh/hpaa069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2329: Show issues Location:
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  7. Book: Henrich's principles and practice of dialysis

    Henrich, William L. / Lerma, Edgar V. / Weir, Matthew R.

    2017  

    Title variant Principles and practice of dialysis
    Author's details edited by Edgar V. Lerma, MD, FACP, FASN, FNKF; Matthew R. Weir, MD
    Language English
    Size xiii, 748 Seiten, Illustrationen, Diagramme
    Edition Fifth edition
    Publisher Wolters Kluwer
    Publishing place Philadelphia
    Publishing country United States
    Document type Book
    Note Zugang zur Internetausgabe über Code
    HBZ-ID HT019014043
    ISBN 978-1-4963-1820-6 ; 1-4963-1820-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 A 2368 available for loan (reading room) Lesesaal EG
    Zugang zur Internetausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  8. Article ; Online: Initial Drops in Glomerular Filtration Rate with Certain Drug Classes Retard Kidney Disease Progression.

    Bakris, George L / Weir, Matthew R

    American journal of nephrology

    2022  Volume 53, Issue 7, Page(s) 513–515

    MeSH term(s) Disease Progression ; Glomerular Filtration Rate ; Humans ; Kidney ; Kidney Diseases
    Language English
    Publishing date 2022-06-10
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 604540-6
    ISSN 1421-9670 ; 0250-8095
    ISSN (online) 1421-9670
    ISSN 0250-8095
    DOI 10.1159/000524890
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1635: Show issues Location:
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  9. Article ; Online: The role of blood pressure control in the prevention of cardiorenal disease in patients with chronic kidney disease.

    Bonifant, George / Weir, Matthew R

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2022  Volume 38, Issue 2, Page(s) 264–270

    MeSH term(s) Humans ; Blood Pressure ; Hypertension/complications ; Renal Insufficiency, Chronic/complications ; Heart Diseases ; Kidney ; Cardio-Renal Syndrome/etiology ; Cardio-Renal Syndrome/prevention & control
    Language English
    Publishing date 2022-11-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfac313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 329: Show issues

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  10. Article ; Online: Therapeutic Potential of Newer Drugs for Treating Hyperkalemia.

    Weir, Matthew R

    Clinical journal of the American Society of Nephrology : CJASN

    2019  Volume 14, Issue 6, Page(s) 787–788

    MeSH term(s) Angiotensin-Converting Enzyme Inhibitors ; Humans ; Hyperkalemia ; Renin-Angiotensin System
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors
    Language English
    Publishing date 2019-05-20
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.04750419
    Database MEDical Literature Analysis and Retrieval System OnLINE

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