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  1. Article ; Online: Living Donor Liver Transplantation Using the RAPID Technique in the Cirrhotic Setting Is Still in Its Developmental Stage.

    Lim, Chetana / Scatton, Olivier

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2021  Volume 27, Issue 5, Page(s) 772–774

    MeSH term(s) Carcinoma, Hepatocellular ; Humans ; Liver Cirrhosis/surgery ; Liver Neoplasms ; Liver Transplantation ; Living Donors
    Language English
    Publishing date 2021-02-12
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1002/lt.25971
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    Zs.A 4702: Show issues Location:
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  2. Article ; Online: Comment on "Survival Following Liver Transplantation for Patients With Nonresectable Liver-only Colorectal Metastases": Shaking the Coconut Tree.

    Azoulay, Daniel / Lim, Chetana

    Annals of surgery

    2020  Volume 271, Issue 5, Page(s) e122–e124

    MeSH term(s) Cocos ; Colorectal Neoplasms ; Humans ; Liver Neoplasms ; Liver Transplantation ; Trees
    Language English
    Publishing date 2020-04-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000003605
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  3. Article ; Online: The left lateral sectionectomy first approach during total hepatectomy for difficult liver transplantation.

    Laroche, Sophie / Lim, Chetana / Perdigao, Fabiano / Goumard, Claire / Savier, Eric / Rousseau, Géraldine / Scatton, Olivier

    HPB : the official journal of the International Hepato Pancreato Biliary Association

    2023  Volume 25, Issue 3, Page(s) 384–386

    MeSH term(s) Humans ; Hepatectomy ; Liver Transplantation ; Laparoscopy ; Living Donors ; Liver Neoplasms/surgery
    Language English
    Publishing date 2023-01-20
    Publishing country England
    Document type Letter
    ZDB-ID 2131251-5
    ISSN 1477-2574 ; 1365-182X
    ISSN (online) 1477-2574
    ISSN 1365-182X
    DOI 10.1016/j.hpb.2023.01.004
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  4. Article ; Online: Liver Transplantation From Controlled Donation After Circulatory Death Donors With Normothermic Regional Perfusion Versus Donation After Brain Death Donors.

    Savier, Eric / Lim, Chetana / Scatton, Olivier

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2021  Volume 28, Issue 3, Page(s) 508–509

    MeSH term(s) Brain Death ; Humans ; Liver Transplantation/adverse effects ; Perfusion ; Tissue Donors
    Language English
    Publishing date 2021-11-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1002/lt.26363
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  5. Article ; Online: Anticipating Potential Perioperative Complication: In Reply to Monden and Colleagues.

    Turco, Célia / Lim, Chetana / Goumard, Claire / Scatton, Olivier

    Journal of the American College of Surgeons

    2020  Volume 231, Issue 4, Page(s) 499–500

    MeSH term(s) Hepatectomy ; Humans ; Laparoscopy ; Liver ; Postoperative Complications
    Language English
    Publishing date 2020-08-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1181115-8
    ISSN 1879-1190 ; 1072-7515
    ISSN (online) 1879-1190
    ISSN 1072-7515
    DOI 10.1016/j.jamcollsurg.2020.06.012
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  6. Article ; Online: Complex Hepatectomy Under Total Vascular Exclusion of the Liver Preserving the Caval Flow with Portal Hypothermic Perfusion and Temporary Portacaval Shunt: A Proof of Concept.

    Azoulay, Daniel / Salloum, Chady / Allard, Marc-Antoine / Serrablo, Alejandro / Moussa, Maya / Romano, Pierluigi / Pietraz, Daniel / Golse, Nicolas / Lim, Chetana

    Annals of surgical oncology

    2024  

    Abstract: Background: Hypothermic liver perfusion decreases ischemia/reperfusion injury during hepatectomy under standard total vascular exclusion (TVE) of the liver. This surgery needs venovenous bypass and is hampered by high morbi-mortality. TVE preserving the ...

    Abstract Background: Hypothermic liver perfusion decreases ischemia/reperfusion injury during hepatectomy under standard total vascular exclusion (TVE) of the liver. This surgery needs venovenous bypass and is hampered by high morbi-mortality. TVE preserving the inferior vena cava (IVC) flow is hemodynamically well tolerated but remains limited in duration when performed under liver normothermia. The objective of this study was to report the results of TVE preserving the caval flow, modified to allow hypothermic liver perfusion and obviate splanchnic congestion.
    Patients and methods: The technique, indicated for tumors abutting large tributaries of the hepatic veins but sparing their roots in IVC and the latter, was applied when TVE was anticipated to last for ≥ 60 min. It combines continuous TVE preserving the IVC flow with hypothermic liver perfusion and temporary portacaval shunt (PCS). Results are given as median (range).
    Results: Vascular control was achieved in 13 patients with excellent hemodynamical tolerance. PCS was direct or via an interposed synthetic graft (five and eight cases, respectively). Liver temperature dropped to 16.5 (6-24) °C under perfusion of 2 (2-4) L of cold perfusate. TVE lasted 67 (54-125) min and 4.5 (0-8) blood units were transfused. Resection was major in nine cases and was complete in all cases. Five complications occurred in four patients, and the 90-day mortality rate was zero.
    Conclusions: This technique maintains stable hemodynamics and combines the advantages of in situ or ex situ standard TVE with hypothermic liver perfusion, without their inherent prolongation of ischemia time and need for venovenous bypass.
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-024-15227-7
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    Zs.A 4042: Show issues Location:
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  7. Article ; Online: Prognosis of a Heterogeneous TRG Pathological Response to Neoadjuvant Chemotherapy in Patients who Undergo Resection for Colorectal Liver Metastases.

    Laroche, Sophie / Scatton, Olivier / Charlotte, Frederic / Bachet, Jean-Baptiste / Lim, Chetana / Fuks, David / Goumard, Claire

    Annals of surgical oncology

    2024  

    Abstract: Background: Optimal management of colorectal liver metastasis (CRLM) is based on a combination of chemotherapy and surgical resection. The tumor regression grade (TRG) score is a histological scoring system to evaluate response to chemotherapy. The ... ...

    Abstract Background: Optimal management of colorectal liver metastasis (CRLM) is based on a combination of chemotherapy and surgical resection. The tumor regression grade (TRG) score is a histological scoring system to evaluate response to chemotherapy. The prognosis of a heterogeneous response in cases of multiple metastases has not been evaluated according to the TRG score.
    Patients and methods: All patients who underwent liver resection for multiple CRLM after neoadjuvant chemotherapy in two tertiary centers from January 2015 to April 2019 were retrospectively included. Oncological characteristics and outcome between TRG 1-2-3 (good response group), TRG 4-5 (poor response group) and heterogeneous TRG (good and poor TRG among different lesions within the same patient) groups were compared.
    Results: Among the 327 patients included, 134 (41.0%) had good response (TRG 1-2-3), 120 (36.7%) had poor response (TRG 4-5), and 73 (22.3%) had heterogeneous response. The type and number of cycles of chemotherapy, k-Ras mutational status, and tumor number or size did not differ between the three groups. Use of irinotecan-based and anti-VEGF neoadjuvant therapy was associated with better TRG response [irinotecan-based: hazard ratio (OR) = 1.744; p = 0.045; anti-VEGF neoadjuvant therapy: 2.054; p = 0.005). Overall survival (OS) was higher in the 1-2-3 TRG group than in the heterogeneous TRG group (2-year OS = 81.3% vs. 60.3%, respectively; p = 0.003) and the 4-5 TRG group (2-year OS = 81.3% vs. 55.0%, respectively; p = 0.012) and similar between the heterogeneous and 4-5 TRG groups.
    Conclusions: The proportion of heterogeneous pathological response according to TRG is 22.3%, and the prognosis is comparable to that of poor pathological response.
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-024-15196-x
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    Zs.A 4042: Show issues Location:
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  8. Article ; Online: Patients' perceptions of the definition of a textbook outcome following liver transplantation.

    Bonnet, Jeremy / Scatton, Olivier / Goumard, Claire / Savier, Eric / Perdigao, Fabiano / Rousseau, Géraldine / Lim, Chetana

    HPB : the official journal of the International Hepato Pancreato Biliary Association

    2023  Volume 25, Issue 12, Page(s) 1523–1530

    Abstract: Background: A textbook outcome (TO) describes the results of a successful liver transplantation (LT) in which all aspects of the LT and posttransplant courses were uneventful. We compared patient perceived experience of a TO with clinically defined TO.!# ...

    Abstract Background: A textbook outcome (TO) describes the results of a successful liver transplantation (LT) in which all aspects of the LT and posttransplant courses were uneventful. We compared patient perceived experience of a TO with clinically defined TO.
    Methods: This was a single-institution cohort study with retrospective chart review including patients who underwent LT from 2019 to 2021. Patients were asked to complete the survey at a scheduled posttransplant visit. The survey was designed to assess their viewpoints on the definition of a TO. A clinically defined TO was defined as no mortality, no severe complications, no need for reintervention, no prolonged hospital and intensive care unit stays, and no readmission.
    Results: Of the 182 patients who were contacted, 132 (72.5%) completed the survey. Overall, 98 patients (74%) considered that they had experienced a TO. The clinically defined TO rate was 22.0%. Multivariate analysis showed that patients who did not experience severe complications were more likely to consider that they had a TO (P = 0.01; odds ratio: 3.2; 95% confidence interval: 1.3-7.9).
    Conclusions: From patients' perspectives, survival and avoidance of complications were the major characteristics of a TO.
    MeSH term(s) Humans ; Liver Transplantation/adverse effects ; Cohort Studies ; Retrospective Studies ; Multivariate Analysis ; Length of Stay
    Language English
    Publishing date 2023-07-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2131251-5
    ISSN 1477-2574 ; 1365-182X
    ISSN (online) 1477-2574
    ISSN 1365-182X
    DOI 10.1016/j.hpb.2023.07.905
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  9. Article ; Online: Laparoscopic Anatomic Liver Resection of Segment 8 Using the Transfissural Glissonean Approach: The Ton That Tung Technique Revisited.

    Turco, Célia / Lim, Chetana / Goumard, Claire / Scatton, Oliver

    Journal of the American College of Surgeons

    2020  Volume 230, Issue 5, Page(s) 836

    MeSH term(s) Aleurites ; Hepatectomy ; Humans ; Laparoscopy ; Liver/surgery
    Language English
    Publishing date 2020-04-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1181115-8
    ISSN 1879-1190 ; 1072-7515
    ISSN (online) 1879-1190
    ISSN 1072-7515
    DOI 10.1016/j.jamcollsurg.2020.01.003
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  10. Article ; Online: Standardized Technique of Selective Left Liver Vascular Exclusion During Laparoscopic Liver Resection for Benign and Malignant Tumors.

    Vandermeulen, Morgan / Lim, Chetana / Goumard, Claire / Scatton, Olivier

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

    2021  Volume 25, Issue 10, Page(s) 2720–2725

    Abstract: Background: Tumors located close to major hepatic veins pose a technical challenge to standard laparoscopic liver resection. Hepatic outflow occlusion may reduce the risks of bleeding from hepatic vein and gas embolism. The aim of this study was to ... ...

    Abstract Background: Tumors located close to major hepatic veins pose a technical challenge to standard laparoscopic liver resection. Hepatic outflow occlusion may reduce the risks of bleeding from hepatic vein and gas embolism. The aim of this study was to detail our standardized laparoscopic approach for a safe extrahepatic control of the common trunk of middle and left hepatic veins during laparoscopic liver resection and to assess its feasibility in patients with tumors located in both right and left lobes of the liver.
    Methods: Data of 25 consecutive patients who underwent laparoscopic liver resection with extrahepatic control of the common trunk of middle and left hepatic veins were reviewed.
    Results: All patients underwent primary hepatectomy. The vast majority (84%) of patients had malignant tumors. The control of the common trunk of middle and left hepatic veins was achieved in 96% of patients. There were 14 (56%) major hepatectomies and 11 (44%) minor hepatectomies. Some form of vascular clamping was performed in 23 (62%) patients: Pringle maneuver in 17 (median time = 45 min; range, 10-109) and selective vascular exclusion of the liver in 6 patients (median time = 30 min; range, 15-94). The median duration of operation was 254 min (range, 70-441). There was one case (4%) of gas embolism but without any complications during the postoperative course. Conversion to open surgery was performed in 2 (7.7%) patients: 1 for oncologic reason and 1 for non-progression during the transection plane. Perioperative blood transfusion rate was nil. The overall morbidity rate was 24%.
    Conclusions: The laparoscopic approach for an extrahepatic control of the common trunk of middle and left hepatic veins is reproducible, safe, and effective, and can be applied during laparoscopic liver resection for tumors close to major hepatic veins.
    MeSH term(s) Blood Loss, Surgical ; Hepatectomy/adverse effects ; Hepatic Veins/surgery ; Humans ; Laparoscopy ; Liver Neoplasms/surgery
    Language English
    Publishing date 2021-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2012365-6
    ISSN 1873-4626 ; 1934-3213 ; 1091-255X
    ISSN (online) 1873-4626 ; 1934-3213
    ISSN 1091-255X
    DOI 10.1007/s11605-021-05059-1
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