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Article ; Online: Correction: Clinical performance of lung ultrasound in predicting time-dependent changes in lung aeration in ARDS patients.

Costamagna, Andrea / Steinberg, Irene / Pivetta, Emanuele / Arina, Pietro / Veglia, Simona / Brazzi, Luca / Fanelli, Vito

Journal of clinical monitoring and computing

2024

Language	English
Publishing date	2024-03-16
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	1418733-4
ISSN	1573-2614 ; 1387-1307 ; 0748-1977
ISSN (online)	1573-2614
ISSN	1387-1307 ; 0748-1977
DOI	10.1007/s10877-024-01137-2
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Article ; Online: Feature Selection Based on a Genetic Algorithm for Optimizing Weaning Success.

Rosati, Samanta / Scotto, Andrea / Fanelli, Vito / Balestra, Gabriella

Studies in health technology and informatics

2023 Volume 302, Page(s) 566–570

Abstract: Finding the right time for weaning from ventilator is a difficult clinical decision. Several systems based on machine or deep learning are reported in literature. However, the results of these applications are not completely satisfactory and may be ... ...

Abstract	Finding the right time for weaning from ventilator is a difficult clinical decision. Several systems based on machine or deep learning are reported in literature. However, the results of these applications are not completely satisfactory and may be improved. An important aspect is represented by the features used as input of these systems. In this paper we present the results of the application of genetic algorithms to perform feature selection on a dataset containing 13688 patients under mechanical ventilation characterizing by 58 variables, extracted from the MIMIC III database. The results show that all features are important, but four of them are essential: 'Sedation_days', 'Mean_Airway_Pressure', 'PaO2', and 'Chloride'. This is only the initial step to obtain a tool to be added to the other clinical indices for minimize the risk of extubation failure.
MeSH term(s)	Humans ; Ventilator Weaning/methods ; Respiration, Artificial/methods ; Ventilators, Mechanical ; Time Factors ; Algorithms
Language	English
Publishing date	2023-05-19
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI230206
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Article ; Online: Hemodynamic Insights From Simultaneous Common Carotid and Internal Jugular Doppler Ultrasonography in a Patient With Hypoxemia and Multiple Organ Dysfunction.

Kenny, Jon-Émile S / Eibl, Joseph K / Horner, Christine / Arcozzi, Daniele / Bonomi, Federico / Fanelli, Vito / Visioli, Antonio / Goffi, Alberto / Piva, Simone

Chest

2024 Volume 165, Issue 4, Page(s) e107–e112

MeSH term(s)	Humans ; Multiple Organ Failure ; Ultrasonography ; Hemodynamics ; Ultrasonography, Doppler ; Hypoxia/etiology ; Jugular Veins/diagnostic imaging
Language	English
Publishing date	2024-03-11
Publishing country	United States
Document type	Case Reports
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2023.11.023
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Zs.MO 349: Show issues

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Article ; Online: Assisted mode of mechanical ventilation: choose wisely.

Costamagna, Andrea / Fanelli, Vito

Minerva anestesiologica

2019 Volume 85, Issue 8, Page(s) 814–815

MeSH term(s)	Feasibility Studies ; Humans ; Interactive Ventilatory Support ; Prospective Studies ; Respiration, Artificial ; Respiratory Insufficiency
Language	English
Publishing date	2019-05-03
Publishing country	Italy
Document type	Editorial ; Comment
ZDB-ID	123584-9
ISSN	1827-1596 ; 0026-4717 ; 0375-9393
ISSN (online)	1827-1596
ISSN	0026-4717 ; 0375-9393
DOI	10.23736/S0375-9393.19.13706-6
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Article ; Online: Chitosan/snail slime films as multifunctional platforms for potential biomedical and cosmetic applications: physical and chemical characterization.

Gubitosa, Jennifer / Rizzi, Vito / Fini, Paola / Fanelli, Fiorenza / Sibillano, Teresa / Corriero, Nicola / Cosma, Pinalysa

Journal of materials chemistry. B

2023 Volume 11, Issue 12, Page(s) 2638–2649

Abstract: Due to the pollution problem, the use of more sustainable materials with a reduced environmental impact, spanning across biocompatible and biodegradable polymers, is growing worldwide in many different fields, particularly when referring to applications ... ...

Abstract	Due to the pollution problem, the use of more sustainable materials with a reduced environmental impact, spanning across biocompatible and biodegradable polymers, is growing worldwide in many different fields, particularly when referring to applications in Life Sciences. Accordingly, with the aim of developing multifunctional materials for potential cosmetic/biomedical purposes, this work reports the physical and chemical characterization of chitosan-based films blended with snail slime, exhibiting antioxidant and sunscreen features. A suitable formulation for preparing free-standing chitosan platforms, mixing low molecular weight chitosan, lactic acid, glycerol, and snail slime into an appropriate ratio, is thus described. The results obtained by morphological analysis and ATR-FTIR spectroscopy, XRD, swelling analysis (also when varying pH, ionic strength, and temperature), and WVTR measurements evidence a uniform distribution of snail slime inside the chitosan network, forming more compacted structures. At first, the UV-Vis analysis is used to investigate the theoretical Sun Protection Factor, finding that these innovative platforms can be used for preventing sunburn. Then, the antioxidant features are investigated using the ABTS assay, displaying a snail slime-mediated and dose-dependent boosted activity.
MeSH term(s)	Chitosan/chemistry ; Antioxidants ; Polymers ; Sunscreening Agents ; Spectroscopy, Fourier Transform Infrared
Chemical Substances	Chitosan (9012-76-4) ; Antioxidants ; Polymers ; Sunscreening Agents
Language	English
Publishing date	2023-03-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d2tb02119f
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Article ; Online: Cytokines Removal During

Boffini, Massimo / Marro, Matteo / Simonato, Erika / Scalini, Fabrizio / Costamagna, Andrea / Fanelli, Vito / Barbero, Cristina / Solidoro, Paolo / Brazzi, Luca / Rinaldi, Mauro

Transplant international : official journal of the European Society for Organ Transplantation

2023 Volume 36, Page(s) 10777

Abstract: ... Ex ... ...

Abstract	Ex Vivo
MeSH term(s)	Humans ; Cytokines ; Extracorporeal Circulation ; Interleukin-10 ; Perfusion ; Lung Transplantation ; Tissue and Organ Harvesting/methods
Chemical Substances	Cytokines ; Interleukin-10 (130068-27-8)
Language	English
Publishing date	2023-08-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.3389/ti.2023.10777
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Article ; Online: Clinical performance of lung ultrasound in predicting time-dependent changes in lung aeration in ARDS patients.

Costamagna, Andrea / Steinberg, Irene / Pivetta, Emanuele / Arina, Pietro / Veglia, Simona / Brazzi, Luca / Fanelli, Vito

Journal of clinical monitoring and computing

2022 Volume 37, Issue 2, Page(s) 473–480

Abstract: To evaluate whether lung ultrasound is reliable bedside tool to monitor changes of lung aeration at the early and late stages of ARDS. LUS was performed in ARDS patients that underwent at least two consecutive CT scan at ICU admission and at least 1 week ...

Abstract	To evaluate whether lung ultrasound is reliable bedside tool to monitor changes of lung aeration at the early and late stages of ARDS. LUS was performed in ARDS patients that underwent at least two consecutive CT scan at ICU admission and at least 1 week after admission. Twelve fields were evaluated and graded from 0 (normal) to 3 (consolidation). Changes of LUS score in twelve fields (ΔLUS
MeSH term(s)	Humans ; Respiratory Distress Syndrome/diagnostic imaging ; Lung/diagnostic imaging ; Ultrasonography
Language	English
Publishing date	2022-08-08
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1418733-4
ISSN	1573-2614 ; 1387-1307 ; 0748-1977
ISSN (online)	1573-2614
ISSN	1387-1307 ; 0748-1977
DOI	10.1007/s10877-022-00902-5
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Article: Electromyographic signature of isometric squat in the highest refuge in Europe.

Rua, Riccardo / Bondi, Danilo / Santangelo, Carmen / Pignatelli, Pamela / Pietrangelo, Tiziana / Fulle, Stefania / Fanelli, Vito / Verratti, Vittore

European journal of translational myology

2023 Volume 33, Issue 3

Abstract: Reports of electromyography during hypoxic exercise are contrasting, due to protocol and muscle diversity. This work aimed to investigate alterations in muscle activation and myoelectrical fatigue during exercise at high-altitude in those muscles ... ...

Abstract	Reports of electromyography during hypoxic exercise are contrasting, due to protocol and muscle diversity. This work aimed to investigate alterations in muscle activation and myoelectrical fatigue during exercise at high-altitude in those muscles primarily involved in trekking. Twelve young adults balanced by gender and age were tested at low (1,667 m) and high (4,554 m, "Capanna Margherita", Italy) altitude, during an isometric squat lasting 60 seconds. High-density surface electromyography was performed from the quadriceps of right limb. The root mean square (RMS), median frequency with its slope, and muscle fiber conduction velocity (MFCV) were computed. Neither males nor females showed changes in median frequency (Med: 36.13 vs 35.63 Hz) and its slope (Med: -9 vs -12 degree) in response to high-altitude trekking, despite a great inter-individual heterogeneity, nor differences were found for MFCV. RMS was not significantly equivalent, with greater values at low altitude (0.385 ± 0.104 mV) than high altitude (0.346 ± 0.090 mV). Unexpected results can be due either to a postural compensation of the whole body compensating for a relatively greater effort or to the inability to support muscle activation after repeated physical efforts. Interesting results may emerge by measuring simultaneously electromyography, muscle oxygenation and kinematics comparing trekking at normoxia vs hypoxia.
Language	English
Publishing date	2023-09-12
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2545577-1
ISSN	2037-7460 ; 2037-7452
ISSN (online)	2037-7460
ISSN	2037-7452
DOI	10.4081/ejtm.2023.11637
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Article ; Online: Early treatment with low-molecular-weight heparin reduces mortality rate in SARS-CoV-2 patients.

DE Vito, Andrea / Saderi, Laura / Fiore, Vito / Geremia, Nicholas / Princic, Elija / Fanelli, Chiara / Muredda, Alberto A / Panu Napodano, Catello / Moi, Giulia / Maida, Ivana / Fois, Alessandro G / Sotgiu, Giovanni / Madeddu, Giordano / Babudieri, Sergio

Panminerva medica

2022 Volume 65, Issue 3, Page(s) 286–291

Abstract: Background: Since the beginning of the SARS-CoV-2 pandemic, millions of people have been infected and died. Different therapeutic approaches have been recommended, but only a few have shown clinical advantages. Low-molecular-weight heparin (LMWH) has ... ...

Abstract	Background: Since the beginning of the SARS-CoV-2 pandemic, millions of people have been infected and died. Different therapeutic approaches have been recommended, but only a few have shown clinical advantages. Low-molecular-weight heparin (LMWH) has been recommended to prevent COVID-19-related thrombo-embolic events. We aimed to evaluate the impact of early treatment with LMWH on hospital admission and death in patients with SARS-CoV-2 infection. Methods: We conducted an observational monocentric retrospective study to evaluate the preventive role of LMWH on the mortality rate of COVID-19 patients. SARS-CoV-2 infected patients were recruited from the beginning of the Italian epidemic to March 31, 2021. We excluded patients with missing data and those chronically exposed to LMWH. Treatment prescription was based on international and national guidelines and modified depending on clinical presentation and drug-drug interactions. Results: Seven hundred thirty-four SARS-CoV-2 infected patients were recruited, with 357 (48.6%) males and a median (IQR) age of 77.9 (65-85.7) years. 77.5% of people developed SARS-CoV-2-related symptoms and 62.8% were admitted to the hospital, and 20.2% died. Four hundred ninety-two (67%) started LMWH. In particular, 296 (40.3%) were treated within five days since symptoms onset. At logistic regression, early LMWH therapy was associated with lower mortality. Furthermore, remdesivir treatment showed a lower risk of death. On the contrary, age, BMI>30 kg/m Conclusions: Early treatment with LMWH was associated with lower mortality in our cohort. Further studies are needed to better assess the role of wider LMWH administration in terms of timing and regimen dose.
MeSH term(s)	Male ; Humans ; Aged ; Aged, 80 and over ; Female ; Heparin, Low-Molecular-Weight/therapeutic use ; Heparin, Low-Molecular-Weight/adverse effects ; SARS-CoV-2 ; COVID-19 ; Retrospective Studies ; Anticoagulants/therapeutic use
Chemical Substances	Heparin, Low-Molecular-Weight ; Anticoagulants
Language	English
Publishing date	2022-05-27
Publishing country	Italy
Document type	Observational Study ; Journal Article
ZDB-ID	123572-2
ISSN	1827-1898 ; 0031-0808
ISSN (online)	1827-1898
ISSN	0031-0808
DOI	10.23736/S0031-0808.22.04572-4
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Article ; Online: The current and future off-label uses of dalbavancin: a narrative review.

De Vito, A / Fiore, V / Colpani, A / Zauli, B / Fanelli, C / Tiseo, G / Occhineri, S / Babudieri, S / Falcone, M / Madeddu, G

European review for medical and pharmacological sciences

2023 Volume 27, Issue 3, Page(s) 1222–1238

Abstract: Dalbavancin is a novel long-acting semi-synthetic lipoglycopeptide. It is licensed for acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) ... ...

Abstract	Dalbavancin is a novel long-acting semi-synthetic lipoglycopeptide. It is licensed for acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci. Many studies on dalbavancin alternative use in clinical practice have been published recently, including osteomyelitis, prosthetic joint infections (PJIs), and infective endocarditis (IE). Thus, we conducted a narrative review on dalbavancin efficacy in difficult-to-treat infections, such as osteomyelitis, PJIs, and IE. We performed a comprehensive literature search through electronic databases (PubMed-MEDLINE) and search engines (Google Scholar). We included peer-reviewed publications (articles and reviews), and grey literature on dalbavancin use in osteomyelitis, PJIs, and IE. No time or language restrictions have been established. Despite the great interest in clinical practice, only observational studies and case series on the use of dalbavancin in infections other than ABSSSI are available. The reported success rate was extremely variable between studies, ranging from 44% to 100%. A low success rate has been reported for osteomyelitis and joint infections, while in endocarditis, the success rate was higher than 70% in all studies. However, there is no literature agreement about the correct regimen of dalbavancin for this type of infection heretofore. Dalbavancin showed great efficacy and a good safety profile, not only in patients with ABSSSI but also in those with osteomyelitis, PJIs, and endocarditis. Further randomized clinical trials are needed to assess the optimal dosing schedule depending on the site of infection. Implementing therapeutic drug monitoring for dalbavancin may represent the future step to achieving optimal pharmacokinetic/pharmacodynamic target attainment.
MeSH term(s)	Humans ; Anti-Bacterial Agents/therapeutic use ; Methicillin-Resistant Staphylococcus aureus ; Off-Label Use ; Osteomyelitis/drug therapy ; Endocarditis, Bacterial ; Gram-Positive Bacterial Infections/drug therapy
Chemical Substances	dalbavancin (808UI9MS5K) ; Anti-Bacterial Agents
Language	English
Publishing date	2023-03-01
Publishing country	Italy
Document type	Review ; Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202302_31233
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