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  1. Article ; Online: Cerebral Lactate Uptake After Half-Molar Sodium Lactate Therapy in Traumatic Brain Injury: A Brief Report.

    Plourde, Guillaume / Ichai, Carole / Quintard, Hervé

    Journal of neurotrauma

    2024  

    Abstract: Exogenous sodium lactate has many advantages after traumatic brain injury, including intracranial pressure control and alternative energetic supply. It remains unclear, however, whether half-molar sodium lactate (HSL) is effectively incorporated in brain ...

    Abstract Exogenous sodium lactate has many advantages after traumatic brain injury, including intracranial pressure control and alternative energetic supply. It remains unclear, however, whether half-molar sodium lactate (HSL) is effectively incorporated in brain metabolism, which we can verify using the arteriovenous difference in lactate (AVD
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645092-1
    ISSN 1557-9042 ; 0897-7151
    ISSN (online) 1557-9042
    ISSN 0897-7151
    DOI 10.1089/neu.2023.0508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nutrition in critical care.

    Ichai, Carole

    Critical care (London, England)

    2014  Volume 18, Issue 4, Page(s) 2540

    Language English
    Publishing date 2014-08
    Publishing country England
    Document type Journal Article
    ISSN 1466-609X
    ISSN (online) 1466-609X
    DOI 10.1186/cc13957
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Nutritional and metabolic supplementation for the injured brain: an update.

    Quintard, Hervé / Ichai, Carole

    Current opinion in critical care

    2019  Volume 25, Issue 2, Page(s) 126–131

    Abstract: Purpose of review: Energy dysfunction is increasingly recognized as a key factor in the pathogenesis of acute brain injury (ABI). This one characterized by a high metabolic rate and nitrogen loss is often associated with an undernutrition support. We ... ...

    Abstract Purpose of review: Energy dysfunction is increasingly recognized as a key factor in the pathogenesis of acute brain injury (ABI). This one characterized by a high metabolic rate and nitrogen loss is often associated with an undernutrition support. We review the metabolism evolution and nutritional status in brain injured patient and summarize evidence on nutritional support in this condition.
    Recent findings: The role of nutrition support for improving prognosis in brain injured patient has been underlined recently. A fast nutrition institution whatever the route is essential to prevent an imbalance in caloric support. Moreover, hypermetabolic state must be prevented with a sufficient nitrogen support. Glycemic control is particularly relevant in this group of patient, with the discovery of new fuel that could potentially improve cerebral metabolism and replace glucose. Few data support also the use of immunonutrition input in this group of patients.
    Summary: Nutritional support is a key parameter in brain injured patient and must be initiated quickly to counteract hypermetabolic state by caring to improve caloric and nitrogen input. Recent clinical data support the use of immunonutrition, glutamine and zinc in this particular setting.
    MeSH term(s) Brain Injuries/therapy ; Dietary Supplements ; Glutamine ; Humans ; Nutritional Status ; Nutritional Support
    Chemical Substances Glutamine (0RH81L854J)
    Language English
    Publishing date 2019-04-16
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000000588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Multidisciplinary management of tracheobronchial injury.

    Boutros, Jacques / Marquette, Charles-Hugo / Ichai, Carole / Leroy, Sylvie / Benzaquen, Jonathan

    European respiratory review : an official journal of the European Respiratory Society

    2022  Volume 31, Issue 163

    Abstract: Tracheobronchial injury is a heterogeneous entity comprising multiple rare and potentially life-threatening scenarios. We performed a systematic literature review focusing on post-intubation tracheal injuries (PiTIs) and post-traumatic tracheobronchial ... ...

    Abstract Tracheobronchial injury is a heterogeneous entity comprising multiple rare and potentially life-threatening scenarios. We performed a systematic literature review focusing on post-intubation tracheal injuries (PiTIs) and post-traumatic tracheobronchial injuries (PTTBIs).PiTIs are often longitudinal lacerations of the middle third of the membranous trachea. Subcutaneous emphysema of the face and trunk following tracheal intubation should immediately trigger the diagnosis. Diagnosis may be suspected on the chest computed tomography (CT) and should be confirmed by bronchoscopic examination. Conservative management is encouraged for a spontaneously breathing or stable patient on noninvasive ventilation. Surgical repair is mandatory when mechanical ventilation is required and if bridging of the injury is impossible.PTTBIs are often associated with other severe injuries. Patients often present with massive subcutaneous emphysema and intractable pneumothorax. Diagnosis may be suspected on the chest CT and should be confirmed by bronchoscopic examination. Early surgical repair is indicated. In selected patients, conservative management can be considered.
    MeSH term(s) Bronchi/diagnostic imaging ; Humans ; Intubation, Intratracheal/adverse effects ; Noninvasive Ventilation ; Tomography, X-Ray Computed ; Trachea/diagnostic imaging
    Language English
    Publishing date 2022-01-25
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0126-2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Reply to: Comment on 'Comparison of presumed cardiac and respiratory causes of out-of-hospital cardiac arrest'.

    Orban, Jean-Christophe / Kerever, Sébastien / Mongardon, Nicolas / Ichai, Carole

    Resuscitation

    2019  Volume 140, Page(s) 212–213

    MeSH term(s) Cardiopulmonary Resuscitation ; Heart ; Humans ; Out-of-Hospital Cardiac Arrest
    Language English
    Publishing date 2019-05-09
    Publishing country Ireland
    Document type Letter ; Comment
    ZDB-ID 189901-6
    ISSN 1873-1570 ; 0300-9572
    ISSN (online) 1873-1570
    ISSN 0300-9572
    DOI 10.1016/j.resuscitation.2019.04.049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Antiedematous Effect of Exogenous Lactate Therapy in Traumatic Brain Injury: A Physiological and Mechanistic Approach.

    Duhaut, David Emmanuel / Heurteaux, Catherine / Gandin, Carine / Ichai, Carole / Quintard, Hervé

    Neurocritical care

    2021  Volume 35, Issue 3, Page(s) 747–755

    Abstract: Background: Sodium lactate (SL) has been described as an efficient therapy in treating raised intracranial pressure (ICP). However, the precise mechanism by which SL reduces intracranial hypertension is not well defined. An antiedematous effect has been ...

    Abstract Background: Sodium lactate (SL) has been described as an efficient therapy in treating raised intracranial pressure (ICP). However, the precise mechanism by which SL reduces intracranial hypertension is not well defined. An antiedematous effect has been proposed but never demonstrated. In this context, the involvement of chloride channels, aquaporins, or K-Cl cotransporters has also been suggested, but these mechanisms have never been assessed when using SL.
    Methods: In a rat model of traumatic brain injury (TBI), we compared the effect of SL versus mannitol 20% on ICP, cerebral tissue oxygen pressure, and brain water content. We attempted to clarify the involvement of chloride channels in the antiedematous effects associated with lactate therapy in TBI.
    Results: An equimolar single bolus of SL and mannitol significantly reduced brain water content and ICP and improved cerebral tissue oxygen pressure 4 h after severe TBI. The effect of SL on brain water content was much longer than that of mannitol and persisted at 24 h post TBI. Western blot and immunofluorescence staining analyses performed 24 h after TBI revealed that SL infusion is associated with an upregulation of aquaporin 4 and K-Cl cotransporter 2.
    Conclusions: SL is an effective therapy for treating brain edema after TBI. This study suggests, for the first time, the potential role of chloride channels in the antiedematous effect induced by exogenous SL.
    MeSH term(s) Animals ; Brain Edema/complications ; Brain Edema/etiology ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/drug therapy ; Intracranial Hypertension/complications ; Intracranial Hypertension/etiology ; Intracranial Pressure ; Lactic Acid ; Mannitol/pharmacology ; Mannitol/therapeutic use ; Rats ; Saline Solution, Hypertonic
    Chemical Substances Saline Solution, Hypertonic ; Lactic Acid (33X04XA5AT) ; Mannitol (3OWL53L36A)
    Language English
    Publishing date 2021-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-021-01219-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Désordres métaboliques et réanimation

    Ichai, Carole

    de la physiopathologie au traitement

    2011  

    Author's details [edited by] Carole Ichai, Hervé Quintard, Jean-Christophe Orban
    MeSH term(s) Metabolic Diseases/therapy ; Metabolic Diseases/physiopathology ; Resuscitation
    Language French
    Size x, 507 p. :, ill.
    Publisher Springer
    Publishing place Paris
    Document type Book
    ISBN 9782287990267 ; 2287990267
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Article ; Online: Optimizing continuous renal replacement therapy in the ICU: a team strategy.

    Joannes-Boyau, Olivier / Velly, Lionel / Ichai, Carole

    Current opinion in critical care

    2018  Volume 24, Issue 6, Page(s) 476–482

    Abstract: Purpose of review: The consideration of acute kidney injury, its incidence and its impact on the outcome of patients has grown continuously in recent years, leading to an increase in the use of renal replacement therapy (RRT) techniques. However, the ... ...

    Abstract Purpose of review: The consideration of acute kidney injury, its incidence and its impact on the outcome of patients has grown continuously in recent years, leading to an increase in the use of renal replacement therapy (RRT) techniques. However, the successful conduct of RRT depends on the effectiveness of the entire team, doctors and nurses. It is therefore important to know the essential elements to be implemented in the ICU to ensure optimal RRT.
    Recent findings: Recent studies show that the successful conduct of a RRT session requires a good knowledge of the principles of the technique, regular basic training, identification of experts, drafting clear and well followed protocols and good communication between the various stakeholders. In addition, the use of the latest advances, such as regional citrate anticoagulation, allows further optimization of therapy, only if, again, both physicians and nurses are properly trained and highly involved.
    Summary: We now have a better understanding of the measures to be deployed to optimize RRT. Organization, training, evaluation and protocols are the key points of the team's efficiency for a safe and effective implementation of RRT.
    MeSH term(s) Acute Kidney Injury/therapy ; Anticoagulants/therapeutic use ; Clinical Competence/standards ; Clinical Protocols ; Critical Care/methods ; Critical Care/standards ; Humans ; Intensive Care Units ; Renal Replacement Therapy/instrumentation ; Renal Replacement Therapy/methods ; Simulation Training/statistics & numerical data
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2018-10-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000000564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: ICU specialists facing terrorist attack: the Nice experience.

    Orban, Jean-Christophe / Quintard, Hervé / Ichai, Carole

    Intensive care medicine

    2017  Volume 43, Issue 5, Page(s) 683–685

    MeSH term(s) Disaster Planning ; Emergency Medical Services/methods ; Emergency Medical Services/statistics & numerical data ; France ; Humans ; Intensive Care Units/organization & administration ; Intensive Care Units/statistics & numerical data ; Mass Casualty Incidents ; Terrorism ; Trauma Centers/organization & administration ; Trauma Centers/statistics & numerical data ; Triage/methods ; Triage/organization & administration ; Wounds and Injuries/therapy
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-016-4570-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Early sedation in traumatic brain injury: a multicentre international observational study.

    Russo, Giovanni / Harrois, Anatole / Anstey, James / Van Der Jagt, Mathieu / Taccone, Fabio / Udy, Andrew / Citerio, Giuseppe / Duranteau, Jacques / Ichai, Carole / Badenes, Rafael / Prowle, John / Ercole, Ari / Oddo, Mauro / Schneider, Antoine / Wolf, Stefan / Helbok, Raimund / Nelson, David / Cooper, Jamie

    Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine

    2023  Volume 24, Issue 4, Page(s) 319–329

    Abstract: Objectives: ...

    Abstract Objectives:
    Language English
    Publishing date 2023-10-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2401976-8
    ISSN 1441-2772
    ISSN 1441-2772
    DOI 10.51893/2022.4.OA2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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