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  1. Article ; Online: Response to the Letter to the Editor: "Patient Selection Is Essential for Explantation of Infected Abdominal Aortic Endografts".

    Perini, Paolo / Freyrie, Antonio

    Angiology

    2024  , Page(s) 33197231226274

    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Letter
    ZDB-ID 80040-5
    ISSN 1940-1574 ; 0003-3197
    ISSN (online) 1940-1574
    ISSN 0003-3197
    DOI 10.1177/00033197231226274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Siponimod-Related Bilateral Macular Edema: A Transient and Completely Reversible Disorder.

    Miscioscia, Alessandro / Rinaldi, Francesca / Pilotto, Elisabetta / Perini, Paola / Gallo, Paolo

    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

    2023  Volume 44, Issue 1, Page(s) e6–e7

    MeSH term(s) Humans ; Macular Edema/chemically induced ; Macular Edema/diagnosis ; Macular Edema/drug therapy ; Azetidines ; Benzyl Compounds
    Chemical Substances siponimod (RR6P8L282I) ; Azetidines ; Benzyl Compounds
    Language English
    Publishing date 2023-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1189901-3
    ISSN 1536-5166 ; 1070-8022
    ISSN (online) 1536-5166
    ISSN 1070-8022
    DOI 10.1097/WNO.0000000000001788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Futility and life expectancy: an increasing ethical and clinical challenge in emergency surgery.

    Giordano, Alessio / Bergamini, Carlo / Martellucci, Jacopo / Scheiterle, Maximilian / Perini, Davina / Cammelli, Francesca / Guagni, Tommaso / Batacchi, Stefano / Bonizzoli, Manuela / Prosperi, Paolo

    Minerva surgery

    2024  

    Language English
    Publishing date 2024-03-04
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3067899-7
    ISSN 2724-5438
    ISSN (online) 2724-5438
    DOI 10.23736/S2724-5691.24.10274-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Systematic review and meta-analysis of incidence, indications, and outcomes of early open conversions after EVAR for abdominal aortic aneurysms.

    Cicala, Nicola / Perini, Paolo / Catasta, Alexandra / Fornasari, Anna / Ucci, Alessandro / Freyrie, Antonio

    International angiology : a journal of the International Union of Angiology

    2024  

    Abstract: Introduction: The purpose of this study is to report incidence, indications, and outcomes of early open conversions (EOC) after endovascular aortic repair (EVAR), defined as surgical conversion performed within 30 days from the initial EVAR.: Evidence ...

    Abstract Introduction: The purpose of this study is to report incidence, indications, and outcomes of early open conversions (EOC) after endovascular aortic repair (EVAR), defined as surgical conversion performed within 30 days from the initial EVAR.
    Evidence aquisition: A systematic review of the literature was performed (database searched: PubMed, Web of Science, Scopus, Cochrane Library; last search April 2023). Articles reporting EOC after EVAR comprising at least five patients were included. Meta-analyses of proportions were performed using a random-effects model.
    Evidence synthesis: Seventeen non-randomized studies, published between 1999 and 2022, were included. A total of 35,970 patients had previously undergone EVAR, of these 438 patients underwent EOC. Estimated incidence of EOC was 1.4% (95% CI 1.1-1.4; I
    Conclusions: The incidence of EOC seems to decrease over time. Causes of EOC were mainly related to access problems and incorrect positioning of the endograft. Most of the EOC were performed intraoperatively carrying a high mortality rate.
    Language English
    Publishing date 2024-03-19
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 604910-2
    ISSN 1827-1839 ; 0392-9590
    ISSN (online) 1827-1839
    ISSN 0392-9590
    DOI 10.23736/S0392-9590.24.05153-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Same-session EUS-directed transgastric interventions: from tissue acquisition to choledochoduodenostomy.

    Binda, Cecilia / Giuffrida, Paolo / Fabbri, Stefano / Coluccio, Chiara / Petraroli, Chiara / Perini, Barbara / Fabbri, Carlo

    VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy

    2023  Volume 9, Issue 4, Page(s) 182–184

    Language English
    Publishing date 2023-12-13
    Publishing country United States
    Document type Journal Article
    ISSN 2468-4481
    ISSN (online) 2468-4481
    DOI 10.1016/j.vgie.2023.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Endoscopic Ultrasound-Guided Drainage of Pancreatic Fluid Collections: Not All Queries Are Already Solved.

    Binda, Cecilia / Fabbri, Stefano / Perini, Barbara / Boschetti, Martina / Coluccio, Chiara / Giuffrida, Paolo / Gibiino, Giulia / Petraroli, Chiara / Fabbri, Carlo

    Medicina (Kaunas, Lithuania)

    2024  Volume 60, Issue 2

    Abstract: Pancreatic fluid collections (PFCs) are well-known complications of acute pancreatitis. The overinfection of these collections leads to a worsening of the prognosis with an increase in the morbidity and mortality rate. The primary strategy for managing ... ...

    Abstract Pancreatic fluid collections (PFCs) are well-known complications of acute pancreatitis. The overinfection of these collections leads to a worsening of the prognosis with an increase in the morbidity and mortality rate. The primary strategy for managing infected pancreatic necrosis (IPN) or symptomatic PFCs is a minimally invasive step-up approach, with endosonography-guided (EUS-guided) transmural drainage and debridement as the preferred and less invasive method. Different stents are available to drain PFCs: self-expandable metal stents (SEMSs), double pigtail stents (DPPSs), or lumen-apposing metal stents (LAMSs). In particular, LAMSs are useful when direct endoscopic necrosectomy is needed, as they allow easy access to the necrotic cavity; however, the rate of adverse events is not negligible, and to date, the superiority over DPPSs is still debated. Moreover, the timing for necrosectomy, the drainage technique, and the concurrent medical management are still debated. In this review, we focus attention on indications, timing, techniques, complications, and particularly on aspects that remain under debate concerning the EUS-guided drainage of PFCs.
    MeSH term(s) Humans ; Endosonography/methods ; Acute Disease ; Pancreatitis, Acute Necrotizing/diagnostic imaging ; Pancreatitis, Acute Necrotizing/surgery ; Pancreatitis, Acute Necrotizing/etiology ; Stents/adverse effects ; Drainage/methods ; Ultrasonography, Interventional ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2024-02-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina60020333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Therapy of Pediatric-Onset Multiple Sclerosis: State of the Art, Challenges, and Opportunities.

    Margoni, Monica / Rinaldi, Francesca / Perini, Paola / Gallo, Paolo

    Frontiers in neurology

    2021  Volume 12, Page(s) 676095

    Abstract: Treatment of pediatric-onset multiple sclerosis (POMS) has been tailored after observational studies and data obtained from clinical trials in adult-onset multiple sclerosis (AOMS) patients. There are an increasing number of new therapeutic agents for ... ...

    Abstract Treatment of pediatric-onset multiple sclerosis (POMS) has been tailored after observational studies and data obtained from clinical trials in adult-onset multiple sclerosis (AOMS) patients. There are an increasing number of new therapeutic agents for AOMS, and many will be formally studied for use also in POMS. However, there are important efficacy and safety concerns regarding the use of these therapies in children and young adults. This review will discuss the current state of the art of POMS therapy and will focus on the newer therapies (oral and infusion disease-modifying drugs) and on those still currently under investigation.
    Language English
    Publishing date 2021-05-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2021.676095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Acute Type B Aortic Dissection Complicated With Spinal Cord Ischemia and Paraplegia Treated With Endovascular Scissor Technique.

    Catasta, Alexandra / Freyrie, Antonio / Bramucci, Alberto / Bianchini Massoni, Claudio / Perini, Paolo

    Vascular and endovascular surgery

    2023  Volume 58, Issue 2, Page(s) 223–229

    Abstract: Spinal cord ischemia leading to paraplegia is a rare, life-limiting complication of acute type B aortic dissection. We report a case of spinal cord ischemia occurred in a young woman treated with endovascular scissor technique in urgent setting. The ... ...

    Abstract Spinal cord ischemia leading to paraplegia is a rare, life-limiting complication of acute type B aortic dissection. We report a case of spinal cord ischemia occurred in a young woman treated with endovascular scissor technique in urgent setting. The patient had an uneventful post-procedural course. After 4 months, computed tomography angiography confirmed false lumen reperfusion and major symptoms were regressed. In selected cases, this procedure is a tool to improve false lumen perfusion in type B dissections, and demonstrated to be helpful in our case of spinal cord ischaemia.
    MeSH term(s) Female ; Humans ; Aortic Aneurysm, Thoracic/surgery ; Blood Vessel Prosthesis Implantation/adverse effects ; Endovascular Procedures/adverse effects ; Treatment Outcome ; Aortic Dissection/complications ; Aortic Dissection/diagnostic imaging ; Aortic Dissection/surgery ; Spinal Cord Ischemia/diagnostic imaging ; Spinal Cord Ischemia/etiology ; Paraplegia/etiology ; Retrospective Studies ; Spinal Cord
    Language English
    Publishing date 2023-08-28
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2076272-0
    ISSN 1938-9116 ; 1538-5744
    ISSN (online) 1938-9116
    ISSN 1538-5744
    DOI 10.1177/15385744231198715
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Neurodegeneration in the retina of motoneuron diseases: a longitudinal study in amyotrophic lateral sclerosis and Kennedy's disease.

    Miscioscia, Alessandro / Puthenparampil, Marco / Blasi, Lorenzo / Rinaldi, Francesca / Perini, Paola / Sorarù, Gianni / Gallo, Paolo

    Journal of neurology

    2023  Volume 270, Issue 9, Page(s) 4478–4486

    Abstract: Background: To what extent retinal atrophy in neurodegenerative diseases reflects the severity and/or the chronicity of brain pathology or is a local independent phenomenon remains to be clarified. Moreover, whether retinal atrophy has a clinical ( ... ...

    Abstract Background: To what extent retinal atrophy in neurodegenerative diseases reflects the severity and/or the chronicity of brain pathology or is a local independent phenomenon remains to be clarified. Moreover, whether retinal atrophy has a clinical (diagnostic and prognostic) value in these diseases remains unclear.
    Objective: To add light on the pathological significance and clinical value of retinal atrophy in patients with amyotrophic lateral sclerosis (ALS) and Kennedy's disease (KD).
    Methods: Thirty-five ALS, thirty-seven KD, and forty-nine age-matched healthy controls (HC) were included in a one-year longitudinal study. Spectrum-domain optical coherence tomography (OCT) was performed at study entry (T0) and after 12 months (T1). Disease duration and functional rating scale (FRS) for ALS and KD patients were correlated to retinal thicknesses.
    Results: Compared to HC, peripapillary retinal nerve fiber layer (pRNFL) thickness was significantly thinner in both ALS (p = 0.034) and KD (p = 0.003). pRNFL was thinner in KD compared to ALS, but the difference was not significant. In KD, pRNFL atrophy significantly correlated with both disease severity (r = 0.296, p = 0.035) and disease duration (r = - 0.308, p = 0.013) while no significant correlation was found in ALS (disease severity: r = 0.147, p = 0.238; disease duration: r = - 0.093, p = 0.459). During the follow-up, pRNFL thickness remained stable in KD while significantly decreased in ALS (p = 0.043).
    Conclusions: Our study provides evidence of retinal atrophy in both ALS and KD and suggests that retinal thinning is a primary local phenomenon in motoneuron diseases. The clinical value of pRNFL atrophy in KD is worthy of further investigation.
    MeSH term(s) Humans ; Amyotrophic Lateral Sclerosis/complications ; Amyotrophic Lateral Sclerosis/diagnostic imaging ; Amyotrophic Lateral Sclerosis/pathology ; Longitudinal Studies ; Bulbo-Spinal Atrophy, X-Linked ; Retina/diagnostic imaging ; Retina/pathology ; Motor Neuron Disease/pathology ; Retinal Degeneration/diagnostic imaging ; Retinal Degeneration/etiology ; Retinal Degeneration/pathology ; Tomography, Optical Coherence/methods ; Atrophy/pathology ; Motor Neurons/pathology
    Language English
    Publishing date 2023-06-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-023-11802-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Surgical Medical Education via 3D Bioprinting: Modular System for Endovascular Training.

    Foresti, Ruben / Fornasari, Anna / Bianchini Massoni, Claudio / Mersanne, Arianna / Martini, Chiara / Cabrini, Elisa / Freyrie, Antonio / Perini, Paolo

    Bioengineering (Basel, Switzerland)

    2024  Volume 11, Issue 2

    Abstract: There is currently a shift in surgical training from traditional methods to simulation-based approaches, recognizing the necessity of more effective and controlled learning environments. This study introduces a completely new 3D-printed modular system ... ...

    Abstract There is currently a shift in surgical training from traditional methods to simulation-based approaches, recognizing the necessity of more effective and controlled learning environments. This study introduces a completely new 3D-printed modular system for endovascular surgery training (M-SET), developed to allow various difficulty levels. Its design was based on computed tomography angiographies from real patient data with femoro-popliteal lesions. The study aimed to explore the integration of simulation training via a 3D model into the surgical training curriculum and its effect on their performance. Our preliminary study included 12 volunteer trainees randomized 1:1 into the standard simulation (SS) group (3 stepwise difficulty training sessions) and the random simulation (RS) group (random difficulty of the M-SET). A senior surgeon evaluated and timed the final training session. Feedback reports were assessed through the Student Satisfaction and Self-Confidence in Learning Scale. The SS group completed the training sessions in about half time (23.13 ± 9.2 min vs. 44.6 ± 12.8 min). Trainees expressed high satisfaction with the training program supported by the M-SET. Our 3D-printed modular training model meets the current need for new endovascular training approaches, offering a customizable, accessible, and effective simulation-based educational program with the aim of reducing the time required to reach a high level of practical skills.
    Language English
    Publishing date 2024-02-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering11020197
    Database MEDical Literature Analysis and Retrieval System OnLINE

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