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  1. Article ; Online: Invited commentary.

    Bazan, Hernan A

    Journal of vascular surgery

    2018  Volume 68, Issue 6, Page(s) 1781

    MeSH term(s) Carotid Stenosis ; Humans
    Language English
    Publishing date 2018-11-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 605700-7
    ISSN 1097-6809 ; 0741-5214
    ISSN (online) 1097-6809
    ISSN 0741-5214
    DOI 10.1016/j.jvs.2018.02.050
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  2. Article ; Online: Impact of presenting stroke severity and thrombolysis on outcomes following urgent carotid interventions.

    Hayson, Aaron / Burton, Jeffrey / Allen, Joseph / Sternbergh, Waldemar C / Fort, Daniel / Bazan, Hernan A

    Journal of vascular surgery

    2023  Volume 78, Issue 3, Page(s) 702–710

    Abstract: Background: Carotid interventions are increasingly performed in select patients following acute stroke. We aimed to determine the effects of presenting stroke severity (National Institutes of Health Stroke Scale [NIHSS]) and use of systemic thrombolysis ...

    Abstract Background: Carotid interventions are increasingly performed in select patients following acute stroke. We aimed to determine the effects of presenting stroke severity (National Institutes of Health Stroke Scale [NIHSS]) and use of systemic thrombolysis (tissue plasminogen activator [tPA]) on discharge neurological outcomes (modified Rankin scale [mRS]) after urgent carotid endarterectomy (uCEA) and urgent carotid artery stenting (uCAS).
    Methods: Patients undergoing uCEA/uCAS at a tertiary Comprehensive Stroke Center (January 2015 to May 2022) were divided into two cohorts: (1) no thrombolysis (uCEA/uCAS only) and (2) use of thrombolysis before the carotid intervention (tPA + uCEA/uCAS). Outcomes were discharge mRS and 30-day complications. Regression models were used to determine an association between tPA use and presenting stroke severity (NIHSS) and discharge neurological outcomes (mRS).
    Results: Two hundred thirty-eight patients underwent uCEA/uCAS (uCEA/uCAS only, n = 186; tPA + uCEA/uCAS, n = 52) over 7 years. In the thrombolysis cohort compared with the uCEA/uCAS only cohort, the mean presenting stroke severity was higher (NIHSS = 7.6 vs 3.8; P = .001), and more patients presented with moderate to severe strokes (57.7% vs 30.2% with NIHSS >4). The 30-day stroke, death, and myocardial infarction rates in the uCEA/uCAS only vs tPA + uCEA/uCAS were 8.1% vs 11.5% (P = .416), 0% vs 9.6% (P < .001), and 0.5% vs 1.9% (P = .39), respectively. The 30-day stroke/hemorrhagic conversion and myocardial infarction rates did not differ with tPA use; however, the difference in deaths was significantly higher in the tPA + uCEA/uCAS cohort (P < .001). There was no difference in neurological functional outcome with or without thrombolysis use (mean mRS, 2.1 vs 1.7; P = .061). For both minor strokes (NIHSS ≤4 vs NIHSS >4: relative risk, 1.58 vs 1.58, tPA vs no tPA, respectively, P = .997) and moderate strokes (NIHSS ≤10 vs NIHSS >10: relative risk, 1.94 vs 2.08, tPA vs no tPA, respectively; P = .891), the likelihood of discharge functional independence (mRS score of ≤2) was not influenced by tPA.
    Conclusions: Patients with a higher presenting stroke severity (NIHSS) had worse neurological functional outcomes (mRS). Patients presenting with minor and moderate strokes were more likely to have discharge neurological functional independence (mRS of ≤2), regardless of whether they received tPA or not. Overall, presenting NIHSS is predictive of discharge neurological functional autonomy and is not influenced by the use of thrombolysis.
    MeSH term(s) Humans ; Tissue Plasminogen Activator/adverse effects ; Carotid Stenosis/complications ; Carotid Stenosis/diagnostic imaging ; Carotid Stenosis/therapy ; Treatment Outcome ; Retrospective Studies ; Stents/adverse effects ; Stroke/diagnosis ; Stroke/etiology ; Stroke/therapy ; Thrombolytic Therapy/adverse effects ; Carotid Arteries ; Myocardial Infarction/diagnosis ; Myocardial Infarction/etiology ; Myocardial Infarction/therapy ; Severity of Illness Index ; Fibrinolytic Agents/adverse effects ; Brain Ischemia/diagnosis ; Brain Ischemia/etiology ; Brain Ischemia/therapy
    Chemical Substances Tissue Plasminogen Activator (EC 3.4.21.68) ; Fibrinolytic Agents
    Language English
    Publishing date 2023-06-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605700-7
    ISSN 1097-6809 ; 0741-5214
    ISSN (online) 1097-6809
    ISSN 0741-5214
    DOI 10.1016/j.jvs.2023.04.031
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  3. Article ; Online: Variantes en el número de copias y consanguinidad parental en neonatos de altura con anomalías congénitas en Perú.

    Abarca Barriga, Hugo Hernán / Chavesta Velásquez, Felix / Barletta Carrillo, Claudia / Paucarmayta Tacuri, Abel / Bazán Hurtado, Margaret / Vásquez Loarte, Tania / Ordoñez Rondón, Luis / Ordoñez Linares, Marco / Rondón Abuhadba, Evelina Andrea

    Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina)

    2022  Volume 79, Issue 2, Page(s) 132–140

    Abstract: Introduction: Congenital abnormalities could be caused by copy number variation or homozygous variants inherited of parental consanguineous. Purpose.: Objetive: To show copy number variants and regions of homozygosity in neonates with malformative ... ...

    Title translation Copy number variation and parental consanguinity elevated in newborns of high altitude with major congenital anomalies in Perú.
    Abstract Introduction: Congenital abnormalities could be caused by copy number variation or homozygous variants inherited of parental consanguineous. Purpose.
    Objetive: To show copy number variants and regions of homozygosity in neonates with malformative syndrome or one congenital anomaly major associated to facial dysmorphia or hypotonia.
    Methodology: Performed chromosomal microarray analysis (CGH/SNP) to 60 neonates with congenital anomalies born in Hospital Antonio Lorena and Hospital Regional Cusco.
    Results: 70% of the newborns had an abnormal test (n=42); 48,3% (n=29) patients had with regions of homozygosity above to 0,5% (endogamy coefficient up to 1/64). Pathogenic or likely pathogenic copy number variations with or without region of homozygosity were present in 14,2% (n=6) newborns with congenital abnormalities. We founded five patients with uncertain pathogenic copy number variations that have not been described previously and might correlate with phenotype.
    Conclusion: We founded a similar frequency of CNV in newborns with congenital abnormalities compared to previous reports. Nonetheless, parental consanguinity was increased compared to other countries of South America. This is the first report in Peru that showed to CMA as a useful diagnostic method in patients with congenital abnormalities and is pioneer in relation to other countries in Latinoamerica.
    MeSH term(s) Altitude ; Consanguinity ; DNA Copy Number Variations ; Humans ; Infant, Newborn ; Parents ; Peru ; Retrospective Studies
    Language Spanish
    Publishing date 2022-06-06
    Publishing country Argentina
    Document type Journal Article
    ZDB-ID 390127-0
    ISSN 1853-0605 ; 0014-6722 ; 0301-7281
    ISSN (online) 1853-0605
    ISSN 0014-6722 ; 0301-7281
    DOI 10.31053/1853.0605.v79.n2.34538
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  4. Article ; Online: Utility of Amiodarone Pre-Treatment as a Facilitator of the Acute Success of Electrical Cardioversion in Persistent Atrial Fibrillation.

    Alegret, Josep M / Viñolas, Xavier / Tajes, Hernán / Valdovinos, Pilar / Palomares, Raquel / Arias, Miguel A / Bazán, Víctor

    Cardiovascular drugs and therapy

    2020  Volume 34, Issue 1, Page(s) 89–94

    Abstract: Purpose: The usefulness and mechanisms of antiarrhythmic drug (AAD) pre-treatment as a facilitator of the acute success of electrical cardioversion (ECV) in atrial fibrillation (AF) remain controversial. We sought to analyze the role of AAD treatment ... ...

    Abstract Purpose: The usefulness and mechanisms of antiarrhythmic drug (AAD) pre-treatment as a facilitator of the acute success of electrical cardioversion (ECV) in atrial fibrillation (AF) remain controversial. We sought to analyze the role of AAD treatment with this purpose, differentiating its possible utility either facilitating the restoration of sinus rhythm (SR) or reducing immediate AF recurrences (IAFR).
    Methods: We analyzed 2962 consecutive patients with persistent AF undergoing ECV prospectively included in 3 national registries. The acute success of ECV was indicated by the reversion to SR without presenting an IAFR (< 2 h).
    Results: A total of 1410 patients (48%) received AAD treatment prior to ECV (80% amiodarone, 15% class Ic AAD, 2% other AAD). The rate of restoration of SR was similar between the patients treated with amiodarone (92%), class Ic AAD (91%) and who did not receive AAD pre-treatment (91%) (p = 0.92). However, those treated with amiodarone had fewer IAFR than those in the other two groups (amiodarone 3% vs class Ic 7% vs without treatment 6%; p = 0.002), so the ECV success rate was higher in the amiodarone group than in the other groups (amiodarone 89% vs Ic 84% vs without treatment 86%; p = 0.04). After adjusting for multiple variables, amiodarone remained as an independent predictor of a lower occurrence of IAFR (OR = 0.57; p = 0.01) and of a successful ECV (OR 1.37; p = 0.01).
    Conclusions: For patients with persistent AF undergoing ECV, AAD has a neutral effect on the restoration of SR but amiodarone increases its effectiveness due to a lower incidence of IAFR.
    MeSH term(s) Aged ; Amiodarone/therapeutic use ; Anti-Arrhythmia Agents/therapeutic use ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/physiopathology ; Atrial Fibrillation/therapy ; Electric Countershock/adverse effects ; Female ; Heart Rate/drug effects ; Humans ; Male ; Middle Aged ; Recurrence ; Registries ; Retrospective Studies ; Risk Factors ; Spain ; Time Factors ; Treatment Outcome
    Chemical Substances Anti-Arrhythmia Agents ; Amiodarone (N3RQ532IUT)
    Language English
    Publishing date 2020-02-24
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 639068-7
    ISSN 1573-7241 ; 0920-3206
    ISSN (online) 1573-7241
    ISSN 0920-3206
    DOI 10.1007/s10557-019-06934-5
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  5. Article ; Online: An evolution in thinking from modern carotid registries: CAS and CEA will be complimentary and not competitive techniques.

    Bazan, Hernan A

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2010  Volume 75, Issue 4, Page(s) 526–527

    MeSH term(s) Angioplasty/adverse effects ; Angioplasty/instrumentation ; Angioplasty/mortality ; Carotid Stenosis/complications ; Carotid Stenosis/diagnosis ; Carotid Stenosis/mortality ; Carotid Stenosis/therapy ; Endarterectomy, Carotid/adverse effects ; Endarterectomy, Carotid/mortality ; Evidence-Based Medicine ; Guideline Adherence ; Humans ; Patient Selection ; Practice Guidelines as Topic ; Registries ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Stents ; Stroke/etiology ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2010-03-01
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.22482
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  6. Article ; Online: Carotid string sign is not necessarily a functional occlusion: admit, anticoagulate, and revascularize urgently.

    Bazan, Hernan A

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2010  Volume 75, Issue 7, Page(s) 1110

    MeSH term(s) Angioplasty, Balloon/adverse effects ; Angioplasty, Balloon/instrumentation ; Anticoagulants/therapeutic use ; Carotid Stenosis/diagnostic imaging ; Carotid Stenosis/therapy ; Humans ; Ischemic Attack, Transient/etiology ; Patient Admission ; Radiography ; Severity of Illness Index ; Stents ; Time Factors ; Treatment Outcome ; Ultrasonography, Doppler
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2010-06-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.22623
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  7. Article ; Online: Does stenting of thoracic aortic coarctation induce a late exercise-induced hypertension? Stay tuned...

    Bazan, Hernan A

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2010  Volume 75, Issue 2, Page(s) 262

    MeSH term(s) Angioplasty, Balloon/adverse effects ; Angioplasty, Balloon/instrumentation ; Aortic Coarctation/physiopathology ; Aortic Coarctation/surgery ; Aortic Coarctation/therapy ; Blood Pressure ; Exercise ; Humans ; Hypertension/etiology ; Hypertension/physiopathology ; Stents ; Time Factors ; Treatment Outcome ; Vascular Surgical Procedures/adverse effects
    Language English
    Publishing date 2010-02-01
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.22420
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  8. Article ; Online: Think of the angiosome concept when revascularizing the patient with critical limb ischemia.

    Bazan, Hernan A

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2010  Volume 75, Issue 6, Page(s) 837

    MeSH term(s) Aged ; Aged, 80 and over ; Blood Vessel Prosthesis Implantation ; Female ; Humans ; Ischemia/therapy ; Leg/blood supply ; Limb Salvage/methods ; Male ; Middle Aged ; Regional Blood Flow ; Vascular Patency
    Language English
    Publishing date 2010-05-01
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.22572
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  9. Article ; Online: Why "fistula first" matters: increased durability, less interventions, and decreased costs.

    Bazan, Hernan A

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2010  Volume 75, Issue 1, Page(s) 22

    MeSH term(s) Angiography/economics ; Angioplasty, Balloon/economics ; Arteriovenous Shunt, Surgical/adverse effects ; Arteriovenous Shunt, Surgical/economics ; Blood Vessel Prosthesis Implantation/adverse effects ; Blood Vessel Prosthesis Implantation/economics ; Cost Savings ; Cost-Benefit Analysis ; Graft Occlusion, Vascular/diagnostic imaging ; Graft Occlusion, Vascular/economics ; Graft Occlusion, Vascular/etiology ; Graft Occlusion, Vascular/prevention & control ; Health Care Costs ; Health Care Rationing/economics ; Humans ; Kidney Failure, Chronic/economics ; Kidney Failure, Chronic/therapy ; Models, Economic ; Practice Guidelines as Topic ; Referral and Consultation/economics ; Renal Dialysis/economics ; Thrombosis/diagnostic imaging ; Thrombosis/economics ; Thrombosis/etiology ; Thrombosis/prevention & control ; Time Factors ; Treatment Outcome ; Vascular Patency
    Language English
    Publishing date 2010-01-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.22374
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  10. Article ; Online: Treating tibial chronic total occlusions: the next frontier in peripheral vascular disease.

    Bazan, Hernan A

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2010  Volume 76, Issue 4, Page(s) 589

    MeSH term(s) Angioplasty, Balloon/instrumentation ; Arterial Occlusive Diseases/diagnostic imaging ; Arterial Occlusive Diseases/therapy ; Chronic Disease ; Constriction, Pathologic ; Equipment Design ; Humans ; Radiography ; Tibial Arteries/diagnostic imaging ; Treatment Outcome
    Language English
    Publishing date 2010-10-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.22786
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