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  1. Article ; Online: Immunohistochemistry of Lung Cancer Biomarkers.

    Beasley, Mary Beth

    Advances in anatomic pathology

    2024  

    Abstract: Immunohistochemical (IHC) staining represents a comparatively inexpensive testing method that is attractive as a potential alternative to molecular sequencing methods or fluorescence in situ hybridization for pulmonary biomarker testing. While a variety ... ...

    Abstract Immunohistochemical (IHC) staining represents a comparatively inexpensive testing method that is attractive as a potential alternative to molecular sequencing methods or fluorescence in situ hybridization for pulmonary biomarker testing. While a variety of IHC tests directed at actionable genetic alterations have been developed and evaluated since the advent of targeted therapy, specific antibody clones for anaplastic lymphoma kinase, ROS-1, and potentially neurotrophic tropmyosin receptor kinase have been the primary antibodies that provide sufficiently robust results to be utilized as either a primary testing or screening method to direct targeted therapy. Antibodies for a variety of other targets such as epidermal growth factor receptors, for example, have lacked sufficient sensitivity and specificity to cover the range of mutations that may occur and are generally not recommended in lieu of molecular testing with the exception of limited resource settings. IHC is also used as a predictive marker for response to immunotherapy through evaluation of programmed death ligand 1 expression. In addition, multiple antibody-drug conjugates (ADCs) are under investigation, designed to deliver drugs directly to tumor cells through binding to specific target antigens. Some ADCs have already received accelerated FDA approval, and IHC was incorporated in many clinical trials evaluating ADC efficacy. As such, it is anticipated that ADCs may have a companion diagnostic IHC to guide patient selection.
    Language English
    Publishing date 2024-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1212493-x
    ISSN 1533-4031 ; 1072-4109
    ISSN (online) 1533-4031
    ISSN 1072-4109
    DOI 10.1097/PAP.0000000000000450
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  2. Article ; Online: Interstitial Lung Abnormalities.

    Beasley, Mary Beth

    Surgical pathology clinics

    2023  Volume 17, Issue 2, Page(s) 215–225

    Abstract: Interstitial lung abnormalities (ILA) is a radiographic term, which has recently undergone clarification of definition with creation of 3 subtypes. ILA is defined as incidental identification of computed tomography abnormalities in a patient who is not ... ...

    Abstract Interstitial lung abnormalities (ILA) is a radiographic term, which has recently undergone clarification of definition with creation of 3 subtypes. ILA is defined as incidental identification of computed tomography abnormalities in a patient who is not suspected of having an interstitial lung disease (ILD). A subset of ILA may progress to clinically significant ILD and is associated with morbidities not related to progression such as an increased incidence of sepsis-related acute respiratory distress syndrome (ARDS). ILA has been associated with an increased incidence of treatment-related complications in patients with lung cancer. Information on corresponding histology is limited; knowledge gaps exist concerning optimal patient management.
    MeSH term(s) Humans ; Lung Diseases, Interstitial/pathology ; Lung Diseases, Interstitial/diagnosis ; Tomography, X-Ray Computed ; Lung/pathology ; Lung/diagnostic imaging ; Lung Neoplasms/pathology ; Lung Neoplasms/diagnosis ; Lung Neoplasms/complications
    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1875-9157
    ISSN (online) 1875-9157
    DOI 10.1016/j.path.2023.11.007
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  3. Article ; Online: Chronic Airway Disease and Vaping - A First Step.

    Beasley, Mary Beth

    NEJM evidence

    2022  Volume 1, Issue 6, Page(s) EVIDe2200096

    Abstract: Chronic Airway Disease and Vaping - A First StepThe 2019 outbreak of acute lung disease associated with vaping led to the characterization of electronic cigarette (e-cigarette) or vaping-associated lung injury (EVALI), which primarily corresponds ... ...

    Abstract Chronic Airway Disease and Vaping - A First StepThe 2019 outbreak of acute lung disease associated with vaping led to the characterization of electronic cigarette (e-cigarette) or vaping-associated lung injury (EVALI), which primarily corresponds histologically to diffuse alveolar damage, acute fibrinous and organizing pneumonia, or organizing pneumonia on its own.
    Language English
    Publishing date 2022-05-24
    Publishing country United States
    Document type Editorial
    ISSN 2766-5526
    ISSN (online) 2766-5526
    DOI 10.1056/EVIDe2200096
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  4. Article ; Online: Acute lung injury-from cannabis to COVID.

    Beasley, Mary Beth

    Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

    2021  Volume 35, Issue Suppl 1, Page(s) 1–7

    Abstract: Recent world events have refocused attention on the pathology associated with clinical acute respiratory distress syndrome (ARDS). The vast majority of cases of clinical ARDS will have diffuse alveolar damage (DAD) histologically, but other histologies ... ...

    Abstract Recent world events have refocused attention on the pathology associated with clinical acute respiratory distress syndrome (ARDS). The vast majority of cases of clinical ARDS will have diffuse alveolar damage (DAD) histologically, but other histologies may occur less frequently. The aim of this paper is to provide a review of the pathology of DAD and acute fibrinous and organizing pneumonia and provide insights into the pathologic features associated with the E-cigarette/vaping-associated lung-injury outbreak and the ongoing SARS-CoV-2 pandemic.
    MeSH term(s) Acute Lung Injury/etiology ; COVID-19/complications ; Cannabis ; Electronic Nicotine Delivery Systems ; Humans ; Lung/pathology ; Respiratory Distress Syndrome/etiology ; Vaping/adverse effects
    Language English
    Publishing date 2021-09-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645073-8
    ISSN 1530-0285 ; 0893-3952
    ISSN (online) 1530-0285
    ISSN 0893-3952
    DOI 10.1038/s41379-021-00915-6
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  5. Article ; Online: Speaking the Same Language: The Fleischner Society Glossary for Thoracic Imaging.

    Hariri, Lida P / Beasley, Mary Beth / Sholl, Lynette M / Wikenheiser-Brokamp, Kathryn A

    Radiology

    2024  Volume 310, Issue 3, Page(s) e240414

    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.240414
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  6. Article: A 44-year-old stone worker with progressive dyspnea: lessons from a new twist on an old foe.

    Manglani, Ravi / Akbar, Sara / Beasley, Mary Beth / Epelbaum, Oleg

    Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

    2022  Volume 93, Issue 2

    Abstract: Silicosis is typically an indolent lung disease caused by long-standing occupational exposure to respirable crystalline silica, classically in professions such as sandblasting and mining.  An increasingly popular industry that has earned particular ... ...

    Abstract Silicosis is typically an indolent lung disease caused by long-standing occupational exposure to respirable crystalline silica, classically in professions such as sandblasting and mining.  An increasingly popular industry that has earned particular interest because of its association with silicosis is customization and installation of artificial stone countertops for domestic applications. In addition to causing a spike in cases of chronic and accelerated silicosis, both quite familiar to respiratory clinicians, outbreaks of artificial stone silicosis have brought to the fore a historically rare entity known as acute silicosis, or silicoproteinosis, a more rapid presentation of the disease. Failure to suspect this uncommon condition can lead to diagnostic confusion and therefore ineffective treatment as was true initially of the patient we describe herein.  The case description is followed by a clinical, radiological, and pathological overview of acute artificial stone silicosis (or silicoproteinosis), which is an emerging pneumoconiosis with sparse coverage in the literature to date.  This case also adds to the few existing reports on the use of therapeutic whole lung lavage for silicoproteinosis.
    MeSH term(s) Humans ; Adult ; Silicosis/diagnosis ; Silicosis/diagnostic imaging ; Silicon Dioxide ; Occupational Exposure/adverse effects ; Dyspnea/diagnosis ; Dyspnea/etiology ; Occupations
    Chemical Substances Silicon Dioxide (7631-86-9)
    Language English
    Publishing date 2022-09-13
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 1160940-0
    ISSN 1122-0643 ; 1120-0391
    ISSN 1122-0643 ; 1120-0391
    DOI 10.4081/monaldi.2022.2345
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  7. Article ; Online: Pleural mesothelioma classification update.

    Beasley, Mary Beth / Galateau-Salle, Francoise / Dacic, Sanja

    Virchows Archiv : an international journal of pathology

    2021  Volume 478, Issue 1, Page(s) 59–72

    Abstract: The 2015 WHO classification of pleural mesotheliomas includes three major histologic subtypes-epithelioid, sarcomatoid, and biphasic. Recent genomic data has supported the need for a more granular and clinically valid classification beyond the three ... ...

    Abstract The 2015 WHO classification of pleural mesotheliomas includes three major histologic subtypes-epithelioid, sarcomatoid, and biphasic. Recent genomic data has supported the need for a more granular and clinically valid classification beyond the three current subtypes. Because of tumor rarity and overlapping histologic features with other tumor types, diagnostic immunohistochemical work up is essential component in establishing the final diagnosis of mesothelioma. The use of BAP1 and CDKN2A/MTAP improves the diagnostic sensitivity of effusion specimens and are valuable in establishing the diagnosis of epithelioid mesothelioma. The major change in the forthcoming WHO classification is the inclusion of mesothelioma in situ as a diagnostic category. In this review, we discuss recently proposed changes in the histologic classification of pleural mesothelioma, differential diagnosis, and importance of ancillary diagnostic studies.
    MeSH term(s) Biomarkers, Tumor/metabolism ; Cyclin-Dependent Kinase Inhibitor p16/metabolism ; Diagnosis, Differential ; Humans ; Immunohistochemistry ; Mesothelioma, Malignant/diagnosis ; Mesothelioma, Malignant/metabolism ; Mesothelioma, Malignant/pathology ; Pleural Neoplasms/diagnosis ; Pleural Neoplasms/metabolism ; Pleural Neoplasms/pathology ; Tumor Suppressor Proteins/metabolism ; Ubiquitin Thiolesterase/metabolism
    Chemical Substances BAP1 protein, human ; Biomarkers, Tumor ; CDKN2A protein, human ; Cyclin-Dependent Kinase Inhibitor p16 ; Tumor Suppressor Proteins ; Ubiquitin Thiolesterase (EC 3.4.19.12)
    Language English
    Publishing date 2021-01-21
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1184867-4
    ISSN 1432-2307 ; 0945-6317
    ISSN (online) 1432-2307
    ISSN 0945-6317
    DOI 10.1007/s00428-021-03031-7
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  8. Article ; Online: Development of the Doctor of Nursing Practice Nurse Practitioner Minimum Data Set (DNP NP MDS).

    Faraz Covelli, Asefeh / Buchholz, Susan Weber / Fowler, Leanne H / Beasley, Sharon / Bigley, Mary Beth

    Journal of professional nursing : official journal of the American Association of Colleges of Nursing

    2022  Volume 39, Page(s) 54–68

    Abstract: Background: While the number of Doctor of Nursing Practice (DNP) programs has grown steadily, there is limited data on how national organizations are collecting data on DNP-prepared nurse practitioners (NPs) and no standard instrument exists to collect ... ...

    Abstract Background: While the number of Doctor of Nursing Practice (DNP) programs has grown steadily, there is limited data on how national organizations are collecting data on DNP-prepared nurse practitioners (NPs) and no standard instrument exists to collect data on DNP-prepared NPs.
    Purpose: The purpose of this study was to develop a universal minimum data set (MDS) for the DNP-prepared NP population.
    Method: Instrument development consisted of several sequential stages, including conceptualization and item generation, preliminary evaluation of items, field testing the survey, and analysis of scale development data.
    Findings: A set of 16 core variables and 19 additional variables were developed to collect standardized data on the demographics, education, and practice patterns of DNP-prepared NPs. Pilot testing revealed high correlations between the activities DNP-prepared NPs are prepared for and typically participate in a typical workweek and in their career. The MDS demonstrated high reliability in our sample.
    Discussion: The DNP NP MDS can be used for data collection by various stakeholders, including national organizations, to facilitate improved tracking of outcome data for the DNP-prepared NP workforce. It can also provide data-driven support for the need and significance of the DNP degree for NPs.
    MeSH term(s) Education, Nursing, Graduate ; Humans ; Nurse Practitioners/education ; Reproducibility of Results
    Language English
    Publishing date 2022-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632951-2
    ISSN 1532-8481 ; 8755-7223
    ISSN (online) 1532-8481
    ISSN 8755-7223
    DOI 10.1016/j.profnurs.2021.12.012
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  9. Article ; Online: Pulmonary Pathology Society Survey on Practice Approaches in the Histologic Diagnosis of Fibrotic Interstitial Lung Disease: Consensus and Opportunities.

    Smith, Maxwell L / Mino-Kenudson, Mari / Butterfield, Richard J / Dacic, Sanja / Colby, Thomas V / Churg, Andrew / Beasley, Mary Beth / Hariri, Lida P

    Archives of pathology & laboratory medicine

    2023  Volume 148, Issue 2, Page(s) 168–177

    Abstract: Context.—: The pathologic diagnosis of usual interstitial pneumonia (UIP) remains a challenging area, and application of histologic UIP guidelines has proved difficult.: Objective.—: To understand current practice approaches by pulmonary pathologists ...

    Abstract Context.—: The pathologic diagnosis of usual interstitial pneumonia (UIP) remains a challenging area, and application of histologic UIP guidelines has proved difficult.
    Objective.—: To understand current practice approaches by pulmonary pathologists for the histologic diagnosis of UIP and other fibrotic interstitial lung diseases (ILDs).
    Design.—: The Pulmonary Pathology Society (PPS) ILD Working Group developed and sent a 5-part survey on fibrotic ILD electronically to the PPS membership.
    Results.—: One hundred sixty-one completed surveys were analyzed. Of the respondents, 89% reported using published histologic features in clinical guidelines for idiopathic pulmonary fibrosis (IPF) in their pathologic diagnosis; however, there was variability in reporting terminology, quantity and quality of histologic features, and the use of guideline categorization. Respondents were very likely to have access to pulmonary pathology colleagues (79%), pulmonologists (98%), and radiologists (94%) to discuss cases. Half of respondents reported they may alter their pathologic diagnosis based on additional clinical and radiologic history if it is pertinent. Airway-centered fibrosis, granulomas, and types of inflammatory infiltrates were considered important, but there was poor agreement on how these features are defined.
    Conclusions.—: There is significant consensus among the PPS membership on the importance of histologic guidelines/features of UIP. There are unmet needs for (1) consensus and standardization of diagnostic terminology and incorporation of recommended histopathologic categories from the clinical IPF guidelines into pathology reports, (2) agreement on how to incorporate into the report relevant clinical and radiographic information, and (3) defining the quantity and quality of features needed to suggest alternative diagnoses.
    MeSH term(s) Humans ; Consensus ; Tomography, X-Ray Computed/methods ; Lung Diseases, Interstitial/diagnosis ; Lung Diseases, Interstitial/pathology ; Idiopathic Pulmonary Fibrosis/diagnosis ; Idiopathic Pulmonary Fibrosis/pathology ; Lung/diagnostic imaging ; Lung/pathology ; Fibrosis
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2022-0530-OA
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  10. Article ; Online: Pulmonary Manifestations of Acute Lung Injury: More Than Just Diffuse Alveolar Damage.

    Hughes, Kenneth T / Beasley, Mary Beth

    Archives of pathology & laboratory medicine

    2017  Volume 141, Issue 7, Page(s) 916–922

    Abstract: Context: - Acute pulmonary injury may occur as a result of myriad direct or indirect pulmonary insults, often resulting in hypoxemic respiratory failure and clinical acute respiratory distress syndrome. Histologically, most patients will exhibit diffuse ...

    Abstract Context: - Acute pulmonary injury may occur as a result of myriad direct or indirect pulmonary insults, often resulting in hypoxemic respiratory failure and clinical acute respiratory distress syndrome. Histologically, most patients will exhibit diffuse alveolar damage on biopsy, but other histologic patterns may be encountered, such as acute eosinophilic pneumonia, acute fibrinous and organizing pneumonia, and diffuse alveolar hemorrhage with capillaritis.
    Objective: - To review the diagnostic features of various histologic patterns associated with a clinical picture of acute lung injury, and to discuss key features in the differential diagnosis.
    Data sources: - The review is drawn from pertinent peer-reviewed literature and the personal experience of the authors.
    Conclusions: - Acute pulmonary injury is a significant cause of morbidity and mortality. In addition to diffuse alveolar damage, pathologists should be aware of alternate histologic patterns of lung disease that may present with a similar clinical presentation because this may impact treatment decisions and disease outcome.
    MeSH term(s) Acute Lung Injury/diagnosis ; Acute Lung Injury/pathology ; Humans
    Language English
    Publishing date 2017-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2016-0342-RA
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