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Article: Usefulness of Combined Measurement of Surfactant Protein D, Thrombin-Antithrombin III Complex, D-Dimer, and Plasmin-α2 Plasmin Inhibitor Complex in Acute Exacerbation of Interstitial Lung Disease: A Retrospective Cohort Study.

Takeshita, Yuichiro / To, Masako / Kurosawa, Yusuke / Furusho, Naho / Kinouchi, Toru / Tsushima, Kenji / Tada, Yuji / To, Yasuo / Sakao, Seiichiro

Journal of clinical medicine

2024 Volume 13, Issue 8

Abstract: Background/ ... ...

Abstract	Background/Objectives
Language	English
Publishing date	2024-04-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13082427
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The National Early Warning Score on admission predicts severe disease and in-hospital mortality of the coronavirus disease 2019 Delta variant: A retrospective cohort study.

Endo, Takuro / Khoujah, Danya / Motohashi, Takako / Shinozaki, Tomohiro / Tsushima, Kenji / Fujitani, Shigeki / Shiga, Takashi

Acute medicine & surgery

2023 Volume 10, Issue 1, Page(s) e851

Abstract: Background: Clinical risk scores are widely used in emergency medicine, and some studies have evaluated their use in patients with coronavirus disease 2019 (COVID-19). However, no studies have evaluated their use in patients with the COVID-19 Delta ... ...

Abstract	Background: Clinical risk scores are widely used in emergency medicine, and some studies have evaluated their use in patients with coronavirus disease 2019 (COVID-19). However, no studies have evaluated their use in patients with the COVID-19 Delta variant. We aimed to study the performance of four different clinical scores (National Early Warning Score [NEWS], quick Sequential Organ Failure Assessment [qSOFA], Confusion, Respiratory rate, Blood pressure, and Age ≥65 [CRB-65], and Kanagawa score) in predicting the risk of severe disease (defined as the need for intubation and in-hospital mortality) in patients with the COVID-19 Delta variant. Methods: This was a retrospective cohort study of patients hospitalized with suspected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant infection between June 1 and December 31, 2021. The primary outcomes were the sensitivity and specificity of the aforementioned clinical risk scores at admission to predict severe disease. Areas under the receiver operating characteristic curves (AUROCs) were compared between the clinical risk scores and we identified new cut-off points for all four scores. Results: A total of 249 adult patients were included, of whom 18 developed severe disease. A NEWS ≥7 at admission predicted severe disease with 72.2% sensitivity and 86.2% specificity. The NEWS (AUROC 0.88) was superior to both the qSOFA (AUROC 0.74) and the CRB-65 (AUROC 0.67), and there was no significant difference between the NEWS and Kanagawa score (AUROC 0.86). Conclusion: The NEWS at hospital admission predicted the severity of the COVID-19 Delta variant with high accuracy.
Language	English
Publishing date	2023-05-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2751184-4
ISSN	2052-8817 ; 2052-8817
ISSN (online)	2052-8817
ISSN	2052-8817
DOI	10.1002/ams2.851
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Article ; Online: Avian retroviral cardiomyopathy induced by infectious molecular clones of avian leukosis viruses (fowl glioma-inducing virus variants).

Nishiura, Hayate / Tsushima, Aya / Kato, Azusa / Saito, Shun / Iwamoto, Takeshi / Kondo, Yui / Hatai, Hitoshi / Ochiai, Kenji

Avian pathology : journal of the W.V.P.A

2023 Volume 52, Issue 4, Page(s) 264–276

Abstract: We previously described cardiomyocyte abnormality caused by Km_5666 strain, a variant of fowl glioma-inducing virus (FGV) prototype, which is an avian leukosis virus (ALV). However, the cardiac involvement appeared to be eradicated from the flock after a ...

Abstract	We previously described cardiomyocyte abnormality caused by Km_5666 strain, a variant of fowl glioma-inducing virus (FGV) prototype, which is an avian leukosis virus (ALV). However, the cardiac involvement appeared to be eradicated from the flock after a few years. An epidemiological survey from 2017 to 2020 was performed to elucidate the current prevalence of the cardiopathogenic strains in this flock. Four of the 71 bantams pathologically examined showed both glioma and cardiomyocyte abnormality, from which three ALV strains were detected. DNA sequencing revealed that several different ALV strains coexisted in each bantam and that the conserved Km_5666 virus fluid also contained at least two different ALV strains. We generated three infectious molecular clones from these samples, named KmN_77_clone_A, KmN_77_clone_B, and Km_5666_clone. The
MeSH term(s)	Animals ; Avian Leukosis Virus/genetics ; Chickens ; Avian Leukosis ; Glioma/veterinary ; Clone Cells/pathology ; Poultry Diseases
Language	English
Publishing date	2023-06-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1476380-1
ISSN	1465-3338 ; 0307-9457
ISSN (online)	1465-3338
ISSN	0307-9457
DOI	10.1080/03079457.2023.2215187
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Article ; Online: Neuro-Behçet's disease with atypical subcortical nodular lesions: A case report and treatment approach.

Yoshimoto, Kiyomi / Kobayashi, Tadanao / Matsuoka, Hidetoshi / Nishimura, Nobushiro / Kawashima, Hiromasa / Yoneima, Ryo / Tsushima, Emiko / Ono, Shiro / Nishio, Kenji

Modern rheumatology case reports

2023

Abstract: Neuro-Behçet's disease (NB) is a rare complication of Behçet's disease (BD) characterised by central nervous system involvement. While NB typically presents with brainstem lesions, we report an unusual case of NB in a 27-year-old male with multiple ... ...

Abstract	Neuro-Behçet's disease (NB) is a rare complication of Behçet's disease (BD) characterised by central nervous system involvement. While NB typically presents with brainstem lesions, we report an unusual case of NB in a 27-year-old male with multiple subcortical nodular brain lesions but without brainstem, thalamic, or basal ganglia involvement, making this presentation exceptionally rare. The patient had a prior diagnosis of BD and was HLA-B51 positive. He presented with a sudden loss of consciousness, which was attributed to a seizure. Imaging studies showed low-density areas in the white matter of the bilateral temporal lobes and the right frontoparietal lobe on brain CT. Cerebrospinal fluid examination indicated elevated initial pressure and protein concentration, along with increased interleukin-6. Despite presenting with nodular brain lesions, distinguishing between NB and infectious diseases such as tuberculosis (TB) was challenging, and required brain biopsy revealing vasculitis. However, even with this biopsy result, TB could not be ruled out, so TB was treated at the same time. Treatment with anti-TB drugs and standard steroid therapy initially failed to improve the patient's condition. However, increasing the steroid dosage considering the increased steroid degradation by rifampicin, including pulse therapy with 2 g of methylprednisolone, followed by 18 mg of betamethasone, led to remission of the nodular brain lesions and resolution of the nasopharyngeal ulcer. This case highlights the diagnostic challenge of differentiating between NB and TB based on imaging alone and the potential efficacy of high-dose steroid therapy in cases of steroid-resistant NB with subcortical nodular brain lesions.
Language	English
Publishing date	2023-12-08
Publishing country	England
Document type	Journal Article
ISSN	2472-5625
ISSN (online)	2472-5625
DOI	10.1093/mrcr/rxad070
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Article: A case of bunashimeji mushroom-induced hypersensitivity pneumonitis diagnosed by inhalational provocation test in a hospital room.

Akagami, Tomoe / Nakagome, Kazuyuki / Takagi, Sotaro / Yamazaki, Susumu / Minezaki, Shohei / Nakamura, Hidetoshi / Tsushima, Kenji / Nagata, Makoto

Respirology case reports

2023 Volume 11, Issue 5, Page(s) e01134

Abstract: A 66-year-old woman was admitted to our hospital with a 2-month history of dry cough and exertional dyspnea. She had worked as a mushroom farmer and had been exposed to mushroom for more than 40 years. The patient showed elevated levels of KL-6 (2966 U/ ... ...

Abstract	A 66-year-old woman was admitted to our hospital with a 2-month history of dry cough and exertional dyspnea. She had worked as a mushroom farmer and had been exposed to mushroom for more than 40 years. The patient showed elevated levels of KL-6 (2966 U/mL) and surfactant protein D (410 ng/mL), and computed tomography of the chest revealed ground-glass opacities and fine nodular shadows in both lungs, suggesting mushroom-induced hypersensitivity pneumonitis. Pulmonary function testing revealed decreases in forced vital capacity (78% of predicted) and carbon monoxide diffusing capacity (67% of predicted). The inhalational provocation test was positive for bunashimeji mushrooms. Precipitating antibody was only identified for spores or bodies of bunashimeji mushrooms, and lymphocyte stimulation testing with spores or bodies of bunashimeji mushrooms also yielded positive results. Bunashimeji mushroom-induced hypersensitivity pneumonitis was therefore diagnosed. Radiological findings and pulmonary function were improved by corticosteroid therapy and the patient has since remained healthy with allergen avoidance.
Language	English
Publishing date	2023-04-04
Publishing country	United States
Document type	Case Reports
ZDB-ID	2750180-2
ISSN	2051-3380
ISSN	2051-3380
DOI	10.1002/rcr2.1134
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Article ; Online: Relationship between Anti-SARS-CoV-2 S Abs and IFN-λ3 Levels in the Administration of Oxygen following COVID-19 Vaccination.

Takeshita, Yuichiro / To, Yasuo / Kurosawa, Yusuke / Kinouchi, Toru / Tsuya, Kota / Tada, Yuji / Tsushima, Kenji

ImmunoHorizons

2022 Volume 7, Issue 1, Page(s) 97–105

Abstract: Although the effectiveness of vaccination at preventing hospitalization and severe coronavirus disease (COVID-19) has been reported in numerous studies, the detailed mechanism of innate immunity occurring in host cells by breakthrough infection is ... ...

Abstract	Although the effectiveness of vaccination at preventing hospitalization and severe coronavirus disease (COVID-19) has been reported in numerous studies, the detailed mechanism of innate immunity occurring in host cells by breakthrough infection is unclear. One hundred forty-six patients were included in this study. To determine the effects of vaccination and past infection on innate immunity following SARS-CoV-2 infection, we analyzed the relationship between anti-SARS-CoV-2 S Abs and biomarkers associated with the deterioration of COVID-19 (IFN-λ3, C-reactive protein, lactate dehydrogenase, ferritin, procalcitonin, and D-dimer). Anti-S Abs were classified into two groups according to titer: high titer (≥250 U/ml) and low titer (<250 U/ml). A negative correlation was observed between anti-SARS-CoV-2 S Abs and IFN-λ3 levels (r = -0.437, p < 0.001). A low titer of anti-SARS-CoV-2 S Abs showed a significant association with oxygen demand in patients, excluding aspiration pneumonia. Finally, in a multivariate analysis, a low titer of anti-SARS-CoV-2 S Abs was an independent risk factor for oxygen demand, even after adjusting for age, sex, body mass index, aspiration pneumonia, and IFN-λ3 levels. In summary, measuring anti-SARS-CoV-2 S Abs and IFN-λ3 may have clinical significance for patients with COVID-19. To predict the oxygen demand of patients with COVID-19 after hospitalization, it is important to evaluate the computed tomography findings to determine whether the pneumonia is the result of COVID-19 or aspiration pneumonia.
MeSH term(s)	Humans ; COVID-19/immunology ; COVID-19/therapy ; Oxygen/administration & dosage ; Pneumonia, Aspiration ; SARS-CoV-2 ; Antibodies, Viral/blood ; Interferons/immunology
Chemical Substances	Oxygen (S88TT14065) ; Antibodies, Viral ; interferon-lambda, human ; Interferons (9008-11-1)
Language	English
Publishing date	2022-12-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2573-7732
ISSN (online)	2573-7732
DOI	10.4049/immunohorizons.2200093
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Article ; Online: Utility of nintedanib for severe idiopathic pulmonary fibrosis: a single-center retrospective study [Response to letter].

Abe, Mitsuhiro / Tsushima, Kenji / Tatsumi, Koichiro

Drug design, development and therapy

2019 Volume 13, Page(s) 1687–1688

MeSH term(s)	Humans ; Idiopathic Pulmonary Fibrosis ; Indoles ; Protein Kinase Inhibitors ; Retrospective Studies
Chemical Substances	Indoles ; Protein Kinase Inhibitors ; nintedanib (G6HRD2P839)
Language	English
Publishing date	2019-05-14
Publishing country	New Zealand
Document type	Journal Article ; Comment
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S207537
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Article: Real-world effects of once-daily inhaled steroid (fluticasone furoate) combined with long-acting beta-2 agonist (vilanterol) and long-acting muscarinic antagonist (umeclidinium) on lung function tests of asthma patients in Japan.

Umeda, Akira / Shimada, Hisato / Yamane, Tateki / Mochizuki, Taichi / Inoue, Yasushi / Tsushima, Kenji / Miyagawa, Kazuya / Mochida, Atsumi / Takeda, Hiroshi / Okada, Yasumasa / Masaki, Katsunori / Matsusaka, Masako / Fukunaga, Koichi

Frontiers in physiology

2023 Volume 14, Page(s) 1131949

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-04-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2023.1131949
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Article ; Online: Avian retroviral cardiomyopathy induced by infectious molecular clones of avian leukosis viruses (fowl glioma-inducing virus variants)

Nishiura, Hayate / Tsushima, Aya / Kato, Azusa / Saito, Shun / Iwamoto, Takeshi / Kondo, Yui / Hatai, Hitoshi / Ochiai, Kenji

Avian Pathology. 2023 July 04, v. 52, no. 4 p.264-276

2023

Abstract	We previously described cardiomyocyte abnormality caused by Km_5666 strain, a variant of fowl glioma-inducing virus (FGV) prototype, which is an avian leukosis virus (ALV). However, the cardiac involvement appeared to be eradicated from the flock after a few years. An epidemiological survey from 2017 to 2020 was performed to elucidate the current prevalence of the cardiopathogenic strains in this flock. Four of the 71 bantams pathologically examined showed both glioma and cardiomyocyte abnormality, from which three ALV strains were detected. DNA sequencing revealed that several different ALV strains coexisted in each bantam and that the conserved Km_5666 virus fluid also contained at least two different ALV strains. We generated three infectious molecular clones from these samples, named KmN_77_clone_A, KmN_77_clone_B, and Km_5666_clone. The envSU of KmN_77_clone_A shared high sequence identity with that of Km_5666 (94.1%). In contrast, the envSU of KmN_77_clone_B showed >99.2% nucleotide similarity with that of an FGV variant without cardiopathogenicity. Furthermore, Km_5666_clone experimentally reproduced both gliomas and cardiomyocyte abnormality in chickens. From these results, it is suggested that the pathogenic determinant of cardiomyocyte abnormality is located in envSU similar to that of Km_5666. The cloning technique described here is beneficial for evaluating the viral pathogenicity in cases where affected birds are coinfected with several different ALV strains.
Keywords	Avian leukosis virus ; Bantam ; DNA ; birds ; cardiomyocytes ; cardiomyopathy ; epidemiological studies ; flocks ; glioma ; mixed infection ; pathogenicity ; prototypes ; sequence analysis ; viruses ; cerebellar hypoplasia ; experimental infection ; molecular clone
Language	English
Dates of publication	2023-0704
Size	p. 264-276.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1476380-1
ISSN	1465-3338 ; 0307-9457
ISSN (online)	1465-3338
ISSN	0307-9457
DOI	10.1080/03079457.2023.2215187
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Article ; Online: Clinical Characteristics and Risk Factors of Lung Injury Induced by Nab-Paclitaxel.

Yoshioka, Keiichiro / Abe, Mitsuhiro / Shiko, Yuki / Koshikawa, Ken / Kawasaki, Yohei / Iwasawa, Shunichiro / Terada, Jiro / Tsushima, Kenji / Tatsumi, Koichiro / Suzuki, Takuji

Drug design, development and therapy

2022 Volume 16, Page(s) 759–767

Abstract: Background/aim: Nab-paclitaxel (Nab-PTX) has been widely used to treat several advanced cancers. Nab-PTX can cause drug-induced lung injury (DILI); however, its clinical and radiographic features have not been clarified. We aimed to assess the clinical ... ...

Abstract	Background/aim: Nab-paclitaxel (Nab-PTX) has been widely used to treat several advanced cancers. Nab-PTX can cause drug-induced lung injury (DILI); however, its clinical and radiographic features have not been clarified. We aimed to assess the clinical characteristics of Nab-PTX-induced lung injury and identify its associated risk factors. Patients and methods: We retrospectively investigated 304 patients who received Nab-PTX at Chiba University Hospital between November 2010 and November 2017. We obtained information regarding the clinical course, laboratory findings, and chest computed tomography findings from their medical records. Results: Forty-one patients (13%) developed DILI. Grade 1 lung injury occurred in 27 patients (8.8%), grade 2, 8 patients (2.6%); grade 3, 3 patients (0.9%); grade 4, 1 (0.3%); and grade 5, 2 (0.6%). Multivariate analysis revealed that age >56 years (odds ratio [OR]: 3.0), pre-existing interstitial lung changes (OR: 3.2), and combined drugs with gemcitabine (OR: 2.7) were independent risk factors for DILI owing to Nab-PTX administration. Conclusion: Nab-PTX-induced lung injury is not rare; however, most cases are asymptomatic (grade 1). Older age, pre-existing interstitial lung changes, and combined drugs with gemcitabine could increase the incidence of Nab-PTX-induced lung injury; such patients should be treated with greater care.
MeSH term(s)	Albumins ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Humans ; Lung Injury/chemically induced ; Lung Injury/epidemiology ; Middle Aged ; Paclitaxel ; Retrospective Studies ; Risk Factors
Chemical Substances	130-nm albumin-bound paclitaxel ; Albumins ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2022-03-22
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S342283
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