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  1. Article ; Online: Hemostasis - A Balancing Act.

    van den Berg, H Marijke / Srivastava, Alok

    The New England journal of medicine

    2023  Volume 389, Issue 9, Page(s) 853–856

    MeSH term(s) Humans ; Hemostasis/drug effects ; Hemostasis/physiology
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2304535
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  2. Book ; Online: Modernity, Minority, and the Public Sphere: Jews and Christians in the Middle East

    Goldstein-Sabbah, S.R. / Murre-van den Berg Nijmegen, H.L. / Murre-van den Berg, H.L. / Murre-van den Berg, H.L.

    2016  

    Keywords Middle Eastern history
    Size 1 electronic resource (330 pages)
    Publisher Brill
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021027756
    ISBN 9789004323285 ; 9004323287
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Outcomes of Immediate Total Thyroidectomy in First-Side Loss of Neuromonitoring Signal.

    Ramesh, Sruthi / Van Den Berg, Nadia H / Sheahan, Patrick

    JAMA otolaryngology-- head & neck surgery

    2024  

    Abstract: Importance: Use of intraoperative neuromonitoring (IONM) during thyroidectomy can nearly eliminate the risk of postoperative bilateral vocal cord palsy (VCP) by indicating staged surgery in cases of loss of signal (LOS) on the first side of planned ... ...

    Abstract Importance: Use of intraoperative neuromonitoring (IONM) during thyroidectomy can nearly eliminate the risk of postoperative bilateral vocal cord palsy (VCP) by indicating staged surgery in cases of loss of signal (LOS) on the first side of planned total thyroidectomy. However, aborting planned total thyroidectomy may lead to persistence of symptoms, delay in adjuvant treatment, and patient inconvenience and distress. There are few data to guide a selective approach to total thyroidectomy in patients with first-side LOS.
    Objective: To investigate outcomes of immediate bilateral surgery in patients undergoing total thyroidectomy with first-side LOS.
    Design, setting, and participants: This cohort study was a retrospective review of outcomes for patients undergoing thyroidectomy between January 2016 and July 2023 at an academic tertiary referral center for thyroid surgery. Consecutive patients scheduled for total thyroidectomy using IONM were included. Exclusion criteria were preoperative VCP, deliberate sacrifice of recurrent laryngeal nerve (RLN), inadvertent RLN resection, and surgery performed without IONM.
    Exposures: Total thyroidectomy performed using IONM.
    Main outcome measures: Vocal mobility on first postoperative day as assessed by flexible laryngoscopy; secondary outcome measures included subjective voice assessment, other postoperative complications, and long-term vocal mobility.
    Results: Among 400 patients undergoing planned total thyroidectomy (mean age, 50.5 years [range, 4-88 years]; 318 female [79.5%]), 51 (12.8%) had first-side LOS, of whom 37 (9.3%) had persistent LOS. Twenty-nine patients (56% of procedures with first-side LOS, including 18 with persistent LOS) proceeded to immediate total thyroidectomy. Postoperatively, 16 patients (55% of patients undergoing total thyroidectomy following first-side LOS, including 14 of 18 with persistent LOS) had impaired vocal mobility. One patient had bilateral VCP that did not require tracheostomy, and 2 had postoperative hypoparathyroidism. Of those whose surgery was aborted after first-side LOS, 8 of 22 (36%) underwent completion thyroidectomy at a later stage. In those undergoing completion thyroidectomy, 2 of 8 (25%) had temporary VCP after the second surgery, 2 (25%) had permanent hypoparathyroidism, and 1 (12.5%) developed inoperable cancer. Postoperative VCP was fully reversible in all but 1 patient.
    Conclusion and relevance: Among patients planned for total thyroidectomy who develop first-side LOS, immediate total thyroidectomy may be considered among those who have pressing reasons for same, and where surgical difficulties might be anticipated in a secondary surgery.
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2024.0698
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  4. Article ; Online: H. Berg, T. Wijsenbeek, E. Fischer, Venter, fabriqueur, fabrikant. Joodse ondernemers en ondernemingen in Nederland, 1796-1940

    M.H. van Kuik

    BMGN : Low Countries Historical Review, Vol 110, Iss 3, Pp 432-

    1995  Volume 433

    Keywords History (General) and history of Europe ; D ; History (General) ; D1-2009
    Publishing date 1995-01-01T00:00:00Z
    Publisher Utrecht University Library Open Access Journals
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article ; Online: H. Berg, T. Wijsenbeek, E. Fischer, Venter, fabriqueur, fabrikant. Joodse ondernemers en ondernemingen in Nederland, 1796-1940

    M.H. van Kuik

    BMGN : Low Countries Historical Review, Vol 110, Iss 3, Pp 432-

    1995  Volume 433

    Keywords History (General) and history of Europe ; D ; History (General) ; D1-2009
    Publishing date 1995-01-01T00:00:00Z
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Book: Towards healthy cities

    Otgaar, Alexander H. J. / Klijs, Jeroen / Berg, Leo van den

    comparing conditions for change

    (EURICUR series)

    2011  

    Author's details Alexander Otgaar ; Jeroen Klijs ; Leo van den Berg
    Series title EURICUR series
    Keywords Urban Health ; Social Change ; Environmental Health ; WHO Healthy Cities Project ; Urban health--Case studies ; Health promotion ; Health status indicators ; Health planning--Citizen participation ; Social responsibility of business
    Subject code 362.10425
    Language English
    Size 122 S. : Ill., graph. Darst.
    Publisher Ashgate
    Publishing place Farnham u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT016657283
    ISBN 978-1-4094-2066-8 ; 1-4094-2066-3 ; 9781409420675 ; 1409420671
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2011 A 901 order for loan Magazin

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  7. Article ; Online: Harmonized standard operating procedures for administering the ALS functional rating scale-revised.

    Shefner, Jeremy M / Bunte, Tommy / Kittle, Gale / Genge, Angela / van den Berg, Leonard H

    Amyotrophic lateral sclerosis & frontotemporal degeneration

    2024  Volume 25, Issue 1-2, Page(s) 26–33

    Abstract: The ALS Functional Rating Scale-Revised is the most commonly used primary outcome measure in current ALS clinical trials. While rigorous training and certification is generally recognized as critical to reliable performance, differences have existed ... ...

    Abstract The ALS Functional Rating Scale-Revised is the most commonly used primary outcome measure in current ALS clinical trials. While rigorous training and certification is generally recognized as critical to reliable performance, differences have existed between training in the two groups responsible for most training in ALS outcome measures. We present a harmonized standard operating procedure which is intended to further reduce response variability by the use of identical training in North America and Europe.
    MeSH term(s) Humans ; Amyotrophic Lateral Sclerosis/diagnosis ; Outcome Assessment, Health Care ; Europe
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2705049-X
    ISSN 2167-9223 ; 2167-8421
    ISSN (online) 2167-9223
    ISSN 2167-8421
    DOI 10.1080/21678421.2023.2260832
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    Zs.A 5874: Show issues Location:
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  8. Article ; Online: Model calculations and measurements of shooting sound in practical situations.

    Salomons, E M / van der Eerden, F J M / van den Berg, F H A

    The Journal of the Acoustical Society of America

    2024  Volume 155, Issue 2, Page(s) 1162–1181

    Abstract: Shooting sound in practical situations with propagation distances up to 300 m is investigated by means of model calculations and measurements. The results illustrate uncertainties in the model calculations for practical situations. The measurements were ... ...

    Abstract Shooting sound in practical situations with propagation distances up to 300 m is investigated by means of model calculations and measurements. The results illustrate uncertainties in the model calculations for practical situations. The measurements were performed with various small-caliber weapons. Microphones were placed at positions screened by a noise barrier, and also at unscreened positions. The measured signals contain muzzle sound and bullet sound. The model calculations for muzzle sound and bullet sound take into account emission spectra and various propagation attenuation terms, including ground attenuation and barrier attenuation. The bullet sound model is based on a nonlinear theory of N waves generated by supersonic projectiles. For the unscreened situation, model and measurement results show that the sound levels are considerably reduced by ground attenuation. Ground-level variations and ground roughness in the measurement area play an important role. At a 300 m distance, the A-weighted bullet sound level is higher than the A-weighted muzzle sound level, which underlines the importance of bullet sound. For the screened situation, model and measurement results are used to analyze diffraction of bullet sound by the horizontal and vertical edges of the barrier. The diffraction is explained by considering Fresnel zones on the bullet trajectory.
    Language English
    Publishing date 2024-02-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219231-7
    ISSN 1520-8524 ; 0001-4966
    ISSN (online) 1520-8524
    ISSN 0001-4966
    DOI 10.1121/10.0024752
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    Zs.B 591: Show issues Location:
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  9. Article ; Online: Neural stem cell homeostasis is affected in cortical organoids carrying a mutation in Angiogenin.

    Ferguson, Ross / van Es, Michael A / van den Berg, Leonard H / Subramanian, Vasanta

    The Journal of pathology

    2024  Volume 262, Issue 4, Page(s) 410–426

    Abstract: Mutations in Angiogenin (ANG) and TARDBP encoding the 43 kDa transactive response DNA binding protein (TDP-43) are associated with amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD). ANG is neuroprotective and plays a role in stem cell ... ...

    Abstract Mutations in Angiogenin (ANG) and TARDBP encoding the 43 kDa transactive response DNA binding protein (TDP-43) are associated with amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD). ANG is neuroprotective and plays a role in stem cell dynamics in the haematopoietic system. We obtained skin fibroblasts from members of an ALS-FTD family, one with mutation in ANG, one with mutation in both TARDBP and ANG, and one with neither mutation. We reprogrammed these fibroblasts to induced pluripotent stem cells (iPSCs) and generated cortical organoids as well as induced stage-wise differentiation of the iPSCs to neurons. Using these two approaches we investigated the effects of FTD-associated mutations in ANG and TARDBP on neural precursor cells, neural differentiation, and response to stress. We observed striking neurodevelopmental defects such as abnormal and persistent rosettes in the organoids accompanied by increased self-renewal of neural precursor cells. There was also a propensity for differentiation to later-born neurons. In addition, cortical neurons showed increased susceptibility to stress, which is exacerbated in neurons carrying mutations in both ANG and TARDBP. The cortical organoids and neurons generated from patient-derived iPSCs carrying ANG and TARDBP gene variants recapitulate dysfunctions characteristic of frontotemporal lobar degeneration observed in FTD patients. These dysfunctions were ameliorated upon treatment with wild type ANG. In addition to its well-established role during the stress response of mature neurons, ANG also appears to play a role in neural progenitor dynamics. This has implications for neurogenesis and may indicate that subtle developmental defects play a role in disease susceptibility or onset. © 2024 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
    MeSH term(s) Humans ; Amyotrophic Lateral Sclerosis/genetics ; Frontotemporal Dementia/genetics ; Frontotemporal Dementia/pathology ; Neural Stem Cells/metabolism ; Mutation ; Homeostasis ; Ribonuclease, Pancreatic
    Chemical Substances angiogenin (EC 3.1.27.-) ; Ribonuclease, Pancreatic (EC 3.1.27.5)
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3119-7
    ISSN 1096-9896 ; 0022-3417
    ISSN (online) 1096-9896
    ISSN 0022-3417
    DOI 10.1002/path.6244
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  10. Article ; Online: Pattern of regional recurrence after selective neck dissection for clinically positive neck in mucosal squamous carcinoma.

    Altawil, Mohammad / Stanisz, Isabella / Van Den Berg, Nadia H / Sheahan, Patrick

    Head & neck

    2024  

    Abstract: Background: Selective neck dissection (SND) has traditionally been applied to clinically negative (cN0) necks in mucosal squamous cell carcinoma (SCC). We aimed to examine the oncological safety and patterns of regional recurrence (RR) of SND in ... ...

    Abstract Background: Selective neck dissection (SND) has traditionally been applied to clinically negative (cN0) necks in mucosal squamous cell carcinoma (SCC). We aimed to examine the oncological safety and patterns of regional recurrence (RR) of SND in clinically positive (cN+) necks.
    Methods: Retrospective review of prospective cohort of 206 patients with mucosal SCC undergoing neck dissection. RR was classified as occurring within previously dissected levels, within ipsilateral undissected levels, within unusual locations of ipsilateral neck, or contralateral neck.
    Results: Seven of seventy-seven (9.1%) cN+ patients undergoing SND developed isolated RR, versus 16.2% after MRND, and 8.7% after SND for cN0 disease. RR was rarely seen within undissected levels of the ipsilateral neck. RR and survival rates were not associated with ND extent (SND vs. MRND) among either cN+ or pN+ patients.
    Conclusion: SND can be safely performed in most patients with cN+ SCC, who do not have gross sternocleidomastoid infiltration or level V metastases.
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645165-2
    ISSN 1097-0347 ; 0148-6403 ; 1043-3074
    ISSN (online) 1097-0347
    ISSN 0148-6403 ; 1043-3074
    DOI 10.1002/hed.27727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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