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  1. Book: Novel treatment approaches for malignant lymphoma

    Löwenberg, Bob

    selected articles from the Blood journal

    (Blood ; [131, Beilage (2018)])

    2018  

    Author's details edited by Bob Löwenberg, MD, PhD and Nancy Berliner, MD
    Series title Blood ; [131, Beilage (2018)]
    Collection
    Language English
    Size xiii, 90 Seiten, Illustrationen, Diagramme
    Publisher The American Society of Hematology
    Publishing place Washington, DC
    Publishing country United States
    Document type Book
    HBZ-ID HT019807621
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Introduction to a review series on myelodysplastic syndromes.

    Löwenberg, Bob

    Blood

    2019  Volume 133, Issue 10, Page(s) 1001

    MeSH term(s) Epigenomics ; Genomics ; Hematology/methods ; Hematology/trends ; Humans ; Inflammation ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/therapy
    Language English
    Publishing date 2019-01-22
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2018-12-886549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Introduction to the review series on leukemic stem cells.

    Löwenberg, Bob

    Blood

    2017  Volume 129, Issue 12, Page(s) 1567

    MeSH term(s) Animals ; Humans ; Leukemia/genetics ; Leukemia/metabolism ; Leukemia/pathology ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology
    Language English
    Publishing date 2017-02-03
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2017-01-753319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Acute myelogenous leukaemia and myelodysplasia

    Löwenberg, Bob

    (Baillière's clinical haematology ; 9,1)

    1996  

    Author's details B. Löwenberg, guest ed
    Series title Baillière's clinical haematology ; 9,1
    Collection
    Keywords Leukemia, Myelocytic, Acute ; Myelodysplastic Syndromes ; Myelodysplasie ; Akute myeloische Leukämie
    Subject AML
    Language English
    Size X, 209 S. : Ill., graph. Darst.
    Publisher Baillière Tindall
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT007131118
    ISBN 0-7020-2106-7 ; 978-0-7020-2106-0
    Database Catalogue ZB MED Medicine, Health

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  5. Article ; Online: Introduction to a review series on hematologic disease at older age.

    Löwenberg, Bob

    Blood

    2017  Volume 131, Issue 5, Page(s) 473

    MeSH term(s) Age of Onset ; Aged ; Aged, 80 and over ; Aging/physiology ; DNA Damage/physiology ; Hematologic Diseases/diagnosis ; Hematologic Diseases/epidemiology ; Hematologic Diseases/genetics ; Hematologic Diseases/therapy ; Humans ; Incidence ; Late Onset Disorders/diagnosis ; Late Onset Disorders/genetics ; Late Onset Disorders/therapy ; Review Literature as Topic
    Language English
    Publishing date 2017-11-15
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2017-10-804625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The long road: improving outcome in elderly "unfit" AML?

    Löwenberg, Bob / Huls, Gerwin

    Blood

    2020  Volume 135, Issue 24, Page(s) 2114–2115

    MeSH term(s) Aged ; Bridged Bicyclo Compounds, Heterocyclic ; Humans ; Leukemia, Myeloid, Acute/therapy ; Sulfonamides
    Chemical Substances Bridged Bicyclo Compounds, Heterocyclic ; Sulfonamides ; venetoclax (N54AIC43PW)
    Language English
    Publishing date 2020-07-15
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020005651
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Blood's 70th anniversary: a rich history.

    Löwenberg, Bob

    Blood

    2015  Volume 126, Issue 24, Page(s) 2529–2530

    MeSH term(s) Hematology/history ; Hematology/trends ; History, 20th Century ; History, 21st Century ; Periodicals as Topic/history
    Language English
    Publishing date 2015-12-03
    Publishing country United States
    Document type Editorial ; Historical Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2015-10-673954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Conference proceedings: Proceedings of the Third International Symposium on Minimal Residual Disease in Acute Leukemia

    Löwenberg, Bob

    28 - 30 March, 1990, Rotterdam, The Netherlands

    (Bone marrow transplantation ; 6, Suppl. 1)

    1990  

    Event/congress International Symposium on Minimal Residual Disease in Acute Leukemia (3, 1990, Rotterdam)
    Author's details ed. B. Löwenberg
    Series title Bone marrow transplantation ; 6, Suppl. 1
    Collection
    Keywords Leukemia / congresses
    Size 134 S. : Ill., graph. Darst.
    Publisher Macmillan
    Publishing place Basingstoke
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT003577627
    Database Catalogue ZB MED Medicine, Health

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  9. Article ; Online: Professor Anton Hagenbeek 1948-2021: Father of MRD and lymphoma expert.

    Löwenberg, Bob / Kersten, Marie José / Gale, Robert Peter / van Oers, Marinus

    Bone marrow transplantation

    2021  Volume 56, Issue 8, Page(s) 2038–2039

    Language English
    Publishing date 2021-07-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-021-01375-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Towards precision medicine for AML.

    Döhner, Hartmut / Wei, Andrew H / Löwenberg, Bob

    Nature reviews. Clinical oncology

    2021  Volume 18, Issue 9, Page(s) 577–590

    Abstract: With rapid advances in sequencing technologies, tremendous progress has been made in understanding the molecular pathogenesis of acute myeloid leukaemia (AML), thus revealing enormous genetic and clonal heterogeneity, and paving the way for precision ... ...

    Abstract With rapid advances in sequencing technologies, tremendous progress has been made in understanding the molecular pathogenesis of acute myeloid leukaemia (AML), thus revealing enormous genetic and clonal heterogeneity, and paving the way for precision medicine approaches. The successful development of precision medicine for patients with AML has been exemplified by the introduction of targeted FLT3, IDH1/IDH2 and BCL-2 inhibitors. When used as single agents, these inhibitors display moderate antileukaemic activity. However, augmented clinical activity has been demonstrated when they are administered in combination with drugs with broader mechanisms of action targeting epigenetic and/or other oncogenic signalling pathways or with conventional cytotoxic agents. The development of immunotherapies has been hampered by the expression of antigens that are expressed by both leukaemic and non-malignant haematopoietic progenitor cells; nonetheless, a diverse range of immunotherapies are now entering clinical development. This myriad of emerging agents also creates challenges, such as how to safely combine agents with different mechanisms of action, the need to circumvent primary and secondary resistance, and new challenges in future clinical trial design. In this Review, we discuss the current state of precision medicine for AML, including both the potential to improve patient outcomes and the related challenges.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Epigenesis, Genetic/physiology ; Humans ; Leukemia, Myeloid, Acute/epidemiology ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/pathology ; Leukemia, Myeloid, Acute/therapy ; Molecular Targeted Therapy/methods ; Mutation ; Precision Medicine/methods ; Precision Medicine/trends
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2021-05-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2491410-1
    ISSN 1759-4782 ; 1759-4774
    ISSN (online) 1759-4782
    ISSN 1759-4774
    DOI 10.1038/s41571-021-00509-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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