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Article ; Online: Placenta Accreta Spectrum Disorder: Uterine Dehiscence, Not Placental Invasion.

Sabre, Alexander

2020 Volume 136, Issue 3, Page(s) 631–632

MeSH term(s)	Female ; Humans ; Placenta ; Placenta Accreta ; Pregnancy ; Puerperal Disorders ; Surgical Wound Dehiscence
Language	English
Publishing date	2020-08-18
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	207330-4
ISSN	1873-233X ; 0029-7844
ISSN (online)	1873-233X
ISSN	0029-7844
DOI	10.1097/AOG.0000000000004072
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Article ; Online: Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Twins Compared with Singletons.

Sabre, Alexander / Sisti, Giovanni / Gaither, Kecia

Southern medical journal

2021 Volume 114, Issue 1, Page(s) 28–31

Abstract: Objectives: It is well known that twin pregnancies confer a high degree of adverse perinatal outcomes. Fetal growth restriction, preterm labor/delivery, and hypertensive disorders of pregnancy are among the causal etiologies associated. Hematologic ... ...

Abstract	Objectives: It is well known that twin pregnancies confer a high degree of adverse perinatal outcomes. Fetal growth restriction, preterm labor/delivery, and hypertensive disorders of pregnancy are among the causal etiologies associated. Hematologic parameters, specifically, the neutrophil:lymphocyte ratio (NLR), the platelet:lymphocyte ratio (PLR), and some of the routine complete blood cell count components denote a peculiar inflammatory and immunologic profile and have been used as clinical markers for specific obstetric syndromes. To our knowledge, no study has ever evaluated NLR/PLR in twins as a distinct population from singletons. Our primary objective was to analyze NLR/PLR in twins compared with singletons. Our secondary objective was to compare white blood cells, neutrophils, lymphocytes, and platelets between twins and singletons. Methods: We conducted a retrospective case-control study comparing NLR/PLR markers in twin gestations (dichorionic/diamniotic and monochorionic/dichorionic) versus singleton pregnancies, from January 2019 to April 2020. We excluded pregnancies with potential confounding factors such as human immunodeficiency virus, chronic hypertension, smoking, pregestational diabetes mellitus, or cases with miscarriage/intrauterine fetal demise. We included twin pregnancies (two fetuses) as cases and singletons as controls. Results: We recruited 29 twins and 29 singletons, matched for age, body mass index, and parity. NLR was statistically significantly higher in the first trimester in twins compared with singletons (3.3 vs 2.7, Conclusions: We speculate that a decrease in NLR from the first to the second trimester and a decrease in platelet in the second trimester reflect both the physiologic inflammatory/immune reaction of early pregnancy and denote a vital response for the development of normal placentation in twin gestations.
MeSH term(s)	Body Mass Index ; Case-Control Studies ; Humans ; Infant, Newborn ; Leukocyte Count/methods ; Leukocyte Count/statistics & numerical data ; Lymphocytes ; Neutrophils ; Retrospective Studies ; Twins/statistics & numerical data
Language	English
Publishing date	2021-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	185329-6
ISSN	1541-8243 ; 0038-4348
ISSN (online)	1541-8243
ISSN	0038-4348
DOI	10.14423/SMJ.0000000000001190
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Article ; Online: Utilization of platelet count in prediction of post-embolization syndrome after uterine artery embolization.

Sabre, Alexander / Sisti, Giovanni / Arruarana, Victor Sebastian / Alexander, Gabrielle / Upadhyay, Ruchi

Journal of gynecology obstetrics and human reproduction

2021 Volume 50, Issue 5, Page(s) 102094

Abstract: Objective: To analyze the predictive value of neutrophils, lymphocytes, platelets, neutrophils to lymphocytes ratio (NLR), platelets to lymphocytes ratio (PLR) in identifying the occurrence of post-embolization syndrome (PES) after uterine artery ... ...

Abstract	Objective: To analyze the predictive value of neutrophils, lymphocytes, platelets, neutrophils to lymphocytes ratio (NLR), platelets to lymphocytes ratio (PLR) in identifying the occurrence of post-embolization syndrome (PES) after uterine artery embolization (UAE). Methods: We conducted a retrospective observational study in a single tertiary care center located in New York City during period of November 2014 - December 2018, for patients who underwent UAE. PES was defined as the occurrence of pelvic pain, nausea or fever within one week after the procedure. Results: We enrolled 62 patients: 12 of them had PES and 50 served as controls. Platelets were statistically significantly higher in patients with PES (p=0.036). Specifically, a platelet count greater than 336×10 Conclusion: Patients with a preprocedural platelet count less than 336×10
MeSH term(s)	Adult ; Algorithms ; Area Under Curve ; Female ; Fever/blood ; Fever/etiology ; Humans ; Leukocyte Count ; Lymphocyte Count ; Middle Aged ; Nausea/blood ; Nausea/etiology ; Neutrophils/cytology ; Pelvic Pain/blood ; Pelvic Pain/etiology ; Platelet Count ; Predictive Value of Tests ; Retrospective Studies ; Sensitivity and Specificity ; Syndrome ; Uterine Artery Embolization/adverse effects
Language	English
Publishing date	2021-02-15
Publishing country	France
Document type	Journal Article ; Observational Study
ISSN	2468-7847
ISSN (online)	2468-7847
DOI	10.1016/j.jogoh.2021.102094
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Article: Abnormal uterine bleeding types according to the PALM-COEIN FIGO classification in a medically underserved American community

Sabre, Alexander / Serventi, Lisa / Nuritdinova, Dilfuza / Schiattarella, Antonio / Sisti, Giovanni

Journal of the Turkish German Gynecological Association

2021 Volume 22, Issue 2, Page(s) 91–96

Abstract: Objective: To describe the distribution of abnormal uterine bleeding (AUB) type according to the polyp (AUB-P); adenomyosis (AUB-A); leiomyoma (AUB-L); malignancy and hyperplasia (AUB-M); coagulopathy (AUB-C); ovulatory dysfunction (AUB-O); endometrial ( ...

Abstract	Objective: To describe the distribution of abnormal uterine bleeding (AUB) type according to the polyp (AUB-P); adenomyosis (AUB-A); leiomyoma (AUB-L); malignancy and hyperplasia (AUB-M); coagulopathy (AUB-C); ovulatory dysfunction (AUB-O); endometrial (AUB-E); iatrogenic (AUB-I); and not yet classified International Federation of Gynecology and Obstetrics classification system in a medically underserved American inner-city population. Our secondary objective was to find an association between risk factors and type of AUB. Material and methods: We conducted a descriptive cross-sectional analysis at our outpatient women’s health clinic located in the Bronx, New York City, from November 2016 to December 2019. Results: Among 390 patients, the most common AUB type was AUB-L (n=185, 47.4%), followed AUB-P (n=100, 25.6%), AUB-A (n=55, 14.1%), AUB-O (n=19, 4.9%), AUB-M (n=15, 3.8%), AUB-E (n=14, 3.6%) and AUB-I (n=2, 0.5%). Race was distributed as follows: Hispanic (68.2%), Black (25.9%), Caucasian (3.3%), and Asian (2.1%). Comorbidities included hypertension (36.4%), diabetes (15.6%), and thyroid disease (6.9%). The median age at diagnosis was significantly higher in AUB-M (59 years old, p<0.001), AUB-P (52.5 years old, p<0.001), AUB-E (51.5 years old, p=0.001) compared to AUB-L (46 years old). The median body mass index (BMI) was significantly higher in AUB-E (34.2 kg/m Conclusion: In an American population of medically underserved patients, the most common cause of AUB was leiomyoma and the most common race was Hispanic. Women with AUB-L were younger, with lower BMI, and with fewer cases of hypertension and DM when compared to other types of AUB.
Language	English
Publishing date	2021-02-26
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2425806-4
ISSN	1309-0380 ; 1303-9695 ; 1309-0399
ISSN (online)	1309-0380 ; 1303-9695
ISSN	1309-0399
DOI	10.4274/jtgga.galenos.2021.2020.0228
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Article ; Online: Predictive value of preoperative complete blood count components on the occurrence of surgical site infection after elective cesarean section.

Sisti, Giovanni / Sabre, Alexander / Mercado, Felipe / Upadhyay, Ruchi / Joseph, Julie / Schiattarella, Antonio

Minerva obstetrics and gynecology

2022 Volume 75, Issue 2, Page(s) 126–131

Abstract: Background: To analyze the predictive value of the preoperative complete blood count components on the occurrence of surgical site infection (SSI) after elective cesarean section.: Methods: We conducted a retrospective case control study in a ... ...

Abstract	Background: To analyze the predictive value of the preoperative complete blood count components on the occurrence of surgical site infection (SSI) after elective cesarean section. Methods: We conducted a retrospective case control study in a tertiary care hospital located in New York City during the period of November 1, 2018, to October 30, 2020. We included patients who developed SSI after elective cesarean section as cases and patients who did not develop SSI as controls. We tested the ability of neutrophil, lymphocyte, platelet, hemoglobin, hematocrit, total white blood cells, neutrophil to lymphocyte ratio, hemoglobin to platelet ratio, platelet to lymphocyte ratio, platelet to neutrophil ratio, platelet to hemoglobin ratio and neutrophil to hemoglobin ratio to identify the occurrence of SSI after cesarean section. Results: We compared ten cases and 20 controls. The median lymphocyte and lymphocyte to hemoglobin ratio were statistically significantly higher in cases compared to controls (P=0.049 and P=0.04, respectively). A lymphocyte value higher than 1.5 x10 Conclusions: The preoperative lymphocyte and lymphocyte to hemoglobin ratio should be incorporated into patient counseling and preoperative algorithms to identify patients who will develop SSI. The biological mechanisms involved remain to be investigated and our data should be confirmed by further and larger studies.
MeSH term(s)	Cesarean Section/adverse effects ; Surgical Wound Infection ; Humans ; Female ; Pregnancy ; Adult ; Case-Control Studies ; Retrospective Studies ; Blood Cell Count ; New York City ; Lymphocyte Count
Language	English
Publishing date	2022-03-02
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3062815-5
ISSN	2724-6450
ISSN (online)	2724-6450
DOI	10.23736/S2724-606X.21.04951-4
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Article ; Online: Coronavirus infection in a high-risk obstetrical population of the South Bronx, New York.

Curi, Berenice / Sabre, Alexander / Benjamin, Israel / Serventi, Lisa / Nuritdinova, Dilfuza

American journal of obstetrics & gynecology MFM

2020 Volume 2, Issue 4, Page(s) 100203

MeSH term(s)	Adult ; Asthma/epidemiology ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/physiopathology ; COVID-19/therapy ; COVID-19 Testing/methods ; Comorbidity ; Diabetes Mellitus/epidemiology ; Female ; Fetal Death/etiology ; Fetal Death/prevention & control ; Humans ; Hypertension/epidemiology ; Maternal Mortality ; New York/epidemiology ; Pregnancy ; Pregnancy Outcome/epidemiology ; Pregnancy, High-Risk ; Premature Birth/epidemiology ; Premature Birth/etiology ; Risk Assessment ; SARS-CoV-2/isolation & purification ; Severity of Illness Index
Keywords	covid19
Language	English
Publishing date	2020-08-18
Publishing country	Switzerland
Document type	Journal Article
ISSN	2589-9333
ISSN (online)	2589-9333
DOI	10.1016/j.ajogmf.2020.100203
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Article ; Online: Abnormal uterine bleeding types according to the PALM-COEIN FIGO classification in a medically underserved American community

Alexander Sabre / Lisa Serventi / Dilfuza Nuritdinova / Antonio Schiattarella / Giovanni Sisti

Journal of the Turkish-German Gynecological Association, Vol 22, Iss 2, Pp 91-

2021 Volume 96

Abstract: Objective:To describe the distribution of abnormal uterine bleeding (AUB) type according to the polyp (AUB-P); adenomyosis (AUB-A); leiomyoma (AUB-L); malignancy and hyperplasia (AUB-M); coagulopathy (AUB-C); ovulatory dysfunction (AUB-O); endometrial ( ... ...

Abstract	Objective:To describe the distribution of abnormal uterine bleeding (AUB) type according to the polyp (AUB-P); adenomyosis (AUB-A); leiomyoma (AUB-L); malignancy and hyperplasia (AUB-M); coagulopathy (AUB-C); ovulatory dysfunction (AUB-O); endometrial (AUB-E); iatrogenic (AUB-I); and not yet classified International Federation of Gynecology and Obstetrics classification system in a medically underserved American inner-city population. Our secondary objective was to find an association between risk factors and type of AUB.Material and Methods:We conducted a descriptive cross-sectional analysis at our outpatient women’s health clinic located in the Bronx, New York City, from November 2016 to December 2019.Results:Among 390 patients, the most common AUB type was AUB-L (n=185, 47.4%), followed AUB-P (n=100, 25.6%), AUB-A (n=55, 14.1%), AUB-O (n=19, 4.9%), AUB-M (n=15, 3.8%), AUB-E (n=14, 3.6%) and AUB-I (n=2, 0.5%). Race was distributed as follows: Hispanic (68.2%), Black (25.9%), Caucasian (3.3%), and Asian (2.1%). Comorbidities included hypertension (36.4%), diabetes (15.6%), and thyroid disease (6.9%). The median age at diagnosis was significantly higher in AUB-M (59 years old, p<0.001), AUB-P (52.5 years old, p<0.001), AUB-E (51.5 years old, p=0.001) compared to AUB-L (46 years old). The median body mass index (BMI) was significantly higher in AUB-E (34.2 kg/m2, p=0.048) and AUB-O (32.6 kg/m2, p=0.038) compared to AUB-L (30 kg/m2). Race was equally distributed among the AUB types. AUB-M (66.6%, p=0.002), AUB-E (57.1%, p=0.022), AUB-P (47%, p<0.001), and AUB-A (30.8%, p<0.001), had statistically significantly more cases of hypertension compared to AUB-L (28.1%). AUB-P (27%, p<0.001), AUB-M (26.6%, p=0.025), AUB-E (35.7%, p=0.001) and AUB-A (9%, p<0.001) had more patients with diabetes mellitus (DM) than AUB-L (3.3%).Conclusion:In an American population of medically underserved patients, the most common cause of AUB was leiomyoma and the most common race was Hispanic. Women with AUB-L were younger, with lower BMI, and with fewer cases of hypertension and DM when compared to other types of AUB.
Keywords	aub ; palm-coein ; abnormal uterine bleeding ; myoma ; polyp ; Medicine ; R ; Gynecology and obstetrics ; RG1-991
Subject code	610
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Galenos Yayinevi
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Ectopic Molar Tubal Pregnancy

Alexander Michael Sabre, Ashley D Molina, Manonmani Arul, Malvina Elmadjian.

International Journal of Medical Reviews and Case Reports, Vol 3, Iss

An Important Histological Presentation

2019 Volume 8

Abstract: Ectopic localization of molar pregnancy is rare from review of literature. To date, only 132 cases have been reported. The identification of molar pregnancies in this setting is critical given their malignant potential and post-surgical management. We ... ...

Abstract	Ectopic localization of molar pregnancy is rare from review of literature. To date, only 132 cases have been reported. The identification of molar pregnancies in this setting is critical given their malignant potential and post-surgical management. We present a case of tubal hydatiform molar pregnancy with features suggestive of partial mole, detailing the patient’s initial presentation, explorative surgical evaluation, and finally the revelation of diagnosis based upon pathological determination. It is essential for providers to not only be informed of an unusual pathology but of the importance and value of histological examination of tubal specimens post-surgery with the pertinence to diagnose cases of molar pregnancy for prompt and appropriate post-operative surveillance.
Keywords	ectopic pregmancy ; molar pregnancy ; gynecology ; gynecological malignancy ; laprascopy ; Medicine ; R
Language	English
Publishing date	2019-08-01T00:00:00Z
Publisher	Bulgarian Association of Young Surgeons
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Fever of unknown origin in a patient with confirmed west nile virus meningoencephalitis.

Sabre, Alexander / Farricielli, Laurie

Case reports in infectious diseases

2014 Volume 2014, Page(s) 120709

Abstract: West Nile Virus (WNV), an RNA arbovirus and member of the Japanese encephalitis virus antigenic complex, causes a wide range of clinical symptoms, from asymptomatic to encephalitis and meningitis. Nearly all human infections of WNV are due to mosquito ... ...

Abstract	West Nile Virus (WNV), an RNA arbovirus and member of the Japanese encephalitis virus antigenic complex, causes a wide range of clinical symptoms, from asymptomatic to encephalitis and meningitis. Nearly all human infections of WNV are due to mosquito bites with birds being the primary amplifying hosts. Advanced age is the most important risk factor for neurological disease leading most often to poor prognosis in those afflicted. We report a case of WNV meningoencephalitis in a 93-year-old Caucasian male who presented with fever of unknown origin (FUO) and nuchal rigidity that rapidly decompensated within 24 h to a persistent altered mental state during inpatient stay. The patient's ELISA antibody titers confirmed pathogenesis of disease by WNV; he given supportive measures and advanced to an excellent recovery. In regard to the approach of FUO, it is important to remain impartial yet insightful to all elements when determining pathogenesis in atypical presentation.
Language	English
Publishing date	2014-12-14
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2627642-2
ISSN	2090-6633 ; 2090-6625
ISSN (online)	2090-6633
ISSN	2090-6625
DOI	10.1155/2014/120709
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Article: Coronavirus infection in a high risk obstetric population of the South Bronx, New York

Curi, Berenice / Sabre, Alexander / Benjamin, Israel / Serventi, Lisa / Nuritdinova, Dilfuza

Am J Obstet Gynecol MFM

Abstract: COVID-19 in high risk urban populations, Coronavirus clinical course obstetrics. ...

Abstract	COVID-19 in high risk urban populations, Coronavirus clinical course obstetrics.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #770859
Database	COVID19

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