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Article ; Online: Division of labor of Y-family polymerases in translesion-DNA synthesis for distinct types of DNA damage.

Inomata, Yuriko / Abe, Takuya / Tsuda, Masataka / Takeda, Shunichi / Hirota, Kouji

PloS one

2021 Volume 16, Issue 6, Page(s) e0252587

Abstract: ... is restarted via bypass replication by translesion DNA-synthesis polymerases, including the Y-family ... play complementary roles in bypassing MMS-induced damage. Our findings indicate that the three Y-family ...

Abstract	Living organisms are continuously under threat from a vast array of DNA-damaging agents, which impact genome DNA. DNA replication machinery stalls at damaged template DNA. The stalled replication fork is restarted via bypass replication by translesion DNA-synthesis polymerases, including the Y-family polymerases Polη, Polι, and Polκ, which possess the ability to incorporate nucleotides opposite the damaged template. To investigate the division of labor among these polymerases in vivo, we generated POLη-/-, POLι-/-, POLκ-/-, double knockout (KO), and triple knockout (TKO) mutants in all combinations from human TK6 cells. TKO cells exhibited a hypersensitivity to ultraviolet (UV), cisplatin (CDDP), and methyl methanesulfonate (MMS), confirming the pivotal role played by these polymerases in bypass replication of damaged template DNA. POLη-/- cells, but not POLι-/- or POLκ-/- cells, showed a strong sensitivity to UV and CDDP, while TKO cells showed a slightly higher sensitivity to UV and CDDP than did POLη-/- cells. On the other hand, TKO cells, but not all single KO cells, exhibited a significantly higher sensitivity to MMS than did wild-type cells. Consistently, DNA-fiber assay revealed that Polη plays a crucial role in bypassing lesions caused by UV-mimetic agent 4-nitroquinoline-1-oxide and CDDP, while all three polymerases play complementary roles in bypassing MMS-induced damage. Our findings indicate that the three Y-family polymerases play distinctly different roles in bypass replication, according to the type of DNA damage generated on the template strand.
MeSH term(s)	Cell Line ; Cisplatin/pharmacology ; DNA/genetics ; DNA/metabolism ; DNA Damage/drug effects ; DNA Damage/radiation effects ; DNA Repair ; DNA Replication ; DNA-Directed DNA Polymerase/deficiency ; DNA-Directed DNA Polymerase/genetics ; DNA-Directed DNA Polymerase/metabolism ; Gene Knockout Techniques ; Humans ; Methyl Methanesulfonate/pharmacology ; Ultraviolet Rays
Chemical Substances	DNA (9007-49-2) ; Methyl Methanesulfonate (AT5C31J09G) ; DNA polymerase iota (EC 2.7.7.-) ; DNA-Directed DNA Polymerase (EC 2.7.7.7) ; POLK protein, human (EC 2.7.7.7) ; Rad30 protein (EC 2.7.7.7) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2021-06-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0252587
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Article ; Online: Answer to the letter to the editor of S. He, et al. concerning "impact of surgical treatment on lipid metabolism in patients with lumbar spinal disorders: prospective observational study" by Nakajima et al. (Eur Spine J [2023]; doi:10.1007/s00586-023-07976-y).

Nakajima, Yukio / Hachiya, Kurenai / Michikawa, Takehiro / Nagai, Sota / Takeda, Hiroki / Kawabata, Soya / Yoshioka, Atsushi / Kimata, Hirona / Ikeda, Daiki / Kaneko, Shinjiro / Ohno, Yoshiharu / Hachiya, Yudo / Fujita, Nobuyuki

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

2023 Volume 33, Issue 2, Page(s) 748–750

MeSH term(s)	Humans ; Lipid Metabolism ; Lumbar Vertebrae/surgery ; Prospective Studies
Language	English
Publishing date	2023-12-06
Publishing country	Germany
Document type	Observational Study ; Letter
ZDB-ID	1115375-1
ISSN	1432-0932 ; 0940-6719
ISSN (online)	1432-0932
ISSN	0940-6719
DOI	10.1007/s00586-023-08048-x
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Article ; Online: Recomendaciones para el diagnóstico y el tratamiento de los síntomas posquirúrgicos persistentes en la enfermedad de Hirschsprung.

Rocca, Ana M / Nastri, Mariana / Takeda, Silvia / Neder, Daniela / Mortarini, Alejandra / Paz, Enrique / Lavorgna, Silvana / Bazo, Mariana / Dibenedetto, Víctor

Archivos argentinos de pediatria

2020 Volume 118, Issue 5, Page(s) 350–357

Abstract: Hirschsprung disease is characterized by the lack of migration of intrinsic parasympathetic ganglia from neural crest and consequently absence of them at varying length of the bowel, resulting in functional obstruction. The incidence is 1 per 5000 births. ...

Title translation	Recommendations for the diagnosis and treatment of persistent postsurgical symptoms in Hirschsprung disease.
Abstract	Hirschsprung disease is characterized by the lack of migration of intrinsic parasympathetic ganglia from neural crest and consequently absence of them at varying length of the bowel, resulting in functional obstruction. The incidence is 1 per 5000 births. After surgery, short term and long term comorbidity commonly occurs. The aim of this article is to revise the main causes of ongoing symptoms after surgery in Hirschsprung disease patients and to show a diagnostic and therapeutic algorithm that can be developed in our community.
MeSH term(s)	Algorithms ; Hirschsprung Disease/physiopathology ; Hirschsprung Disease/surgery ; Humans ; Infant, Newborn ; Intestinal Obstruction/etiology ; Postoperative Complications/diagnosis ; Postoperative Complications/therapy
Language	Spanish
Publishing date	2020-09-09
Publishing country	Argentina
Document type	Journal Article
ZDB-ID	424449-7
ISSN	1668-3501 ; 0325-0075 ; 0004-0487
ISSN (online)	1668-3501
ISSN	0325-0075 ; 0004-0487
DOI	10.5546/aap.2020.350
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Article: A rare der(Y)t(Y;1)(q12;q12) in a patient with post-polycythemic myelofibrosis: a case report.

Manabe, Masahiro / Takeda, Osami / Okita, Junya / Takakuwa, Teruhito / Harada, Naonori / Nakano, Hirofumi / Okamoto, Shuichiro / Aoyama, Yasutaka / Kumura, Takeo / Ohta, Tadanobu / Furukawa, Yoshio / Mugitani, Atsuko

American journal of blood research

2013 Volume 3, Issue 2, Page(s) 186–190

Abstract: We describe a case of post-polycythemic myelofibrosis harboring der(Y)t(Y;1)(q12;q12). The patient ... of his condition, the polycythemia developed into myelofibrosis. Chromosome analysis detected der(Y)t(Y;1)(q12;q12 ... We discuss the association between der(Y)t(Y;1)(q11~12;q12~21) and tumorigenesis along ...

Abstract	We describe a case of post-polycythemic myelofibrosis harboring der(Y)t(Y;1)(q12;q12). The patient was a 69-year-old man and was initially diagnosed with polycythemia vera. During the clinical course of his condition, the polycythemia developed into myelofibrosis. Chromosome analysis detected der(Y)t(Y;1)(q12;q12). We discuss the association between der(Y)t(Y;1)(q11~12;q12~21) and tumorigenesis along with a review of literature.
Language	English
Publishing date	2013-05-05
Publishing country	United States
Document type	Case Reports
ZDB-ID	2620435-6
ISSN	2160-1992
ISSN	2160-1992
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Article ; Online: Division of labor of Y-family polymerases in translesion-DNA synthesis for distinct types of DNA damage.

Yuriko Inomata / Takuya Abe / Masataka Tsuda / Shunichi Takeda / Kouji Hirota

PLoS ONE, Vol 16, Iss 6, p e

2021 Volume 0252587

Abstract	Living organisms are continuously under threat from a vast array of DNA-damaging agents, which impact genome DNA. DNA replication machinery stalls at damaged template DNA. The stalled replication fork is restarted via bypass replication by translesion DNA-synthesis polymerases, including the Y-family polymerases Polη, Polι, and Polκ, which possess the ability to incorporate nucleotides opposite the damaged template. To investigate the division of labor among these polymerases in vivo, we generated POLη-/-, POLι-/-, POLκ-/-, double knockout (KO), and triple knockout (TKO) mutants in all combinations from human TK6 cells. TKO cells exhibited a hypersensitivity to ultraviolet (UV), cisplatin (CDDP), and methyl methanesulfonate (MMS), confirming the pivotal role played by these polymerases in bypass replication of damaged template DNA. POLη-/- cells, but not POLι-/- or POLκ-/- cells, showed a strong sensitivity to UV and CDDP, while TKO cells showed a slightly higher sensitivity to UV and CDDP than did POLη-/- cells. On the other hand, TKO cells, but not all single KO cells, exhibited a significantly higher sensitivity to MMS than did wild-type cells. Consistently, DNA-fiber assay revealed that Polη plays a crucial role in bypassing lesions caused by UV-mimetic agent 4-nitroquinoline-1-oxide and CDDP, while all three polymerases play complementary roles in bypassing MMS-induced damage. Our findings indicate that the three Y-family polymerases play distinctly different roles in bypass replication, according to the type of DNA damage generated on the template strand.
Keywords	Medicine ; R ; Science ; Q
Subject code	612
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Substitutional disorder in Sr2-yEuyB2-2xSi2+3xAl2-xN8+x (x ≃ 0.12, y ≃ 0.10).

Funahashi, Shiro / Michiue, Yuichi / Takeda, Takashi / Xie, Rong-Jun / Hirosaki, Naoto

Acta crystallographica. Section C, Structural chemistry

2014 Volume 70, Issue Pt 5, Page(s) 452–454

Abstract: A novel nitride, Sr2-yEuyB2-2xSi2+3xAl2-xN8+x (x ≃ 0.12, y ≃ 0.10) (distrontium europium diboron ...

Abstract	A novel nitride, Sr2-yEuyB2-2xSi2+3xAl2-xN8+x (x ≃ 0.12, y ≃ 0.10) (distrontium europium diboron disilicon dialuminium octanitride), with the space group P62c, was synthesized from Sr3N2, EuN, Si3N4, AlN and BN under nitrogen gas pressure. The structure consists of a host framework with Sr/Eu atoms accommodated in the cavities. The host framework is constructed by the linkage of MN4 tetrahedra (M = Si, Al) and BN3 triangles, and contains substitutional disorder described by the alternative occupation of B2 or Si2N on the (0, 0, z) axis. The B2:Si2N ratio contained in an entire crystal is about 9:1.
Language	English
Publishing date	2014-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2025703-X
ISSN	2053-2296 ; 1600-5759 ; 0108-2701
ISSN (online)	2053-2296 ; 1600-5759
ISSN	0108-2701
DOI	10.1107/S2053229614007414
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Article ; Online: Estimulación eléctrica y natación en la fase aguda de la axonotmesis: influencia sobre la regeneración nerviosa y la recuperación funcional.

Oliveira, L S / Sobral, L L / Takeda, S Y M / Betini, J / Guirro, R R J / Somazz, M C / Teodori, R M

Revista de neurologia

2008 Volume 47, Issue 1, Page(s) 11–15

Abstract: Introduction: Little attention has been given to the influence of low-frequency phasic electrical stimulation (LFPES) and physical exercise on the quality of peripheral nerve regeneration and functional recovery. AIM. To evaluate the influence of LFPES, ...

Title translation	Electrical stimulation and swimming in the acute phase of axonotmesis: their influence on nerve regeneration and functional recovery.
Abstract	Introduction: Little attention has been given to the influence of low-frequency phasic electrical stimulation (LFPES) and physical exercise on the quality of peripheral nerve regeneration and functional recovery. AIM. To evaluate the influence of LFPES, swimming and the association between the two in terms of the morphology of the regenerated sciatic nerve following axonotmesis. Materials and methods: Thirty Wistar mice (222.05 +/- 42.2 g) were distributed into groups: control (C), denervated (D), denervated + swimming (DS), denervated + electrostimulation (DE) and denervated + swimming + electrostimulation (DSE). After 24 hours of axonotmesis, the soleus muscle of the DE and DSE groups was stimulated electrically. The DS and DSE groups swam over a period of 22 days. The number of axons, morphometric data on the nerve and the functional index of the sciatic nerve (FIS) were evaluated. Results: The number of axons in the denervated groups was higher than in the control group, and in the DE group the figure was higher than in the D group. The axonal diameter was smaller in the denervated groups, yet in the DS group it was higher than in the D group. The other morphometric parameters were quite similar to those of the C group. The FIS between days 7 and 14 of the post-operative period was different to the pre-operative index and that measured on day 21 of the post-operative period; the DSE group, however, differed from the pre-operative values. Conclusions: Swimming and LFPES, applied on an individual basis, do not affect the maturation of the regenerated fibres or functional recovery. LFPES favoured axonal regeneration and combining the treatments delayed functional recovery without having any influence on nerve regeneration.
MeSH term(s)	Animals ; Axons/physiology ; Denervation ; Electric Stimulation Therapy ; Exercise Therapy ; Male ; Mice ; Nerve Regeneration ; Peripheral Nerves/physiology ; Peripheral Nerves/surgery ; Recovery of Function ; Swimming
Language	Spanish
Publishing date	2008-07
Publishing country	Spain
Document type	English Abstract ; Journal Article
ZDB-ID	1468278-3
ISSN	1576-6578 ; 0210-0010
ISSN (online)	1576-6578
ISSN	0210-0010
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Article: Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor.

Gicquiaux, Hervé / Lecat, Sandra / Gaire, Mireille / Dieterlen, Alain / Mély, Yves / Takeda, Kenneth / Bucher, Bernard / Galzi, Jean-Luc

The Journal of biological chemistry

2001 Volume 277, Issue 8, Page(s) 6645–6655

Abstract: ... reduction in the number of receptors at the cell surface. The neuropeptide Y (NPY) Y(1) receptor undergoes ... fast desensitization. We examined agonist-induced signaling and internalization using NPY Y(1 ... receptors fused to green fluorescent protein (EGFP). When expressed in HEK293 cells, EGFP-hNPY Y(1 ...

Abstract	Desensitization of G protein-coupled receptors (GPCRs) involves receptor phosphorylation and reduction in the number of receptors at the cell surface. The neuropeptide Y (NPY) Y(1) receptor undergoes fast desensitization. We examined agonist-induced signaling and internalization using NPY Y(1) receptors fused to green fluorescent protein (EGFP). When expressed in HEK293 cells, EGFP-hNPY Y(1) receptors were localized at the plasma membrane, desensitized rapidly as assessed using calcium responses, and had similar properties compared to hNPY Y(1) receptors. Upon agonist challenge, the EGFP signal decreased rapidly (t(1/2) = 107 +/- 3 s) followed by a slow recovery. This decrease was blocked by BIBP3226, a Y(1) receptor antagonist, or by pertussis toxin, in agreement with Y(1) receptor activation. Internalization of EGFP-hNPY Y(1) receptors to acidic endosomal compartments likely accounts for the decrease in the EGFP signal, being absent after pretreatment with monensin. Concanavalin A and hypertonic sucrose, which inhibit clathrin-mediated endocytosis, blocked the decrease in fluorescence. After agonist, intracellular EGFP signals were punctate and co-localized with transferrin-Texas Red, a marker of clathrin-associated internalization and recycling, but not with LysoTracker Red, a lysosomal pathway marker, supporting receptor trafficking to recycling endosomes rather than the late endosomal/lysosomal pathway. Pulse-chase experiments revealed no receptor degradation after internalization. The slow recovery of fluorescence was unaffected by cycloheximide or actinomycin D, indicating that de novo synthesis of receptors was not limiting. Use of a multicompartment model to fit our fluorescence data allows simultaneous determination of internalization and recycling rate constants. We propose that rapid internalization of receptors via the clathrin-coated pits recycling pathway may largely account for the rapid desensitization of NPY Y(1) receptors.
MeSH term(s)	Arginine/analogs & derivatives ; Arginine/pharmacology ; Calcium/metabolism ; Cell Line ; Concanavalin A/pharmacology ; Endosomes/metabolism ; GTP-Binding Proteins/metabolism ; Green Fluorescent Proteins ; Humans ; Hypertonic Solutions ; Kinetics ; Luminescent Proteins/metabolism ; Models, Biological ; Neuropeptide Y/pharmacology ; Phosphorylation ; Protein Transport ; Receptors, Neuropeptide Y/antagonists & inhibitors ; Receptors, Neuropeptide Y/drug effects ; Receptors, Neuropeptide Y/genetics ; Receptors, Neuropeptide Y/physiology ; Recombinant Fusion Proteins/metabolism ; Signal Transduction ; Spectrometry, Fluorescence/methods ; Stress, Mechanical ; Sucrose/pharmacology ; Transfection
Chemical Substances	BIBP 3226 ; Hypertonic Solutions ; Luminescent Proteins ; Neuropeptide Y ; Receptors, Neuropeptide Y ; Recombinant Fusion Proteins ; neuropeptide Y-Y1 receptor ; Concanavalin A (11028-71-0) ; Green Fluorescent Proteins (147336-22-9) ; Sucrose (57-50-1) ; Arginine (94ZLA3W45F) ; GTP-Binding Proteins (EC 3.6.1.-) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2001-12-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M107224200
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Article: Persistent Urinary Incontinence After Nephrectomy: A Case of Inverted-Y Ureteral Duplication with Ectopic Ureteral Insertion into the Vagina.

Shimura, Hiroshi / Mitsui, Takahiko / Aoki, Tadashi / Kamiyama, Manabu / Yamagishi, Takashi / Takeda, Masayuki

Urology case reports

2016 Volume 9, Page(s) 58–61

Abstract: Inverted-Y ureteral duplication is one of the rarest anomalies of ureteral branching ... ureteral insertion into the vagina. She had inverted-Y ureteral duplication between the bladder and vagina ... a rare case of inverted-Y ureteral duplication with ectopic ureteral insertion into the vagina as well ...

Abstract	Inverted-Y ureteral duplication is one of the rarest anomalies of ureteral branching. We encountered a 20-year-old female patient with persistent incontinence even after nephrectomy for ectopic ureteral insertion into the vagina. She had inverted-Y ureteral duplication between the bladder and vagina, and urine was being transported from the bladder to the vagina. To the best of our knowledge, this is a rare case of inverted-Y ureteral duplication with ectopic ureteral insertion into the vagina as well as the ureter into the bladder, which became apparent due to persistent urinary incontinence even after nephrectomy.
Language	English
Publishing date	2016-10-07
Publishing country	United States
Document type	Case Reports
ZDB-ID	2745459-9
ISSN	2214-4420
ISSN	2214-4420
DOI	10.1016/j.eucr.2016.09.001
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Article: Distinct motifs of neuropeptide Y receptors differentially regulate trafficking and desensitization.

Ouedraogo, Moussa / Lecat, Sandra / Rochdi, Moulay Driss / Hachet-Haas, Muriel / Matthes, Hans / Gicquiaux, Hervé / Verrier, Sophie / Gaire, Mireille / Glasser, Nicole / Mély, Yves / Takeda, Kenneth / Bouvier, Michel / Galzi, Jean-Luc / Bucher, Bernard

Traffic (Copenhagen, Denmark)

2008 Volume 9, Issue 3, Page(s) 305–324

Abstract: Activated human neuropeptide Y Y(1) receptors rapidly desensitize and internalize through clathrin ... coated pits and recycle from early and recycling endosomes, unlike Y(2) receptors that neither ... internalize nor desensitize. To identify motifs implicated in Y(1) receptor desensitization and trafficking ...

Abstract	Activated human neuropeptide Y Y(1) receptors rapidly desensitize and internalize through clathrin-coated pits and recycle from early and recycling endosomes, unlike Y(2) receptors that neither internalize nor desensitize. To identify motifs implicated in Y(1) receptor desensitization and trafficking, mutants with varying C-terminal truncations or a substituted Y(2) C-terminus were constructed. Point mutations of key putative residues were made in a C-terminal conserved motif [phi-H-(S/T)-(E/D)-V-(S/T)-X-T] that we have identified and in the second intracellular i2 loop. Receptors were analyzed by functional assays, spectrofluorimetric measurements on living cells, flow cytometry, confocal imaging and bioluminescence resonance energy transfer assays for beta-arrestin activation and adaptor protein (AP-2) complex recruitment. Inhibitory GTP-binding protein-dependent signaling of Y(1) receptors to adenylyl cyclase and desensitization was unaffected by C-terminal truncations or mutations, while C-terminal deletion mutants of 42 and 61 amino acids no longer internalized. Substitutions of Thr357, Asp358, Ser360 and Thr362 by Ala in the C-terminus abolished both internalization and beta-arrestin activation but not desensitization. A Pro145 substitution by His in an i2 consensus motif reported to mediate phosphorylation-independent recruitment of beta-arrestins affected neither desensitization, internalization or recycling kinetics of activated Y(1) receptors nor beta-arrestin activation. Interestingly, combining Pro145 substitution by His and C-terminal substitutions significantly attenuates Y(1) desensitization. In the Y(2) receptor, replacement of His155 with Pro at this position in the i2 loop motif promotes agonist-mediated desensitization, beta-arrestin activation, internalization and recycling. Overall, our results indicate that beta-arrestin-mediated desensitization and internalization of Y(1) and Y(2) receptors are differentially regulated by the C-terminal motif and the i2 loop consensus motif.
MeSH term(s)	Adenylyl Cyclases/metabolism ; Amino Acid Motifs ; Amino Acid Sequence ; Amino Acid Substitution ; Arrestins/metabolism ; Biological Transport, Active ; Cell Line ; Cyclic AMP/metabolism ; Green Fluorescent Proteins/chemistry ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Humans ; Kinetics ; Microscopy, Confocal ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; Receptors, Neuropeptide Y/agonists ; Receptors, Neuropeptide Y/chemistry ; Receptors, Neuropeptide Y/genetics ; Receptors, Neuropeptide Y/metabolism ; Recombinant Fusion Proteins/chemistry ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Sequence Homology, Amino Acid ; Transfection ; beta-Arrestins
Chemical Substances	Arrestins ; Receptors, Neuropeptide Y ; Recombinant Fusion Proteins ; beta-Arrestins ; enhanced green fluorescent protein ; neuropeptide Y-Y1 receptor ; neuropeptide Y2 receptor ; Green Fluorescent Proteins (147336-22-9) ; Cyclic AMP (E0399OZS9N) ; Adenylyl Cyclases (EC 4.6.1.1)
Language	English
Publishing date	2008-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1483852-7
ISSN	1600-0854 ; 1398-9219
ISSN (online)	1600-0854
ISSN	1398-9219
DOI	10.1111/j.1600-0854.2007.00691.x
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