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Article ; Online: The Role of Mechanical Circulatory Support in Patients With Severe Left Ventricular Impairment Treated With Transcatheter Aortic Valve Implantation and Percutaneous Coronary Intervention.

Panoulas, Vasileios / Greenough, Natasha / Sulemane, Samir / Monteagudo-Vela, Maria / Lees, Nicholas

Cardiovascular revascularization medicine : including molecular interventions

2021 Volume 28S, Page(s) 169–175

Abstract: Transcatheter aortic valve implantation (TAVI) has become an established treatment for patients with severe aortic stenosis (AS) in an ever-growing patient population. It is not uncommon for patients who are undergoing TAVI to have technically difficult ... ...

Abstract	Transcatheter aortic valve implantation (TAVI) has become an established treatment for patients with severe aortic stenosis (AS) in an ever-growing patient population. It is not uncommon for patients who are undergoing TAVI to have technically difficult anatomy, simultaneous severe left ventricular (LV) impairment and/or extensive coronary artery disease. In this case series we present examples where the use of mechanical circulatory support (MCS) facilitated a safe aortic and coronary intervention in extremely complex patients who would have otherwise carried prohibitive procedural risk.
MeSH term(s)	Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/surgery ; Humans ; Percutaneous Coronary Intervention/adverse effects ; Retrospective Studies ; Transcatheter Aortic Valve Replacement/adverse effects ; Treatment Outcome
Language	English
Publishing date	2021-04-06
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2212113-4
ISSN	1878-0938 ; 1553-8389
ISSN (online)	1878-0938
ISSN	1553-8389
DOI	10.1016/j.carrev.2021.03.020
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Article ; Online: Acute pulmonary embolism in conjunction with intramural right ventricular thrombus in a SARS-CoV-2-positive patient.

Sulemane, Samir / Baltabaeva, Aigul / Barron, Anthony J / Chester, Ruth / Rahman-Haley, Shelley

European heart journal cardiovascular Imaging

2020 Volume 21, Issue 9, Page(s) 1054

MeSH term(s)	COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/methods ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Echocardiography/methods ; Follow-Up Studies ; Heart Diseases/diagnostic imaging ; Heart Diseases/drug therapy ; Heart Diseases/etiology ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/drug effects ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Pandemics ; Platelet Aggregation Inhibitors/administration & dosage ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pulmonary Embolism/diagnostic imaging ; Pulmonary Embolism/drug therapy ; Pulmonary Embolism/etiology ; Risk Assessment ; Thrombosis/diagnostic imaging ; Thrombosis/drug therapy ; Thrombosis/etiology ; Treatment Outcome
Chemical Substances	Platelet Aggregation Inhibitors
Keywords	covid19
Language	English
Publishing date	2020-05-05
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2638345-7
ISSN	2047-2412 ; 2047-2404
ISSN (online)	2047-2412
ISSN	2047-2404
DOI	10.1093/ehjci/jeaa115
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Article ; Online: Echocardiographic assessment in patients with chronic kidney disease: Current update.

Sulemane, Samir / Panoulas, Vasileios F / Nihoyannopoulos, Petros

Echocardiography (Mount Kisco, N.Y.)

2017 Volume 34, Issue 4, Page(s) 594–602

Abstract: Patients with chronic kidney disease (CKD) carry a high cardiovascular risk. An abundance of evidence has emerged in recent years establishing minor reductions in estimated glomerular filtration rate as an independent risk factor for cardiovascular ... ...

Abstract	Patients with chronic kidney disease (CKD) carry a high cardiovascular risk. An abundance of evidence has emerged in recent years establishing minor reductions in estimated glomerular filtration rate as an independent risk factor for cardiovascular mortality. Additionally, cardiac changes, such as left ventricular hypertrophy and impaired left ventricular systolic function, have been associated with an unfavorable prognosis. Despite the significant prevalence of underlying cardiac abnormalities, symptoms may not manifest in many patients with CKD. A range of available and emerging echocardiographic modalities may assist with diagnosing heart disease in CKD. Furthermore, some of these emerging techniques can give an important insight into the pathophysiology of subclinical dysfunction in CKD. This review discusses how current and emerging echocardiographic modalities such as speckle tracking echocardiography and 3D echocardiography might help cardiologists in providing important information to help with diagnosis and risk stratification of cardiac-related morbidity and mortality in patients with renal disease, as well applicability of these tools to current clinical practice.
MeSH term(s)	Cardiovascular Diseases/complications ; Cardiovascular Diseases/diagnostic imaging ; Echocardiography/methods ; Heart/diagnostic imaging ; Humans ; Renal Insufficiency, Chronic/complications
Language	English
Publishing date	2017-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	843645-9
ISSN	1540-8175 ; 0742-2822
ISSN (online)	1540-8175
ISSN	0742-2822
DOI	10.1111/echo.13495
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Zs.A 2170: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 359: Show issues

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Article: Acute pulmonary embolism in conjunction with intramural right ventricular thrombus in a SARS-CoV-2-positive patient

Sulemane, Samir / Baltabaeva, Aigul / Barron, Anthony J / Chester, Ruth / Rahman-Haley, Shelley

Eur Heart J Cardiovasc Imaging

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #125284
Database	COVID19

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Article ; Online: Acute pulmonary embolism in conjunction with intramural right ventricular thrombus in a SARS-CoV-2-positive patient

Sulemane, Samir / Baltabaeva, Aigul / Barron, Anthony J / Chester, Ruth / Rahman-Haley, Shelley

European Heart Journal - Cardiovascular Imaging

2020 Volume 21, Issue 9, Page(s) 1054–1054

Keywords	Radiology Nuclear Medicine and imaging ; Cardiology and Cardiovascular Medicine ; General Medicine ; covid19
Language	English
Publisher	Oxford University Press (OUP)
Publishing country	uk
Document type	Article ; Online
ZDB-ID	2638345-7
ISSN	2047-2412 ; 2047-2404
ISSN (online)	2047-2412
ISSN	2047-2404
DOI	10.1093/ehjci/jeaa115
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Subclinical markers of cardiovascular disease predict adverse outcomes in chronic kidney disease patients with normal left ventricular ejection fraction.

Sulemane, Samir / Panoulas, Vasileios F / Bratsas, Athanasios / Grapsa, Julia / Brown, Edwina A / Nihoyannopoulos, Petros

The international journal of cardiovascular imaging

2017 Volume 33, Issue 5, Page(s) 687–698

Abstract: Emerging cardiovascular biomarkers, such as speckle tracking echocardiography (STE) and aortic pulse wave velocity (aPWV), have recently demonstrated the presence of subclinical left ventricular dysfunction and arterial stiffening in patients with ... ...

Abstract	Emerging cardiovascular biomarkers, such as speckle tracking echocardiography (STE) and aortic pulse wave velocity (aPWV), have recently demonstrated the presence of subclinical left ventricular dysfunction and arterial stiffening in patients with chronic kidney disease (CKD) and no previous cardiovascular history. However, limited information exists on the prognostic impact of these biomarkers. We aimed to investigate whether STE and aPWV predict major adverse cardiac events (MACE) in this patient population. In this cohort study we prospectively analysed 106 CKD patients with no overt cardiovascular disease (CVD) and normal left ventricular ejection fraction. Cardiac deformation was measured using STE while aPWV was measured using arterial tonometry. The primary end-point was the composite of all-cause mortality, acute coronary syndrome, stable angina requiring revascularization (either using percutaneous coronary intervention or coronary artery bypass surgery), hospitalization for heart failure and stroke. Over a median follow up period of 49 months (interquartile range 11-63 months), 26 patients (24.5%) reached the primary endpoint. In a multivariable Cox hazards model, global longitudinal strain (GLS) (HR 1.12, 95% CI 1.02-1.29, p = 0.041) and aPWV (HR 1.31, 95% CI 1.05-1.41, p = 0.021) were significant, independent predictors of MACE. GLS and aPWV independently predict MACE in CKD patients with normal EF and no clinically overt CVD.
MeSH term(s)	Adult ; Aged ; Cardiovascular Diseases/diagnostic imaging ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/physiopathology ; Cardiovascular Diseases/therapy ; Chi-Square Distribution ; Coronary Artery Bypass ; Disease Progression ; Echocardiography, Doppler, Pulsed ; Female ; Hospitalization ; Humans ; Kaplan-Meier Estimate ; Kidney/physiopathology ; Male ; Middle Aged ; Multivariate Analysis ; Percutaneous Coronary Intervention ; Predictive Value of Tests ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Pulse Wave Analysis ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/mortality ; Renal Insufficiency, Chronic/physiopathology ; Reproducibility of Results ; Risk Factors ; Stroke Volume ; Time Factors ; Vascular Stiffness ; Ventricular Function, Left
Language	English
Publishing date	2017-05
Publishing country	United States
Document type	Journal Article ; Observational Study
ZDB-ID	2055311-0
ISSN	1875-8312 ; 1573-0743 ; 1569-5794 ; 0167-9899
ISSN (online)	1875-8312 ; 1573-0743
ISSN	1569-5794 ; 0167-9899
DOI	10.1007/s10554-016-1059-x
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Zs.A 2104: Show issues

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Article ; Online: Erratum to: 'Left ventricular twist mechanics and its relation with aortic stiffness in chronic kidney disease patients without overt cardiovascular disease'.

Sulemane, Samir / Panoulas, Vasileios F / Konstantinou, Klio / Bratsas, Athanasios / Graspa, Julia / Tam, Frederick W / Brown, Edwina A / Nihoyannopoulos, Petros

Cardiovascular ultrasound

2016 Volume 14, Page(s) 15

Language	English
Publishing date	2016-04-19
Publishing country	England
Document type	Published Erratum
ISSN	1476-7120
ISSN (online)	1476-7120
DOI	10.1186/s12947-016-0059-2
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Article ; Online: Longitudinal changes of right ventricular deformation mechanics during trastuzumab therapy in breast cancer patients.

Keramida, Kalliopi / Farmakis, Dimitrios / Bingcang, Jose / Sulemane, Samir / Sutherland, Stephanie / Bingcang, Roma A / Ramachandran, Kanchana / Tzavara, Chara / Charalampopoulos, Georgios / Filippiadis, Dimitrios / Kouris, Nikolaos / Nihoyannopoulos, Petros

European journal of heart failure

2019 Volume 21, Issue 4, Page(s) 529–535

Abstract: Background: Trastuzumab improves dramatically the prognosis of HER2-positive breast cancer patients, but it may lead to cardiotoxicity with left ventricular (LV) systolic dysfunction. Its effects on right ventricular (RV) function have not however been ... ...

Abstract	Background: Trastuzumab improves dramatically the prognosis of HER2-positive breast cancer patients, but it may lead to cardiotoxicity with left ventricular (LV) systolic dysfunction. Its effects on right ventricular (RV) function have not however been elucidated. We sought to assess LV and RV deformation mechanics during treatment with trastuzumab in breast cancer patients. Methods and results: We studied 101 consecutive women (mean age 54.3 ± 11.4 years) receiving trastuzumab for 12 months; 62 of them (61.4%) had previously received anthracyclines and 26 (25.7%) were receiving taxanes concurrently with trastuzumab. Comprehensive two-dimensional echocardiography with speckle tracking imaging of LV and RV global longitudinal strain (GLS) and RV free wall longitudinal strain (FWLS) analyses were performed at baseline and every 3 months up to treatment completion. Cardiotoxicity was defined as a decrease of baseline LV ejection fraction > 10 percentage units to a value < 50%. At 3 months, only LV GLS was significantly reduced (-19.5 ± 2.7 to -18.7 ± 2.8, P = 0.0410), while at 6 months, LV GLS, RV GLS and RV FWLS had significantly declined reaching their lowest values (-17.9 ± 6.1, P = 0.002, -19.6 ± 5.2, P = 0.003 and -19.7 ± 5.6, P = 0.004, respectively). Ten women (9.9%) developed cardiotoxicity. A RV GLS percent change of -14.8% predicted cardiotoxicity with 66.7% sensitivity and 70.8% specificity (area under the curve 0.68, 95% confidence interval 0.54-0.81), classifying correctly 90% of women with cardiotoxicity. This cut-off is quite similar to the 15% change of LV GLS previously suggested as predictive of cardiotoxicity. Conclusions: Deformation mechanics of both the left and right ventricle follow similar temporal pattern and degree of impairment during trastuzumab therapy, confirming the global and uniform effect of trastuzumab on myocardial function.
MeSH term(s)	Adult ; Anthracyclines ; Antineoplastic Agents, Immunological/adverse effects ; Antineoplastic Agents, Immunological/pharmacology ; Antineoplastic Agents, Immunological/therapeutic use ; Biomechanical Phenomena ; Breast Neoplasms/drug therapy ; Cardiotoxicity/diagnostic imaging ; Cardiotoxicity/etiology ; Cardiotoxicity/physiopathology ; Echocardiography ; Female ; Heart Failure/chemically induced ; Heart Failure/diagnostic imaging ; Heart Failure/physiopathology ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/drug effects ; Heart Ventricles/physiopathology ; Humans ; Middle Aged ; Retrospective Studies ; Taxoids ; Trastuzumab/adverse effects ; Trastuzumab/pharmacology ; Trastuzumab/therapeutic use ; Ventricular Dysfunction, Left ; Ventricular Dysfunction, Right/chemically induced ; Ventricular Dysfunction, Right/diagnostic imaging ; Ventricular Dysfunction, Right/physiopathology ; Ventricular Function, Left ; Ventricular Function, Right/drug effects
Chemical Substances	Anthracyclines ; Antineoplastic Agents, Immunological ; Taxoids ; Trastuzumab (P188ANX8CK)
Language	English
Publishing date	2019-02-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1483672-5
ISSN	1879-0844 ; 1388-9842
ISSN (online)	1879-0844
ISSN	1388-9842
DOI	10.1002/ejhf.1385
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Zs.A 5299: Show issues

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Article ; Online: Left ventricular twist mechanics and its relation with aortic stiffness in chronic kidney disease patients without overt cardiovascular disease.

Sulemane, Samir / Panoulas, Vasileios F / Konstantinou, Klio / Bratsas, Athanasios / Tam, Frederick W / Brown, Edwina A / Nihoyannopoulos, Petros

Cardiovascular ultrasound

2016 Volume 14, Page(s) 10

Abstract: Background: Recent studies hypothesized left ventricular (LV) twist as a potential biomarker for evaluation of sub clinical myocardial disease, however its relationship with aortic stiffness has yet to be investigated. Chronic kidney disease (CKD) has ... ...

Abstract	Background: Recent studies hypothesized left ventricular (LV) twist as a potential biomarker for evaluation of sub clinical myocardial disease, however its relationship with aortic stiffness has yet to be investigated. Chronic kidney disease (CKD) has been identified as a risk factor for both myocardial and arterial disease. As such we sought to explore the relationship between aortic stiffness and LV twist in CKD patients without known cardiovascular disease (CVD). Methods: In this prospective, observational study we enrolled 106 CKD patients (Stages 1 to 5) with normal LVEF as assessed by conventional echocardiography. Aortic stiffness was measured using aortic pulse wave velocity (aPWV). We defined increased aPWV as ≥10 m/s. LV Twist was measured using two-dimensional speckle tracking echocardiography. Results: Patients with increased aPWV had higher LV twist (p = 0.002) but similar LVEF (p = 0.486). Aortic PWV correlated crudely with age (p < 0.001), the presence of diabetes (p < 0.001), hypertension (p < 0.001), eGFR (p < 0.001), LVMI (p = 0.01), e/e' (p < 0.001) and LV twist (p = 0.003). In multivariable analyses after adjusting for age, gender, cardiovascular risk factors and hypertensive medication, aPWV was independently associated with LV twist (β = 0.163, p = 0.025). Conclusions: Aortic stiffness independently associates with LV Twist in asymptomatic CKD patients. These findings suggest a close interaction between LV twist mechanics and arterial remodeling even before CVD becomes clinically relevant.
MeSH term(s)	Aorta/diagnostic imaging ; Aorta/physiopathology ; Asymptomatic Diseases ; Echocardiography/methods ; Elastic Modulus ; Female ; Heart Ventricles/diagnostic imaging ; Heart Ventricles/physiopathology ; Humans ; Image Interpretation, Computer-Assisted/methods ; Male ; Middle Aged ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/diagnostic imaging ; Renal Insufficiency, Chronic/physiopathology ; Reproducibility of Results ; Sensitivity and Specificity ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/etiology ; Ventricular Dysfunction, Left/physiopathology
Language	English
Publishing date	2016-03-09
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ISSN	1476-7120
ISSN (online)	1476-7120
DOI	10.1186/s12947-016-0053-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Early detection of subclinical left ventricular myocardial dysfunction in patients with chronic kidney disease.

Panoulas, Vasileios F / Sulemane, Samir / Konstantinou, Klio / Bratsas, Athanasios / Elliott, Sarah J / Dawson, David / Frankel, Andrew H / Nihoyannopoulos, Petros

European heart journal cardiovascular Imaging

2015 Volume 16, Issue 5, Page(s) 539–548

Abstract: Aims: To identify subclinical left ventricular (LV) myocardial dysfunction using speckle tracking echocardiography (STE) in patients with chronic kidney disease (CKD), preserved LV ejection fraction (LVEF), and no cardiovascular history or symptoms.: ... ...

Abstract	Aims: To identify subclinical left ventricular (LV) myocardial dysfunction using speckle tracking echocardiography (STE) in patients with chronic kidney disease (CKD), preserved LV ejection fraction (LVEF), and no cardiovascular history or symptoms. Methods and results: Cross-sectional comparisons of conventional and STE parameters were performed between controls and patients with different stages of CKD. CKD patients were followed up for major adverse cardiovascular events (MACEs). We recruited 106 CKD patients and 38 controls. Mean age was 54.4 ± 15.1 and 36.9 ± 11.5 years, respectively (P < 0.001), with 49.1 vs. 52.6% being female (P = 0.705). There were 29 (27.4%) patients with CKD stages 1/2, 38 (35.8%) with stage 3, and 39 (36.8%) with stages 4/5. Global longitudinal strain (GLS) was more impaired when moving from controls to CKD stages 4/5 (-20.67 ± 3.06, -20.39 ± 2.29, -18.33 ± 3.81, -18.01 ± 2.64, controls vs. CKD stages 1/2, vs. CKD stage 3, vs. CKD stages 4/5, respectively, Padjusted = 0.016), whereas LV twist (16.2 ± 4.8, 18.51 ± 4.36, 19.91 ± 5.35, 24.6 ± 5.35, Padjusted < 0.001) and LV twist rate (101.7 ± 30.3, 110.4 ± 30.1, 121 ± 31.4, 154.8 ± 36.7, Padjusted < 0.001) increased. Risk factor-adjusted GLS (standardized beta β = -0.245, P = 0.025), strain rate (SR) [global longitudinal strain rates (GLSRs); β = -0.236, P = 0.019], and early diastolic longitudinal strain rate (GLSRe; β = 0.247, P = 0.019) were significantly associated with estimated glomerular filtration rate (eGFR), whereas LV twist (β = -0.432, P < 0.001), LV twist rate (β = -0.433, P < 0.001), and number of segments with diastolic dysfunction (β = -340, P < 0.001) were inversely and independently associated with eGFR. Impaired GLS (more than -16%) was observed in almost a quarter of CKD patients and associated with a reduced estimated MACE-free survival at 12-month follow-up (88.5 vs 93.7%, Plogrank = 0.038). Conclusion: In CKD patients with no cardiovascular symptoms or history and preserved LVEF, STE can identify subclinical abnormalities of both systolic (decreased GLS and GLSR, increased LV twist, and twist rate) and diastolic (decreased GLSRe and increased number of segments with diastolic dysfunction) LV function.
MeSH term(s)	Adult ; Biopsy ; Case-Control Studies ; Cross-Sectional Studies ; Early Diagnosis ; Echocardiography/methods ; Female ; Humans ; Male ; Middle Aged ; Renal Insufficiency, Chronic/complications ; Ventricular Dysfunction, Left/diagnostic imaging ; Ventricular Dysfunction, Left/etiology
Language	English
Publishing date	2015-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2638345-7
ISSN	2047-2412 ; 2047-2404
ISSN (online)	2047-2412
ISSN	2047-2404
DOI	10.1093/ehjci/jeu229
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