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Article ; Online: Comparison of Heat Resistance of Listeria monocytogenes in Milk as Determined by Two Methods.

Donnelly, Catherine W / Briggs, Elizabeth H / Donnelly, L Scott

2019 Volume 50, Issue 1, Page(s) 14–17

Abstract: The thermal resistance of 3 strains of Listeria monocytogenes was compared using test tube versus sealed tube methods of thermal inactivation. All L. monocytogenes strains were rapidly inactivated in milk when survival was measured using sealed tube ... ...

Abstract	The thermal resistance of 3 strains of Listeria monocytogenes was compared using test tube versus sealed tube methods of thermal inactivation. All L. monocytogenes strains were rapidly inactivated in milk when survival was measured using sealed tube thermal inactivation methods. Calculated D
Language	English
Publishing date	2019-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	243284-5
ISSN	1944-9097 ; 0362-028X
ISSN (online)	1944-9097
ISSN	0362-028X
DOI	10.4315/0362-028X-50.1.14
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Article ; Online: Psychrotrophic Growth and Thermal Inactivation of Listeria monocytogenes as a Function of Milk Composition.

Donnelly, Catherine W / Briggs, Elizabeth H

Journal of food protection

2019 Volume 49, Issue 12, Page(s) 994–998

Abstract: Listeria monocytogenes strains 19111, 19113, 19115, F5027 and F5069 were grown in 11% nonfat milk solids, skim milk and whole milk at 4, 10, 22, and 37°C to determine the influence of temperature and milk composition on growth and thermal resistance. ... ...

Abstract	Listeria monocytogenes strains 19111, 19113, 19115, F5027 and F5069 were grown in 11% nonfat milk solids, skim milk and whole milk at 4, 10, 22, and 37°C to determine the influence of temperature and milk composition on growth and thermal resistance. Milk composition affected cellular growth. The psychrotrophic growth of L. monocytogenes serotype 4b strains was enhanced in whole milk when compared to skim milk or 11% NFMS. This enhancement of psychrotrophic growth was not observed for serotype 1 or 3 strains. The stimulatory effect of whole milk on serotype 4b L. monocytogenes strains was most dramatic at 10°C where cells increased from 7.9 × 10° to 5.8 × 10
Language	English
Publishing date	2019-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	243284-5
ISSN	1944-9097 ; 0362-028X
ISSN (online)	1944-9097
ISSN	0362-028X
DOI	10.4315/0362-028X-49.12.994
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Article ; Online: Sally Lucas Jean, R.N. (1878-1971): Her historical legacy and lessons for contemporary public health nursing education.

Carr, Bryn / Scofield, Elizabeth / Owens, Janine / Donnelly, Gloria / Aboul-Enein, Basil H

Public health nursing (Boston, Mass.)

2022 Volume 40, Issue 1, Page(s) 183–190

Abstract: Sally Lucas Jean, RN (1878-1971) pioneered health education in the United States and globally. At the time of her death in 1971, aged 93, her legacy included serving on boards of leading American health associations, spearheading public health projects ... ...

Abstract	Sally Lucas Jean, RN (1878-1971) pioneered health education in the United States and globally. At the time of her death in 1971, aged 93, her legacy included serving on boards of leading American health associations, spearheading public health projects worldwide and transforming thinking on contemporary public health education. Sally Lucas Jean's influence continues today, from her input on educational children's television programs, policies on child health and her involvement in developing the early foundations of health communication. In this historical reflection, we examine her role in defining health education and communication, alongside influencing and applying strategies to improve public health nursing.
MeSH term(s)	Child ; Female ; Humans ; United States ; Public Health Nursing ; Health Education ; Educational Status ; Communication ; Policy ; Education, Nursing
Language	English
Publishing date	2022-09-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	632563-4
ISSN	1525-1446 ; 0737-1209
ISSN (online)	1525-1446
ISSN	0737-1209
DOI	10.1111/phn.13125
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Article ; Online: Promoting appropriate utilisation of laboratory tests for inflammation at an academic medical centre.

Bartlett, Kristen J / Vo, Ann P / Rueckert, Justin / Wojewoda, Christina / Steckel, Elizabeth H / Stinnett-Donnelly, Justin / Repp, Allen B

BMJ open quality

2020 Volume 9, Issue 1

Abstract: Erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) are commonly ordered in clinical practice to evaluate for inflammation. CRP is a more sensitive and specific test for detecting acute phase inflammation, and the American Society for ... ...

Abstract	Erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) are commonly ordered in clinical practice to evaluate for inflammation. CRP is a more sensitive and specific test for detecting acute phase inflammation, and the American Society for Clinical Pathology recommends ordering CRP rather than ESR to detect acute phase inflammation in patients with undiagnosed conditions. We sought to understand CRP and ESR ordering practices and reduce unnecessary use of ESR testing at our academic medical centre. We surveyed physician leaders in clinical areas with high utilisation of ESR testing to understand the drivers of potential overutilisation of these tests. Based on survey responses, we designed an intervention focused on education, clinical decision support within the electronic medical record and quarterly audit and feedback. We evaluated appropriateness of ESR ordering before and after the intervention via structured chart audit. Comparison of monthly rates of ESR tests during the preintervention and postintervention periods was conducted using interrupted time series analysis. Clinical habit and ease of test ordering were identified as key drivers of ESR overuse. Compared with the preintervention period, we observed a 33% reduction in the number of ESR tests per month and a 25% reduction in combined CRP and ESR tests per month during the postintervention period. This reduction corresponded to an annual avoidance of 2633 ESR tests with a corresponding estimated direct cost avoidance of $23 701 annually. Although the rate of ESR testing decreased, there was no significant improvement in the clinical appropriateness of residual ESR test ordering following the intervention. A multifaceted intervention was associated with significant decreases in unnecessary ESR tests and concurrent ESR and CRP tests at our academic medical centre. Despite these reductions, there are continued opportunities to reduce inappropriate ESR testing.
MeSH term(s)	Academic Medical Centers/organization & administration ; Academic Medical Centers/statistics & numerical data ; Blood Sedimentation ; C-Reactive Protein/analysis ; Clinical Laboratory Techniques/methods ; Clinical Laboratory Techniques/standards ; Clinical Laboratory Techniques/trends ; Decision Support Systems, Clinical ; Disease Progression ; Feedback ; Humans ; Inflammation/blood ; Inflammation/diagnosis ; Inflammation/physiopathology ; Interrupted Time Series Analysis
Chemical Substances	C-Reactive Protein (9007-41-4)
Language	English
Publishing date	2020-02-25
Publishing country	England
Document type	Journal Article
ISSN	2399-6641
ISSN (online)	2399-6641
DOI	10.1136/bmjoq-2019-000788
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Article: Moderate intrinsic phenotypic alterations in

Lorenzini, Ileana / Alsop, Eric / Levy, Jennifer / Gittings, Lauren M / Lall, Deepti / Rabichow, Benjamin E / Moore, Stephen / Pevey, Ryan / Bustos, Lynette M / Burciu, Camelia / Bhatia, Divya / Singer, Mo / Saul, Justin / McQuade, Amanda / Tzioras, Makis / Mota, Thomas A / Logemann, Amber / Rose, Jamie / Almeida, Sandra /

Gao, Fen-Biao / Marks, Michael / Donnelly, Christopher J / Hutchins, Elizabeth / Hung, Shu-Ting / Ichida, Justin / Bowser, Robert / Spires-Jones, Tara / Blurton-Jones, Mathew / Gendron, Tania F / Baloh, Robert H / Van Keuren-Jensen, Kendall / Sattler, Rita

Frontiers in cellular neuroscience

2023 Volume 17, Page(s) 1179796

Abstract: While motor and cortical neurons are affected ... ...

Abstract	While motor and cortical neurons are affected in
Language	English
Publishing date	2023-06-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452963-1
ISSN	1662-5102
ISSN	1662-5102
DOI	10.3389/fncel.2023.1179796
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Article ; Online: Promoting appropriate utilisation of laboratory tests for inflammation at an academic medical centre

Kristen J Bartlett / Ann P Vo / Justin Rueckert / Christina Wojewoda / Elizabeth H Steckel / Justin Stinnett-Donnelly / Allen B Repp

BMJ Open Quality, Vol 9, Iss

2020 Volume 1

Abstract	Erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) are commonly ordered in clinical practice to evaluate for inflammation. CRP is a more sensitive and specific test for detecting acute phase inflammation, and the American Society for Clinical Pathology recommends ordering CRP rather than ESR to detect acute phase inflammation in patients with undiagnosed conditions. We sought to understand CRP and ESR ordering practices and reduce unnecessary use of ESR testing at our academic medical centre. We surveyed physician leaders in clinical areas with high utilisation of ESR testing to understand the drivers of potential overutilisation of these tests. Based on survey responses, we designed an intervention focused on education, clinical decision support within the electronic medical record and quarterly audit and feedback. We evaluated appropriateness of ESR ordering before and after the intervention via structured chart audit. Comparison of monthly rates of ESR tests during the preintervention and postintervention periods was conducted using interrupted time series analysis. Clinical habit and ease of test ordering were identified as key drivers of ESR overuse. Compared with the preintervention period, we observed a 33% reduction in the number of ESR tests per month and a 25% reduction in combined CRP and ESR tests per month during the postintervention period. This reduction corresponded to an annual avoidance of 2633 ESR tests with a corresponding estimated direct cost avoidance of $23 701 annually. Although the rate of ESR testing decreased, there was no significant improvement in the clinical appropriateness of residual ESR test ordering following the intervention. A multifaceted intervention was associated with significant decreases in unnecessary ESR tests and concurrent ESR and CRP tests at our academic medical centre. Despite these reductions, there are continued opportunities to reduce inappropriate ESR testing.
Keywords	Medicine (General) ; R5-920
Subject code	310
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Harm minimization in severe and enduring anorexia nervosa.

Russell, Janice / Mulvey, Bridget / Bennett, Hayley / Donnelly, Brooke / Frig, Elizabeth

International review of psychiatry (Abingdon, England)

2019 Volume 31, Issue 4, Page(s) 391–402

Abstract: For many sufferers of anorexia nervosa, the time course is long, and the prospect of disability and family burden great. This is all too often the case, even with early diagnosis and treatment. The term severe and enduring anorexia nervosa has been ... ...

Abstract	For many sufferers of anorexia nervosa, the time course is long, and the prospect of disability and family burden great. This is all too often the case, even with early diagnosis and treatment. The term severe and enduring anorexia nervosa has been applied to these survivors. Yet, a majority of patients do eventually recover and, even where this is not the case, adaptive medical stability and function can be maintained despite alarming dilapidation. Managing the years of illness so as to have the best outcome physically and psychologically, even where full weight recovery does not occur, or has not yet occurred, is the topic of this article. Literature pertaining to harm minimization in chronic, severe, enduring, and long-standing anorexia nervosa was selectively reviewed using an Ovid data base and Google Scholar. The authors' own clinical experience over almost four decades in public and private hospital and community settings has also informed much of what has been written. The authors would like to think that it is possible to do better than the familiar injunction (variously attributed to Hippocrates, Galen, and others) of '
MeSH term(s)	Anorexia Nervosa/rehabilitation ; Anorexia Nervosa/therapy ; Harm Reduction ; Humans ; Patient Education as Topic ; Psychotherapy ; Social Support
Language	English
Publishing date	2019-05-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1018090-4
ISSN	1369-1627 ; 0954-0261
ISSN (online)	1369-1627
ISSN	0954-0261
DOI	10.1080/09540261.2019.1601073
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Article ; Online: A polygenic risk score added to a QRISK®2 cardiovascular disease risk calculator demonstrated robust clinical acceptance and clinical utility in the primary care setting.

Fuat, Ahmet / Adlen, Ella / Monane, Mark / Coll, Ruth / Groves, Sarah / Little, Elizabeth / Wild, Jonathan / Kamali, Farzan J / Soni, Yusuf / Haining, Shona / Riding, Helen / Riveros-Mckay, Fernando / Peneva, Iliana / Lachapelle, Alexander / Giner-Delgado, Carla / Weale, Michael E / Plagnol, Vincent / Harrison, Seamus / Donnelly, Peter

European journal of preventive cardiology

2024 Volume 31, Issue 6, Page(s) 716–722

Abstract: Aims: The aim of the study was to assess the real-world feasibility, acceptability, and impact of an integrated risk tool for cardiovascular disease (CVD IRT, combining the standard QRISK®2 risk algorithm with a polygenic risk score), implemented within ...

Abstract	Aims: The aim of the study was to assess the real-world feasibility, acceptability, and impact of an integrated risk tool for cardiovascular disease (CVD IRT, combining the standard QRISK®2 risk algorithm with a polygenic risk score), implemented within routine primary practice in the UK National Health Service. Methods and results: The Healthcare Evaluation of Absolute Risk Testing Study (NCT05294419) evaluated participants undergoing primary care health checks. Both QRISK2 and CVD IRT scores were returned to the healthcare providers (HCPs), who then communicated the results to participants. The primary outcome of the study was feasibility of CVD IRT implementation. Secondary outcomes included changes in CVD risk (QRISK2 vs. CVD IRT) and impact of the CVD IRT on clinical decision-making. A total of 832 eligible participants (median age 55 years, 62% females, 97.5% White ethnicity) were enrolled across 12 UK primary care practices. Cardiovascular disease IRT scores were obtained on 100% of the blood samples. Healthcare providers stated that the CVD IRT could be incorporated into routine primary care in a straightforward manner in 90.7% of reports. Participants stated they were 'likely' or 'very likely' to recommend the use of this test to their family or friends in 86.9% of reports. Participants stated that the test was personally useful (98.8%) and that the results were easy to understand (94.6%). When CVD IRT exceeded QRISK2, HCPs planned changes in management for 108/388 (27.8%) of participants and 47% (62/132) of participants with absolute risk score changes of >2%. Conclusion: Amongst HCPs and participants who agreed to the trial of genetic data for refinement of clinical risk prediction in primary care, we observed that CVD IRT implementation was feasible and well accepted. The CVD IRT results were associated with planned changes in prevention strategies.
MeSH term(s)	Female ; Humans ; Middle Aged ; Male ; Genetic Risk Score ; Cardiovascular Diseases/prevention & control ; State Medicine ; Risk Factors ; Primary Health Care
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2626011-6
ISSN	2047-4881 ; 2047-4873
ISSN (online)	2047-4881
ISSN	2047-4873
DOI	10.1093/eurjpc/zwae004
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Article ; Online: Household characteristics associated with surface contamination of SARS-CoV-2 and frequency of RT-PCR and viral culture positivity-California and Colorado, 2021.

Shragai, Talya / Pratt, Caroline / Castro Georgi, Joaudimir / Donnelly, Marisa A P / Schwartz, Noah G / Soto, Raymond / Chuey, Meagan / Chu, Victoria T / Marcenac, Perrine / Park, Geun Woo / Ahmad, Ausaf / Albanese, Bernadette / Totten, Sarah Elizabeth / Austin, Brett / Bunkley, Paige / Cherney, Blake / Dietrich, Elizabeth A / Figueroa, Erica / Folster, Jennifer M /

Godino, Claire / Herzegh, Owen / Lindell, Kristine / Relja, Boris / Sheldon, Sarah W / Tong, Suxiang / Vinjé, Jan / Thornburg, Natalie J / Matanock, Almea M / Hughes, Laura J / Stringer, Ginger / Hudziec, Meghan / Beatty, Mark E / Tate, Jacqueline E / Kirking, Hannah L / Hsu, Christopher H

PloS one

2022 Volume 17, Issue 10, Page(s) e0274946

Abstract: While risk of fomite transmission of SARS-CoV-2 is considered low, there is limited environmental data within households. This January-April 2021 investigation describes frequency and types of surfaces positive for SARS-CoV-2 by real-time reverse ... ...

Abstract	While risk of fomite transmission of SARS-CoV-2 is considered low, there is limited environmental data within households. This January-April 2021 investigation describes frequency and types of surfaces positive for SARS-CoV-2 by real-time reverse transcription polymerase chain reaction (RT-PCR) among residences with ≥1 SARS-CoV-2 infection, and associations of household characteristics with surface RT-PCR and viable virus positivity. Of 1232 samples from 124 households, 27.8% (n = 342) were RT-PCR positive with nightstands (44.1%) and pillows (40.9%) most frequently positive. SARS-CoV-2 lineage, documented household transmission, greater number of infected persons, shorter interval between illness onset and sampling, total household symptoms, proportion of infected persons ≤12 years old, and persons exhibiting upper respiratory symptoms or diarrhea were associated with more positive surfaces. Viable virus was isolated from 0.2% (n = 3 samples from one household) of all samples. This investigation suggests that while SARS-CoV-2 on surfaces is common, fomite transmission risk in households is low.
MeSH term(s)	COVID-19/epidemiology ; COVID-19 Testing ; Child ; Colorado ; Humans ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2/genetics
Language	English
Publishing date	2022-10-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0274946
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Article: Targeting maladaptive overcontrol with radically open dialectical behaviour therapy in a day programme for adolescents with restrictive eating disorders: an uncontrolled case series.

Baudinet, Julian / Simic, Mima / Griffiths, Helena / Donnelly, Cecily / Stewart, Catherine / Goddard, Elizabeth

Journal of eating disorders

2020 Volume 8, Issue 1, Page(s) 68

Abstract: Background: Radically Open Dialectical Behaviour Therapy (RO-DBT) was developed to target maladaptive overcontrol, a proposed core difficulty of restrictive eating disorders. RO-DBT is now the main group treatment model at the Intensive day Treatment ... ...

Abstract	Background: Radically Open Dialectical Behaviour Therapy (RO-DBT) was developed to target maladaptive overcontrol, a proposed core difficulty of restrictive eating disorders. RO-DBT is now the main group treatment model at the Intensive day Treatment Programme (ITP), Maudsley Hospital. This ITP case series aimed to investigate whether overcontrol is associated with restrictive eating disorder symptoms in adolescents and to evaluate ITP outcomes since RO-DBT skills classes were introduced. Method: Self-report measures of eating disorder symptoms and temperament, personality and social characteristics linked to overcontrol were collected at assessment and discharge from ITP for all consecutive adolescents who attended between February 2015 and January 2019 (N = 131). Weight change, global outcomes and treatment needs post-ITP were also recorded. Results: Eating disorder symptoms at assessment were significantly correlated with overcontrol factors, including social connectedness (r = -.67), reward responsivity (r = -.54), and cognitive inflexibility (r = .52). Adolescents stayed in ITP on average 13.40 weeks. 70.8% had a Good-Intermediate outcome on Morgan-Russell scale. 4.6% did not respond and were referred to inpatient treatment from ITP. Significant improvements in drive for thinness (d = .33), depressive mood (d = .41), social connectedness (d = .48), and emotional expressiveness (d = .97) were reported at discharge. No changes were observed in perfectionism or negative temperament. Conclusions: This study offers preliminary evidence that eating disorder symptoms are associated with overcontrol factors in adolescence and that they can improve with RO-DBT informed day programme treatment. RO-DBT is a promising treatment that offers a new way of conceptualising treatment targets and recovery for adolescent restrictive eating disorders.
Language	English
Publishing date	2020-11-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2699357-0
ISSN	2050-2974
ISSN	2050-2974
DOI	10.1186/s40337-020-00338-9
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