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  1. Article: Acute Kidney Injury in the Patient with Cancer.

    Meraz-Munoz, Alejandro / Langote, Amit / D Jhaveri, Kenar / Izzedine, Hassane / Gudsoorkar, Prakash

    Diagnostics (Basel, Switzerland)

    2021  Volume 11, Issue 4

    Abstract: Over the last three decades, advancements in the diagnosis, treatment, and supportive care of patients with cancer have significantly improved their overall survival. However, these advancements have also led to a higher rate of cancer-related ... ...

    Abstract Over the last three decades, advancements in the diagnosis, treatment, and supportive care of patients with cancer have significantly improved their overall survival. However, these advancements have also led to a higher rate of cancer-related complications. Acute kidney injury (AKI) and chronic kidney disease (CKD) are highly prevalent in patients with cancer, and they are associated with an increased risk of all-cause mortality. This bidirectional interplay between cancer and kidney, termed "the kidney-cancer connection" has become a very active area of research. This review aims to provide an overview of some of the most common causes of AKI in patients with cancer. Cancer therapy-associated AKI is beyond the scope of this review and will be discussed separately.
    Language English
    Publishing date 2021-03-29
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics11040611
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Tubulointerstitial nephritis and uveitis syndrome (TINU): a step forward to understanding an elusive oculorenal syndrome.

    Izzedine, Hassane

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2008  Volume 23, Issue 4, Page(s) 1095–1097

    MeSH term(s) Diagnosis, Differential ; Humans ; Nephritis, Interstitial/diagnosis ; Nephritis, Interstitial/etiology ; Syndrome ; Uveitis, Anterior/diagnosis ; Uveitis, Anterior/etiology
    Language English
    Publishing date 2008-04
    Publishing country England
    Document type Comment ; Editorial
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfm940
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2198: Show issues Location:
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  3. Article ; Online: Selpercatinib and Pseudo-Decreases in Kidney Function.

    Izzedine, Hassan / Bouderlique, Elise / Besse, Benjamin

    The New England journal of medicine

    2024  Volume 390, Issue 13, Page(s) 1241–1243

    MeSH term(s) Humans ; Pyrazoles ; Pyridines ; Urinary Tract Physiological Phenomena ; Kidney ; Lung Neoplasms ; Protein Kinase Inhibitors
    Chemical Substances selpercatinib (CEGM9YBNGD) ; Pyrazoles ; Pyridines ; Protein Kinase Inhibitors
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2400216
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  4. Article ; Online: Acute Kidney Injury in the Patient with Cancer

    Alejandro Meraz-Munoz / Amit Langote / Kenar D. Jhaveri / Hassane Izzedine / Prakash Gudsoorkar

    Diagnostics, Vol 11, Iss 611, p

    2021  Volume 611

    Abstract: Over the last three decades, advancements in the diagnosis, treatment, and supportive care of patients with cancer have significantly improved their overall survival. However, these advancements have also led to a higher rate of cancer-related ... ...

    Abstract Over the last three decades, advancements in the diagnosis, treatment, and supportive care of patients with cancer have significantly improved their overall survival. However, these advancements have also led to a higher rate of cancer-related complications. Acute kidney injury (AKI) and chronic kidney disease (CKD) are highly prevalent in patients with cancer, and they are associated with an increased risk of all-cause mortality. This bidirectional interplay between cancer and kidney, termed “the kidney–cancer connection” has become a very active area of research. This review aims to provide an overview of some of the most common causes of AKI in patients with cancer. Cancer therapy-associated AKI is beyond the scope of this review and will be discussed separately.
    Keywords acute kidney injury (AKI) ; kidney replacement therapy (KRT) ; thrombotic microangiopathy (TMA) ; hematopoietic stem cell transplant (HSCT) ; tumor lysis syndrome (TLS) ; Medicine (General) ; R5-920
    Subject code 610 ; 616
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Toxicités rénales des thérapies ciblées en oncologie.

    Izzedine, Hassan

    Nephrologie & therapeutique

    2019  Volume 16, Issue 1, Page(s) 1–8

    Abstract: The advent of new molecules oncology including targeted therapies, has resulted in improved patient survival over standard chemotherapy. The renal toxicities of these anticancer agents are more and more recognized and vary according to the targeted ... ...

    Title translation Renal toxicities of targeted therapies in oncology.
    Abstract The advent of new molecules oncology including targeted therapies, has resulted in improved patient survival over standard chemotherapy. The renal toxicities of these anticancer agents are more and more recognized and vary according to the targeted therapeutic target. This article reviews the renal toxicity associated with targeted anticancer therapies directed against Epidermal growth factor receptor, Human epidermal growth factor-2, B-rapidly accelerated fibrosarcoma, Mitogen-activated protein kinase, Anaplastic lymphoma kinase, Programmed cell death-1/programmed cell death ligand-1, Cytotoxic T lymphocyte antigen-4 and Vascular endothelial growth factor/receptor. The early diagnosis and management of these renal adverse events is essential for the clinician who cares for such patients.
    MeSH term(s) ErbB Receptors/antagonists & inhibitors ; Humans ; Kidney Diseases/chemically induced ; Molecular Targeted Therapy/adverse effects ; Neoplasms/drug therapy ; Receptor, ErbB-2/antagonists & inhibitors
    Chemical Substances EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language French
    Publishing date 2019-12-06
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1016/j.nephro.2019.06.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Transposition of the great arteries and autosomal-dominant polycystic kidney disease.

    Izzedine, Hassane / Rottembourg, Jacques

    Clinical kidney journal

    2013  Volume 6, Issue 3, Page(s) 350–351

    Language English
    Publishing date 2013-05-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sft050
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    Zs.A 6587: Show issues Location:
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  7. Article ; Online: Pathophysiology and Pathology of Acute Kidney Injury in Patients With COVID-19.

    Ng, Jia H / Bijol, Vanesa / Sparks, Matthew A / Sise, Meghan E / Izzedine, Hassane / Jhaveri, Kenar D

    Advances in chronic kidney disease

    2020  Volume 27, Issue 5, Page(s) 365–376

    Abstract: Acute kidney injury (AKI) is common among hospitalized patients with Coronavirus Infectious Disease 2019 (COVID-19), with the occurrence of AKI ranging from 0.5% to 80%. The variability in the occurrence of AKI has been attributed to the difference in ... ...

    Abstract Acute kidney injury (AKI) is common among hospitalized patients with Coronavirus Infectious Disease 2019 (COVID-19), with the occurrence of AKI ranging from 0.5% to 80%. The variability in the occurrence of AKI has been attributed to the difference in geographic locations, race/ethnicity, and severity of illness. AKI among hospitalized patients is associated with increased length of stay and in-hospital deaths. Even patients with AKI who survive to hospital discharge are at risk of developing chronic kidney disease or end-stage kidney disease. An improved knowledge of the pathophysiology of AKI in COVID-19 is crucial to mitigate and manage AKI and to improve the survival of patients who developed AKI during COVID-19. The goal of this article is to provide our current understanding of the etiology and the pathophysiology of AKI in the setting of COVID-19.
    MeSH term(s) Acute Kidney Injury/etiology ; Acute Kidney Injury/metabolism ; Acute Kidney Injury/pathology ; Acute Kidney Injury/physiopathology ; Anti-Bacterial Agents/adverse effects ; Antiviral Agents/adverse effects ; Apolipoprotein L1/genetics ; Ascorbic Acid/adverse effects ; Azotemia/metabolism ; Azotemia/pathology ; Azotemia/physiopathology ; COVID-19/metabolism ; COVID-19/pathology ; COVID-19/physiopathology ; Cytokines/metabolism ; Disease Progression ; Glomerulonephritis/metabolism ; Glomerulonephritis/pathology ; Glomerulonephritis/physiopathology ; Glomerulonephritis, Membranous/metabolism ; Glomerulonephritis, Membranous/pathology ; Glomerulonephritis, Membranous/physiopathology ; Hospital Mortality ; Humans ; Kidney Tubules, Proximal/injuries ; Length of Stay ; Myoglobin/metabolism ; Nephritis, Interstitial/metabolism ; Nephritis, Interstitial/pathology ; Nephritis, Interstitial/physiopathology ; Nephrosis, Lipoid/metabolism ; Nephrosis, Lipoid/pathology ; Nephrosis, Lipoid/physiopathology ; Renal Insufficiency, Chronic ; Rhabdomyolysis/metabolism ; SARS-CoV-2 ; Severity of Illness Index ; Thrombotic Microangiopathies/metabolism ; Thrombotic Microangiopathies/pathology ; Thrombotic Microangiopathies/physiopathology ; Vitamins/adverse effects ; COVID-19 Drug Treatment
    Chemical Substances Anti-Bacterial Agents ; Antiviral Agents ; Apolipoprotein L1 ; Cytokines ; Myoglobin ; Vitamins ; Ascorbic Acid (PQ6CK8PD0R)
    Language English
    Publishing date 2020-10-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ISSN 1548-5609 ; 1548-5595
    ISSN (online) 1548-5609
    ISSN 1548-5595
    DOI 10.1053/j.ackd.2020.09.003
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4627: Show issues Location:
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  8. Article ; Online: Néphrotoxicité médicamenteuse.

    Izzedine, Hassan

    Nephrologie & therapeutique

    2018  Volume 14, Issue 3, Page(s) 127–134

    Abstract: Drug-induced nephrotoxicity (DIN) remains a current problem with economic and medical consequences. It affects all nephron segments. Recovery of renal function is based on the identification of risk factors, early diagnosis of renal disease, rapid (if ... ...

    Title translation Drug nephrotoxicity.
    Abstract Drug-induced nephrotoxicity (DIN) remains a current problem with economic and medical consequences. It affects all nephron segments. Recovery of renal function is based on the identification of risk factors, early diagnosis of renal disease, rapid (if possible) cessation of the causative agent and, in some cases, adjunctive therapy. Prevention is based on identification of early markers of DIN, correction of risk factors, initial assessment of renal function for adequate dosage adjustment and exclusion of other nephrotoxic factors. It has recently been proposed to standardize the phenotype of iatrogenic renal disease and, on the other hand, new markers of renal toxicity allowing early diagnosis and therefore better management of nephrotoxicity.
    MeSH term(s) Biomarkers/blood ; Early Diagnosis ; Humans ; Iatrogenic Disease ; Kidney/drug effects ; Kidney/pathology ; Kidney Diseases/chemically induced ; Kidney Diseases/diagnosis ; Phenotype ; Risk Factors
    Chemical Substances Biomarkers
    Language French
    Publishing date 2018-03-11
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1016/j.nephro.2017.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Nephrocalcinosis in primary Sjögren's syndrome.

    Gharbi, Chems / Rottembourg, Jacques / Izzedine, Hassane

    Clinical kidney journal

    2014  Volume 7, Issue 2, Page(s) 217

    Language English
    Publishing date 2014-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfu002
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    Zs.A 6587: Show issues Location:
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  10. Article: Hypertension and Angiotensin System Inhibitors in Patients with Metastatic Renal Cell Carcinoma.

    Derosa, Lisa / Izzedine, Hassane / Albiges, Laurence / Escudier, Bernard

    Oncology reviews

    2016  Volume 10, Issue 2, Page(s) 298

    Abstract: Arterial hypertension (HTN) is a class effect of anti-vascular endothelial growth factor (VEGF) therapies, including the monoclonal antibody bevacizumab. Data are conflicting regarding the role of the renin-angiotensin system on angiogenesis and recent ... ...

    Abstract Arterial hypertension (HTN) is a class effect of anti-vascular endothelial growth factor (VEGF) therapies, including the monoclonal antibody bevacizumab. Data are conflicting regarding the role of the renin-angiotensin system on angiogenesis and recent data suggest that the use of angiotensin system inhibitors (ASIs; angiotensin receptor blockers or angiotensin-converting enzyme inhibitors) is associated with improved survival in metastatic renal cell carcinoma (mRCC), particularly when used with VEGF targeted therapies. The aim of this review is to discuss the available treatment options for mRCC and associated incidence of hypertension as well as summarize the known data about ASIs use and mRCC. Additionally, given that the optimal management of HTN remains unclear, we will focus on prevention strategies and propose potential therapeutic approaches.
    Language English
    Publishing date 2016-11-24
    Publishing country Italy
    Document type Review ; Journal Article
    ZDB-ID 2390302-8
    ISSN 1970-5565 ; 1970-5565 ; 1970-5557
    ISSN (online) 1970-5565
    ISSN 1970-5565 ; 1970-5557
    DOI 10.4081/oncol.2016.298
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    Zs.A 6550: Show issues Location:
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