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  1. Article ; Online: Hepatopulmonary Syndrome: A Forgotten Liver-induced Lung Vascular Disorder.

    Rodríguez-Roisin, Robert

    Archivos de bronconeumologia

    2022  Volume 59, Issue 3, Page(s) 137–138

    MeSH term(s) Humans ; Hepatopulmonary Syndrome ; Lung/blood supply ; Liver Transplantation
    Language Spanish
    Publishing date 2022-12-23
    Publishing country Spain
    Document type Editorial
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2022.12.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mechanisms of hypoxaemia in severe pulmonary hypertension associated with COPD.

    Piccari, Lucilla / Blanco, Isabel / Torralba, Yolanda / Arismendi, Ebymar / Gistau, Concepción / Ramírez, Ana / Gimeno-Santos, Elena / Roca, Josep / Burgos, Felip / Rodríguez-Roisín, Roberto / Barberà, Joan Albert

    The European respiratory journal

    2023  Volume 62, Issue 1

    MeSH term(s) Humans ; Hypertension, Pulmonary/complications ; Hypoxia/complications ; Respiration Disorders/complications ; Pulmonary Disease, Chronic Obstructive/complications ; Oxygen
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-07-20
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.00463-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hepatopulmonary Disorders: Gas Exchange and Vascular Manifestations in Chronic Liver Disease.

    Rodríguez-Roisin, Robert / Krowka, Michael J / Agustí, Alvar

    Comprehensive Physiology

    2018  Volume 8, Issue 2, Page(s) 711–729

    Abstract: This review concentrates on the determinants of gas exchange abnormalities in liver-induced pulmonary vascular disorders, more specifically in the hepatopulmonary syndrome. Increased alveolar-arterial ... ...

    Abstract This review concentrates on the determinants of gas exchange abnormalities in liver-induced pulmonary vascular disorders, more specifically in the hepatopulmonary syndrome. Increased alveolar-arterial O
    MeSH term(s) Hemodynamics ; Hepatopulmonary Syndrome/diagnosis ; Hepatopulmonary Syndrome/physiopathology ; Hepatopulmonary Syndrome/therapy ; Humans ; Liver Transplantation ; Pressure ; Pulmonary Gas Exchange/physiology ; Vasoconstriction/physiology ; Ventilation-Perfusion Ratio
    Language English
    Publishing date 2018-03-25
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2040-4603
    ISSN (online) 2040-4603
    DOI 10.1002/cphy.c170020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Arguments against inhaled glucocorticoids in COPD by phenotype instead of by severity.

    Rodríguez-Roisin, Robert

    Archivos de bronconeumologia

    2011  Volume 47, Issue 6, Page(s) 269–270

    MeSH term(s) Administration, Inhalation ; Glucocorticoids/administration & dosage ; Humans ; Phenotype ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/genetics ; Severity of Illness Index
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2011-06
    Publishing country Spain
    Document type Editorial
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2011.03.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Enriched Systemic Biomarkers in Symptomatic Unobstructed Smokers: Moving Forward?

    Rodriguez-Roisin, Roberto / Celli, Bartolome R

    Chest

    2019  Volume 155, Issue 5, Page(s) 886–887

    MeSH term(s) Biomarkers ; Humans ; Inflammation ; Smokers ; Spirometry
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-05-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2019.02.314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Nonpulmonary influences on gas exchange.

    Rodriguez-Roisin, Roberto

    Comprehensive Physiology

    2014  Volume 4, Issue 4, Page(s) 1455–1494

    Abstract: There are several determinants governing arterial and mixed venous blood PO2 and PCO2. Ventilation-perfusion imbalance, increased intrapulmonary shunt, and diffusion limitation to oxygen encompass the pulmonary factors. Alternatively, inspired oxygen ... ...

    Abstract There are several determinants governing arterial and mixed venous blood PO2 and PCO2. Ventilation-perfusion imbalance, increased intrapulmonary shunt, and diffusion limitation to oxygen encompass the pulmonary factors. Alternatively, inspired oxygen concentration, overall ventilation, cardiac output, and oxygen consumption (uptake) are contemplated as the four most influential nonpulmonary determinants. All three pulmonary factors plus oxygen uptake cannot be directly modulated, but all the other remaining nonpulmonary determinants are. Inspired oxygen concentration, the amount and pattern of total ventilation, and cardiac output may be, at least in part, relatively well clinically controlled. Arterial PO2 (PaO2) may fall if inspired PO2, overall ventilation, and/or cardiac output decrease, and/or oxygen consumption increases, even though the pulmonary factors remain unchanged. Conversely, if inspired oxygen fraction, ventilation, and/or cardiac output increase, and/or oxygen consumption decreases, PaO2 may improve regardless of the changes operated at the level of the pulmonary determinants. Several pathophysiologic features deserve to be underlined. First, the importance of understanding the role played by mixed venous PO2 as a vital nonpulmonary determinant governing PaO2. Second, the response to 100% oxygen breathing repeatedly exhibits a consistent amount of agreement in the main findings. Third, there is always an interactive interplay between pulmonary and nonpulmonary determinants of PaO2 and arterial PCO2 (PaCO2) in any respiratory disease state following the use of pharmacologic or nonpharmacologic approaches. All in all both PaO2 and PaCO2 become the end-point outcomes of the complex interaction of pulmonary and nonpulmonary factors modulating pulmonary gas exchange. This needs to be unraveled to improve the understanding and management of most acute and chronic respiratory disease states.
    MeSH term(s) Animals ; Carbon Dioxide/blood ; Hemodynamics ; Humans ; Hypoxia/metabolism ; Hypoxia/physiopathology ; Oxygen/blood ; Oxygen Consumption ; Pulmonary Gas Exchange
    Chemical Substances Carbon Dioxide (142M471B3J) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2014-10
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2040-4603
    ISSN (online) 2040-4603
    DOI 10.1002/cphy.c100001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The GOLD initiative 2011: a change of paradigm?

    Rodríguez-Roisin, Roberto / Agustí, Alvar

    Archivos de bronconeumologia

    2012  Volume 48, Issue 8, Page(s) 286–289

    Abstract: Ten years after the publication of the first GOLD strategy (Global Strategy for the Diagnosis, Management, and Prevention of COPD) for chronic obstructive pulmonary disease (COPD), the new revision published on the GOLD website at the end of 2011 ... ...

    Abstract Ten years after the publication of the first GOLD strategy (Global Strategy for the Diagnosis, Management, and Prevention of COPD) for chronic obstructive pulmonary disease (COPD), the new revision published on the GOLD website at the end of 2011 represents a significant change in the diagnostic approach, clinical evaluation and therapeutic treatment of the disease. This revision debates not only the most significant aspects, which remain relatively intact, but also, and in particular, those that have been substantially modified compared with the GOLD revision from 2006.
    MeSH term(s) Air Pollution, Indoor/adverse effects ; Comorbidity ; Consensus Development Conferences as Topic ; Disease Management ; Goals ; Health Promotion ; Humans ; International Cooperation ; Oxygen Inhalation Therapy ; Practice Guidelines as Topic ; Pulmonary Disease, Chronic Obstructive/classification ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/prevention & control ; Pulmonary Disease, Chronic Obstructive/therapy ; Respiration, Artificial ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/therapy ; Risk ; Severity of Illness Index ; Smoking Prevention ; Spirometry
    Language Spanish
    Publishing date 2012-08
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2012.02.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Goals of COPD treatment: Focus on symptoms and exacerbations.

    Vogelmeier, Claus F / Román-Rodríguez, Miguel / Singh, Dave / Han, MeiLan K / Rodríguez-Roisin, Roberto / Ferguson, Gary T

    Respiratory medicine

    2020  Volume 166, Page(s) 105938

    Abstract: Chronic obstructive pulmonary disease (COPD) is currently a leading cause of death worldwide, and its burden is expected to rise in the coming years. Common COPD symptoms include dyspnea, cough and/or sputum production. Some patients may experience acute ...

    Abstract Chronic obstructive pulmonary disease (COPD) is currently a leading cause of death worldwide, and its burden is expected to rise in the coming years. Common COPD symptoms include dyspnea, cough and/or sputum production. Some patients may experience acute worsening of symptoms (known as an exacerbation), and therefore require additional therapy. Exacerbations are mainly triggered by respiratory infections and environmental factors. Healthcare professionals face many challenges in COPD management, including the heterogeneity of the disease and under-reporting of symptoms. The authors review these challenges and provide recommendations for the best methods to assess COPD. The goals of COPD treatment include recognising the impact that both symptoms and exacerbations have on patients' lives when considering optimal patient-focused management. The review discusses the need for COPD management strategies to include both pharmacologic and non-pharmacologic approaches and provides recommendations for monitoring treatment outcomes and adjusting management strategies accordingly. Novel treatment strategies including precision medicine and point-of-care testing are also discussed.
    MeSH term(s) Disease Progression ; Humans ; Monitoring, Physiologic ; Point-of-Care Systems ; Precision Medicine ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/etiology ; Pulmonary Disease, Chronic Obstructive/therapy ; Quality of Life ; Treatment Outcome
    Language English
    Publishing date 2020-03-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1003348-8
    ISSN 1532-3064 ; 0954-6111
    ISSN (online) 1532-3064
    ISSN 0954-6111
    DOI 10.1016/j.rmed.2020.105938
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Latin American Thoracic Association (ALAT): 30 Years of History.

    Torres-Duque, Carlos A / Casas, Alejandro / Zabert, Gustavo / Jardim, José R / Celli, Bartolomé / Rodríguez-Roisin, Roberto

    Archivos de bronconeumologia

    2020  Volume 56, Issue 7, Page(s) 413–415

    Title translation Asociación Latinoamericana del Tórax (ALAT): 30 años de historia.
    MeSH term(s) Humans ; Latin America ; Pulmonary Disease, Chronic Obstructive
    Language Spanish
    Publishing date 2020-03-31
    Document type Editorial
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2020.02.005
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  10. Article ; Online: Enfermedad pulmonar obstructiva crónica: la década prodigiosa. Implicaciones para su diagnóstico, prevención y tratamiento.

    López-Giraldo, Alejandra / Rodríguez-Roisin, Robert / Agustí, Alvar

    Medicina clinica

    2015  Volume 144, Issue 11, Page(s) 507–513

    Abstract: Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous illness, which causes an important socio-economic burden. The last decade has witnessed significant advances in the understanding and knowledge of COPD with a paradigm shift in ... ...

    Title translation Chronic obstructive pulmonary disease: The golden decade. Implications for the diagnosis, prevention and treatment of chronic obstructive pulmonary disease.
    Abstract Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous illness, which causes an important socio-economic burden. The last decade has witnessed significant advances in the understanding and knowledge of COPD with a paradigm shift in both the assessment and management of the disease. The article here reviews these changes with a particular focus on the last revision (2013) of the Global Strategy for the Diagnosis, Management, and Prevention of chronic obstructive pulmonary disease.
    MeSH term(s) Air Pollutants/adverse effects ; Anti-Inflammatory Agents/therapeutic use ; Bronchodilator Agents/therapeutic use ; Combined Modality Therapy ; Disease Management ; Disease Progression ; Exercise ; Humans ; Lung Transplantation ; Oxygen Inhalation Therapy ; Pneumonectomy/methods ; Practice Guidelines as Topic ; Pulmonary Disease, Chronic Obstructive/classification ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/therapy ; Respiration, Artificial ; Severity of Illness Index ; Spirometry ; Surveys and Questionnaires ; Tobacco Smoke Pollution/adverse effects ; Tobacco Smoke Pollution/prevention & control ; United States
    Chemical Substances Air Pollutants ; Anti-Inflammatory Agents ; Bronchodilator Agents ; Tobacco Smoke Pollution
    Language Spanish
    Publishing date 2015-06-08
    Publishing country Spain
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2014.03.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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