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  1. Article ; Online: The m

    Macveigh-Fierro, Daniel / Cicerchia, Angelina / Cadorette, Ashley / Sharma, Vasudha / Muller, Mandy

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 8

    Abstract: The role of N6-methyladenosine (m ...

    Abstract The role of N6-methyladenosine (m
    MeSH term(s) Adenosine/analogs & derivatives ; Adenosine/genetics ; Adenosine/metabolism ; Cell Line, Tumor ; Endoribonucleases/genetics ; Endoribonucleases/metabolism ; Gene Expression/genetics ; Gene Expression Regulation, Viral/genetics ; HEK293 Cells ; Herpesviridae Infections/genetics ; Herpesviridae Infections/virology ; Herpesvirus 8, Human/genetics ; Herpesvirus 8, Human/pathogenicity ; Humans ; Interleukin-6/genetics ; Interleukin-6/metabolism ; Methylation ; RNA Helicases/genetics ; RNA Helicases/metabolism ; RNA Stability/genetics ; RNA Stability/physiology ; RNA, Messenger/metabolism ; RNA, Viral/genetics ; Viral Proteins/metabolism ; Virus Replication/genetics
    Chemical Substances Interleukin-6 ; RNA, Messenger ; RNA, Viral ; Viral Proteins ; N-methyladenosine (CLE6G00625) ; Endoribonucleases (EC 3.1.-) ; RNA Helicases (EC 3.6.4.13) ; YTHDC2 protein, human (EC 3.6.4.13) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2022-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2116662119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Show issues Location:
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  2. Article ; Online: 5-methylcytosine (m

    Zhang, Yuexiu / Zhang, Li-Sheng / Dai, Qing / Chen, Phylip / Lu, Mijia / Kairis, Elizabeth L / Murugaiah, Valarmathy / Xu, Jiayu / Shukla, Rajni Kant / Liang, Xueya / Zou, Zhongyu / Cormet-Boyaka, Estelle / Qiu, Jianming / Peeples, Mark E / Sharma, Amit / He, Chuan / Li, Jianrong

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 42, Page(s) e2123338119

    Abstract: 5-methylcytosine (m ...

    Abstract 5-methylcytosine (m
    MeSH term(s) 5-Methylcytosine/metabolism ; Animals ; Antiviral Agents ; DEAD Box Protein 58/metabolism ; Humans ; Immunity, Innate/genetics ; Interferon Type I/genetics ; Interferons ; Ligands ; Mice ; RNA Polymerase III ; Virus Diseases ; Virus Replication/genetics
    Chemical Substances Antiviral Agents ; Interferon Type I ; Ligands ; 5-Methylcytosine (6R795CQT4H) ; Interferons (9008-11-1) ; RNA Polymerase III (EC 2.7.7.6) ; DEAD Box Protein 58 (EC 3.6.4.13)
    Language English
    Publishing date 2022-10-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2123338119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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  3. Article ; Online: Primer for Designing Main Protease (M

    Thakur, Abhishek / Sharma, Gaurav / Badavath, Vishnu Nayak / Jayaprakash, Venkatesan / Merz, Kenneth M / Blum, Galia / Acevedo, Orlando

    The journal of physical chemistry letters

    2022  Volume 13, Issue 25, Page(s) 5776–5786

    Abstract: ... upon experimentally validated inhibitors of SARS-CoV-2 main protease (M ...

    Abstract The COVID-19 outbreak has been devastating, with hundreds of millions of infections and millions of deaths reported worldwide. In response, the application of structure-activity relationships (SAR) upon experimentally validated inhibitors of SARS-CoV-2 main protease (M
    MeSH term(s) Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Cysteine Endopeptidases/metabolism ; Humans ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Peptide Hydrolases ; Protease Inhibitors/chemistry ; Protease Inhibitors/pharmacology ; SARS-CoV-2 ; Viral Nonstructural Proteins ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents ; Protease Inhibitors ; Viral Nonstructural Proteins ; Peptide Hydrolases (EC 3.4.-) ; Cysteine Endopeptidases (EC 3.4.22.-)
    Language English
    Publishing date 2022-06-21
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.2c01193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Frequency and spectrum of M

    Naaz, Neha / Choudhary, Sana / Sharma, Nidhi / Hasan, Nazarul / Al Shaye, Najla A / Abd El-Moneim, Diaa

    Frontiers in plant science

    2023  Volume 13, Page(s) 1030772

    Abstract: Trigonella foenum ... ...

    Abstract Trigonella foenum graecum
    Language English
    Publishing date 2023-01-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2022.1030772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Esterase-Activatable Synthetic M

    Malla, Javid Ahmad / Sharma, Virender Kumar / Lahiri, Mayurika / Talukdar, Pinaki

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2020  Volume 26, Issue 52, Page(s) 11946–11949

    Abstract: The formation of a supramolecular synthetic M ...

    Abstract The formation of a supramolecular synthetic M
    MeSH term(s) Apoptosis ; Autophagy ; Esterases/chemistry ; Lysosomes/chemistry ; Lysosomes/metabolism ; Neoplasms/drug therapy
    Chemical Substances Esterases (EC 3.1.-)
    Language English
    Publishing date 2020-08-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202002964
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  6. Article ; Online: Identification and molecular characterization of genes modulating progression of an oocyte from M-I to M-II in rat ovary.

    Sharma, Alka / Dubey, Pawan K / Kumar, Pradeep / Tiwari, Kavindra Nath / Tripathi, Anima

    American journal of reproductive immunology (New York, N.Y. : 1989)

    2024  Volume 91, Issue 2, Page(s) e13825

    Abstract: ... analyzed the expression pattern of regulatory genes that are involved in the transition from M-I to M-II ... play a crucial role in regulating the progression of the meiotic cell cycle from the M-I to M-II stages ... specifically during the transition from the M-I to M-II stage. It might be useful for determining biomarker ...

    Abstract Background: To achieve oocyte competence for successful fertilization, bidirectional communication between oocyte and granulosa cells is crucial. The acquisition of meiotic competency in oocyte is facilitated by various regulatory genes however, expression pattern of these genes is not well documented during meiotic transition from Metaphase-I to Metaphase-II stage. Therefore, the present research analyzed the expression pattern of regulatory genes that are involved in the transition from M-I to M-II stages in rat oocyte.
    Methods: The analysis of the data was conducted by applying an array of bioinformatic tools. The investigation of gene group interactions was carried out by employing the STRING database, which relies on co-expression information. The gene ontology (GO) analysis was performed utilizing the comparative GO database. Functional annotation for GO and pathway enrichment analysis were performed for genes involved in networking. The GO obtained through computational simulations was subsequently validated using quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis.
    Results: The findings of our study suggest that there is a distinct gene expression pattern in both the oocyte and granulosa cells. This pattern indicates that oocyte-secreted factors, such as BMP15 and GDF9, play a crucial role in regulating the progression of the meiotic cell cycle from the M-I to M-II stages. We have also examined the level of mRNA expression of genes including CYP11A1, CYP19A1, and STAR, which are crucial for the steroidogenesis.
    Conclusions: It is fascinating to observe that the oscillatory pattern of specific key genes may hold significance in the process of in vitro oocyte maturation, specifically during the transition from the M-I to M-II stage. It might be useful for determining biomarker genes and potential pathways that play a role in attaining oocyte competency, thereby aiding in the assessment of oocyte quality for the purpose of achieving successful fertilization.
    MeSH term(s) Female ; Animals ; Rats ; Ovary ; Oocytes/physiology ; Granulosa Cells/metabolism
    Language English
    Publishing date 2024-02-04
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 604542-x
    ISSN 1600-0897 ; 0271-7352 ; 8755-8920 ; 1046-7408
    ISSN (online) 1600-0897
    ISSN 0271-7352 ; 8755-8920 ; 1046-7408
    DOI 10.1111/aji.13825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1653: Show issues Location:
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  7. Article: Tc-99 m Ubiquicidin Imaging in Orbital Aspergilloma: an Illustration.

    Angamuthu, Meivel / Damle, Nishikant / Khan, Dikhra / Meel, Rachna / Sharma, Sanjay / Bal, Chandrasekhar

    Nuclear medicine and molecular imaging

    2023  Volume 57, Issue 3, Page(s) 162–163

    Abstract: ... We demonstrate that Tc-99 m ubiquicidin scan can yield positive results in aspergillosis too, enabling ...

    Abstract Aspergillus infection is relatively rare disease, and we present a case of orbital aspergillus infection who presented with right orbital pain and swelling. Right orbital lesion was identified on CT, MRI, and PET-CT imaging followed by confirmation of aspergillus on histopathological examination. We demonstrate that Tc-99 m ubiquicidin scan can yield positive results in aspergillosis too, enabling its differentiation from non-infective pathologies.
    Language English
    Publishing date 2023-01-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2541855-5
    ISSN 1869-3482 ; 1869-3474
    ISSN (online) 1869-3482
    ISSN 1869-3474
    DOI 10.1007/s13139-022-00784-0
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  8. Article ; Online: Survival outcomes following autologous stem cell transplant with melphalan 140mg/m

    Sharma, Nidhi / Benson, Evan / Zhao, Qiuhong / Nunnelee, Jordan / Cottini, Francesca / Elder, Patrick / Rosko, Ashley / Bumma, Naresh / Khan, Abdullah / Umyarova, Elvira / Devarakonda, Srinivas / Efebera, Yvonne A / Benson, Don M

    Leukemia & lymphoma

    2023  Volume 64, Issue 7, Page(s) 1315–1321

    Abstract: ... is 200 mg/m ...

    Abstract The standard preparative regimen for autologous stem cell transplant (ASCT) in multiple myeloma (MM) is 200 mg/m
    MeSH term(s) Humans ; Melphalan/adverse effects ; Multiple Myeloma/therapy ; Multiple Myeloma/drug therapy ; Treatment Outcome ; Transplantation, Autologous ; Stem Cell Transplantation ; Hematopoietic Stem Cell Transplantation ; Transplantation Conditioning ; Disease-Free Survival
    Chemical Substances Melphalan (Q41OR9510P)
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2023.2213366
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    Zs.A 2997: Show issues Location:
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  9. Article ; Online: Sunda pangolin (M. javanica) detected for the first time in the Illegal wildlife seizures from northeast India.

    Wangmo, Lenrik Konchok / Ghosh, Avijit / Singh, Vinaya Kumar / Dolker, Stanzin / Banerjee, Dhriti / Sharma, Lalit Kumar / Thakur, Mukesh

    Forensic science international. Genetics

    2024  Volume 70, Page(s) 103023

    MeSH term(s) Animals ; Humans ; Animals, Wild ; Pangolins ; India
    Language English
    Publishing date 2024-02-03
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2493339-9
    ISSN 1878-0326 ; 1872-4973
    ISSN (online) 1878-0326
    ISSN 1872-4973
    DOI 10.1016/j.fsigen.2024.103023
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    Zs.A 6764: Show issues Location:
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  10. Article ; Online: Prevalence of CTX-M

    Koirala, Sushma / Khadka, Sujan / Sapkota, Sanjeep / Sharma, Suprina / Khanal, Santosh / Thapa, Alina / Khadka, Dhruba Kumar / Poudel, Pramod

    BioMed research international

    2021  Volume 2021, Page(s) 9958294

    Abstract: The emergence of multidrug resistant (MDR) bacteria which is attributable to extended ... ...

    Abstract The emergence of multidrug resistant (MDR) bacteria which is attributable to extended spectrum
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Cross-Sectional Studies ; Drug Resistance, Multiple, Bacterial/drug effects ; Drug Resistance, Multiple, Bacterial/physiology ; Escherichia coli/drug effects ; Escherichia coli/metabolism ; Escherichia coli Infections/drug therapy ; Escherichia coli Infections/microbiology ; Female ; Hospitals ; Humans ; Klebsiella Infections/drug therapy ; Klebsiella Infections/microbiology ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/metabolism ; Male ; Microbial Sensitivity Tests/methods ; Nepal ; Prevalence ; beta-Lactamases/metabolism
    Chemical Substances Anti-Bacterial Agents ; beta-Lactamases (EC 3.5.2.6)
    Language English
    Publishing date 2021-06-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2021/9958294
    Database MEDical Literature Analysis and Retrieval System OnLINE

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