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  1. Article ; Online: Seymour J. Klebanoff: Discoverer of WBC killing mechanisms.

    Rosen, Henry / Liles, W Conrad / Van Voorhis, Wesley C

    Proceedings of the National Academy of Sciences of the United States of America

    2016  Volume 113, Issue 46, Page(s) 12891–12892

    Language English
    Publishing date 2016-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1616687113
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    Zs.A 1148: Show issues Location:
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  2. Article ; Online: Data retrieval from archival renal biopsies using nonlinear microscopy.

    Cahill, Lucas C / Yoshitake, Tadayuki / Rosen, Milan / Weber, Timothy D / Fujimoto, James G / Rosen, Seymour

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0299506

    Abstract: Thorough examination of renal biopsies may improve understanding of renal disease. Imaging of renal biopsies with fluorescence nonlinear microscopy (NLM) and optical clearing enables three-dimensional (3D) visualization of pathology without microtome ... ...

    Abstract Thorough examination of renal biopsies may improve understanding of renal disease. Imaging of renal biopsies with fluorescence nonlinear microscopy (NLM) and optical clearing enables three-dimensional (3D) visualization of pathology without microtome sectioning. Archival renal paraffin blocks from 12 patients were deparaffinized and stained with Hoechst and Eosin for fluorescent nuclear and cytoplasmic/stromal contrast, then optically cleared using benzyl alcohol benzyl benzoate (BABB). NLM images of entire biopsy fragments (thickness range 88-660 μm) were acquired using NLM with fluorescent signals mapped to an H&E color scale. Cysts, glomeruli, exudative lesions, and Kimmelstiel-Wilson nodules were segmented in 3D and their volumes, diameters, and percent composition could be obtained. The glomerular count on 3D NLM volumes was high indicating that archival blocks could be a vast tissue resource to enable larger-scale retrospective studies. Rapid optical clearing and NLM imaging enables more thorough biopsy examination and is a promising technique for analysis of archival paraffin blocks.
    MeSH term(s) Humans ; Paraffin ; Retrospective Studies ; Microscopy, Fluorescence ; Coloring Agents ; Biopsy ; Information Storage and Retrieval ; Imaging, Three-Dimensional/methods ; Microscopy, Confocal
    Chemical Substances Paraffin (8002-74-2) ; Coloring Agents
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0299506
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  3. Article ; Online: Rapid examination of lung tissues by nonlinear microscopy.

    Sun, Yue / Weber, Timothy D / Fujimoto, James G / Rosen, Seymour / VanderLaan, Paul A

    American journal of clinical pathology

    2024  

    Abstract: Objectives: Traditional histopathology is a time-intensive and labor-intensive process involving tissue formalin fixation, paraffin embedding, and microtoming into thin sections for H&E staining. Frozen section analysis is a modality used during surgery ...

    Abstract Objectives: Traditional histopathology is a time-intensive and labor-intensive process involving tissue formalin fixation, paraffin embedding, and microtoming into thin sections for H&E staining. Frozen section analysis is a modality used during surgery to quickly evaluate tissue, but it has limitations, such as the size and number of the specimens that can be analyzed as well as difficulties with fatty and bony tissues. Our objective was to investigate the performance of nonlinear microscopy, a fluorescence microscopy technique, for the rapid examination of resected lung tumors.
    Methods: In this proof-of-principle study, nonlinear microscopy imaging of resected lung tissue was performed on a total of 73 tissue specimens collected from 13 patients who underwent lobectomy, segmentectomy, or wedge resection for pulmonary nodules.
    Results: Two pathologists reviewed the digital nonlinear microscopy images in comparison to the corresponding histopathologic H&E slides from a variety of pulmonary pathologies.
    Conclusions: This study demonstrated that nonlinear microscopy readily replicates traditional H&E staining for both lung tumors and nonneoplastic pulmonary structures. Nonlinear microscopy provides many advantages over frozen section analysis and is an optical imaging platform that has the potential to augment rapid pathologic evaluation of resected tissues in the age of digital pathology.
    Language English
    Publishing date 2024-04-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1093/ajcp/aqae046
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  4. Article ; Online: Yolk sac differentiation in urothelial carcinoma - A rare variant originating from aberrant differentiation of sarcomatoid components.

    Krishnamurthy, Kritika / Rosen, Seymour / Ye, Huihui / Sun, Yue

    Annals of diagnostic pathology

    2022  Volume 58, Page(s) 151923

    Abstract: Yolk sac differentiation occurs in somatic neoplasms of the gastrointestinal and gynecologic tracts; it has rarely been reported in urothelial carcinoma. Here, we report three cases of yolk sac differentiation in sarcomatoid urothelial carcinoma. The ... ...

    Abstract Yolk sac differentiation occurs in somatic neoplasms of the gastrointestinal and gynecologic tracts; it has rarely been reported in urothelial carcinoma. Here, we report three cases of yolk sac differentiation in sarcomatoid urothelial carcinoma. The epithelioid component of the sarcomatoid urothelial carcinoma showed divergent differentiation, including squamous, conventional glandular, small cell carcinoma, and yolk sac components. The sarcomatoid component showed malignant spindle cells admixed with focal chondroid and rhabdoid elements. In all three cases, the yolk sac areas were admixed with the sarcomatoid component and showed a glandular pattern, with vacuolated, eosinophilic cytoplasm. These areas were positive for SALL4, variably positive for glypican 3 and AFP, and negative for the conventional urothelial markers GATA3, p63, and 34βE12. Yolk sac differentiation is an extremely rare occurrence in sarcomatoid urothelial carcinoma.
    MeSH term(s) Biomarkers, Tumor ; Carcinoma, Transitional Cell/diagnosis ; Carcinoma, Transitional Cell/pathology ; Female ; Humans ; Urinary Bladder Neoplasms/pathology ; Urothelium/pathology ; Yolk Sac/pathology
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2022-02-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1440011-x
    ISSN 1532-8198 ; 1092-9134
    ISSN (online) 1532-8198
    ISSN 1092-9134
    DOI 10.1016/j.anndiagpath.2022.151923
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    Zs.A 5463: Show issues Location:
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  5. Article ; Online: Rapid Examination of Nonprocessed Renal Cell Carcinoma Using Nonlinear Microscopy.

    Guzmán-Arocho, Yaileen D / Weber, Timothy D / St Jacques, Taylor / Fujimoto, James G / Rosen, Seymour / Sun, Yue

    Archives of pathology & laboratory medicine

    2024  

    Abstract: Context.—: Histology, the traditional method of examining surgical tissue under a microscope, is a time-consuming process involving the fixation of tissue in formalin, dehydration, embedding in paraffin, and cutting into thin sections for hematoxylin- ... ...

    Abstract Context.—: Histology, the traditional method of examining surgical tissue under a microscope, is a time-consuming process involving the fixation of tissue in formalin, dehydration, embedding in paraffin, and cutting into thin sections for hematoxylin-eosin (H&E) staining. Frozen section analysis is a faster alternative used in surgery to quickly evaluate tissue, but it has limitations, such as the size of the specimens that can be analyzed and difficulties with fatty and bony tissues.
    Objective.—: To rapidly examine nonprocessed kidney tumors using nonlinear microscopy (NLM), a fluorescence microscopy technique that can rapidly visualize fresh or fixed, rapidly stained, nonprocessed tissue resembling H&E histology. This technology eliminates the need for fixation, embedding, microtome sectioning, or slide preparation.
    Design.—: In this study, a total of 190 tissue specimens were collected from 46 patients who underwent partial or radical nephrectomy.
    Results.—: Two genitourinary pathologists confirmed that diagnostically important features present in the H&E images could also be identified in the NLM images.
    Conclusions.—: The results of this study demonstrated that NLM had a high degree of correspondence with H&E staining for the classical variants of renal cell carcinoma. NLM offers several clinical benefits, such as facilitating rapid renal cell carcinoma diagnosis, assessment of targeted kidney biopsies for both tumor and medical kidney diseases, and collection of fresh renal cell carcinoma tissue for molecular studies.
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2023-0320-OA
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  6. Article ; Online: Concerning cellular and molecular pathways of renal repair after acute kidney injury.

    Rosen, Seymour / Heyman, Samuel

    Kidney international

    2018  Volume 94, Issue 1, Page(s) 218

    MeSH term(s) Acute Kidney Injury ; Humans ; Kidney
    Language English
    Publishing date 2018-06-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2018.04.001
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    Zs.A 797: Show issues Location:
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  7. Book: PATHOLOGY OF GLOMERULAR DISEASE

    Rosen, Seymour

    (CONTEMPORARY ISSUES IN SURGICAL PATHOLOGY ; V. 1)

    1983  

    Author's details EDITED BY SEYMOUR ROSEN
    Series title CONTEMPORARY ISSUES IN SURGICAL PATHOLOGY ; V. 1
    Contemporary issues in surgical pathology
    Collection Contemporary issues in surgical pathology
    Keywords GLOMERULONEPHRITIS / PATHOLOGY
    Size XII, 274 S. : ILL.
    Publisher CHURCHILL LIVINGSTONE
    Publishing place NEW YORK ; EDINBURGH
    Document type Book
    HBZ-ID HT002427494
    ISBN 0-443-08198-0 ; 978-0-443-08198-9
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1984 A 2590 order for loan Magazin

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  8. Article ; Online: Soluble Urokinase Receptor and Acute Kidney Injury.

    Schley, Gunnar / Rosen, Seymour / Heyman, Samuel N

    The New England journal of medicine

    2020  Volume 382, Issue 22, Page(s) 2167

    MeSH term(s) Acute Kidney Injury ; Humans ; Receptors, Urokinase Plasminogen Activator ; Urokinase-Type Plasminogen Activator
    Chemical Substances Receptors, Urokinase Plasminogen Activator ; Urokinase-Type Plasminogen Activator (EC 3.4.21.73)
    Language English
    Publishing date 2020-05-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2003613
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  9. Article ; Online: Diffuse WT1 Positivity in Smooth Muscle Component Supports Dual Differentiation of Mesothelial Cells in the Histogenesis of Leiomyoadenomatoid Tumors-A Report of two Cases.

    Krishnamurthy, Kritika / Merkulova, Yekaterina / Guzman-Arocho, Yaileen / Rosen, Seymour / Sun, Yue

    International journal of surgical pathology

    2022  Volume 31, Issue 5, Page(s) 866–871

    Abstract: Leiomyoadenomatoid tumors of the epididymis are exceedingly rare biphasic tumors composed of an adenomatoid component in the form of gland-like structures lined by single flat or cuboidal cells admixed with smooth muscle. Radiological and gross findings ... ...

    Abstract Leiomyoadenomatoid tumors of the epididymis are exceedingly rare biphasic tumors composed of an adenomatoid component in the form of gland-like structures lined by single flat or cuboidal cells admixed with smooth muscle. Radiological and gross findings cannot distinguish leiomyoadenomatoid tumors from the more common classic adenomatoid tumors or leiomyomas, and careful microscopic examination is critical in the identification of this esoteric variant. The histogenesis of this entity remains ambiguous. Common hypotheses include a collision tumor, a variant of an adenomatoid tumor with a smooth muscle component, or an adenomatoid tumor arising in the background of reactive smooth muscle hyperplasia. We present 2 cases of leiomyoadenomatoid tumors with diffuse nuclear WT1 positivity in both the adenomatoid and smooth muscle components, supporting the mesothelial origin of these tumors.
    MeSH term(s) Male ; Humans ; Adenomatoid Tumor/pathology ; Adenoma ; Leiomyoma/diagnosis ; Epididymis/pathology ; Muscle, Smooth/pathology ; WT1 Proteins
    Chemical Substances WT1 protein, human ; WT1 Proteins
    Language English
    Publishing date 2022-12-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1336393-1
    ISSN 1940-2465 ; 1066-8969
    ISSN (online) 1940-2465
    ISSN 1066-8969
    DOI 10.1177/10668969221137521
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  10. Article ; Online: Rapid histological imaging of bone without microtome sectioning using nonlinear microscopy.

    Yoshitake, Tadayuki / Rosen, Seymour / Cahill, Lucas C / Lamothe, Simon / Ward, Ashley / Fujimoto, James G

    Bone

    2021  Volume 154, Page(s) 116254

    Abstract: Tissue preparation for histologic evaluation of bone is particularly lengthy, limiting its use in intraoperative or intraprocedural histological evaluation. Nonlinear microscopy (NLM) is an optical sectioning microscopy method that can visualize ... ...

    Abstract Tissue preparation for histologic evaluation of bone is particularly lengthy, limiting its use in intraoperative or intraprocedural histological evaluation. Nonlinear microscopy (NLM) is an optical sectioning microscopy method that can visualize pathology in freshly excised tissue without requiring physical microtome sectioning. This study describes a rapid protocol for NLM imaging of bone and associated cartilage. NLM imaging was performed on 71 specimens of normal bone as well as arthritic, malignant and inflammatory bone tissue from 40 patients who underwent joint replacement, amputation, bone marrow biopsy or autopsy. Specimens ranged in size from core needle biopsies to transections of entire femoral heads. Specimens were stained with acridine orange and sulforhodamine 101, nuclear and cytoplasmic/stromal fluorescent dyes, for 5 min, then rinsed for 30 s. NLM fluorescent images were displayed using colors analogous to hematoxylin and eosin (H&E) to facilitate interpretation. Pathologists examined NLM images of the specimens in real time by rapidly translating the specimen to areas of interest, similar to a standard transmission light microscope. By adjusting the NLM focus depth, images from a few-μm-thick layer could be obtained down to ~100 μm below the tissue surface, analogous to serial sectioning. Following real-time NLM imaging, the tissue was processed for conventional paraffin histology, and H&E slides were compared to recorded NLM images. Similarities and differences between NLM and paraffin H&E were assessed. NLM enabled visualization of normal bone architecture, including the lamellar matrix and osteocytes of trabecular bone, articular cartilage, as well as pathological bone features such osteoarthritis, osteomyelitis, and malignancy with an appearance resembling the paraffin H&E. Differences such as changes in cell border sharpness, cellular and nucleolar size, and color patterns were noted, suggesting that training is required for accurate evaluation of bone pathology with NLM. Irregular surface contours and debris generated by gross tissue preparation of bone can make some regions difficult to evaluate with NLM, but the ability to perform rapid three-dimensional translation and sub-surface imaging reduced these problems. NLM is a promising technique for rapid evaluation of bone pathology. Further studies assessing diagnostic performance are warranted.
    MeSH term(s) Biopsy ; Bone and Bones/diagnostic imaging ; Fluorescent Dyes ; Hematoxylin ; Humans ; Microscopy/methods
    Chemical Substances Fluorescent Dyes ; Hematoxylin (YKM8PY2Z55)
    Language English
    Publishing date 2021-11-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 632515-4
    ISSN 1873-2763 ; 8756-3282
    ISSN (online) 1873-2763
    ISSN 8756-3282
    DOI 10.1016/j.bone.2021.116254
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